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| 1 | Metadiscourse in Academic Writing: A Reappraisal显示文摘 | Ken Hyland Polly Tse | 2004 | Applied Linguistics2004，，： | 6 |
| 2 | Review of evolution of clinical, training and educational services and research program for autism spectrum disorders in Hong Kong显示文摘The evolution of a local fragmented model of services for children with autism in Hong Kong emerged gradually over the past three decades with lack of government funding or support. This had been due to increasing number of children with autism being detected and referred for earlier assessment. With increasing pressure from parents due to long waiting time for assessment and training services and the increasing polarization by mass media there had been a gradual increasing public awareness over the past five years. Though still highly fragmented in the availability of services, there is a growing 'business model' available in the community due to increasing need and lack of public funding for support. There is a lack of strategic planning for medical diagnostic and management issues in Hong Kong. Our University of Hong Kong based Autism Research Program was pioneered in 1985 based on the increasing load of autism cases referred for assessment for other developmental problems and diagnosed as Autism in the Duchess of Kent Children's Hospital. As the first author has been the staff of the University of Hong Kong, this program flourished as a research based program. The benefits of early identification and intervention of autism spectrum disorder(ASD) had been increasingly recognized, and with the increased public awareness and increasing trend of earlier diagnosis, there has been a continuously high demand from parents for earlier assessment and training for children suspected to have ASD. This model had not received extra funding for this integrated program for research, teaching and training in autism. We had to apply for various donations and grants to support the development of this pioneer program. The research output and organization of forums for public education and awareness are reviewed. The latter part of the paper reports the summary of clinical profile of autism cases(N=1441) assessed from 1985 to 2010 June under the University of Hong Kong. As the waiting time for initial developmental assessment for any children in Hong Kong is 12?24 months, we also report our preliminary experience with a newly launched triaging service provision for children suspected to be ASD since 2009, including multi-disciplinary assessment and parallel interim training in our university affiliated child assessment centre in Hong(N=89). | Virginia Chun-Nei WONG Cheuk-Wing FUNG So-Lun LEE Polly Tsz Yan WONG | 2015 | Science China(Life Sciences)2015，58，10： | 6 |
| 3 | Non-steroidal anti-inflammatory drugs and statins in relation to colorectal cancer risk显示文摘AIM:To investigate the association between individual or combined use of non-steroidal anti-inflammatory drugs(NSAIDs) or statins and colorectal cancer risk.METHODS:In a population-based case-control study in women,we examined the association between NSAIDs and statin use and the risk of colorectal cancers.We further investigated whether the use of statins modifies the protective effect of NSAIDs.Female cases(n = 669) of colorectal cancer aged 50-74 years were identified from a statewide registry in Wisconsin during 1999-2001.Community control women(n = 1375) were randomly selected from lists of licensed drivers and Medicare beneficiaries.Medication use and risk factor information were gathered during a structured telephone interview.A multivariable logistic regression model was used to calculate odds ratio(OR) and 95% conf idence interval(CI) .RESULTS:Overall,NSAIDs users had a 30% reduction in risk of colorectal cancer(95% CI:0.56-0.88) .Statin use was not associated with colorectal cancer risk(OR = 1.17,95% CI:0.74-1.85) ,regardless of structural type(lipophilic or hydrophilic) ,duration of use,or recency.There was no evidence of an interaction between NSAIDs and statins and colorectal cancer risk(P-interaction = 0.28) .CONCLUSION:Although our results confirm the inverse association between NSAIDs use and colorectal cancer risk,they do not support a risk reduction in statin users,or an interaction effect of combined NSAIDs and statin use. | Mazyar Shadman Polly A Newcomb John M Hampton Karen J Wernli Amy Trentham-Dietz | 2009 | World Journal of Gastroenterology2009，15，19： | 5 |
| 4 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 5 | Primary Hepatolithiasis, Recurrent Pyogenic Cholangitis, and Oriental Cholangiohepatitis—A Tale of 3 Countries显示文摘 | Wilson M.S. Tsui Polly W.Y. Lam Wai-ki Lee Yiu-kay Chan | 2011 | Advances in Anatomic Pathology2011，，4： | 4 |
| 6 | Association Between Molecular Subtypes of Colorectal Cancer and Patient Survival显示文摘 | Amanda I. Phipps Paul J. Limburg John A. Baron Andrea N. Burnett-Hartman Daniel J. Weisenberger Peter W. Laird Frank A. Sinicrope Christophe Rosty Daniel D. Buchanan John D. Potter Polly A. Newcomb | 2014 | Gastroenterology2014，，： | 3 |
| 7 | 2012中国城市形象广告片效果研究报告显示文摘序根据中国社会科学院城市发展与环境研究所正式发布的2012年城市蓝皮书《中国城市发展报告(2012)》的数据显示,2011年,中国城镇人口达到6.91亿,城镇化率首次突破50%关口,达到了51.27%,城镇常住人口超过了农村常住人口。人口城镇化率超过50%,这是中国社会结构的一个历史性变化,表明中国已经结束了以乡村型社会为主体的时代。 | 张华 王梦岐 宗昊 Polly Sun | 2013 | 广告大观(综合版)2013，，5： | 2 |
| 8 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 9 | Homogentisic acid γ-lactone suppresses the virulence factors of Pseudomonas aeruginosa by quenching its quorum sensing signal molecules显示文摘Bacterial quorum sensing(QS) molecules are involved in the coordination of certain behaviors such as biofilm formation, virulence and antibiotic resistance. QS molecules(autoinducers) and their corresponding receptors have been recognized as important therapeutic targets for drug-resistant infections and biofilm-associated infections(BAI). This study assessed the multiple biological effects of homogentisic acid y-lactone(HgAL), a furanone derivative. The anti-QS and anti-biofilm effects of HgAL against PAO1 strain were evaluated using CLSM, SEM, HPLC and other biochemical methods The results showed that HgAL could effectively inhibit the production of pyocyanin and extracellular matrix, as well as reduce the adherence ability and biofilm formation of Pseudomonas aeruginosa. Inhibition of virulence is attributed to the suppressive effect of HgAL on biosynthesis of 3-oxo-C_(12)-HSLand C4-HSL(two kinds of QS signaling molecules in P. aeruginosa). Our results support HgAL as a potential agent for prevention of BAI in the healthcare settings. | Shuihong Li Polly H.M. Leung Xinya Xu Chunhui Wu | 2018 | Chinese Chemical Letters2018，29，2： | 2 |
| 10 | A randomized controlled trial of topical tea tree preparation for MRSA colonized wounds显示文摘Background:The prevalence of MRSA(Methicillin-resistant Staphylococcus aureus)colonized wounds in home care residents is expected to grow continuously as a result of the substantial proportion of older people requiring institutionalized care due to chronic disease and declining functional status,which contribute to more frequent skin breakdown and wound formation.Tea tree oil has been claimed to have anti-bacterial,analgesic and anti-inflammatory effects that have been suggested in many in-vitro studies to have good efficacy against MRSA.The aims of this study were to evaluate the effectiveness of 10%topical tea tree preparation to eradicateMRSA and to ascertain its influence on wound healing forMRSA-colonized wounds.Methods:It was a randomized controlled trial,single-blind study.Those with stage II or above MRSA-colonized wounds and who had given their informed consent formed the sample.The determined sample sizewasbasedonthe effect size of our previouspilot study,whichwas 0.46.Five outcome measurements were taken for the MRSA bacterial count and wound healing condition at baseline and at 1-week intervals during the 4-week dressing intervention period.Results:Thirty-two participants were recruited from two non-government nursing homes,16 in the control group and 16 in the tea tree oil group.The control group residents received routine saline gauze dressing,while the tea tree oil group residents received the 10%topical tea tree preparation dressing.In the tea tree oil group,all chronic wounds that had previously been delayed in healing were healed within 28 days without adverse reaction.MRSA was also completely eradicated in 14(87.5%)out of 16 wounds in the group receiving the 10%topical tea tree preparation. | Rainbow L.P.Lee Polly H.M.Leung Thomas K.S.Wong | 2014 | International Journal of Nursing Sciences2014，1，1： | 2 |
| 11 | Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a southwest oncology group syudy 显示文摘 | Dennis J Ahene Polly Feigl Gang Quan | 1998 | Cancer research1998，58，： | 1 |
| 12 | Straight -forward ver- sus anatomic trajectory technique of thoracic pedicle screw fixation : a biomechanical analysis 显示文摘 | Lehman RA Jr Polly DW Jr Kuklo TR | 2003 | Spine2003，28，： | 1 |
| 13 | Effect of different cycli- ng-off criteria and positive end-expiratory pressure during pre- ssure support ventilation in patients with chronic obstructive p- ulmonary disease显示文摘 | Chiumello D Polli F Tallarini F | 2007 | Crit Care Med2007，35，11： | 1 |
| 14 | Detection of the His1069Gln mutation in Wilson' s disease by rapid poly- merase chain reaction显示文摘 | Maier-Dobeersberger T Ferenci P Polli C | 1997 | Ann Intern Med1997，127，1： | 1 |
| 15 | Debate: to fuse or not to fuse to thesacrum, the fate of the L5- S1 disc 显示文摘 | Polly DW Jr Hamill CL Bridwell KH | 2006 | Spine2006，31，19： | 1 |
| 16 | PUPPI:The Pressure Ulcer Prevention Protocol Interventions显示文摘 | Kimberly Catania Cheryl Huang Polly James | 2007 | American Journal of Nursing2007，107，4： | 1 |
| 17 | Calculations of dietary exposure to aerylamide 显示文摘 | Polly E Boon Anika de Mul Hilko van der Voet | 2005 | Mutation Research2005，580，12： | 1 |
| 18 | Cx26 deafness: mutation analysis and clinical variability显示文摘 | Murgia A Orzan E Polli R | 1999 | J Med Genet1999，36，： | 1 |
| 19 | Analysis of iliac crest bone grafting process measures 显示文摘 | Dhawan A Kukto TR Polly DW Jr | 2006 | Am J Orthop2006，35，7： | 1 |
| 20 | Disc degeneration as-sessed by quantitative T2* (3'2 Star) correlated with functional lumbar mechanics显示文摘 | Ellingson AM Mehta H Polly DW | 2013 | Spine2013，38，24： | 1 |
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