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| 1 | 84例全麻剖宫产分析显示文摘目的:分析全麻下剖宫产不同分娩时间,急诊/择期和正常体重/低体重新生儿与Apgar评分的关系以及产妇术中知晓的发生率。方法:84例妊娠36周以上临产妇。根据麻醉诱导至胎儿娩出<10min或≥10min;切开子宫至胎儿娩出<3min或≥3min;急诊或择期;低体重或正常体重(<2.5kg或≥2.5kg)分别分组,比较各对应组新生儿Apgar1,5min评分。麻醉诱导用硫喷妥钠与司可林;麻醉维持用N2O,氟烷,潘库溴铵或阿屈库铵。胎儿娩出后静注吗啡或芬太尼。结果:Apgar 1min与5min评分在麻醉诱导至胎儿娩出小于10min组,切开子宫至胎儿娩出小于3min组,择期组均较其对应组高,(P>0.05);低体重新生儿组Apgar 1min与5min评分较正常体重组明显低(P<0.05)。术中知晓的发生率为10.71%。结论:全麻下胎儿分娩时间越短越好。术前母婴状态将直接影响其新生儿Apgar评分。全麻下剖宫产低体重新生儿易于出现Apgar评分低。 | 刘新伟 Megea Pole | 2005 | 重庆医科大学学报2005，30，4： | 19 |
| 2 | Design of 16S rRNA gene primers for 454 pyrosequencing of the human foregut microbiome显示文摘AIM:To design and validate broad-range 16S rRNA primers for use in high throughput sequencing to classify bacteria isolated from the human foregut microbiome.METHODS:A foregut microbiome dataset was constructed using 16S rRNA gene sequences obtained from oral,esophageal,and gastric microbiomes produced by Sanger sequencing in previous studies represented by 219 bacterial species.Candidate primers evaluated were from the European rRNA database.To assess the effect of sequence length on accuracy of classification,16S rRNA genes of various lengths were created by trimming the full length sequences.Sequences spanning various hypervariable regions were selected to simulate the amplicons that would be obtained using possible primer pairs.The sequences were compared with full length 16S rRNA genes for accuracy in taxonomic classification using online software at the Ribosomal Database Project (RDP).The universality of the primer set was evaluated using the RDP 16S rRNA database which is comprised of 433 306 16S rRNA genes,represented by 36 phyla.RESULTS:Truncation to 100 nucleotides(nt)downstream from the position corresponding to base 28 in the Escherichia coli 16S rRNA gene caused misclassification of 87(39.7%)of the 219 sequences,compared with misclassification of only 29(13.2%)sequences with truncation to 350 nt.Among 350-nt sequence reads within various regions of the 16S rRNA gene,the reverse read of an amplicon generated using the 343F/798R primers had the least(8.2%)effect on classification.In comparison,truncation to 900 nt mimicking single pass Sanger reads misclassified 5.0%of the 219 sequences.The 343F/798R amplicon accurately assigned 91.8%of the 219 sequences at the species level.Weighted by abundance of the species in the esophageal dataset,the 343F/798R amplicon yielded similar classification accuracy without a significant loss in species coverage(92%).Modification of the 343F/798R primers to 347F/803R increased their universality among foregut species.Assuming that a typicalpolymerase chain reaction can tolerate 2 mismatches between a primer and a template,the modified 347F and 803R primers should be able to anneal 98%and 99.6%of all 16S rRNA genes in the RDP database.CONCLUSION:347F/803R is the most suitable pair of primers for classification of foregut 16S rRNA genes but also possess universality suitable for analyses of other complex microbiomes. | Carlos W Nossa William E Oberdorf Jφrn A Aas Bruce J Paster Todd Z DeSantis Eoin L Brodie Daniel Malamud Michael A Poles Zhiheng Pei | 2010 | World Journal of Gastroenterology2010，16，33： | 16 |
| 3 | Intrahepatic natural killer T cell populations are increased in human hepatic steatosis显示文摘AIM: To determine if natural killer T cell (NKT) populations are affected in nonalcoholic fatty liver disease (NAFLD). METHODS: Patients undergoing bariatric surgery underwent liver biopsy and blood sampling during surgery. The biopsy was assessed for steatosis and immunocyte infiltration. Intrahepatic lymphocytes (IHLs) were isolated from the remainder of the liver biopsy, and peripheral blood mononuclear cells (PBMCs) were isolated from the blood. Expression of surface proteins on both IHLs and PBMCs were quantified using flow cytometry. RESULTS: Twenty-seven subjects participated in thisstudy. Subjects with moderate or severe steatosis had a higher percentage of intrahepatic CD3+/CD56+ NKT cells (38.6%) than did patients with mild steatosis (24.1%, P = 0.05) or those without steatosis (21.5%, P = 0.03). Patients with moderate to severe steatosis also had a higher percentage of NKT cells in the blood (12.3%) as compared to patients with mild steatosis (2.5% P = 0.02) and those without steatosis (5.1%, P = 0.05). CONCLUSION: NKT cells are significantly increased in the liver and blood of patients with moderate to severe steatosis and support the role of NKT cells in NAFLD. | Michael Adler Sarah Taylor Kamalu Okebugwu Herman Yee Christine Fielding George Fielding Michael Poles | 2011 | World Journal of Gastroenterology2011，17，13： | 10 |
| 4 | Challenge of liver disease in systemic lupus erythematosus:Clues for diagnosis and hints for pathogenesis显示文摘Systemic lupus erythematosus(SLE) encompass a broad spectrum of liver diseases. We propose here to classify them as follows:(1) immunological comorbilities(overlap syndromes);(2) non-immunological comorbilities associated to SLE; and(3) a putative liver damage induced by SLE itself, referred to as 'lupus hepatitis'. In the first group, liver injury can be ascribed to overlapping hepatopathies triggered by autoimmune mechanisms other than SLE occurring with higher incidence in the context of lupus(e.g., autoimmune hepatitis, primary biliary cirrhosis). The second group includes non-autoimmune liver diseases, such as esteatosis, hepatitis C, hypercoagulation state-related liver lesions, hyperplasic parenchymal and vascular lesions, porphyria cutanea tarda, and drug-induced hepatotoxicity. Finally, the data in the literature to support the existence of a hepatic disease produced by SLE itself, or the occurrence of a SLE-associated prone condition that increases susceptibility to acquire other liver diseases, is critically discussed. The pathological mechanisms underlying each of these liver disorders are also reviewed. Despite the high heterogeneity in the literature regarding the prevalence of SLE-associated liver diseases and, in most cases, lack of histopathological evidence or clinical studies large enough to support their existence, it is becoming increasingly apparent that liver is an important target of SLE. Consequently, biochemical liver tests should be routinely carried out in SLE patients to discard liver disorders, particularly in those patients chronically exposed to potentially hepatotoxic drugs. Diagnosing liver disease in SLE patients is always challenging, and the systematization of the current information carried out in this review is expected to be of help both to attain a better understanding of pathogenesis and to build an appropriate work-up for diagnosis. | Ferno Bessone Natalia Poles Marcelo G Roma | 2014 | World Journal of Hepatology2014，6，6： | 7 |
| 5 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 6 | Assessing cultural competency skills in gastroenterology fellowship training显示文摘AIM:To assess and teach cultural competency skills at the fellowship training level through the use of objective structured clinical examinations(OSCEs).METHODS:We revised four scenarios to infuse a specific focus on cross-cultural care,and to render them appropriate for gastroenterology fellows.Three are discussed here:(1)Poor Health Literacy;(2)Disclosing/Apologizing for a Complication to a Patient Who Mistrusts the Healthcare System;and(3)Breaking Bad News to a Fatalistic Patient.A fourth case emphasizing shared decision-making will be described elsewhere.Four stations were completed by fellows and observed live by four faculty members,and the fellows’performance was assessed.RESULTS:Eleven fellows from four programs participated in the four OSCE.In the'Poor Health Literacy'case,18%(2/11)of participants recognized that the standardized patient(SP)had below-basic health literacy.None successfully evaluated the SP’s reading skills in a culturally-sensitive manner.In'Disclosing/Apologizing for a Complication',4/11(36%)personally apologized for the complication.1/11 recognized the SP’s mistrust of the medical system.With'Breaking Bad News',27%(3/11)explored the patient’s values to identify her fatalistic beliefs.CONCLUSION:OSCEs can be used to assess deficiencies in culturally-competent care at the fellowship level.OSCEs also afford fellowships the opportunity to inform future training curricula. | Sophie Balzora Benjamin Abiri Xiao-Jing Wang James Mc Keever Michael Poles Sondra Zabar Colleen Gillespie Elizabeth Weinshel | 2015 | World Journal of Gastroenterology2015，21，6： | 2 |
| 7 | Observation of a p mass threshold enhancement in ψ′→π+π-J/ψ(J/ψ→γp) decay显示文摘The decay channel ψ→π+π-J/ψ(J/ψ→γp) is studied using a sample of 1.06×108 ψ events collected by the BESIII experiment at BEPCII. A strong enhancement at threshold is observed in the p invariant mass spectrum. The enhancement can be fitted with an S-wave Breit-Wigner resonance function with a resulting peak mass of M =1861+6-13 (stat)+7-26 (syst) MeV/c2 and a narrow width that is Γ <38 MeV/c2 at the 90% confidence level. These results are consistent with published BESII results. These mass and width values do not match with well established mesons. | 麦迪娜 M. N. Achasov 安磊 安琪 安正华 白景芝 班勇 N. Berger 边渐鸣 I. Boyko R. A. Briere V. Bytev 蔡啸 曹国富 曹学香 常劲帆 G. Chelkov 陈刚 陈和生 陈江川 陈丽平 陈玛丽 陈鹏 陈申见 陈元柏 初元萍 D. Cronin-Hennessy 代洪亮 代建平 D. Dedovich 邓子艳 I. Denysenko M. Destefanis 丁勇 董燎原 董明义 杜书先 段麦英 方建 封常青 傅成栋 傅金林 高原宁 耿聪 K. Goetzen 龚文煊 M. Greco S. Grishin 顾运厅 郭爱强 郭立波 郭玉萍 韩少卿 F. A. Harris 何康林 何苗 何振亚 衡月昆 侯治龙 胡海明 胡继峰 胡涛 胡小为 黄彬 黄光明 黄金书 黄性涛 黄燕萍 姬长胜 纪全 季晓斌 季筱璐 贾卢魁 姜丽丽 江晓山 焦健斌 金大鹏 金山 S. Komamiya W. Kuehn S. Lange 梁干庄 李澄 李翠 李德民 李飞 李刚 李海波 李捷 李家才 李蕾 李陆 李秋菊 李卫东 李卫国 李晓玲 李小男 李学潜 李秀荣 李玉晓 李志兵 梁昊 梁泰然 Y.T. Liang 梁勇飞 廖广睿 廖小涛 刘北江 刘春秀 刘春燕 刘福虎 刘芳 刘峰 刘冠川 刘虎 刘宏邦 刘怀民 刘红薇 刘健 刘觉平 刘坤 刘魁勇 刘树彬 刘晓海 刘玉斌 刘艳芳 刘衍文 刘勇 刘振安 鲁公儒 吕军光 吕绮雯 吕晓睿 卢云鹏 罗成林 罗民兴Zhejiang University 罗涛 罗小兰 马长利 马凤才 马海龙 马秋梅 马想 马骁妍 M. Maggiora 冒亚军 毛泽普 闵建 莫晓虎 N. Yu. Muchnoi Y. Nefedov 宁飞鹏 S. L. Olsen 欧阳群 M. Pelizaeus K. Peters 平加伦 平荣刚 R. Poling 潘振声 祁鸣 钱森 乔从丰 邱进发 荣刚 阮向东 Sarantsev 邵明 沈肖雁 盛华义 S. Sonoda S. Spataro B. Spruck 孙德辉 孙功星 孙俊峰 孙胜森 孙晓东 孙勇杰 孙永昭 孙志嘉 孙振田 唐昌建 唐晓 唐秀福 田浩来 D. Toth G. S. Varner 万霞 王博群 王纪科 王科 王亮亮 王灵淑 王平 王佩良 王强 王思广 王晓东 汪晓莲 王雅迪 王贻芳 王亚乾 王铮 王志刚 王至勇 魏代会 文硕频 U. Wiedner 伍灵慧 吴宁 吴元明 吴智 肖振军 谢宇广 许国发 徐光明 徐昊 徐敏 徐明 徐新平 徐晔 许咨宗 薛镇 严亮 鄢文标 颜永红 杨洪勋 杨明 杨璞 杨世明 杨永栩 叶梅 叶铭汉 俞伯祥 喻纯旭 俞玲 苑长征 袁野 曾云 张丙新 张炳云 张长春 张达华 张宏浩 章红宇 张家文 张建勇 张景芝 张雷 张书华 张学尧 张瑶 张银鸿 张子平 赵川 赵海升 赵家伟 赵京伟 赵雷 赵玲 赵明刚 赵强 赵书俊 赵祥虎 赵豫斌 赵政国 A. Zhemchugov 郑波 郑建平 郑阳恒 郑志鹏 钟彬 周莉 周中良 朱程 朱凯 朱科军 朱启明 朱兴旺 朱永生 朱自安 庄建 邹冰松 邹佳恒 左嘉旭 P. Zweber | 2010 | Chinese Physics C2010，34，4： | 2 |
| 8 | Omissin of nitrous oxide from a propofol based anesthetic does not affect the recovery of women undergoing outpatient gynecologic surgery显示文摘 | Barellano RJ Pole ML Rafuse SE | 2002 | Aensthesiology2002，93，2： | 1 |
| 9 | Cellular environment of metabolites and a metabonomic study of tamoxifen in endometrial cells using gradient high resolution magic angle spinning 1H NMR spectroscopy显示文摘 | Griffin JL Pole JC Nicholson JK | 2003 | Biochim Biophys Acta2003，1619，2： | 1 |
| 10 | Omission of Nitrous Oxide from a Propofol Based Anesthetic does not Affect the Recovery of Women Undergoing Outpatient Gynecologic Surgery显示文摘 | ARELLANO R J POLE M L RAFUSE S E | 2000 | Anesthesiology2000，93，2： | 1 |
| 11 | Gene expression changes induced by estrogen and selective estrogen receptor modulators in primarycultured human endometrial cells:signals that distinguish the human carcinogen tamoxifen显示文摘 | Pole JC Gold LI Orton T | 2005 | Toxicology2005，206，1： | 1 |
| 12 | Cerebral injury during cardiopulmonary bypass : emboli impair memory 显示文摘 | Feam S J Pole R Wesnes K | 2001 | J Thorac cardiovasc surg2001，121，6： | 1 |
| 13 | Chroma- tin structure analyses identify miRNA promoters 显示文摘 | Ozsolak F Poling L L Wang Z X etal | 2008 | Genes Development2008，22，22： | 1 |
| 14 | Strengths of character and postt- raumatic growth 显示文摘 | Peterson C Park N Pole N | 2008 | J Traumat Stress2008，21，2： | 1 |
| 15 | Culture, Language, and the Location of High-Order Service Functions:The Case of Montreal and Toronto显示文摘 | Pole se M | 2004 | Economic Geography2004，80，4： | 1 |
| 16 | Medical image matching -- a review of classification 显示文摘 | VANDENELSEN P A POLE J D VIERGEVER M A | 1993 | IEEE Engineering in Medical and Biology1993，12，1： | 1 |
| 17 | Nitrification modelling in biofilms under inhibitory conditions 显示文摘 | Gheewala S H Pole R K Armachhatre A P | 2004 | Water Research2004，38，1415： | 1 |
| 18 | Errors in anti-D im- nmnoglobulin administration: retrospective analysis of 15 years of reports to the UK confidential haemovigilance scheme显示文摘 | Bolton-Maggs PHB Davies T Poles D | 2013 | Int J Obstet Gynaecol2013，120，7： | 1 |
| 19 | Cerebral injury during cardiopulmonary bypass:emboli impair memory显示文摘 | Fearn SJ Pole R Wesnes K | 2001 | J Thorac Cardiovasc Surg2001，121，6： | 1 |
| 20 | Phase Ⅱ study of biweekly administration of paclitaxel and cisplatin in patients with advanced esophageal cancer显示文摘 | Polee MB Eskens FA Burg ME | 2002 | Br Cancer2002，86，5： | 1 |
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