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| 1 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 2 | Omission of Nitrous Oxide from a Propofol Based Anesthetic does not Affect the Recovery of Women Undergoing Outpatient Gynecologic Surgery显示文摘 | ARELLANO R J POLE M L RAFUSE S E | 2000 | Anesthesiology2000，93，2： | 1 |
| 3 | Culture, Language, and the Location of High-Order Service Functions:The Case of Montreal and Toronto显示文摘 | Pole se M | 2004 | Economic Geography2004，80，4： | 1 |
| 4 | Medical image matching -- a review of classification 显示文摘 | VANDENELSEN P A POLE J D VIERGEVER M A | 1993 | IEEE Engineering in Medical and Biology1993，12，1： | 1 |
| 5 | Proper management of pericardial tamponade as a late corn plication of implantable cardiac device placement显示文摘 | POLING M ZADOE NAYAK H | 2006 | Am J Cardiol2006，98，： | 1 |
| 6 | Vapor-liquid equilibrium data for the NH3-H2O system and its description with a modified cubic equation of state显示文摘 | Smolen T M Manley D B Poling B E | 1991 | J Chem Eng Data1991，36，2： | 1 |
| 7 | Synthetic bioregularors of poly-cis-carotenoid biosynthesis 显示文摘 | Stephen M Poling W J H | 1982 | Phytochemistry1982，21，3： | 1 |
| 8 | Chemical regulation of carotenoid biosynthesis, Part 10: Chemical induction of 13 carotene biosynthesis 显示文摘 | Poling S M Hsu W J Koehrn F J | 1977 | Photochemistry1977，16，5： | 1 |
| 9 | Acylated flavonoids in cullus cultures of Citrus aurantifolia显示文摘 | Berhow M A Nennett R D Poling S M | 1994 | Phytochemistry1994，36，5： | 1 |
| 10 | Synthetic bioregulators of poly-eis- carotenoid biosynthesis显示文摘 | Stephen M Poling W J H | 1982 | Phytochemistry1982，21，3： | 1 |
| 11 | Famide-related pep- tide-3 receptor gene expression in GnRH and kisspeptin neu- rons and GnRH-dependent mechanism of action显示文摘 | Rizwan M Z Poling M C Corr M | 2012 | Endocrinolo- gy2012，153，8： | 1 |
| 12 | In vivo osteopontin-induced macrophage accumulation is dependent on CD44 expression显示文摘 | Marcondes MC Poling M Watry DD | 2008 | Cell Immunol2008，254，1： | 1 |
| 13 | Synthetic bioregularors of poly-cis-carotenoid biosynthesis显示文摘 | STEPHEN M POLING WJH | 1982 | Phytochemistry1982，21，3： | 1 |
| 14 | Syncope in blood donors显示文摘 | Poles FC Boycott M | 1942 | Lancet1942，2，4： | 1 |
| 15 | Lauraceae macrofossils and dispersed cuticle from the Miocene of southern New Zealana显示文摘 | Pole M 2007 | 2007 | Palaeontologia Electronica2007，10，1： | 1 |
| 16 | Ion concentrations in the CO2-NH3 H2O system from 13C NMR spectroscopy 显示文摘 | Holmes II P E Naaz M Poling B E | 1998 | Ind Eng Chem Res1998，37，： | 1 |
| 17 | Legal milestones in range management显示文摘 | Poling M | 1991 | Renewable Resources Journal1991，2，： | 1 |
| 18 | Proper management of pericardial tamponade as a late complication of implantable cardiac device place ment 显示文摘 | POLING M ZADO E NAYAK H COOPER J M | 2006 | Am J Cardiol2006，98，： | 1 |
| 19 | Therapeutic targeting of the oncostatin M receptor-βprevents inflammatory heart failure显示文摘 | Poling J Gajawada P Richter M | 2014 | Basic Res Cardiol2014，109，1： | 1 |
| 20 | Phase Ⅱ study of neoadjuvant chemotherapy with paclitaxel and cisplatin given every 2 weeks for patients with a respectable squamous cell carcinoma of the oesophagus显示文摘 | Polee M B Tilanus H W Eskens F A | | 0，，08： | 1 |
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