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| 1 | Cytokine production in patients with cirrhosis and TLR4 polymorphisms显示文摘AIM:To analyze the cytokine production by peripheral blood cells from cirrhotic patients with and without TLR4 D299G and/or T399I polymorphisms.METHODS:The study included nine patients with cirrhosis and TLR4 D299G and/or T399I polymorphisms,and 10 wild-type patients matched for age,sex and degree of liver failure.TLR4 polymorphisms were determined by sequence-based genotyping.Cytokine production by peripheral blood cells was assessed spontaneously and also after lipopolysaccharide(LPS)and lipoteichoic acid(LTA)stimulation.RESULTS:Patients with TLR4 polymorphisms had a higher incidence of previous hepatic encephalopathy than wild-type patients(78%vs 20%,P=0.02).Spontaneous production of interleukin(IL)-6 and IL-10 was lower in patients with TLR4 polymorphisms than in wild-type patients[IL-6:888.7(172.0-2119.3)pg/m L vs 5540.4(1159.2-26053.9)pg/m L,P<0.001;IL-10:28.7(6.5-177.1)pg/m L vs 117.8(6.5-318.1)pg/m L,P=0.02].However,the production of tumor necrosis factor-α,IL-6 and IL-10 after LPS and LTA stimulation was similar in the two groups.CONCLUSION:TLR4 polymorphisms were associated with a distinctive pattern of cytokine production in cirrhotic patients,suggesting that they play a role in the development of cirrhosis complications. | Juan Camilo Nieto Elisabet Sánchez Eva Román Silvia Vidal Laia Oliva Carlos Guarner-Argente Maria Poca Xavier Torras Cándido Juárez Carlos Guarner German Soriano | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 2 | Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites显示文摘AIM To assess the relationship between the presence of toll-like receptor 4(TLR4) polymorphisms and bacterial infections in cirrhotic patients with ascites. METHODS We prospectively included consecutive patients with cirrhosis and ascites hospitalized during a 6-year period. Patients with human immunodeficiency virus(HIV) infection or any other immunodeficiency, patients with advanced hepatocellular carcinoma(beyond Milan's criteria) or any other condition determining poor short-term prognosis, and patients with a permanent urinary catheter were excluded. The presence of D299 G and/or T399 I TLR4 polymorphisms was determined by sequencing and related to the incidence and probability of bacterial infections, other complications of cirrhosis, hepatocellular carcinoma, and mortality during follow-up. A multivariate analysis to identify predictive variables of mortality in the whole series was performed. RESULTS We included 258 patients: 28(10.8%) were carriers of D299G and/or T399I TLR4 polymorphisms(polymorphism group) and 230 patients were not(wildtype group). The probability of developing any bacterial infection at one-year follow-up was 78% in the polymorphism group and 69% in the wild-type group(P = 0.54). The one-year probability of presenting infections caused by gram-negative bacilli(51% vs 44%, P = 0.68), infections caused by gram-positive cocci(49% vs 40%, P = 0.53), and spontaneous bacterial peritonitis(29% vs 34%, respectively, P = 0.99) did not differ between the two groups. The oneyear probability of transplant-free survival was 55% in the polymorphism group and 66% in the wild-type group(P = 0.15). Multivariate analysis confirmed that age, Child-Pugh score, active alcohol intake, previous hepatic encephalopathy, hepatocellular carcinoma and serum creatinine were associated with a higher risk of death during follow-up. CONCLUSION Genetic polymorphisms D299 G and/or T399 I of TLR4 do not seem to play a relevant role in the predisposition of cirrhotic patients with ascites to bacterial infections. | Edilmar Alvarado-Tapias Carlos Guarner-Argente Elida Oblitas Elisabet Sánchez Silvia Vidal Eva Román Mar Concepción Maria Poca Cristina Gely Oana Pavel Juan Camilo Nieto Cándido Juárez Carlos Guarner Germán Soriano | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 3 | Diffuse axonal injury after head trauma 显示文摘 | Sahuquillo J Poca MA | 2002 | Adv Tech Stand Neurosurg2002，27，： | 1 |
| 4 | Posture- in- duced changes in intracranial pressure: a comparative studyin patients with and without a cerebrospinal fluid block atthe craniovertebral junction 显示文摘 | Poca M A Sahuquillo J Topczewski T | 2006 | Neurosurgery2006，58，5： | 1 |
| 5 | Ventricular enlargement after moderate or severe head injury:a frequent and neglected problem显示文摘 | Poca MA Sahuquillo J Mataro M | 2005 | J Neurotrauma2005，22，11： | 1 |
| 6 | Current surgical treatment of Chiari type Ⅰ malformation and Chiari-syringomyelia complex显示文摘 | Poca MA | 1998 | Neurologia1998，13，： | 1 |
| 7 | Post-surgical changes in brain metabolism detected by magnetic reso- nance spectroscopy in normal pressure hydrocephalus: results of a pilot study显示文摘 | Matarin MM Pueyo R Poca MA | 2007 | J Neurol Neurosurg Psychia- try2007，78，7： | 1 |
| 8 | Eval- uation of the genotoxicity o: Orthosiphon stamineus aqueous extract显示文摘 | Muhammad H Gomes-Carneiro M R Poca K S | 2011 | J Ethnopharmacol2011，133，2： | 1 |
| 9 | Posterior fossa reconstruction:a surgical technique for the treatment of Chiari I malformation and Chiari I/syringomyelia complex-preliminary results and magnetic resonance imaging quantitative assessment of hindbrain migration显示文摘 | Rubio E Poca MA | 1994 | Neurosurgery1994，35，5： | 1 |
| 10 | Functional and magnetic resonance imaging correlates of corpus callosum in normal pressure hydrocephalus before and after shunting 显示文摘 | Mataro M Matarin M Poca MA | 2007 | J Neurol Neuresurg Psychiatry2007，78，4： | 1 |
| 11 | Posterior fossa reconstruction: a surgical technique for the treatment of Chiari Ⅰ malformation and Chiari I/syringomyelia complex - preliminary Results and magnetic resonance imaging quantitative assessment of hindbrain migration 显示文摘 | Sahuquillo J Ruhio E Poca MA | 1994 | Neurosurgery1994，35，： | 1 |
| 12 | Is the placement of shunts in patients with idiopathic normalpressure hydrocephalus worth the risk? Results of a study based on continuous monitoring of intracranial pressure显示文摘 | Poca MA Matar ó M Del Mar Matar í n M | 2004 | J Neurosurg2004，100，： | 1 |
| 13 | Posterior fossa reconstruction:a surgical technique for the treatment of Chiari malformation and Chiari Ⅰ/syringomyelia complex-preliminary results and magnetic resonance imaging quantitative assessment of hindbrain migration显示文摘 | Rubio E Poca MA | 1994 | Neurosurgery1994，35，5： | 1 |
| 14 | Good outcome in patients with normal-pressure hydrocephalus and factors indicating poor prognosis 显示文摘 | Poca MA Mataro M Mataiin M | 2005 | J Neurosurg2005，103，： | 1 |
| 15 | Posterior fossa reconstruction:a surgical technique for the treatment of Chiari Ⅰ malformation and Chiari Ⅰ/Syringomyelia complex 2 preliminary results and magnetic resonance imaging quantitative assessment of hindbrain migration显示文摘 | Sahuquillo J Rubio E Poca MA | 1994 | Neumsurgery1994，35，5： | 1 |
| 16 | Ventricular enlargement after moderate or severe head injury:a frequent and neglected problem显示文摘 | Poca MA Sahuquillo J Mataro M | 2005 | Neurotrauma2005，22，11： | 1 |
| 17 | Ventrieular enlargement after moderate of severe head injury:a frequent and neglected problem显示文摘 | Poca MA Sahuquillo J Mataro M | 2005 | J Neurotrauma2005，22，： | 1 |
| 18 | Functional and magnetic resonance imaging correlates of corpus callosum in normal pressure hydrocephalus before and after shunting显示文摘 | Matar6 M Matarin M Poca MA | 2007 | J Neurol Neurosurg Psychiatry2007，78，4： | 1 |
| 19 | Is intracranial pressure monitoring in the epidural space reliable? Fact and fiction显示文摘 | Poca MA Sahuquillo J Topczewski T | | 0，，04： | 1 |
| 20 | Ventricular enlargement after moderate or severe head injury;a rrequent and neglected problem显示文摘 | Poca MA Sahuquillo J Mataro M | | 0，，11： | 1 |
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