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| 1 | No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer. | Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li | 2009 | World Journal of Gastroenterology2009，15，18： | 11 |
| 2 | No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer显示文摘AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene. | Lynette S Phillips Cheryl L Thompson Alona Merkulova Sarah J Plummer Thomas C Tucker Graham Case Li Li | 2009 | World Journal of Gastroenterology2009，15，30： | 2 |
| 3 | Influence of β nucleation on the mechanical properties of isotactic polypropylene and rubber modified isotactic polypropylene 显示文摘 | Grein C Plummer C J G Kausch H H | 2002 | J Polymer2002，43，： | 1 |
| 4 | Phase separation in epoxy resin-reactive dendritic hyperbranched polymer blends显示文摘 | PLUMMER C J G MEZZENGA R BOOGH L | 2001 | Polymer Engineering and Science2001，41，： | 1 |
| 5 | Seizure detection:correlation of human experts 显示文摘 | WILSON K SCHEUER M L PLUMMER C | 2003 | Clinl Neurophysi- ol2003，114，11： | 1 |
| 6 | Cryogenic Heat Engine Ex-periment 显示文摘 | M C Plummer C P Koehler | 1998 | Advances in Cryogenic Engineering1998，，： | 1 |
| 7 | The Neuropro- tective Properties of the Amyloid Precursor Protein Following Traumatic Brain Injury显示文摘 | Plummer S Van den Heuvel C Thornton E | 2016 | Aging Dis2016，7，2： | 1 |
| 8 | Micro-ntcchmisms ,f slow crack growth in polyethylene under constant tensile loading 显示文摘 | Plummer C J G Goldberg A Ghanem A | 2001 | Polymer2001，42，23： | 1 |
| 9 | Morphology build-up in dendritic hyperbranehed polymer modified epoxy resins : modelling and characterization 显示文摘 | MEZZENGA R PLUMMER C J G BOOGH L | 2001 | Polymer2001，42，： | 1 |
| 10 | Scaling theory for cylindrical, fully-depleted, surrounding-gate MOSFET's 显示文摘 | Plummer J D | 1997 | IEEE Trans Elec Dev Lett1997，18，2： | 1 |
| 11 | Influence of β Nucleation on the Mechanical Properties of Isotactic Polypropylene and Rubber Modified lsotactic Polypropylene显示文摘 | Grein C Plummer C J G Kausch H H | 2002 | Polymer2002，43，11： | 1 |
| 12 | Antimicrobial properties of AUium sativura (garlic)显示文摘 | HARRIS J C COTTRELL S L PLUMMER S | 2001 | Appl Microbiol Biotechnol2001，57，3： | 1 |
| 13 | Loss of p53 sensitizes mice with a mutation in CCM1 (KRIT1) to development of cerebral vascular malformations 显示文摘 | Plummer NW Gallione C J Srinivasan S | 2004 | Am J Pathol2004，165，： | 1 |
| 14 | The morphology of submicronsized core - shell latex particles : An electron microscopy study 显示文摘 | GAILLARD C FUCHS G PLUMMER C J G | 2007 | Micron2007，38，5： | 1 |
| 15 | Environmental education,resilience,and learning:reflection and moving forward显示文摘 | Krasny ME Lundholm C Plummer R | | 0，，： | 1 |
| 16 | Antimicrobial properties of Allium sativum ( garlic ) 显示文摘 | Harris J C Cottrell S L Plummer S | 2001 | Appl Microbiol Biotechnol2001，57，： | 1 |
| 17 | Gastric cancer : epidemiolo- gy and risk factors显示文摘 | de Martel C Forman D Plummer M | 2013 | Gastroenterol Clin North Am2013，42，2： | 1 |
| 18 | Influence of β nucleation on the mechanical properties of isotactic polypropylene and rubber modified isotactic polypropylene 显示文摘 | Groin C Plummer C J G Kausch H H | 2002 | Polymer2002，43，： | 1 |
| 19 | Myostatin induces cachexia by activating the ubiquitinproteolytic system through an NF-kappaB-independent,Fox01*dependent mechanism 显示文摘 | MCFARLANE C PLUMMER E THOMAS M | 2006 | J Cell Physiol2006，209，2： | 1 |
| 20 | Plasma- induced graft polymerization of acrylic acid onto poly ( ethylene terephthalate) films : characterization and hu- man smooth muscle cell growth on grafted films 显示文摘 | GUPTA B PLUMMER C BISSON I | 2002 | Biomaterials2002，23，： | 1 |
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