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| 1 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 2 | Leaf trajectory verification during dynamic intensity modulated radiotherapy using an amorphous silicon flat panel imager显示文摘 | Ploeger LS Brand B | 2004 | Med Phy2004，31，2： | 1 |
| 3 | A method for geometrical verification of dynamic intensity modulated radiotherapy using a scanning electronic portal imaging device显示文摘 | Ploeger LS Smitsmans MH Gilhuijs KG | 2002 | Med Phys2002，29，6： | 1 |
| 4 | 3 -D portal image analysis in clinical practice: 811 evaluation of 2 - D and 3 - D analysis techniques applied to 30 prostate cancer patients 显示文摘 | Remeijer P Geedof E Ploeger L | 2000 | Int J Radiat Oncol Biol Phys2000，46，5： | 1 |
| 5 | Validation of the PHQ-9 as a screening instrument for depression in diabetes patients in specialized outpatient clinics显示文摘 | van Steenbergen-Weijenburg KM de Vroege L Ploeger RR | 2010 | BMC Health Serv Res2010，10，： | 1 |
| 6 | Clinical trial simulation:a review显示文摘 | HOLFORD NHG Ma SC PLOEGER BA | | 0，，02： | 1 |
| 7 | 3-D portal image analysis in clinical practice :an evalution of 2-D and 3-D analysis techniques as applied to 30 prostate cancer patients 显示文摘 | Remeijer P GeerlofE Ploeger L | 2000 | Int J Radiat Oncol Biol Phys2000，46，5： | 1 |
| 8 | A novel method for megavoltage scatter correction in cone-beam CT acquired concurrent with rotational irradiation显示文摘 | van Herk M Ploeger L Sonke JJ | 2011 | Radiother Oncol2011，100，13： | 1 |
| 9 | The effects of acute and chronic exercise on inflammatory markers in children and adultswith a chronic inflammatory disease:a systematic review显示文摘 | Ploeger HE Takken T De Greef MH | 2009 | Exerc Immunol Rev2009，15，1： | 1 |
| 10 | Soil and its influence on rural drought migration: insights from Depression-era Southwestern Saskatchewan, Canada 显示文摘 | McLeman R A Ploeger S K | 2012 | Population and Environment2012，33，4： | 1 |
| 11 | Exercise capacity in pediatric patients with inflammatory bowel disease显示文摘 | Ploeger H E Takken T Wilk B | 2011 | J Pediatr2011，158，5： | 1 |
| 12 | Ex- plaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients显示文摘 | Press RR Ploeger BA den Hartigh J | 2009 | Ther Drug Monit2009，31，2： | 1 |
| 13 | Explaining the gender gap in delinquency:Peer influence and moral evaluations of behavior显示文摘 | Mears D.P Ploeger M Warr M | | 0，，4： | 1 |
| 14 | 3-D portal image analysis in clinical practice:an evaluation of2-D and3-D analysis techniques as applied to 30 prostate cancer patients显示文摘 | Remeijer P Geerl of E Ploeger L | | 0，，05： | 1 |
| 15 | Cognition and the Evolution of Music: Pitfalls and Prospects显示文摘 | Henkjan Honing Annemie Ploeger | 2012 | Topics in Cognitive Science2012，，4： | 1 |
| 16 | A novel method for megavoltage scatter correction in cone-beam CT acquired concurrent with rotational irradiation 显示文摘 | VAN HERK M PLOEGER L SONKE J J | 2011 | Radiother Oncol2011，100，3： | 1 |
| 17 | 3-D portal image analysis in clinical practice: 811 evaluation of 2-D and 3 D analysis techniques applied to 30 prostate canc er patients显示文摘 | Remeijer P Geedof E Ploeger L | 2000 | Int J Radiat Oncol Biol Phys2000，46，5： | 1 |
| 18 | Aromatic choline esters in rapeseed 显示文摘 | CLAUSEN S LARSEN L PLOEGER A | 1985 | World Crops1985，11，： | 1 |
| 19 | Property in 3D-registration of multiple use of space:current practice in Holland and the need for a 3Dcadastre显示文摘 | Stoter J. E Ploeger H. D | | 0，，05： | 1 |
| 20 | 3-D portal image analysis in clinical practice: an evaluation of 2-D and 3-D analysis techniques as applied to 3D prostate cancer patients显示文摘 | Remeijer P Gecrlof E Ploeger L | 2000 | Int J Radiat Oncol Biol Phys2000，46，： | 1 |
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