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    题名 作者 年代 出处 被引量
1Surgical considerations for ‘intrinsic' brainstem gliomas: proposal of a modification in classification显示文摘Mehta VS Chandra PS Singh PK Garg A Rath GK 2009中国神经肿瘤杂志2009,7,3:9
2固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验显示文摘控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R Jan S Jayawardena J Maulik PK Mendis S Munasinghe J Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉 叶鹏 2018中华高血压杂志2018,26,12:7
3Bioactivity and cytocompatibility of zirconia (ZrO(2)) films fabricated by cathodic arc deposition显示文摘Liu X Huang A Ding C Chu PK 2006中国生物学文摘2006,20,5:7
4婚姻状况与心血管病风险的关系:系统评价和荟萃分析显示文摘虽然80%的未来心血管病风险可以从已知的心血管危险因素预测,如老年、男性、高血压、高血脂症、吸烟和糖尿病,但其余20%风险的决定因素仍不明确。婚姻对健康和死亡的益处已经在不同种族的两性中得到证实,并且与各种社会人口学特征无关。Wong CW Kwok CS Narain A Gulati M Mihalidou AS Wu P Alasnag M Myint PK Mamas MA 刘莉 叶鹏 2018中华高血压杂志2018,26,9:5
5新兴的微乳技术(英)显示文摘从本世纪40年代初舒尔曼及其助手发现微乳以来,微乳已被广泛地应用于许多领域。微乳具有很高的界面面积,稳定的热力学特性及对难溶液体的强溶解性,所以它被广泛地用在化妆品、制药、润滑剂、食品、农业喷洒、涂料、环境治理、清洗、燃料、化学合成、微孔介质的合成、提高反应的动力学特性、化学分析等诸多领域。讨论了微乳在新兴技术中的应用研究。V贺哈布拉 ML弗里 PK坎 SE特鲁斯代尔 DO沙欣 于艳 1999日用化学品科学1999,22,1:5
6Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts.Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee 2014World Journal of Clinical Oncology2014,5,5:4
7Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations显示文摘Tamura Y Peng P Liu K Daou M Srivastava PK 0,,:3
8创伤性寰枢椎滑脱伴移位型齿状突骨折:采用“关节重塑”技术实现后路完全复位显示文摘寰枢椎脱位(atlantocaxial dislocation,AAD)是在先天性和创伤性情况下,寰枢关节常见的一种不正常关系,寰枢椎滑脱(atlantoaxial spondyloptosis,AAS)是指寰椎侧块小关节面完全移位,两个关节面之间无接触,是寰枢椎不稳定的一种罕见表现,属于最严重的寰枢椎脱位之一。由于寰枢关节面交锁,传统的后路手术方式或单纯凭借颅骨牵引均无法使寰枢椎完全复位。“关节操作”技术最初由Goel等提出,通过术中C1~C2撑开及进行寰枢关节操作实现颅颈交界区的重新对位。但单独使用该技术并不能达到关节复位,因此需要联合关节重塑技术(通过在C1关节面前下方边缘及C2关节面钻孔以辅助骨刀插入,获得撑开及部分复位),使寰枢关节复位到正常的解剖位置。作者对1例创伤性AAS伴移位型齿状突骨折患儿采取单纯后路手术,通过“关节操作”和“关节重塑”技术实现完全复位,效果良好。kumar a varshney g singh pk 葛苏 马向阳 2018中国骨科临床与基础研究杂志2018,10,1:3
9Heat shock proteins transfer peptides during antigen processing and CTL priming显示文摘Srivastava PK Udono H Blachere NE 0,,:3
10A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides显示文摘Suto R Srivastava PK 0,,:3
11美国器官捐献和移植立法主要事件显示文摘Linden PK 蒋婉洁 吴幼民 2009中华移植杂志(电子版)2009,3,3:3
12形成SIMOX结构的PIII新技术的研究显示文摘本文报道了一种形成SIMOX结构的等离子体浸没离子注入(PIII)的新技术.与传统的离子注入相比,这种新技术具有高离子束流,大面积离子注入,极短的注入时间和低成本等优点.实验中,衬底硅片浸没在高离子密度的氧的等离子体中.在衬底所加的负高压的作用下,氧离子直接注入硅片之中.我们研究了PIII的工艺条件,用PIII制得了具有20到50nm厚的顶层硅层和20到50nm厚的氧化硅埋层的超薄SIMOX硅片,并用RBS、XTEM等技术对样品进行了测试.闵靖 Chu,PK 1995Journal of Semiconductors1995,16,8:3
13Socio-economic determinants for malaria transmission risk in an endemic primary health centre in Assam, India显示文摘Background:Malaria is a major cause of morbidity and mortality in Northeast India.As there is limited information available on the potential influence of socio-economic variables on malaria risk,the present study was conducted to assess the influence of demographic factors,the socio-economic status,and knowledge,awareness and education on malaria occurrence.Methods:Demographics,malaria knowledge and socio-economic variables were collected in four randomly selected health sub-centres of the Orang primary health centre in the Udalguri district,Assam and the association of malaria occurrence with different variables were analysed.The trend of malaria occurrence for different income groups,proximity to health centres and number of mosquito bites per day was also determined using the chi-square test.Relative risk(RR)for gender,house type,knowledge and use of bed nets was determined using Katz approximation.Results:Out of the 71 household heads interviewed,70.4%(50/71)were males.About half(54.9%,39/71)of the participants had a history of malaria in the last two years,of which 64.1%(25/39)were males,while 35.9%(14/39)were females(χ^(2)=5.13;p=0.02;RR=1.79).Of the total population surveyed,49.3%lived in bamboo houses and 35.2%lived at a distance of>3 km from the nearest health centre.The number of participants who had a history of malaria decreased with an increasing monthly income(p<0.0001).Malaria occurrence was higher among the households living in bamboo houses(69.2%),as compared to Kucha houses(20.5%)and Pucca houses(10.3%).No significant association was observed between education level and malaria occurrence(p=0.93).The participants who did not use bed nets regularly reported a high occurrence of malaria infection as compared to those who used bed nets everyday(p<0.0001).Conclusions:Lower income,house type,distance to health sub-centre,knowledge and awareness about malaria,number of mosquito bites per day and use of bed nets were positively associated with malaria occurrence.Increasing the number of health sub-centres close to rural areas,improving the economic status and increasing awareness about malaria prevention measures will thus help to reduce malaria-associated morbidities.Kavita Yadav Sunil Dhiman Bipul Rabha PK Saikia Vijay Veer 2014Infectious Diseases of Poverty2014,3,1:3
14TDZ诱导的黄芩 (Scatellaria baicalensis Georgi)外植体枝再生研究(英文)显示文摘研究了中药黄芩 (ScatellariabaicalensisGeorgi)的微繁技术。TDZ[N phenyl-N’ (1,2 ,3 thidiazol 5 ylurea) ]用于组培中能有效地诱导黄芩完整实生苗、白化下胚轴段和茎段再生新枝。下胚轴段和茎段外植体的组织学研究显示其再生是通过愈伤组织形成新枝。TDZ诱导黄芩 3种组培外植体枝再生的比较表明 ,理想的再生不一定要外植体脱离母体。黄芩完整实生苗的下胚轴上形成的枝明显多于下胚轴段上形成的枝 ,表明完整实生苗中产生的代谢产物提供枝再生所需的物质。 95 %以上的再生体形成根系 ,在无菌培养和温室中可形成完整植株。李焕秀 S J Murch PK Saxena 2000四川农业大学学报2000,18,4:3
15常用抗高血压药物对血压的时间生物学特征的影响显示文摘目的 :探讨 3类常用抗高血压药物对非杓型的高血压病患者BP的时间生物学特征的影响。方法 :共入选非杓型BP分布的高血压病患者 16 1例 ,将其随机分为 3组 ,分别给予赖诺普利 (10mg·d-1) ,非洛地平 (2 5mg·d-1) ,或氢氯噻嗪 (5 0mg·d-1) ,并于治疗前后行 2 4h动态BP监测。采用余弦拟合方法分析治疗前后患者BP时间生物学特征的改变。结果 :赖诺普利组与非洛地平组治疗后 2 4hBP均值明显降低 ,但其振幅、峰值相位无变化 ;氢氯噻嗪治疗降压效果不甚理想 ,但显著增加了患者BP的夜间降低幅度 ,使患者BP由非杓型转变为杓型分布。结论 :氢氯噻嗪治疗可能使非杓型分布的高血压病患者的BP转变为杓型分布 ,从而有助于降低患者相关并发症的发生率。郭艺芳 Stein PK 宋光耀 Domitrovich PP 2002中国临床药学杂志2002,11,4:2
16老年人心脏自主神经活动时相的生物学特征显示文摘目的 本研究旨在以心率变异性 (HRV)为手段 ,探讨老年人心脏自主神经活动时相的生物学特征。 方法 共入选 2组健康受试者 :观察组 33例 ,年龄 65~ 82岁 ,平均 ( 72± 10 )岁 ;对照组 31例 ,2 6~ 35岁 ,平均 ( 30± 4)岁。对 2组对象进行 2 4h动态心电图监测 ,记录每小时HRV的频域指标 (总功率TP ,低频成分LF ,高频成分HF ,及LF/HF)。采用余弦拟合法对所得数据进行处理。 结果 HRV的频域指标呈典型的昼夜节律分布 ;与年轻组相比 ,老年人TP ,LF及HF的均值及振幅明显减低 ;LF/HF的振幅也减低 ,但其均值无显著变化。 2组间各指标的相位无明显变化。 结论 老年人HRV的 2 4h均值及昼夜波动振幅渐低 ,而其相位不变。郭艺芳 宋光耀 Stein PK Domitrovich PD 李绍冰 2002实用老年医学2002,16,2:2
17Variation in MR signal intensity across normal human knee cartilage显示文摘Pradip PK Jasani MK Sebok D 1993JMRI1993,3,3:2
18应用过氧化物酶技术检查肯尼亚疑似犬瘟热显示文摘Gath.,PK 辛勤 1994国外兽医学(畜禽传染病)1994,14,2:2
19站立30s后直立性低血压与老年抑郁之间的纵向关系显示文摘直立性低血压(orthostatic hypotension,OH)与老年抑郁之间存在明确的横向联系。该观察性研究的目的是为了阐明基线症状性OH(symptomatic OH,sOH-30)与抑郁症之问的纵向关系。该样本包含无基线抑郁症的老年人(平均年龄62岁)〉3000名。Robert B Daniel C Sean PK Rose AK 刘青 叶鹏 2018中华高血压杂志2018,26,5:2
20慢性阻塞性肺疾病急性加重患者感染性致病因素分析显示文摘背景和目的:反复急性发作是慢性阻塞性肺疾病(COPD)的临床特点,同时也是患者住院的主要原因,呼吸道感染常常是急性发作的诱因。适当的经验性应用抗生素对于降低此类患者的住院率和病死率非常有意义。不同居住地的COPD患者引起急性发作的病原谱是不同的,因而地区性资料对于指导临床治疗很重要。本研究的目的是阐明我国香港地区COPD急性发作的病原学及其治疗。方法:研究人员分析了我国香港2004年5月至2005年4月因COPD急性发作而住院的患者,Ko FW Ip M Chan PK 李翠联 曹彬 2007中华结核和呼吸杂志2007,30,5:2
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