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| 1 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 2 | Structure of thebiomedical literature 显示文摘 | Narin F Pinski G Gee H H | 1976 | Journal of the American Society for In-formation Science1976，27，1： | 1 |
| 3 | The nationallung screeningtrial: results stratified by demographics,smoking history, and lungcancer histology显示文摘 | Pinsky PF Church TR Izmirlian G | 2013 | Cancer2013，119，22： | 1 |
| 4 | Blood lactate levels are better prognostic indicators than TNF and IL-6 levels in patients with septic shock显示文摘 | Marecaux G Pinsky MR Dupont E | | 0，，： | 1 |
| 5 | Blood lactate levels are better prognostic indicators than TNF and IL - 6 levels in patients with septic shock显示文摘 | Marecaux G Pinsky MR Dupont E et at | 1996 | Intensive Care Med1996，22，5： | 1 |
| 6 | Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care显示文摘 | Angus DC Linde-Zwirble WT Lidicker J Clermont G Carcillo J Pinsky MR | 2001 | Crit Care Med2001，29，： | 1 |
| 7 | Growth hormone-releasing hormone antagonist MZ-4-71 inhibits in vivo proliferation of Caki-I renal adenoearcinoma 显示文摘 | Jungwirth A Schally A V Pinski J Groot K Armatis P Halmos G | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 8 | Citation influence for journal aggregates of scientific publications: Theory, with application to the literature of physics显示文摘 | Pinski G Narin F | 1976 | Information Processing & Management1976，12，5： | 1 |
| 9 | Somatostatin receptor expression in lung cancer显示文摘 | O'Byrne KJ Halmos G Pinski J | 1994 | Eur J Cancer1994，30，11： | 1 |
| 10 | Chronic administration of the luteinizing hormone-releasing hormone (LHRH) antagonist Cetrorelix decreases gonadotrope responsiveness and pituitary LHRH receptor messenger ribonucleic acid levels in 'rats显示文摘 | Pinski J Lamharzi N Halmos G | 1996 | Endocrinology1996，137，： | 1 |
| 11 | Factors related to immunosuppressant medication adherence in renal transplant recipients显示文摘 | Chisholm-Burns M Pinsky B Parker G | 2012 | Clin Transplant2012，26，5： | 1 |
| 12 | Epidemiology of severe in the lnited States:analysis of incidenee,ourtcome,and associatde costs of care 显示文摘 | Angus DC Linde-Zwirble WT lidicked J Clermont G Carcillo J Pinsky MR | 2001 | Crit Care Med2001，29，： | 1 |
| 13 | Growth hormone-releasing hormone antagonist MZ- 4-71 inhibits in vivo proliferation of Caki- Ⅰ renal adenocarcinoma显示文摘 | Jungwirth A Sehally A V Pinski J Groot K Armatis P Halmos G | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 14 | Inhibition of growth of MKN45 human gastric-carcinoma xenografts in nude mice by treatment with bombesin/gastrin-releasing-peptide antagonist(RC-3095) and somatostatin analogue RC-160显示文摘 | Pinski J Halmos G Yano T | 1994 | Int J Cancer1994，57，4： | 1 |
| 15 | Epidemiology of severe sepsis in the United States:analysis of incidence, outcome, and associated costs of care显示文摘 | Angus DC Linde-Zwirble WT Lidicker J Clermont G Carcillo J Pinsky | 2001 | Crit Care Med2001，29，： | 1 |
| 16 | Inhibition of growth of OV-1063 human epithelial ovarian cancer xenografts in nude mice by treatment with luteinizing hormone releasing hormone antagonist SB-75 显示文摘 | Yano T Pinski J Halmos G | 1994 | PNAS1994，91，： | 1 |
| 17 | Epidemiology of severe sepsis in the United States:analysis of incidence outcome and asso- ciated costs of care显示文摘 | Augus D C Lin&Zwirble W T Lidicker J Clermont G Carcillo J Pinsky M R | 2001 | Crit Care Med2001，29，： | 1 |
| 18 | Inhibition of growth of MKN45 human gastric-carcinoma xenografts in nude mice by treatment with bombesin/gastrin-releasing-peptide antagonist (RC-3095) and somatostatin analogue RC-160显示文摘 | Pinski J Halmos G Yano T | 1994 | Int J Cancer1994，57，4： | 1 |
| 19 | Growth hormone-releasing hormone antagonist MZ-4 71 inhibits in vivo proliferation of caki- Ⅰ renal adeno carainoma显示文摘 | Jungwirth A Sehally A V Pinski J Groot K Armatis P Hal mos G | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 20 | Citation influence for journal aggregates of scientific publications: theory, with application to the litera- ture of physics 显示文摘 | PINSKI G NARIN F | 1976 | Information Processing and Management1976，，12： | 1 |
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