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| 1 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 2 | A Low Power,High Sensitivity SiGe HBT Static Frequency Divider up to 90 GHz for Millimeter-Wave Application显示文摘A layout and connection optimization for static frequency divider is presented. The layout optimization provides a new circle topology transistors placement and reasonable connection structure, which reduces the parasitic effectively and enables self-oscillation frequency enhancement. Besides, bandwidth enhancement techniques based on a center-tap capacitor in input balun design and inductive peaking in latch design are adopted to improve further high frequency performance with low power consumption. As a proof of concept, design of a divide-by-2 static frequency divider in 0.13 μm SiGe BiCMOS technology is reported. With single-ended input clock signal, the divider is measured to be operated from 40 to 90 GHz. Phase noise measurements of a 90 GHz input clock signal indicate ideal behavior with no measurable noise contribution from the divider. The divider followed by a buffer that can deliver more than-10 dBm output power, which is sufficient to drive succeeding stage. To the author's knowledge, the divider exhibits a competitive power dissipation and the highest FOM among silicon based frequency dividers that operating higher than 70 GHz. | Peigen Zhou Jixin Chen Pinpin Yan Debin Hou Wei Hong | 2019 | China Communications2019，16，2： | 2 |
| 3 | A high-efficiency, high harmonic rejection E-band SiGe HBT frequency tripler for high-resolution radar application显示文摘Dear editor,With the advances in silicon-based technologies,high performance, low-cost frequency-modulated continuous wave (FMCW) radar sensors enabling advanced driver-assistance convenience in vehicles have been developed extensively in recent years . | Peigen ZHOU Pinpin YAN Jixin CHEN Debin HOU Wei HONG | 2019 | Science China(Information Sciences)2019，62，6： | 1 |
| 4 | Alternations in the gut microbiota and metabolome with newly diagnosed unstable angina显示文摘Gut microbiota plays an important role in coronary heart disease, but its compositional and functional changes in unstable angina(UA) remain unexplored. We performed metagenomic sequencing of 133 newly diagnosed UA patients and 133 sex-and age-matched controls, and profiled the fecal and plasma metabolomes in 30 case-control pairs. The alpha diversity of gut microbiota was increased in UA patients:the adjusted odds ratios(ORs) per standard deviation increase in Shannon and Simpson indices were 1.30(95% confidence interval, 1.01-1.70) and 1.36(1.05-1.81), respectively. Two common species(depleted Klebsiella pneumoniae and enriched Streptococcus parasanguinis;P ≤ 0.002) and three rare species(depleted Weissella confusa, enriched Granulicatella adiacens and Erysipelotrichaceae bacterium 6_1_45;P ≤ 0.005) were associated with UA. The UA-associated gut microbiota was depleted in the pathway of Lphenylalanine degradation(P = 0.001), primarily contributed by Klebsiella pneumoniae. Consistently, we found increased circulating phenylalanine in UA patients(OR = 2.76 [1.17-8.16]). Moreover, Streptococcus parasanguinis was negatively correlated with fecal citrulline(Spearman's r_(s)=-0.470, P = 0.009), a metabolite depleted in UA patients(OR = 0.26 [0.08-0.63]). These findings are informative to help understand the metabolic connection between gut microbiota and UA. | Xuezhen Liu Miaoyan Shen Han Yan Pinpin Long Haijing Jiang Yizhi Zhang Lue Zhou Kuai Yu Gaokun Qiu Handong Yang Xiulou Li Xinwen Min Meian He Xiaomin Zhang Hyungwon Choi Chaolong Wang Tangchun Wu | 2022 | Journal of Genetics and Genomics2022，49，3： | 1 |
| 5 | Effectiveness of DTaP Against Pertussis in≤2-Year-Old Children—Linyi Prefecture,Shandong Province,China,2017–2019显示文摘Summary What is already known about this topic?Vaccine effectiveness(VE)is positively correlated with the number of administered co-purified diphtheria,tetanus,and acellular pertussis vaccine(DTaP)doses.A matched case-control study conducted in Zhongshan City revealed that the co-purified DTaP VE against pertussis-related illnesses in children aged 4–11 months was 42%for one dose,88%for two doses,and 95%for three doses,respectively.What is added by this report?The results of this study contribute to the current body of research.We found that the VE of co-purified DTaP against pertussis-related illness and hospitalization increased substantially,ranging from 24%–26%after one dose to 86%–87%after four doses. | Pinpin Zhu Dan Wu Yan Wang Xiaoxue Liu Lance ERodewald Yixing Li Hui Zheng Lei Cao Yifan Song Li Song Xiaodong Zhao Jianyi Yao Fuzhen Wang Mingshuang Li Qian Zhang Tingting Yan Zundong Yin | 2023 | China CDC weekly2023，5，17： | 0 |
| 6 | Research on Silicon-Based Terahertz Communication Integrated Circuits显示文摘With the increasing number of users and emerging new applications, the demand for mobile data traffic is growing rapidly. The limited spectrum resources of the traditional microwave and millimeter-wave frequency bands can no longer support the future wireless communication systems with higher system capacity and data throughput. The terahertz(THz) frequency bands have abundant spectrum resources, which can provide sufficient bandwidth to expand channel capacity and increase transmission data rate. In addition, with the rapid development of silicon-based semiconductor technology,its characteristic size keeps decreasing, and the radio frequency performance of active devices is gradually approaching the performance of III-V semiconductor technology. The realization of THz communication systems based on low-cost, high-stability, and easy-to-integrate silicon-based process has become a feasible solution. This review summarizes the reported silicon-based THz communication systems, as well as the key sub-circuit chips in these systems, including the local oscillator, power amplifier, low noise amplifier, on-chip antenna and transceiver chip, etc. | ZHOU Peigen CHEN Jixin TANG Siyuan YU Jiayang WANG Chen LI Huanbo LU Haiyan YAN Pinpin HOU Debin CHEN Zhe HONG Wei | 2022 | Chinese Journal of Electronics2022，31，3： | 0 |
| 7 | A 143.2–168.8-GHz signal source with 5.6 dBm peak output power in a 130-nm SiGe BiCMOS process显示文摘Dear editor,With the development of silicon-based processes,a variety of RF devices have become possible to be designed at frequencies above 100 GHz[1].Besides,sub-terahertz systems operating in D-Band have the potential to be applied to a wide range of applications,such as high-resolution radar,energy detection,and broadband ultra high-speed communication[2]. | Peigen ZHOU Jixin CHEN Pinpin YAN Zhigang PENG Debin HOU Zhe CHEN Wei HONG | 2020 | Science China(Information Sciences)2020，63，12： | 0 |
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