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| 1 | Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress显示文摘BACKGROUND:Liver ischemia reperfusion(IR)injury triggers a systemic inflammatory response and is the main cause of organ dysfunction and adverse postoperative outcomes after liver surgery.Pentoxifylline(PTX)and hypertonic saline solution(HTS)have been identified to have beneficial effects against IR injury.This study aimed to investigate if the addition of PTX to HTS is superior to HTS alone for the prevention of liver IR injury. | Vinicius Rocha-Santos Estela RR Figueira Joel A Rocha-Filho Ana MM Coelho Rafael Soraes Pinheiro Telesforo Bacchella Marcel CC Machado Luiz AC D'Albuquerque | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 3 |
| 2 | Beneficial effects of adenosine triphosphate-sensitive K^+ channel opener on liver ischemia/reperfusion injury显示文摘AIM:To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury.METHODS:Wistar male rats underwent partial liver ischemia performed by clamping the pedicle from the medium and left anterior lateral segments for 1 h under mechanical ventilation.They were divided into 3 groups:Control Group,rats submitted to liver manipulation,Saline Group,rats received saline,and Diazoxide Group,rats received intravenous injection diazoxide(3.5 mg/kg) 15 min before liver reperfusion.4 h and 24 h after reperfusion,blood was collected for determination of aspartate transaminase(AST),alanine transaminase(ALT),tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),nitrite/nitrate,creatinine and tumor growth factor-β1(TGF-β1).Liver tissues were assembled for mitochondrial oxidation and phosphorylation,malondialdehyde(MDA) content,and histologic analysis.Pulmonary vascular permeability and myeloperoxidase(MPO) were also determined.RESULTS:Four hours after reperfusion the diazoxide group presented with significant reduction of AST(2009 ± 257 U/L vs 3523 ± 424 U/L,P = 0.005); ALT(1794 ± 295 U/L vs 3316 ± 413 U/L,P = 0.005); TNF-α(17 ± 9 pg/mL vs 152 ± 43 pg/mL,P = 0.013; IL-6(62 ± 18 pg/mL vs 281 ± 92 pg/mL); IL-10(40 ± 9 pg/mL vs 78 ± 10 pg/mL P = 0.03),and nitrite/nitrate(3.8 ± 0.9 μmol/L vs 10.2 ± 2.4 μmol/L,P = 0.025) when compared to the saline group.A significant reduction in liver mitochondrial dysfunction was observed in the diazoxide group compared to the saline group(P < 0.05).No differences in liver MDA content,serum creatinine,pulmonary vascular permeability and MPO activity were observed between groups.Twenty four hours after reperfusion the diazoxide group showed a reduction of AST(495 ± 78 U/L vs 978 ± 192 U/L,P = 0.032); ALT(335 ± 59 U/L vs 742 ± 182 U/L,P = 0.048),and TGF-β1(11 ± 1 ng/mL vs 17 ± 0.5 ng/mL,P = 0.004) serum levels when compared to the saline group.The control group did not present alterations when compared to the diazoxide and saline groups.CONCLUSION:Diazoxide maintains liver mitochondrial function,increases liver tolerance to ischemia/reperfusion injury,and reduces the systemic inflammatory response.These effects require further evaluation for using in a clinical setting. | Mateus Antunes Nogueira Ana Maria Mendona Coelho Sandra Nassa Sampietre Rosely Antunes Patzina Fabiano Pinheiro da Silva Luiz Augusto Carneiro D'Albuquerque Marcel Cerqueira Cesar Machado | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 3 | Immunohistochemical study of the digestive tract of Oligosarcus hepsetus显示文摘AIM: To describe the histology of the digestive tract and to investigate the occurrence of endocrine cells in Oligosarcus hepsetus (O. hepsetus ). METHODS: The digestive tract (DT) of O. hepsetus was divided into esophagus, two stomach regions (glandular and non-glandular) and two intestinal regions (anterior and posterior). These specimens were processed by routine histological techniques and stained with hematoxylin-eosin, Gomori's trichrome, periodic acid Schiff (PAS) and Alcian blue (AB). An immunohistochemical method using avidin-biotin-peroxidase was employed.RESULTS: The esophagus is lined with a non-keratinized stratified squamous epithelium that is reactive to PAS and AB. The stomach has a mucosa lined with a simple columnar epithelium with mucus-secreting cells that are reactive only to PAS. The intestine has a simple columnar epithelium with a brush border and goblet cells that are reactive to PAS and AB. Somatostatin, serotonin and cholecystokinin immunoreactive cells were identified throughout the DT.CONCLUSION: This study revealed adaptations for the species' diet and showed that the distribution and relative frequency of immunoreactive cells are similar to those of other fish. | Danielle A Vieira-Lopes Nadja L Pinheiro Armando Sales Adriana Ventura Francisco G Araújo Iracema D Gomes Aparecida A Nascimento | 2013 | World Journal of Gastroenterology2013，19，12： | 2 |
| 4 | Incentive to manipulate earnings and its connection to analysts' forecasts, trading, and corporate governance 显示文摘 | Igan D Pinheiro M | 2010 | Journal of Economics and Finance2010，，4： | 1 |
| 5 | Effects of early feed restriction and enzyme supplementation on digestiveenzyme activities in broilers显示文摘 | Pinheiro D F Cruz V C Sartori J R | 2004 | Poultry Science2004，83，： | 1 |
| 6 | Delay from fracture tohospital admission: a new risk factor for hip fracture mortality 显示文摘 | Vidal E Moreira-Filho D Pinheiro R | 2012 | Osteoporos Int2012，23，12： | 1 |
| 7 | 限饲和再投喂对不同日龄鸡消化酶促反应的影响显示文摘试验旨在评价限饲和再投喂对两个不同日龄(7和35d)鸡酶活性和胃肠道器官重量的影响,在每种日龄下,鸡被限饲70%(30%自由采食)7d,然后自由采食3d。对照组自由采食10d。对胰腺中糜蛋白酶、胰蛋白酶、淀粉酶、脂肪酶活性和小肠中蔗糖酶、麦芽糖酶的活性进行分析,并且测量了腺胃、肌胃、小肠和大肠的重量。在14d,与对照组相比,限饲组的胰蛋白酶、淀粉酶活性均降低,但在42d,与对照组相比,限饲组蔗糖酶活性降低,表明限饲对酶活性的影响与日龄有关。限饲可以降低完成期(42d)各器官的重量。日龄35~42d的鸡,在再投喂后,器官重量增加,并且达到与对照组一致。在起始期(14d),腺胃和肌胃受限饲的影响很小,在完成期,肌胃也是受影响最小的器官,而小肠时受影响最严重。限饲的所有影响在恢复饲喂3d后被逆转,表明这种改变时快速且可逆的,并且限饲和再投喂与年龄有关。 | Cristiane R A Duarte Maria L M Vicentini P Pinheiro D F | 2014 | 饲料博览2014，0，10： | 1 |
| 8 | Optimization of extraction of high-ester pectin from passion fruit peel (Pasiflora edulits flavicarpa) with citric acid by using response surface methodology显示文摘 | Pinheiro E R Silva I M D A Gonzaga L V | 2008 | Bioresource Tech- nolo2008，99，： | 1 |
| 9 | Genetic deletion of the angiotensin (1 7) receptor Mas leads to glomerular hyperfiltration and microalbu minuria显示文摘 | Pinheiro S V Ferreira A J Kitten G T da Silveira K D da Silva D A Santos S H | 2009 | Kidney Int2009，75，： | 1 |
| 10 | Failure Trends in a Large Disk Drive Population显示文摘 | PINHEIRO E WEBER W D BARROSO L A | 2007 | Proceedings of the 5th USENIX Conference on File and Storage Technologies (FAST''07)2007，，： | 1 |
| 11 | Successful liver allograft inflow reconstruction with the right gastroepiploic vein显示文摘Portal vein thrombosis is a common complication in cirrhotic patients. When portal vein thrombectomy is not a suitable option, a large collateral vessel can be used for allograft venous inflow reconstruction. We describe an unusual case of successful portal revascularization using the right gastroepiploic vein. The patient underwent a cadaveric orthotopic liver transplantation with end-to-end anastomosis of the portal vein to the right gastroepiploic vein. Six months after liver transplantation the patient is well with good liver function. The use of the right gastroepiploic vein for allograft venous reconstruction is feasible and safe, with a great advantage of avoiding the need of venous jump graft. | Rafael S Pinheiro Ruy J Cruz Jr Lucas S Nacif Matheus F Vane Luiz AC D'Albuquerque | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，1： | 1 |
| 12 | Effect of inulin on growth and acidification performance of different probiotic bacteria in co-cultures and mixed culture with Streptococcusthermophilus显示文摘 | Pinheiro D S O R Patrizia P Attilio C | 2009 | Journal of Food Engineering2009，91，1： | 1 |
| 13 | Optimization of extraction of high-ester pectin from passion fruit peel (Passiflora edulis flavicarpa) with citric acid by using response surface methodology显示文摘 | Pinheiro E Silva I M D A Gonzaga L V | 2008 | Bioresource Technology2008，99，13： | 1 |
| 14 | De- sign of bio - nanosystems for oral delivery of functional compounds显示文摘 | Cerqueira M A Pinheiro A C Silva H D | 2014 | Food Engineering Reviews2014，6，12： | 1 |
| 15 | Optimization of extraction of high-ester pectin from passion fruit peel(Passiflora edulis flavicarpa)with citric acid by using response surface methodology显示文摘 | Pinheiro E S Silva I M D A Gonzaga L V | 2008 | Bioresource Technology2008，99，13： | 1 |
| 16 | Cor- relation of the P300 evoked potential in depressive and cogni- tive aspects of aging 显示文摘 | MIRANDA E C PINHEIRO M M PEREIRA L D | 2012 | Braz J Otorhinolaryngol2012，78，5： | 1 |
| 17 | Pre - eclampsi- a: relationship between coagulation, fibrinolysis and inflammation 显示文摘 | DUSSE L M RIOS D R PINHEIRO M B | 2011 | Clin Chim Acta2011，412，12： | 1 |
| 18 | The irr~anopathology of sepsis : pathogen recognition, systemic inflammation, the compensatory anti-inflammatory response, and regulatory T cells 显示文摘 | Lewis D H Chan D L Pinheiro D | 2012 | J Vet Intern Med2012，26，3： | 1 |
| 19 | Fatigue analysis of damaged steel pipelines under cyclic internal pressure 显示文摘 | PINHEIRO B D C PASQUALINO I P | 2009 | International Journal of Fatigue2009，31，5： | 1 |
| 20 | Antrochoanal polyp: a review of sixteen cases显示文摘 | FREITAS M R GIESTA R P PINHEIRO S D | 2006 | Rev Bras Otorrinolaringol (Engl Ed)2006，72，： | 1 |
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