|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Noether symmetries of the nonconservative and nonholonomic systems on time scales显示文摘In this paper we give a new method to investigate Noether symmetries and conservation laws of nonconservative and nonholonomic mechanical systems on time scales , which unifies the Noether's theories of the two cases for the continuous and the discrete nonconservative and nonholonomic systems. Firstly, the exchanging relationships between the isochronous variation and the delta derivatives as well as the relationships between the isochronous variation and the total variation on time scales are obtained. Secondly, using the exchanging relationships, the Hamilton's principle is presented for nonconservative systems with delta derivatives and then the Lagrange equations of the systems are obtained. Thirdly, based on the quasi-invariance of Hamiltonian action of the systems under the infinitesimal transformations with respect to the time and generalized coordinates, the Noether's theorem and the conservation laws for nonconservative systems on time scales are given. Fourthly, the d'Alembert-Lagrange principle with delta derivatives is presented, and the Lagrange equations of nonholonomic systems with delta derivatives are obtained. In addition, the Noether's theorems and the conservation laws for nonholonomic systems on time scales are also obtained. Lastly, we present a new version of Noether's theorems for discrete systems. Several examples are given to illustrate the application of our results. | CAI PingPing FU JingLi GUO YongXin | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，5： | 52 |
| 3 | Source Rocks for the Giant Puguang Gas Field,Sichuan Basin:Implication for Petroleum Exploration in Marine Sequences in South China显示文摘摘要:详细地球化学研究被进行在巨大的 Puguang 煤气的领域里调查稳固的沥青和烃气体的起源。稳固的沥青的二种类型被认出:低硫在在 Xujiahe 形成和高硫的沙岩水库的沥青满足的满意的、低反射(LSLR ) 固体,高反射(HSHR ) 固体在在更低的三叠纪的 Feixianguan 和上面的二叠的 Changxing 形成的碳酸盐水库的沥青。在上面的三叠纪的 Xujiahe 形成的稳固的沥青与摘录相关很好从上面对在同位素的作文的侏罗记 nonmarine 来源岩石三叠纪浸透并且芳香的部分和 biomarker 分发。在 Feixianguan 和 Changxing 形成的稳固的沥青与摘录从显然不同寒武纪并且志留纪岩石但是在同位素的作文两个都从上面的二叠的来源岩石与摘录显示合理关联浸透并且芳香的部分并且在 biomarker 分发,建议二叠特别上面的二叠的 Longtan 形成是在在在 th 的 Feixianguan 和 Changxing 形成的碳酸盐水库的稳固的沥青的主要来源天然气的化学、同位素的作文显示烃气体的多数从生存于富有腐殖质的有机物发源并且是积累的油的热裂开的产品。这研究显示生存于富有腐殖质的有机物统治的那来源岩石存在在上面二叠并且做了主要贡献到巨大的 Puguang 煤气的地,它在华南在海洋的序列为石油探索有重要牵连。 | ZOU Huayao HAO Fang ZHU Yangming GUO Tonglou CAI Xunyu LI Pingping ZHANG Xuefeng | 2008 | Acta Geologica Sinica(English Edition)2008，82，3： | 11 |
| 4 | Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons显示文摘Lgr5+intestinal stem cells(ISCs)reside within specialized niches at the crypt base and harbor self-renewal and differentiation capacities.ISCs in the crypt base are sustained by their surrounding niche for precise modulation of self-renewal and differentiation.However,how intestinal cells in the crypt niche and microbiota in enteric cavity coordinately regulate ISC stemness remains unclear.Here,we show that ISCs are regulated by microbiota and niche enteric serotonergic neurons.The gut microbiota metabolite valeric acid promotes Tph2 expression in enteric serotonergic neurons via blocking the recruitment of the NuRD complex onto Tph2 promoter.5-hydroxytryptamine(5-HT)in turn activates PGE2 production in a PGE2+macrophage subset through its receptors HTR2A/3 A;and PGE2 via binding its receptors EP1/EP4,promotes Wnt/β-catenin signaling in ISCs to promote their self-renewal.Our findings illustrate a complex crosstalk among microbiota,intestinal nerve cells,intestinal immune cells and ISCs,revealing a new layer of ISC regulation by niche cells and microbiota. | Pingping Zhu Tiankun Lu Jiayi Wu Dongdong Fan Benyu Liu Xiaoxiao Zhu Hui Guo Ying Du Feng Liu Yong Tian Zusen Fan | 2022 | Cell Research2022，32，6： | 8 |
| 5 | Quantitative trait loci for Fusarium head blight resistance in wheat cultivars Yangmai 158 and Zhengmai 9023显示文摘Fusarium head blight(FHB)is one of the prevalent fungal diseases of wheat worldwide.Exploring new FHB resistance quantitative trait loci(QTL)in adapted wheat cultivars is a critical step for breeding new FHB-resistant cultivars.In this study,we developed a population of 236 F5:7 recombinant inbred lines(RILs)using two popular Chinese wheat cultivars,Yangmai 158 and Zhengmai 9023,with moderate FHB resistance to identify the QTL for FHB type II resistance.This population was evaluated for percentage of symptomatic spikelets per spike(PSS)using single floret injection in repeated greenhouse experiments.Mean PSSs were 33.2%for Yangmai 158 and 30.3%for Zhengmai 9023.A genetic linkage map of 1002 single nucleotide polymorphisms(SNPs)generated by genotyping-by-sequencing(GBS)was constructed for the RIL population.Six QTL were identified for FHB resistance,and three of them were repeatable in the both experiments.Zhengmai 9023 contributed the resistance allele at one repeatable QTL,designated as Qfhb.7D,whereas Yangmai 158 contributed the resistance alleles at the other two repeatable QTL,Qfhb.3AL and Qfhb.2DS.The additional QTL,Qfhb.4AS was significant in the mean PSS,and Qfhb.2DL and Qfhb.7AS were significant in only one experiment.Replacement of each allele individually at the three repeatable QTL significantly changed PSSs.Qfhb.3AL,Qfhb.2DS,and Qfhb.7D explained 8.35%to 9.89%,5.13%to 7.43%,and 6.15%to 9.32%of the phenotypic variations,respectively.The three repeatable QTL contributed by the two parents were additive and stacking the resistance alleles from all the three repeatable QTL showed the highest level of resistance in the current RIL population.Ten SNPs in the QTL regions of Qfhb.3AL,Qfhb.2DS,and Qfhb.7D were converted into KBioscience competitive allele-specific PCR(KASP)assays.One KASP marker for Qfhb.3AL was validated in a panel of wheat cultivars from China.Some of these KASP markers could be useful for marker-assisted selection to stack these QTL. | Pingping Zhang Chenjin Guo Zhao Liu Amy Bernardo Hongxiang Maa Hongxiang Ma Peng Jiang Guicheng Song Guihua Bai | 2021 | The Crop Journal2021，9，1： | 8 |
| 6 | Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy显示文摘Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers,the majority of patients with solid tumors do not respond well,but the underlying reason remains unclear.Here,we studied ovarian cancer(OvCa),a tumor type generally resistant to current immunotherapies,to investigate PD-1-independent immunosuppression.We found that PD-L1 was not highly expressed in the tumor microenvironment(TME)of human OvCa.Instead,B7-H3,another checkpoint molecule,was highly expressed by both tumor cells and tumor-infiltrating antigen-presenting cells(APCs),which correlated with T-cell exhaustion in patients.Using ID8 OvCa mouse models,we found that B7-H3 expressed on tumor cells,but not host cells,had a dominant role in suppressing antitumor immunity.Therapeutically,B7-H3 blockade,but not PD-1 blockade,prolonged the survival of ID8 tumorbearing mice.Collectively,our results demonstrate that tumor-expressed B7-H3 inhibits the function of CD8^(+)T cells and suggest that B7-H3 may be a target in patients who are not responsive to PD-L1/PD-1 inhibition,particularly OvCa patients. | Dongli Cai Jiaming Li Dingfeng Liu Shanjuan Hong Qin Qiao Qinli Sun Pingping Li Nanan Lyu Tiantian Sun Shan Xie Li Guo Ling Ni Liping Jin Chen Dong | 2020 | Cellular & Molecular Immunology2020，17，3： | 8 |
| 7 | Seed bank and regeneration dynamics of Emmenopterys henryi population on the western side of Wuyi Mountain,South China显示文摘Emmenopterys henryi Oliv.(Rubiaceae) is an endangered tree species that is native to China.The wild populations of E.henryi have declined rapidly because of its poor natural regeneration,but the actual regeneration processes are not yet understood.In field tracking surveys and experiments in the Wuyishan Nature Reserve in Southeast China to determine the most important stage that affects the regeneration process,seed bank characteristics,seed germination,and seedling growth dynamics were studied in the typical habitats of E.henryi,Phyllostachys pubescens and broad-leaved forests.Results showed that in both P.pubescens and broad-leaved forests,more than 70% of the E.henryi seeds were distributed in moss and litter layers,and few were found in the soil beneath them.However,seed germination in the soil layer was significantly higher than in the moss and litter layers.Seed density,overall seed quality,and germination rate in the broad-leaved forest were significantly higher than in P.pubescens forest.Seed germination was highest in the microsites around the edge of the crown projection area of E.henryi mother trees.The order of survival rate of the seedlings on different ground surfaces was soil> moss>litter.In both habitats,the average seed density was 24.9 seeds m^(-2),and the total germination rate was less than 3.5%.However,seedlings developed from only 1% of the germinated seeds,indicating that the seed germination is the most important stage in the natural regeneration of E.henryi. | Lianjin Guo Pingping Xue Mei Li Xinghua Shao | 2017 | Journal of Forestry Research2017，28，5： | 7 |
| 8 | Accumulation Mechanisms and Evolution History of the Giant Puguang Gas Field,Sichuan Basin,China显示文摘稳固的沥青在 Puguang 煤气的地里在整个碳酸盐水库被发现,最大的煤气的地到目前为止在中国在海洋的碳酸盐发现了,证实 Puguang 煤气的地从一座 paleo 油水库演变。液体水管系统在这域里的集中的油累积的时候被重建,并且石油移植小径用一个 3-D 模型被建模并且由 geochemical 参数跟踪了。向前建模并且倒置跟踪与对方一起与一致,两个显示油在 Puguang-Dongyuezhai 结构积累了从一个生产厨房发源到 Puguang 气体地的西北。生存于富有腐殖质的有机物在东北四川盆,是垂直地近来源的岩石和旁边地在生产附近的厨房的液体水管系统的发展,并且集中油统治的器官富人的上面的二叠的来源岩石的免职从生产厨房的一个大区域发源,是为巨大的 Puguang 煤气的地从演变的巨大的paleo油水库的形成的三个要求。Puguang 煤气的地经历了三阶段的进化。累积以后的进程,特别在 hydrocarbon-water-rock 系统的器官无机的相互作用,深刻地不仅改变了石油液体的作文和特征,而且显然在水库改变了物理化学的条件并且导致了碳酸盐矿物质的复杂降水和答案。 | HAO Fang GUO Tonglou DU Chunguo ZOU Huayao CAI Xunyu ZHU Yangming LI Pingping WANG Chunwu ZHANG Yuanchun | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 4 |
| 9 | Recent advances in pharmaceuticals and personal care products in the surface water and sediments in China显示文摘 | Wentao Zhao Ying Guo Shuguang Lu Pingping Yan Qian Sui | 2016 | Frontiers of Environmental Science & Engineering2016，10，6： | 4 |
| 10 | Pore Structure Characteristics of Baking-Free Slag-Sludge Bricks and Its Correlations to Mechanical Properties显示文摘In order to explore the relationship between the macroscopic properties and pore structure characteristics of baking-free slag-sludge bricks,the compressive strength and water absorption rate using aluminum industrial slag and sludge of different substitution rates were tested.Optical instruments and image analysis software were used to measure the parameters of the pore structure.Specifically,a fractal model was built based on the fractal theory,in which the fractal dimension was used as the characteristic index of the pore structure to analyze the correlation and interaction mechanism between the fractal dimension and the macroscopic mechanical properties.Based on this study,conclusions were drawn as follows:(1)The plane pore structure of baking-free bricks shows good fractal characteristics.With the increase of the aluminum industrial slag content,the fractal dimension becomes smaller and the pore structure develops well;with the increase of the sludge content,the fractal dimension becomes larger and the pore structure becomes worse;(2)As the fractal dimension of the plane pore structure increases,the compressive strength of baking-free bricks falls,and the porosity and water absorption rise;(3)The optimum content of baking-free slag-sludge bricks is aluminum industrial slag 30%and sludge 10%.After 7 days of curing,baking-free bricks boast higher performance,and fully meet the performance requirements of solid concrete bricks(MU40),which can reduce time costs,and enhance enterprise revenue. | Lei Guo Pingping Chen Lixia Guo Zhilong Xue Zi Guan Mingru Li | 2021 | Journal of Renewable Materials2021，9，10： | 2 |
| 11 | Research on Key Issues of Consistency Analysis of Vehicle Steering Characteristics显示文摘Given the global lack of effective analysis methods for the impact of design parameter tolerance on performance deviation in the vehicle proof-of-concept stage,it is difficult to decompose performance tolerance to design parameter tolerance.This study proposes a set of consistency analysis methods for vehicle steering performance.The process of consistency analysis and control of automotive performance in the conceptual design phase is proposed for the first time.A vehicle dynamics model is constructed,and the multi-objective optimization software Isight is used to optimize the steering performance of the car.Sensitivity analysis is used to optimize the design performance value.The tolerance interval of the performance is obtained by comparing the original car performance value with the optimized value.With the help of layer-by-layer decomposition theory and interval mathematics,automotive performance tolerance has been decomposed into design parameter tolerance.Through simulation and real vehicle experiments,the validity of the consistency analysis and control method presented in this paper are verified.The decomposition from parameter tolerance to performance tolerance can be achieved at the conceptual design stage. | Yanhua Liu Xin Guan Pingping Lu Rui Guo | 2021 | Chinese Journal of Mechanical Engineering2021，34，2： | 2 |
| 12 | Tensile mechanical properties of greenhouse cucumber cane显示文摘To obtain the mechanical properties of greenhouse cucumber cane,tensile and shear properties of the greenhouse cucumber cane were studied by using computer-controlled electronic universal testing machine and homemade cutting test bench,respectively.Firstly,the root,middle and head of cucumber cane were subjected for tensile tests.The tensile stress-strain curves showed that the root of cumber cane presented the characteristics of plastic material,while the middle and head showed the characteristics of brittle material.The average tensile strength of root,middle and head of fresh cucumber cane were 7.35 MPa,6.30 MPa and 4.68 MPa,respectively.The average elastic modulus of root of fresh cucumber cane was 280.58 MPa,which was much greater than the middle and head with average elastic modulus of 198.81 MPa and 137.22 MPa,respectively.A pendulum impact cutting test-rig and a cutting force measurement system composed of a cantilever weigh sensor,a high frequency DAQ card and motion control card were developed.The cutting mechanical property experiments of different parts of greenhouse cucumber cane were carried out,and the continuous curves of cutting force were measured.The single factor test for cross-sectional area,cutting speed,cutting tool type and manner were analyzed.The results indicated that the peak cutting force increased approximately linearly with the increasing of cutting sectional area,but decreased gradually with the increasing of cutting speed.In the same conditions,the cutting force could be reduced by using straight blade cutting tool and ramp cutting way.Through the multifactor interaction impact test of the cutting way,the blade type and the cutting speed,it was found that the corresponding F-value of the three factors were 21.316,49.141 and 0.222,which suggests that the blade type is the most significant factor for the cutting force. | Xu Yunfeng Zhang Xiliang Sun Xiaojia Wang Jizhang Liu Jizhan Li Zhiguo Guo Qian Li Pingping | 2016 | International Journal of Agricultural and Biological Engineering2016，9，5： | 2 |
| 13 | Poly(benzobisoxazole divinylene):synthesis,photophysical properties,and electron paramagnetic resonance studies显示文摘 | Guo Peiying Wang Shanfeng Wu Pingping Han Zhewen | 2004 | Polymer2004，45，6： | 1 |
| 14 | Supramolecular regulation of photophysical properties and electron paramagnetic resonance studies of novel rod-coil ordered copolymers based on poly (p-phenylene benzobisoxazole)显示文摘 | Wang Shanfeng Guo Peiying Wu Pingping Han Zhewen | 2004 | Macromolecules2004，37，10： | 1 |
| 15 | The fate of CO 2 derived from thermochemical sulfate reduction (TSR) and effect of TSR on carbonate porosity and permeability, Sichuan Basin, China显示文摘 | Fang Hao Xuefeng Zhang Cunwu Wang Pingping Li Tonglou Guo Huayao Zou Yangming Zhu Jianzhang Liu Zhongxian Cai | 2014 | Earth-Science Reviews2014，，： | 1 |
| 16 | Image encryption based on a reality-preserving fractional discrete cosine transform and a chaos-based generating sequence显示文摘 | Jianhua Wu Fangfang Guo Pingping Zeng Nanrun Zhou | 2013 | Journal of Modern Optics2013，，20： | 1 |
| 17 | Preparation properties of a γ-Al2O3 washcoat deposited on a ceramic honeycomb显示文摘 | Jiang Pingping Lu Guanzhong Guo Yanglong | 2005 | Surface & Coatings Technology2005，190，23： | 1 |
| 18 | Enhanced energy-storage performance in a flexible film capacitor with coexistence of ferroelectric and polymorphic antiferroelectric domains显示文摘Advances in flexible electronics are driving dielectric capacitors with high energy storage density toward flexibility and miniaturization.In the present work,an all-inorganic thin film dielectric capacitor with the coexistence of ferroelectric(FE)and antiferroelectric(AFE)phases based on Pb_(0.96)La_(0.04)(Zr_(0.95)Ti_(0.05))O_(3)(PLZT)was prepared on a 2D fluorophlogopite mica substrate via a simple one-step process.The flexible capacitor exhibits a high recoverable energy density(U_(rec))of z 44.2 J/cm^(3),a large electric breakdown strength(E BDS)of 3011 kV/cm,excellent frequency stability(500 Hz-20 kHz)and high thermal stability over 30-190℃.It also demonstrates an outstanding bending endurance,which can maintain a high energy storage performance under various bending radii(R=2-10 mm)or 103 repeated bends at 4 mm.The FE phase is stable near the film surface and the interface with the bottom electrode.The AFE phase with multi-domains has incommensurate modulation structures with super-periodicity of 6.5,6.9 and 5.2.It indicates that the PLZT/LNO/F-Mica capacitor has high potential for energy storage application and may provide great opportunities for exploring new energy storage materials. | Xiaokuo Er Peng Chen Jiesen Guo Yuxuan Hou Xiaobo Yu Pingping Liu Yang Bai Qian Zhan | 2022 | Journal of Materiomics2022，8，2： | 1 |
| 19 | The CREB Regulated Transcription Coactivator 2 Suppresses HIV-1 Transcription by Preventing RNA PolⅡfrom Binding to HIV-1 LTR显示文摘The CREB-regulated transcriptional co-activators(CRTCs),including CRTC1,CRTC2 and CRTC3,enhance transcription of CREB-targeted genes.In addition to regulating host gene expression in response to cAMP,CRTCs also increase the infection of several viruses.While human immunodeficiency virus type 1(HIV-1)long terminal repeat(LTR)promoter harbors a cAMP response element and activation of the cAMP pathway promotes HIV-1 transcription,it remains unknown whether CRTCs have any effect on HIV-1 transcription and HIV-1 infection.Here,we reported that CRTC2 expression was induced by HIV-1 infection,but CRTC2 suppressed HIV-1 infection and diminished viral RNA expression.Mechanistic studies revealed that CRTC2 inhibited transcription from HIV-1 LTR and diminished RNA PolⅡoccupancy at the LTR independent of its association with CREB.Importantly,CRTC2 inhibits the activation of latent HIV-1.Together,these data suggest that in response to HIV-1 infection,cells increase the expression of CRTC2 which inhibits HIV-1 gene expression and may play a role in driving HIV-1 into latency. | Ling Ma Shumin Chen Zhen Wang Saisai Guo Jianyuan Zhao Dongrong Yi Quanjie Li Zhenlong Liu Fei Guo Xiaoyu Li Pingping Jia Jiwei Ding Chen Liang Shan Cen | 2021 | Virologica Sinica2021，36，4： | 1 |
| 20 | Simulation Research on Dynamic Characteristics of Hydraulic Mount显示文摘At present,research on hydraulic mounts has mainly focused on the prediction of the dynamic stiffness and loss angle.Compared to the traditional finite element analysis method,the programming method can be used to analyze hydraulic mounts for a rapid and accurate understanding of the influence of the different mounting parameters on the dynamic stiffness and loss angle.The aims of this study were to investigate the nonlinear dynamic characteristics of a hydraulic mount,and to identify the parameters that affect the dynamic stiffness and loss angle using MATLAB software programs to obtain the influence curves of the parameters,so as to use suitable parameters as the basis for vibration analysis.A nonlinear mechanical model of a hydraulic mount was established according to the basic principles of fluid dynamics.The dynamic stiffness and loss angle of the dimensionless expression were proposed.A numerical calculation method for the dynamic performance evaluation index of the hydraulic mount was derived.A one-to-one correspondence was established between the structural parameters and peak frequency of the evaluation index.The accuracy and applicability of the mechanical model were verified by the test results.The results demonstrated the accuracy of the nonlinear mechanical model of the hydraulic mount,and the vehicle driving comfort was greatly improved by the optimization of the structural parameters. | Yanhua Liu Xin Guan Pingping Lu Rui Guo | 2021 | Chinese Journal of Mechanical Engineering2021，34，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员