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| 1 | Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies显示文摘Chronicity of hepatitis B(CHB)infection is characterized by a weak immune response to the virus.Entecavir(ETV)and adefovir dipivoxil(ADV)are effective in suppressing hepatitis B virus(HBV)replication.However,the underlying immune mechanism in the antiviral response of patients treated with nucleoside or nucleotide analogs is not clearly understood.In this study,regulatory T cells(Tregs)and intracellular cytokines,including IL-2,interferon(IFN)-γ,tumor-necrosis factor(TNF)-α and IL-4,were measured prior to and at 12,24,36 and 48 weeks after treatment with ETV or ADV.The cytokines were increased from 24 to 48 weeks after treatment.Higher levels of Th1 cytokines were observed with ETV(n=29)versus ADV(n=28)treatment.By contrast,the numbers of Tregs in both groups were decreased.The altered cytokine profile and cellular component was accompanied by a decrease in HBV DNA levels in both groups,which may contribute to their therapeutic effect in CHB infection.Our findings suggest that the antiviral effect of the drugs may be attributed not only to their direct effect on virus suppression but also to their immunoregulatory capabilities. | Yanfang Jiang Wanyu Li Lei Yu Jingjing Liu Guijie Xin Hongqing Yan Pinghui Sun Hong Zhang Damo Xu Junqi Niu | 2011 | Cellular & Molecular Immunology2011，8，1： | 16 |
| 2 | The effect of the fibre orientation of electrospun scaffolds on the matrix production of rabbit annulus fibrosus-derived stem cells显示文摘Annulus fibrosus(AF) tissue engineering has recently received increasing attention as a treatment for intervertebral disc(IVD) degeneration; however, such engineering remains challenging because of the remarkable complexity of AF tissue. In order to engineer a functional AF replacement, the fabrication of cell-scaffold constructs that mimic the cellular, biochemical and structural features of native AF tissue is critical.In this study, we fabricated aligned fibrous polyurethane scaffolds using an electrospinning technique and used them for culturing AF-derived stem/progenitor cells(AFSCs). Random fibrous scaffolds, also prepared via electrospinning, were used as a control. We compared the morphology, proliferation, gene expression and matrix production of AFSCs on aligned scaffolds and random scaffolds. There was no apparent difference in the attachment or proliferation of cells cultured on aligned scaffolds and random scaffolds. However, compared to cells on random scaffolds, the AFSCs on aligned scaffolds were more elongated and better aligned, and they exhibited higher gene expression and matrix production of collagen-I and aggrecan. The gene expression and protein production of collagen-II did not appear to differ between the two groups. Together, these findings indicate that aligned fibrous scaffolds may provide a favourable microenvironment for the differentiation of AFSCs into cells similar to outer AF cells, which predominantly produce collagen-I matrix. | Chen Liu Caihong Zhu Jun Li Pinghui Zhou Min Chen Huilin Yang Bin Li | 2015 | Bone Research2015，3，2： | 12 |
| 3 | Salvianolate increases heat shock protein expression in a cerebral ischemia-reperfusion injury model显示文摘Stroke remains a worldwide health problem.Salvianolate exerts a protective effect in various microcirculatory disturbance-related diseases,but studies of the mechanisms underlying its protective action have mainly focused on the myocardium,whereas little research has been carried out in brain tissue following ischemia-reperfusion.We assessed the neuroprotective effects of salvianolate in a rat model of cerebral ischemia-reperfusion injury induced using the suture method At onset and 24 and 48 hours after reperfusion,rats were intraperitoneally injected with salvianolate(18 mg/kg)or saline.Neurological deficit scores at 72 hours showed that the neurological functions of rats that had received salvianolate were significantly better than those of the rats that had received saline.2,3,5-Triphenyltetrazolium chloride was used to stain cerebral tissue to determine the extent of the infarct area.A significantly smaller infarct area and a significantly lower number of apoptotic cells were observed after treatment with salvianolate compared with the saline treatment Expression of heat shock protein 22 and phosphorylated protein kinase B in ischemic brain tissue was significantly greater in rats treated with salvianolate compared with rats treated with saline.Ou findings suggest that salvianolate provides neuroprotective effects against cerebra ischemia-reperfusion injury by upregulating heat shock protein 22 and phosphorylated protein kinase B expression. | Jinnan Zhang Wei Lu Qiang Lei Xi Tao Hong You Pinghui Xie | 2013 | Neural Regeneration Research2013，8，25： | 12 |
| 4 | DNA microarray analysis of fluconazole resistance in a laboratory Candida albicans strain显示文摘几机制为获得的 fluconazole (FLC ) 负责在 Candida albicans 的抵抗。在这研究,我们开发了 FLC 抵抗的 C。通过 FLC 易受影响的 C 的连续文化的 albicans 紧张。有 FLC 的禁止的集中的 albicans 紧张。赞美 DNA 微数组分析和即时反向的抄写聚合酶链反应被用来在易受影响的父母紧张和抵抗女儿紧张在 azole 抵抗的获得期间调查基因表示变化。表示基因代表了的差别工作象运输 ers 一样多样(例如 CDR1, PDR17 ) ,麦角固醇生合成(例如 ERG2, ERG9 ) ,甾醇新陈代谢(例如 ARE2, IPF6464 ) ,精力新陈代谢(例如 ADH3, AOX2 ) 并且抄写因素(例如 FCR1, ECM22 ) 。功能的分析表明膜运输 ers 的那项精力依赖者流出活动增加了,那个麦角固醇内容作为与易受影响的紧张相比在抵抗紧张与甾醇中介的累积减少了。我们发现在导致了 Tac1 的活动过度的抄写因素 TAC1 的一个点变化(N977K ) 能是原因为在在抵抗紧张的 CDR1, CDR2,和 PDR17 的表示上。而且,在导致的 ERG3 的单个氨基酸差别(D19E ) 在里面 Erg3 的激活能在这抵抗紧张在麦角固醇生合成基因的表示说明两甾醇先锋累积和变化。这些调查结果在临床的 C 扩展 FLC 抵抗的潜在的新奇分子的目标的理解。albicans 孤立。 | Lan Yan Jundong Zhang Miaohai Li Yongbing Cao Zheng Xu Yingying Cao Pinghui Gao Yan Wang Yuanying Jiang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，12： | 11 |
| 5 | Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-κB signaling pathway显示文摘The stiffness of the extracellular matrix(ECM)plays an important role in regulating the cellular programming.However,the mechanical characteristics of ECM affecting cell differentiation are still under investigated.Herein,we aimed to study the effect of ECM substrate stiffness on macrophage polarization.We prepared polyacrylamide hydrogels with different substrate stiffness,respectively.After the hydrogels were confirmed to have a good biocompatibility,the bone marrow-derived macrophages(BMMs)from mice were incubated on the hydrogels.With simulated by the low substrate stiffness,BMMs displayed an enhanced expression of CD86 on the cell surface and production of reactive oxygen species(ROS)in cells,and secreted more IL-1βand TNF-αin the supernatant.On the contrary,stressed by the medium stiffness,BMMs expressed more CD206,produced less ROS,and secreted more IL-4 and TGF-β.In vivo study by delivered the hydrogels subcutaneously in mice,more CD68+CD86+cells around the hydrogels with the low substrate stiffness were observed while more CD68+CD206+cells near by the middle stiffness hydrogels.In addition,the expressions of NIK,phosphorylated p65(pi-p65)and phosphorylated IκB(pi-IκB)were significantly increased after stimulation with low stiffness in BMMs.Taken together,these findings demonstrated that substrate stiffness could affect macrophages polarization.Low substrate stiffness promoted BMMs to shift to classically activated macrophages(M1)and the middle one to alternatively activated macrophages(M2),through modulating ROS-initiated NF-κB pathway.Therefore,we anticipated ECM-based substrate stiffness with immune modulation would be under consideration in the clinical applications if necessary. | Mimi Chen Yu Zhang Pinghui Zhou Xingzhi Liu Huan Zhao Xichao Zhou Qiaoli Gu Bin Li Xuesong Zhu Qin Shi | 2020 | Bioactive Materials2020，5，4： | 7 |
| 6 | Hydrogen production by reforming methane in a corona inducing dielectric barrier discharge and catalyst hybrid reactor显示文摘A novel corona inducing dielectric barrier discharge(CIDBD) and catalyst hybrid reactor was developed for reforming methane. This corona inducing technique allows dielectric barrier discharge(DBD) to occur uniformly in a large gap at relatively low applied voltage.Hydrogen production by reforming methane with steam and air was investigated with the hybrid reactor under atmospheric pressure and temperatures below 600°C.The effects of input power,O2/C molar ratio and preheat temperature on methane conversion and hydrogen selectivity were investigated experimentally.It was found that higher methane conversions were obtained at higher discharge power,and methane conversion increased significantly with input power less than 50 W;the optimized molar ratio of O2/C was 0.6 to obtain the highest hydrogen selectivity(112%);under the synergy of dielectric barrier discharge and catalyst,methane conversion was close to the thermodynamic equilibrium conversion rate. | ZHOU ZhiPeng ZHANG JiMin YE TaoHong ZHAO PingHui XIA WeiDong | 2011 | Chinese Science Bulletin2011，56，20： | 6 |
| 7 | Study of the mechanisms of the flame propagation and stabilization in porous media显示文摘The CH4/air premixed gas combustion processes in porous media were numerically studied using the two-temperature reacting fluid model with dispersions and detailed chemical reaction mechanism GRI 3.0. The mechanisms of the propagation and stabilization of submerge flames and surface flames in porous media were illuminated distinctly by considering the magnitude of the terms in the two energy equations, analyzing the sensibility of flame propagation speed to flame location, heat exchange coefficient between gas and solid, thermal conductivity and radiative extinction coefficient of porous media. It was concluded that the propagation mechanism of a submerged flame is similar to that of a free flame with an additional preheat zone and that the surface-flame propagation mechanism in porous media is similar to that of a free flame with heat loss in reaction zone. | ZHAO PingHui YE TaoHong JIANG Hai CHEN YiLiang | 2008 | Science China(Technological Sciences)2008，51，7： | 3 |
| 8 | Numerical investigation on hydrogen production by CH_4-Rich combustion in an alumina foam显示文摘The two-phase volume-averaged model with the detailed chemistry reaction mechanism GRI 3.0 was adopted in the quasi-steady-state simulation of hydrogen production by CH4-rich filtration combustion in an alumina foam under fully developed conditions. The relations among the combustion wave velocity, the inlet gas velocity and the equivalence ratio were discussed, and their influences on the distributions of temperature and species in the alumina foam and on H2 yield, CH4 conversion, H2 selectivity and CO selectivity were analyzed in detail. The results show that the combustion wave velocity increases with the increase of equivalence ratio or inlet gas velocity. The H2 yield exceeded 50% with equivalence ratio between 2.0 and 3.0 and combustion wave velocity larger than 0.4 mm/s. The H2 selectivity exceeded 50% with equivalence ratio larger than 2.0 and CO selectivity exceeded 80% with equivalence ratio between 1.8 and 2.0 and combustion wave velocity larger than 0.4 mm/s. | ZHAO PingHui, YE TaoHong, ZHU MinMing, JIANG Hai & CHEN YiLiang Thermal Science & Energy Engineering Department, University of Science & Technology of China, Hefei 230027, China | 2009 | Science China(Technological Sciences)2009，52，10： | 3 |
| 9 | Gelatin methacrylate hydrogel scaffold carrying resveratrol-loaded solid lipid nanoparticles for enhancement of osteogenic differentiation of BMSCs and effective bone regeneration显示文摘Critical-sized bone defects caused by traumatic fractures,tumour resection and congenital malformation are unlikely to heal spontaneously.Bone tissue engineering is a promising strategy aimed at developing in vitro replacements for bone transplantation and overcoming the limitations of natural bone grafts.In this study,we developed an innovative bone engineering scaffold based on gelatin methacrylate(GelMA)hydrogel,obtained via a two-step procedure:first,solid lipid nanoparticles(SLNs)were loaded with resveratrol(Res),a drug that can promote osteogenic differentiation and bone formation;these particles were then encapsulated at different concentrations(0.01%,0.02%,0.04%and 0.08%)in GelMA to obtain the final Res-SLNs/GelMA scaffolds.The effects of these scaffolds on osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)and bone regeneration in rat cranial defects were evaluated using various characterization assays.Our in vitro and in vivo investigations demonstrated that the different Res-SLNs/GelMA scaffolds improved the osteogenic differentiation of BMSCs,with the ideally slow and steady release of Res;the optimal scaffold was 0.02 Res-SLNs/GelMA.Therefore,the 0.02 Res-SLNs/GelMA hydrogel is an appropriate release system for Res with good biocompatibility,osteoconduction and osteoinduction,thereby showing potential for application in bone tissue engineering. | Bangguo Wei Wenrui Wang Xiangyu Liu Chenxi Xu Yanan Wang Ziqi Wang Jinnuo Xu Jianzhong Guan Pinghui Zhou Yingji Mao | 2021 | Regenerative Biomaterials2021，8，5： | 2 |
| 10 | Theoretical analysis of a quasi-Bessel beam for laser ablation显示文摘A quasi-Bessel beam(QBB)is suitable for laser ablation because it possesses a micrometer-sized focal spot and long depth of focus simultaneously.In this paper,the characterizations of QBBs formed by the ideal axicon and oblate-tip axicon are described.Strong on-axis intensity oscillations occur due to interference between the QBB and the refracted beam by the oblate tip.Using the axicon for laser ablation was theoretically investigated.Simple analytical formulas can be used to predict the required laser parameters,including the laser pulse energy,the generated fluence distributions,and the beam diameters. | Pinghui Wu Chenghua Sui Wenhua Huang | 2014 | Photonics Research2014，2，3： | 1 |
| 11 | Study on the molding characteristics and mechanical properties of injection-molded foaming polypropylene parts显示文摘 | Chen Shiachung Lee Pinghui Huang Jiensheng | 2004 | Journal of Reinforced Plastics and Composites2004，23，4： | 1 |
| 12 | Research on Bird Strike Simulation of Composite Leading Edge显示文摘 | Yijing Guo Pinghui Jia Guanxin Hong | 2012 | AASRI Procedia2012，，： | 1 |
| 13 | Phenylfluorenamine-functionalized poly(N-vinylcarbazole)s as dopant-free polymer hole-transporting materials for inverted quasi-2D perovskite solar cells显示文摘In order to improve the efficiency and stability of inverted three-dimensional(3D) or quasi-2D perovskite solar cells(PSCs) for future commercialization, exploring high efficient dopant-free polymer holetransporting materials(HTMs) is still desired and meaningful. One simple and efficient way to achieve high performance dopant-free HTMs is to synthesize novel non-conjugated side-chain polymers via rational molecular design. In this work, N-(4-methoxyphenyl)-9,9-dimethyl-9H-fluoren-2-amine(FMeNPh) groups are introduced into the poly(N-vinylcarbazole)(PVK) side chains to afford two nonconjugated polymers PVCz-DFMeNPh and PVCz-FMeNPh as dopant-free HTMs in inverted quasi-2D PSCs. Benefited from the flexible properties of polyethylene backbone and excellent optoelectronic natures of FMeNPh side-chain groups, PVCz-DFMeNPh with more FMeNPh units exhibited excellent thermal stability, well-matched energy levels and improved charge mobility as compared to PTAA and PVCzFMeNPh. Moreover, the morphologies investigation of quasi-2D perovskite on PVCz-DFMeNPh shows more compact and homogeneous perovskite films than those on PTAA and PVCz-FMeNPh. As a result,the dopant-free PVCz-DFMeNPh based inverted quasi-2D PSCs deliver power conversion efficiency(PCE) up to 18.44% as well as negligible hysteresis and favorable long-term stability, which represents as excellent performance reported to date for inverted quasi-2D PSCs. The results demonstrate the great potentials of constructing non-conjugated side-chain polymer HTMs based on phenylfluorenamine-func tionalized PVK for the development of high efficient and stable inverted 3D or quasi-2D PSCs. | Zhengwu Pan Han Gao Yingying Yang Qin Zou Darui Peng Pinghui Yang Jiangli Cai Jin Qian Jiewei Li Chengrong Yin Nana Wang Renzhi Li Jianpu Wang Wei Huang | 2022 | Journal of Energy Chemistry2022，31，6： | 1 |
| 14 | Implicit difference approximation for the time fractional diffusion equation显示文摘 | Zhuang Pinghui Liu Fawang | 2006 | Journal of Applied Mathematics and Computing2006，22，3： | 1 |
| 15 | Distribution of mineral elements in dual-toxin transgenic (Bt+CpTI) cotton 显示文摘 | Rui Yukui Wang Wenya Liu Pinghui | 2009 | Plant Biosystem2009，143，1： | 1 |
| 16 | A data - aggregation scheme for WSN based on optimal weight allocation 显示文摘 | Pinghui Zou Yun Lin | 2014 | Journal of Networks2014，9，1： | 1 |
| 17 | New solution and analytical techniques of the implicit numerical method for the anomalous sub-diffusion equation 显示文摘 | ZHUANG Pinghui LIU Fawang ANH V | 2008 | SIAM on Numerical Analysis2008，46，2： | 1 |
| 18 | Seleetive laser sintering of aliphatie-polycarbonate/hydroxyapatite composite scaffolds for medical applications显示文摘 | Xiao HuiS Wei L PingHui S | 2015 | The International Journal of Advaneed Manufac- turing Technology2015，81，14： | 1 |
| 19 | In vitro activity of baicalein against Candida albicans biofilms显示文摘 | YingYing Cao BaoDi Dai Yan Wang Shan Huang YongGang Xu YongBing Cao PingHui Gao ZhenYu Zhu YuanYing Jiang | 2008 | International Journal of Antimicrobial Agents2008，，1： | 1 |
| 20 | The broad spectrum inhibitory effect study of 3rare earth salts used for microbial inoculant additive显示文摘 | Pinghui Huo Jianfeng Li Shangli Shi | 2013 | Applied Mechanics and Materials2013，310，： | 1 |
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