|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Apoptosis and its relationship with cell proliferation,p53,Waf1p21,bcl-2 and c-mycin esophageal carcinogenesis studied with a high-risk population in northern China显示文摘Apoptosisanditsrelationshipwithcelproliferation,p53,Waf1p21,bcl2andcmycinesophagealcarcinogenesisstudiedwithahighriskpopul... | WANG LiDong1, ZHOU Qi1, WEI JunPing1, YANG WanCai1, ZHAO Xin1, WANG LiXia1, ZOU Jian Xiang1, GAO ShanShan1, LI YongXin1 and YANG C.S.2Keywords esophageal neoplasms apoptosis precancerous lesions Waf1 p21 gene p53 | 1998 | World Journal of Gastroenterology1998，4，4： | 295 |
| 2 | Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis显示文摘 | Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang | 2016 | Chinese Medical Journal2016，，7： | 64 |
| 3 | Recent Advances on the Technologies to Increase Fertilizer Use Efficiency显示文摘To increase fertilizer use efficiency (FUE) and to minimize its negative impact on environment have been the focal points in the world for a long time. It is very important to increase FUE in China for its relatively low FUE and serious losses of nutrients. Recent advances of the technologies to increase FUE are reviewed in this article. These include site-specific and real-time nitrogen management, non-destructive quick test of the nitrogen status of plants, new types of slow release and controlled release fertilizers, site-specific nutrient management, and use of urease inhibitor and nitrification inhibitor to decrease nitrogen losses. Future outlook in technologies related to FUE improvement is also discussed. | YAN Xiang JIN Ji-yun HE Ping LIANG Ming-zao | 2008 | Agricultural Sciences in China2008，7，4： | 35 |
| 4 | PVT v2:Improved baselines with Pyramid Vision Transformer显示文摘Transformers have recently lead to encouraging progress in computer vision.In this work,we present new baselines by improving the original Pyramid Vision Transformer(PVT v1)by adding three designs:(i)a linear complexity attention layer,(ii)an overlapping patch embedding,and(iii)a convolutional feed-forward network.With these modifications,PVT v2 reduces the computational complexity of PVT v1 to linearity and provides significant improvements on fundamental vision tasks such as classification,detection,and segmentation.In particular,PVT v2 achieves comparable or better performance than recent work such as the Swin transformer.We hope this work will facilitate state-ofthe-art transformer research in computer vision.Code is available at http://gffzz188fe103f8f1460asqf566vokqxuq6kkb.ffgz.tsg.suse.edu.cn/whai362/PVT. | Wenhai Wang Enze Xie Xiang Li Deng-Ping Fan Kaitao Song Ding Liang Tong Lu Ping Luo Ling Shao | 2022 | Computational Visual Media2022，8，3： | 30 |
| 5 | Influence of temperature and solution composition on the formation of calcium sulfates显示文摘Calcium sulfates (anhydrite and hydrates) were synthesized by mixing CaCl 2 and Na 2 SO 4 solutions at room temperature followed by aging the resulting slurries at elevated temperatures. The variation of the morphology and structure of the calcium sulfates with aging temperature was investigated. Experimental results indicated that CaSO 4 ·2H 2 O plates, CaSO 4 ·0.5H 2 O whiskers and CaSO 4 spindles were formed at ≤100 °C, 130–160 °C and ≥170 °C, respectively. The formation and conversion of the calcium sulfates were discussed on the basis of characterization of the products and chemical analysis of the solutions. Compared to NaCl solution, pure water favors one-dimensional hydrothermal growth of CaSO 4 ·0.5H 2 O whiskers owing to lower supersaturation. | Kangbi Luo Chunmei Li Lan Xiang Huping Li Ping Ning | 2010 | Particuology2010，8，3： | 26 |
| 6 | Circular RNA circ-LDLRAD3 as a biomarker in diagnosis of pancreatic cancer显示文摘AIM To analyze the diagnostic value of a circular RNA(circR NA), circ-LDLRAD3, in pancreatic cancer.METHODS Expression levels of circ-LDLRAD3 were tested in both cells and clinical samples; the latter included 30 paired pancreatic cancer tissues and adjacent non-tumorous tissues, 31 plasma samples from patients with pancreatic cancer, and 31 plasma samples from healthy volunteers. Real-time quantitative reverse transcriptionpolymerase chain reaction(q RT-PCR) was performed to measure expression levels of circ-LDLRAD3 in cells and clinical samples; then, the relationship between clinicopathological factors of patient samples and expression of circ-LDLRAD3 in pancreatic cancer was analyzed. The diagnostic value of circ-LDLRAD3 was verified by receiver operating characteristic(ROC) curve analysis.RESULTS Circ-LDLRAD3 was up-regulated in pancreatic cancer cell lines(P < 0.01), pancreatic cancer tissues(P < 0.01), and plasma samples from patients with pancreatic cancer(P < 0.01). High expression of circLDLRAD3 was significantly associated with venous invasion, lymphatic invasion, and metastasis. The area under the ROC curve of circ-LDLRAD3 alone or combination with CA19-9 was 0.67 and 0.87, respectively, with a sensitivity and specificity of 0.5738(alone) and 0.7049(alone), and 0.8033(combination) and 0.9355(combination), respectively.CONCLUSION These data suggest that circ-LDLRAD3 may be a biomarker in the diagnosis of pancreatic cancer. | Fan Yang Dong-Yan Liu Jin-Tao Guo Nan Ge Ping Zhu Xiang Liu Sheng Wang Guo-Xin Wang Si-Yu Sun | 2017 | World Journal of Gastroenterology2017，23，47： | 25 |
| 7 | Protective effects of polydatin against CCl_4-induced injury to primarily cultured rat hepatocytes显示文摘NTRODUCTIONPolygonumcuspidatumSieb.etZucc.(Polygonaceae)isatraditionalChineseherbaldrug,withbitertasteandcoldnature.Itmainly... | HUANG Zhao Sheng, WANG Zong Wei, LIU Ming Ping, ZHONG Shi Qing, LI Qiao Mei and RONG Xiang Lu | 1999 | World Journal of Gastroenterology1999，5，1： | 24 |
| 8 | Antiviral activities against influenza virus(FM1) of bioactive fractions and representative compounds extracted from Banlangen(Radix Isatidis)显示文摘OBJECTIVE: To study the antiviral activities of clemastanin B(CB), epigoitrin, phenylpropanoids portion(PEP) and the mixture of phenylpropanoids, alkaloids and organic acid fractions(PEP+ALK+OA)from Banlangen(Radix Isatidis).METHODS: The experiment consisted of four parts:therapeutic action, prophylaxsis action, inhibition of virus attachment, and direct virucidal action. Cytopathic effect(CPE) and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium(MTT) were used to assess antiviral activity.RESULTS: CB, epigoitrin, PEP and PEP + ALK + OA fractions from Banlangen(Radix Isatidis) extract significantly increased the viability of MDCK cells pre-infected with the virus compared with the virus control group in all the dilutions(P < 0.01). Pretreated with either pure compounds or chemical frac-tions of Banlangen(Radix Isatidis) extract in all the dilutions significantly improved the viability of MDCK cells(P < 0.01). The inhibition of virus absorption to the host cells by CB, epigoitrin and PEP was in a dose dependent manner.CONCLUSION: CB, epigoitrin, PEP and PEP+ALK+OA exert their anti-influenza activity by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. The primary mode of action of PEP and PEP + ALK + OA is the inhibition of virus replication. The inhibitory effects on virus attachment and multiplication are the main modes for epigoitrin. | Xiao Ping Ye Weiyang Chen Jianwei Li Xiang | 2016 | Journal of Traditional Chinese Medicine2016，36，3： | 21 |
| 9 | Antisense oligonucleotides targeting midkine inhibit tumor growth in an in situ human hepatocellular carcinoma model显示文摘瞄准:评估在里面 antisense oligonucleotidestargeting midkine 的 vivo antitumor 效果(MK -- 作为).Methods:一在里面在老鼠肝 orthotopically.The MK 的 situ 人 hepatocellular 癌( HCC )模型 wasestablished --作为并且5氟尿嘧啶( 5-Fu )是 administeredintravenously.The 肿瘤尺寸,血浆 alpha-fetoprotein (法新社)被肿瘤的测径器 andradiation 免疫分析 respectively.The 形态学测量被组织学的 sections.Human 的 hematoxylin-eosinstaining 评估 MK , p53 , Bax , Bc1-2 ,和 caspase-3 蛋白质内容是 detectedby 西方的 blotting.Results : MK --当显著地在剂量依赖者 manner.After 与盐的组一起在 micecompared 在 situ 人 HCC 生长禁止了有 MK 的处理--作为或 with5-Fu ,血浆法新社集中 manner.Interestingly 在一个剂量依赖者减少了, MK --作为 alsoclearly downregulated Bc1-2 的蛋白质水平,和 upregulated p53 , Bax ,并且在 thehepatocellular 癌 tissue.Conclusion 的 caspase-3 :这些结果表明了那 MK -- 这是在在老鼠的 vivo 的 effectiveantitumor antisense oligonucleotide;它的 antitumor 效果与 pro-apoptotic 蛋白质的 theincrease 被联系例如 p53, Bax,和 caspase-3,并且 theanti-apoptotic 蛋白质的减少, Bc1-2。 | Li-cheng DAI Xiang WANG Xing YAO Li-shan MIN Jin-liang PING Jian-fang HE | 2007 | Acta Pharmacologica Sinica2007，28，3： | 20 |
| 10 | Effect of Chaiqinchengqi decoction on sarco/endoplasmic reticulum Ca^(2+)-ATPase mRNA expression of pancreatic tissues in acute pancreatitis rats显示文摘AIM: To investigate the effect of Chaiqinchengqi decoction (CQCQD) on sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) mRNA expression of pancreatic tissues in acute pancreatitis (AP) rats. METHODS: Thirty Sprague-Dawley (SD) rats were randomized into control group, AP group and CQCQD group (n = 3 × 10). The rats in the CQCQD group were intragastrically administered with CQCQD (10 mL/kg every 2 h) after induction of AP by intraperitoneal injection of caerulein (50 μg/kg.h × 5) within 4 h. At 6 h after the induction of AP model, pancreatic tissues were collected for the pathological observation, mRNA extraction for determination of SERCA1 and SERCA2 mRNA expression or pancreatic acinar cell isolation for measurement of fluorescence intensity (FI) of intracellular calcium ion concentration [Ca2+]i. RESULTS: There was no expression of pancreatic SERCA1 mRNA in the control group and the AP group. The expression of pancreatic SERCA2 mRNA in the AP group was down-regulated (expression ratio = 0.536; P = 0.001) compared with the control group, while that in the CQCQD group was up-regulated (expression ratio= 2.00; P = 0.012) compared with AP group. The FI of intracellular [Ca2+] of pancreatic acinar cells in the AP group (138.2 ± 23.1) was higher than the C group (111.0 ± 18.4) and the CQCQD group (118.7 ± 15.2 ) (P < 0.05) and the pancreatic pathological score in the CQCQD group was lower than that in the AP group (5.7 ± 1.9 vs 9.2 ± 2.7, P < 0.05).CONCLUSION: CQCQD can up-regulate the expression of SERCA2 mRNA of pancreatic tissues, reduce intracellular calcium overload and relieve pancreatic tissue lesions. | Ping Xue Li-Hui Deng Zhao-Da Zhang Xiao-Nan Yang Qing Xia Da-Kai Xiang Lei Huang Mei-Hua Wan | 2008 | World Journal of Gastroenterology2008，14，15： | 20 |
| 11 | Proximal gastrectomy with jejunal interposition and TGRY anastomosis for proximal gastric cancer显示文摘AIM: To compare the short-term outcomes of patients who underwent proximal gastrectomy with jejunal interposition(PGJI) with those undergoing total gastrectomy with Roux-en-Y anastomosis(TGRY).METHODS: From January 2009 to January 2011, thirty-five patients underwent PGJI, and forty-one patients underwent TGRY. The surgical efficacy and short-term follow-up outcomes were compared between the two groups.RESULTS: There were no differences in the demographic and clinicopathological characteristics. The mean operation duration and postoperative hospital stay in the PGJI group were statistically longer than those in the TGRY group(P = 0.00). No anastomosis leakage was observed in two groups. No statistically significant difference was found in endoscopic findings, Visick grade or serum albumin level. The single-meal food intake in the PGJI group was more than that in the TGRY group(P = 0.00). The PG group showed significantly better hemoglobin levels in the second year(P = 0.02). The twoyear survival rate was not significantly different(PGJI vsTGRY, 93.55% vs 92.5%, P = 1.0).CONCLUSION: PGJI is a safe, radical surgical method for proximal gastric cancer and leads to better outcomes in terms of the single-meal food intake and hemoglobin level, compared with TGRY in the short term. | Ping Zhao Shuo-Meng Xiao Ling-Chao Tang Zhi Ding Xiang Zhou Xiao-Dong Chen | 2014 | World Journal of Gastroenterology2014，20，25： | 15 |
| 12 | Effect of endostar combined with cisplatin on expression of VEGF and Sema3A of Lewis lung cancer rats显示文摘Objective:To evaluate the therapeutic effect of endostar(ED) combined with cisplatin(DDP) on model of C57BL/6 rats,and to further investigate the inhibiting mechanism of endostar from tumor angiogenesis.Methods:Lewis lung cancer cells were inoculated in C57BL/6 mouse,then the mouse were randomized into control group(group A),ED(group B),DDP(group C) and ED/DDP (group D).They were treated according to the plan.And the expressions of VEGF and Sema3A were evaluated by immunhistochemisty.Results:The weight of tumor increased in group A and B.It was decreased in group C and D.The tumor volume was increased in all the 4 groups. The VEGF expression of group D was obviously lower than the other group 3,but the Sema3A expressed of group D was significantly strengthener than the other group 3.The VEGF expression of group B and group D were obviously low especially in the 4th-8th days.Pearson correlated analysis showed that the expression VEGF and Sema3A were negatively correlated(r=-0.72, P<0.05).Conclusions:ED combined with DDP could control the tumor growth effectively,and avoid weight loss.ED could reduce VEGF expression,and enhance Sema3A expression.Tumor vessel presents transient normalization.It is easy for DDP perfusion,and to kill tumor cells. | Ping Feng Zhi-Lin Zhang Zhi-Hua Zhang Xiu-Long Zhang Feng Xiang Jian-Hua Tang Bao-Li Xiang | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，1： | 14 |
| 13 | Effect of β2-adrenergic agonist clenbuterol on ischemia/reperfusion injury in isolated rat hearts and cardiomyocyte apoptosis induced by hydrogen peroxide显示文摘目的: 在 ischemia/reperfusion (I/R ) 上观察贝它 2-adrenergic 收缩筋 cienbuterol 的效果在孤立的老鼠心和过氧化氢(H2O2 ) 的损害 -in-duced cardiomyocyte apoptosis.Methods : 孤立的老鼠心受到 30 min 一台 Langendorff 仪器上的全球局部缺血和 60 min 灌注。心脏的功能被心搏率,左室的结束心脏舒张的压力(LVEDP ) ,左室的收缩压,左心室压(+dp/dt_( 最大)) 的最大的上升率和冠的自河(CF ) 评估。在冠的自河, malondialdehyde (MDA ) ,超级氧化物歧化酶(草皮) ,和在心脏的织物的 Ca^(2+)-ATPase 活动的 Lactate 脱氢酶(LDH ) 用商业工具包被测量。 apoptotic cardiomyocyte 被终端 deoxynucleotidyl 检测标记的 调停transferase 的 digoxigenin-dUTP 刻痕结束( TUNEL ) assay.Bax/Bcl-2 mRNA 层次和 caspase-3 的表达式被 RT-PCR 并且免疫弄污检测, respectively.Cultured 新生儿老鼠 cardiomyocytes 与 cienbuterol 被预先孵化,并且氧化压力损害被 H2O2.Cell 生存能力导致, cardiomyocyte apoptosis 被流动血细胞计数( FCM )评估 .Results :在在 I/R 损害以后的孤立的老鼠心, cienbuterol 显著地改进了心脏舒张的功能( LVEDP 和 CF )和Ca^(2+) -ATPase 活动。有 cienbuterol 的处理增加了草皮活动并且减少 MDA 水平和 LDH 与 I/R 组(P<0.05 ) 相比释放。而且, cienbuterol 减少了 apoptosis ,它在TUNEL积极的房间, Bax/Bcl-2 mRNA ,和 caspase-3 expres-sion.In 与减小被联系 导致H2O2 的 cardiomyocyte 损害, cienbuterol 增加了房间生存能力并且与 ICI118551 (选择贝它 2-adrenergic 对手)稀释了 cardiomyocyte apoptosis.Pre处理减少这些与 对待clenbuterol 的组( P<0.05 )相比完成 .Conclusion : Cienbuterol 改善了室的心脏舒张的功能由在 haning Ca^(2+) -ATPase 活动和减少的氧化应力和心脏的肌细胞,在一只试验性的老鼠的 apoptosis 当模特儿心肌层 I/R.It , H2O2 在 vitro.It 导致的减少的 cardiomyocyte apoptosis 对心肌层 I/R 损害在心脏的保护起一个关键作用。 | Ping LIU Ji-zhou XIANG Lei ZHAO Lei YANG Ben-rong HU Qin FU | 2008 | Acta Pharmacologica Sinica2008，29，6： | 14 |
| 14 | Role of Fas/FasL Pathway-mediated Alveolar Macrophages Releasing Inflammatory Cytokines in Human Silicosis显示文摘The role of Fas/Fas ligand (FasL) in mediating alveolar macrophage (AM)-derived inflammatory cytokines in 29 human lung silicosis patients and 6 controls was studied.It showed that the serum levels of IL-1β,TNF-α,IL-8,MIP-1α,MCP-1,and TGF-β1were higher in silicosis patients than in controls,and increased with the progression of silicosis except TGF-β1 and IL-8.TGF-β1,IL-8,MCP-1,MIP-1αwere efficiently down-regulated by anti-FasL antibody or caspase-8 inhibitor,indicating that Fas/FasL signaling promotes the | YAO San Qiao HE Qin Cheng YUAN Ju Xiang CHEN Jie CHEN Gang LU Yao BAI Yu Ping ZHANG Chun Min YUAN Yang XU Ying Jun | 2013 | Biomedical and Environmental Sciences2013，26，11： | 13 |
| 15 | Isolation and identification of bacteria responsible for simultaneous anaerobic ammonium and sulfate removal显示文摘Sulfate-dependent anaerobic ammonium oxidation is a novel biological reaction,in which ammonium is oxidized with sulfate as the electron acceptor under anoxic conditions.Ammonium and sulfate are cosmopolitan chemical species which are an integral part of the global nitrogen and sulfur cycles.A detailed exploration of sulfate-dependent anaerobic ammonium oxidation is quite practical.In this work,a bacterial strain named ASR has been isolated from an anaerobic ammonia and sulfate removing reactor working under steady-state.On the basis of electron microscopy,physiological tests and 16S rDNA phylogenetic sequence analysis,the strain ASR is found to be related to Bacillus benzoevorans.According to the biological carbon source utilization test,the strain ASR could use many carbon sources.Its optimum pH value and temperature were 8.5 and 30 °C,respectively.The test proves that the strain ASR is able to use sulfate to oxidize ammonia anaerobically.The maximum ammonia and sulfate removal rates were 44.4% and 40.0%,respectively.The present study provided biological evidence for the confirmation and development of sulfate-dependent anaerobic ammonium oxidation and brought new insights into the global nitrogen and sulfur cycles. | Cai, Jing Jiang, Jian Xiang Zheng, Ping | 2010 | Science China Chemistry2010，53，3： | 12 |
| 16 | Solution structure of the RNA recognition domain of METTL3-METTL14 N^6-methyladenosine methyltransferase显示文摘N^6-methyladenosine(m6A),a ubiquitous RNA modification,is installed by METTL3-METTL14 complex.The structure of the heterodimeric complex between the methyltransferase domains(MTDs)of METTL3 and METTL14 has been previously determined.However,the MTDs alone possess no enzymatic activity.Here we present the solution structure for the zinc finger domain(ZFD)of METTL3,the inclusion of which fulfills the methyltransferase activity of METTL3-METTL14.We show that the ZFD specifically binds to an RNA containing 5'-GGACU-3'consensus sequence,but does not to one without.The ZFD thus serves as the target recognition domain,a structural feature previously shown for DNA methyltransferases,and cooperates with the MTDs of METTL3-METTL14 for catalysis.However,the interaction between the ZFD and the specific RNA is extremely weak,with the binding affinity at several hundred micromolar under physiological conditions.The ZFD contains two CCCH-type zinc fingers connected by an anti-parallel P-sheet.Mutational analysis and NMR titrations have mapped the functional interface to a contiguous surface.As a division of labor,the RNA-binding interface comprises basic residues from zinc finger 1 and hydrophobic residues fromβ-sheet and zinc finger 2.Further we show that the linker between the ZFD and MTD of METTL3 is flexible but partially folded,which may permit the cooperation between the two domains during catalysis.Together,the structural characterization of METTL3 ZFD paves the way to elucidate the atomic details of the entire process of RNA m6A modification. | Jinbo Huang Xu Dong Zhou Gong Ling-Yun Qin Shuai Yang Yue-Ling Zhu Xiang Wang Delin Zhang Tingting Zou Ping Yin Chun Tang | 2019 | Protein & Cell2019，10，4： | 11 |
| 17 | Enhanced therapeutic effects of combined chemotherapeutic drugs and midkine antisense oligonucleotides for hepatocellular carcinoma显示文摘AIM: To evaluate the effect of combined antisense oligonucleotides targeting midkine (MK-AS) and chemotherapeutic drugs [cisplatin(DDP), 5-fluorouracil (5-FU) and adriamycin (ADM)] on inhibition of HepG2 cell proliferation, and to analyze the efficacy of MK-AS used in combined ADM in in situ human hepatocellular carcinoma (HCC) model. METHODS: HepG2 cells were treated with MK-AS and/or chemotherapeutic drugs mediated by Lipofectin, and cell growth activity was determined by MTS assay. An in situ HCC model was used in this experiment. MK- AS, ADM and MK-AS + ADM were given intravenously for 20 d, respectively. The animal body weight and their tumor weight were measured to assess the effect of the combined therapy in vivo. RESULTS: Combined treatment with MK-AS reduced the IC50 of DDP, 5-FU and ADM in HepG2 cells. MK-AS significantly increased the inhibition rate of DDP, 5-FU and ADM. Additionally, synergism (Q 1.15) occurred at a lower concentration of ADM, 5-FU and DDP with combined MK-AS. Combined treatment with MK-AS and ADM resulted in the more growth inhibition on in situ human HCC model compared with treatment with chemotherapeutic drugs alone. CONCLUSION: MK-AS increases the chemosensitivity in HepG2 cells and in situ human HCC model, and thecombination of MK-AS and ADM has a much better in vitro and in vivo synergism. | Li-Cheng Dai Xiang Wang Xing Yao Yong-Liang Lu Jin-Liang Ping Jian-Fang He | 2007 | World Journal of Gastroenterology2007，13，13： | 10 |
| 18 | Antisense oligonucleotides targeting midkine induced apoptosis and increased chemosensitivity in hepatocellular carcinoma cells显示文摘瞄准:midkine (MK ) 的 Overexpression 在许多恶意被观察了。这研究的这个目的是为指向 MK inhepatocellular 癌(HCC ) 的合适的反感觉 oligonucleotides (ASODN ) 屏蔽房间并且评估它的反肿瘤活动。方法:十 ASODNtargeting MK 被设计并且综合。在有 ASODN 的 transfection 以后,房间增长与山被分析[3-(4,5-dimethylthiazol-2-yl )-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, 内部盐] 试金。另外, MK mRNA,蛋白质层次,以及 apoptosisand caspase-3 活动也在 HepG2 房间被检验。房间增长是有 ASODN 和化学疗法的药的然后分析的再处理。结果:在这个实验,在 10 ASODN 之中的 ASODN5 以一种剂量依赖者方式对 hepatocellular 癌房间的增长显示出更高禁止的活动。在 HepG2 房间, ASODN5 能显著地减少 MK mRNAlevel 和蛋白质内容。在有为 48 h 的 ASODN5 的 transfection 以后,与衰落 ofsurvivin 和 Bcl-2 蛋白质内容伴随了, apoptosis 的显著增加和 caspase-3 活动在 HepG2 房间被观察。而且, ASODN5 转移能显著地增加 chemosensitivity inHepG2 房间。结论:指向 MK 的 Antisense oligonucleotides 在 HCC 上显示出治疗学的效果; ASODN5 有可能性作为一个有效的反肿瘤代理人被发展。 | Li-cheng DAI Xiang WANG Xing YAO Yong-liang LU Jin-liang PING Jian-fang HE | 2006 | Acta Pharmacologica Sinica2006，27，12： | 10 |
| 19 | Underwater image enhancement based on red channel weighted compensation and gamma correction model显示文摘Due to the special characteristics of light in water,the information of the red channel is seriously attenuated in collected image.This causes other colors to dominate the image.This paper proposes an underwater image enhancement algorithm based on red channel weighted compensation and gamma correction model.Firstly,by analyzing the attenuation characteristics of RGB channels,the intensity and the edge information of red channel are compensated by weighting the attenuation coefficient ratio between different channels to correct the chromaticity.Then the gamma correction model is employed to stretch the intensity range to enhance the contrast which makes the image look clearer.The experimental results show that the proposed algorithm can correct the color cast effect and improve the contrast by nearly 2 times for the underwater images with too much red component attenuation. | Wending Xiang Ping Yang Shuai Wang Bing Xu Hui Liu | 2018 | Opto-Electronic Advances2018，1，10： | 10 |
| 20 | A multi-locus backbone tree for Pestalotiopsis, with a polyphasic characterization of 14 new species显示文摘Pestalotiopsis is a taxonomically confused,pathogenic and chemically creative genus requiring a critical reexamination using a multi-gene phylogeny based on ex-type and ex-epitype cultures.In this study 40 isolates of Pestalotiopsis,comprised of 28 strains collected from living and dead plant material of various host plants from China were studied by means of morphology and analysis of ITS,β–tubulin and tef1 gene sequence data.Based on molecular and morphological data we describe 14 new species(Pestalotiopsis asiatica,P.chinensis,P.chrysea,P.clavata,P.diversiseta,P.ellipsospora,P.inflexa,P.intermedia,P.linearis,P.rosea,P.saprophyta,P.umberspora,P.unicolor and P.verruculosa)and three species are epitypified(P.adusta,P.clavispora and P.foedans).Of the 10 gene regions(ACT,β-tubulin,CAL,GPDH,GS,ITS,LSU,RPB 1,SSU and tef1)utilized to resolve cryptic Pestalotiopsis species,ITS,β–tubulin and tef1 proved to be the better markers.The other gene regions were less useful due to poor success in PCR amplification and/or in their ability to resolve species boundaries.As a single gene tef1 met the requirements for an ideal candidate and functions well for species delimitation due to its better species resolution and PCR success.Althoughβ-tubulin showed fairly good differences among species,a combination of ITS,β-tubulin and tef1 gene data gave the best resolution as compared to single gene analysis.This work provides a backbone tree for 22 ex-type/epitypified species of Pestalotiopsis and can be used in future studies of the genus. | Sajeewa S.N.Maharachchikumbura Liang Dong Guo Lei Cai Ekachai Chukeatirote Wen Ping Wu Xiang Sun Pedro W.Crous D.Jayarama Bhat Eric H.C.McKenzie Ali H.Bahkali Kevin D.Hyde | 2012 | Fungal Diversity2012，，5： | 9 |
您所在的机构暂未开通此部分的功能，请联系管理员