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| 1 | Fatty liver disease,an emerging etiology of hepatocellular carcinoma in Argentina显示文摘AIM To investigate any changing trends in the etiologies of hepatocellular carcinoma(HCC) in Argentina during the last years. METHODS A longitudinal cohort study was conducted by 14 regional hospitals starting in 2009 through 2016. All adult patients with newly diagnosed HCC either with pathology or imaging criteria were included. Patients were classified as presenting non-alcoholic fatty liver disease(NAFLD) either by histology or clinically, provided that all other etiologies of liver disease were ruled out, fatty liver was present on abdominal ultrasound and alcohol consumption was excluded. Complete follow-up was assessed in all included subjects since the date of HCC diagnosis until death or last medical visit.RESULTS A total of 708 consecutive adults with HCC were included. Six out of 14 hospitals were liver transplant centers(n = 484). The prevalence of diabetes mellitus was 27.7%. Overall, HCV was the main cause of liver disease related with HCC(37%) including cirrhotic and non-cirrhotic patients, followed by alcoholic liver disease 20.8%, NAFLD 11.4%, cryptogenic 9.6%, HBV 5.4% infection, cholestatic disease and autoimmune hepatitis 2.2%, and other causes 9.9%. A 6-fold increase in the percentage corresponding to NAFLDHCC was detected when the starting year, i.e., 2009 was compared to the last one, i.e., 2015(4.3% vs 25.6%; P < 0.0001). Accordingly, a higher prevalence of diabetes mellitus was present in NAFLD-HCC group 61.7% when compared to other than NAFLD-HCC 23.3%(P < 0.0001). Lower median AFP values at HCC diagnosis were observed between NAFLD-HCC and non-NAFLD groups(6.6 ng/m L vs 26 ng/m L; P = 0.02). Neither NAFLD nor other HCC etiologies were associated with higher mortality.CONCLUSION The growing incidence of NAFLD-HCC documented in the United States and Europe is also observed in Argentina, a confirmation with important Public Health implications. | Federico Pinero Josefina Pages Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Manuel Cobos Carlos Rosales Gustavo Romero Lucas McCormack Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva | 2018 | World Journal of Hepatology2018，10，1： | 4 |
| 2 | Intermediate-advanced hepatocellular carcinoma in Argentina:Treatment and survival analysis显示文摘BACKGROUND Hepatocellular carcinoma(HCC) represents the sixteenth most frequent cancer in Argentina. The rise of new therapeutic modalities in intermediate-advanced HCC opens up a new paradigm for the treatment of HCC.AIM To describe real-life treatments performed in patients with intermediateadvanced HCC before the approval of new systemic options.METHODS This longitudinal observational cohort study was conducted between 2009 and2016 in 14 different regional hospitals from Argentina. Included subjects had intermediate-advanced Barcelona Clinic Liver Cancer(BCLC) HCC stages(BCLC B to D). Primary end point analyzed was survival, which was assessed for each BCLC stage from the date of treatment until last patient follow-up or death.Kaplan Meier survival curves and Cox regression analysis were performed, with hazard ratios(HR) calculations and 95% confidence intervals(95%CI).RESULTS From 327 HCC patients, 41% were BCLC stage B, 20% stage C and 39% stage D.Corresponding median survival were 15 mo(IQR 5-26 mo), 5 mo(IQR 2-13 mo)and 3 mo(IQR 1-13 mo)(P < 0.0001), respectively. Among BCLC-B patients(n =135), 57% received TACE with a median number of 2 sessions(IQR 1-3 sessions).Survival was significantly better in BCLC-B patients treated with TACE HR =0.29(CI: 0.21-0.40) than those without TACE. After tumor reassessment by RECIST 1.1 criteria following the first TACE, patients with complete response achieved longer survival (HR = 0.15(CI: 0.04-0.56, P = 0.005))Eighty-two patients were treated with sorafenib, mostly BCLC-B and C(87.8%). However,12.2% were BCLC-D. Median survival with sorafenib was 4.5 mo(IQR 2.3-11.7 mo);which was lower among BCLC-D patients 3.2 mo(IQR 2.0-14.1 mo). A total of 36 BCLC-B patients presented tumor progression after TACE. In these patients,treatment with sorafenib presented better survival when compared to those patients who received sorafenib without prior TACE [HR = 0.26(CI: 0.09-0.71);P= 0.013].CONCLUSION In this real setting, our results were lower than expected. This highlights unmet needs in Argentina, prior to the introduction of new treatments for HCC. | Federico Pinero Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Gustavo Romero Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva | 2019 | World Journal of Gastroenterology2019，25，27： | 3 |
| 3 | Another major advance in synthetic monofilament absorbable suture 显示文摘 | PINEROS F A DRAKE D B RODEBEAVER P A | 2004 | Journal of Long-Term Effects of Medical Implants2004，14，5： | 1 |
| 4 | Corneal biomechanical properties in normal, post-laser in situ keratomileusis, and kera- toconic eyes显示文摘 | Ortiz D Pinero D Shabayek MH | 2007 | J Cataract Refract Surg2007，33，： | 1 |
| 5 | Corneal wavefront-guided retreatments for significant night vision symptoms after myopic laser refractive surgery显示文摘 | ALIO J PINERO D MUFTUOGLU O | 2008 | Am J Ophthalmol2008，145，1： | 1 |
| 6 | Toric implantable collamer lens for moderate to high myopic astigmatism: 3-year follow-up显示文摘 | Sari E S Pinero D P Kubaloglu A | 2013 | Graefes Arch Clin Exp Ophthalmol2013，251，5： | 1 |
| 7 | Corneal wavefront-guided retreatments for significant night vision symptoms after myopic laser refractive surgery显示文摘 | Alio JL Pinero D Muftuoglu O | | 0，，： | 1 |
| 8 | Hyperglycemia and short-term outcome in patients with spontaneous intracerebral hemorrhage 显示文摘 | GODOY D A PINERO G R SVAMPA S | 2008 | Neurocrit Care2008，9，2： | 1 |
| 9 | Toric implantable collamer lens for moderate to high myopic astigmatism: 3-year follow-up显示文摘 | Sari ES Pinero D Kubaloglu A | 2013 | Graefes Arch Clin Exp Ophthalmol2013，251，5： | 1 |
| 10 | Corneal biomechanical properties in normal,post-laser in situ keratomileusis,and kera- toconic eyes显示文摘 | Ortiz D Pinero D Shabayek MH | 2007 | J Cataract Refract Surg2007，33，8： | 1 |
| 11 | Variations in dietary iron alter brain iron metabolism in developing rats显示文摘 | Pinero D J Li N Q Connor J R | 2000 | J Nutr2000，130，2： | 1 |
| 12 | What is agenus in the Trypanosomatid family? Phylogenetic analysis of two small rRNA sequences 显示文摘 | Gomez E Valdes A M Pinero D | 1991 | Mol Biol Evol1991，，8： | 1 |
| 13 | Seed morphometrics and adaptive geographic differentiation显示文摘 | Venable D L Dyreson E Pinero D | 1998 | Evolution1998，52，： | 1 |
| 14 | Corneal incision quality : mieroineision cataract surgery versus microcoaxial phaeoemulsifieation 显示文摘 | Elkady B Pinero D Alio J L | 2009 | J Cata- ract Refract Surg2009，35，3： | 1 |
| 15 | Iron status and distribution on iron in the brains of the developing rats 显示文摘 | Erikson K Pinero D Connor J | 1997 | J Nutr1997，127，： | 1 |
| 16 | A Meta-Analysis of Col- lege Students' Physical Activity Behaviors显示文摘 | KEATING X D J]ANMIN G PINERO J | 2005 | Joulnal of American Col- lege Health2005，54，2： | 1 |
| 17 | Variations in dietary iron alter behavior in developing rats显示文摘 | Pinero D Jones B Beard J | 2001 | J Nutr2001，131，2： | 1 |
| 18 | Minimizing the IOL power error induced by keratometric power显示文摘 | Camps VJ Pinero DP de Fez D | 2013 | Optom Vis Sci2013，90，7： | 1 |
| 19 | Variations in dietary iron alter behavior in developing rats显示文摘 | Pinero D Jones B Beard J | 2001 | J Nutr2001，131，2： | 1 |
| 20 | Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats 显示文摘 | Erikson K M Pinero D J Connor J R Beard J L | 2009 | The Journal of Nutrition2009，，： | 1 |
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