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| 1 | Pharmacogenetics of anticancer monoclonal antibodies显示文摘Pharmacogenetics is the study of therapeutic and adverse responses to drugs based on an individual’s genetic background.Monoclonal antibodies(mAbs)are a rapidly evolving field in cancer therapy,however a number of newly developed and highly effective mAbs(e.g.,anti-CTLA-4 and anti-PD-1)possess pharmacogenomic profiles that remain largely undefined.Since the first chemotherapeutic mAb Rituximab was approved in 1997 by the US Food and Drug Administration for cancer treatment,a broad number of other mAbs have been successfully developed and implemented into oncological practice.Nowadays,mAbs are considered as one of the most promising new approaches for cancer treatment.The efficacy of mAb treatment can however be significantly affected by genetic background,where genes responsible for antibody presentation and metabolism,for example,can seriously affect patient outcome.This review will focus on current anticancer mAb treatments,patient genetics that shape their efficacy,and the molecular pathways that bridge the two. | Dmitrii Shek Scott ARead Golo Ahlenstiel Irina Piatkov | 2019 | Cancer Drug Resistance2019，2，1： | 2 |
| 2 | Glutaminespecific N-terminal amidase,a component of the N-end rule pathway显示文摘 | Wang H Piatkov KI Brower CS Varshavsky A | | 0，，： | 1 |
| 3 | Substrate-binding sites of UBR1,the ubiquitin ligase of the N-end rule pathway显示文摘 | Xia Z Webster A Du F Piatkov K Ghislain M Varshavsky A | | 0，，： | 1 |
| 4 | High-performance liquid chromatographic determination of arecoline in human saliva显示文摘 | Cox S Irina Piatkov I Vickers E R | 2004 | Journal of Chromatography A2004，，： | 1 |
| 5 | The auto generated fragment of the USP1 deubiquitylase is a physiological substrate of the N-end rule pathway显示文摘 | PIATKOV K I COLNAGHI L B(E)K(E)S M | 2012 | Mol Cell2012，48，6： | 1 |
| 6 | High-performance liquid chromatographic determination of arecoline in human saliva 显示文摘 | Cox S Irina Piatkov I Vickers ER | 2004 | Journal of Chromatography A2004，，1032： | 1 |
| 7 | High performance liquid chromatographic determination of arecoline in human saliva显示文摘 | Cox S Piatkov I Vickers ER | 2004 | J Chromatogr A2004，1032，12： | 1 |
| 8 | High performance liquid chromatographic determination of arecoline in human saliva显示文摘 | Cox S Piatkov I Vickers ER | 2004 | J Chromatogr A2004，，1032： | 1 |
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