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| 1 | 导致成人与儿童患者30天脑室腹腔分流失败的原因分析(英文)显示文摘OBJECTIVE The aim of this study was to provide a comprehensive benchmark of 30-day ventriculoperitoneal(VP)shunt failure rates for a single institution over a 5-year study period for both adult and pediatric patients,to compare this with the results in previously published literature,and to establish factors associated with shunt failure.METHODS A retrospective database search was undertaken to identify all VP shunt operations performed in a single,regional neurosurgical unit during a 5-year period.Data were collected regarding patient age,sex,origin of hydrocephalus,and whether the shunt was a primary or secondary shunt.Operative notes were used to ascertain the type of valve inserted,which components of the shunt were adjusted/replaced(in revision cases),level of seniority of the most senior surgeon who participated in the operation,and number of surgeons involved in the operation.Where appropriate and where available,postoperative imaging was assessed for grade of shunt placement,using a recognized grading system.Univariate and multivariate models were used to establish factors associated with early(30-day)shunt failure.RESULTS Six hundred eighty-three VP shunt operations were performed,of which 321 were pediatric and 362 were adult.The median duration of postoperative follow-up for nonfailed shunts(excluding deaths)was 1263 days(range 525-2226 days).The pediatric 30-day shunt failure rates in the authors'institution were 8.8%for primary shunts and 23.4%for revisions.In adults,the 30-day shunt failure rates are 17.7%for primary shunts and 25.6%for revisions.In pediatric procedures,the number of surgeons involved in the operating theater was significantly associated with shunt failure rate.In adults,the origin of hydrocephalus was a statistically significant variable.Primary shunts lasted longer than revision shunts,irrespective of patient age.CONCLUSIONS A benchmark of 30-day failures is presented and is consistent with current national databases and previously published data by other groups.The number of surgeons involved in shunt operations and the origin of the patient's hydrocephalus should be described in future studies and should be controlled for in any prospective work.The choice of shunt valve was not a significant predictor of shunt failure.Most previous studies on shunts have concentrated on primary shunts,but the high rate of early shunt failure in revision cases(in both adults and children)is perhaps where future research efforts should be concentrated. | Anderson IA Saukila LF Robins JMW Akhunbay-Fudge CY Goodden JR Tyagi AK Phillips N Chumas PD | 2018 | 中华神经外科疾病研究杂志2018，17，3： | 3 |
| 2 | Medium term fol-low-up of a randomized controlled trial of interventions for youngpeople at ultra high risk of psychosis显示文摘 | Phillips U McGony PD Yuen HP | 2007 | Schizophr Res2007，96，1： | 1 |
| 3 | Functional fitness assessment of ol- der cardiac rehabilitation patients 显示文摘 | Pepin V Phillips WT Swan PD | 2004 | J Cardiopulmonary rehabilita- tion2004，24，1： | 1 |
| 4 | Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical samplewith subthreshold symp- toms 显示文摘 | McGeny PD Yung AR Phillips LJ | 2002 | Archives of General Psychiatry2002，59，： | 1 |
| 5 | Ciliary neurotrophic factor activates spinal cord astrocytes, stimulating their production and release of fibroblast growth factor-2, to increase motor neuron survival显示文摘 | Phillip JA John PD Olivia KS | 2002 | Exp Neural2002，173，1： | 1 |
| 6 | Identification of young people at risk of psychosis: validation of Personal Assessment and Crisis Evaluation Clinic intake criteria显示文摘 | Phillips LJ Yung AR McGorry PD | 2000 | Aust N Z J Psychiatry2000，，： | 1 |
| 7 | A review of psychosocial outcomes for patients seeking cosmetic surgery显示文摘 | Honigman PD Phillips KA Castle DJ | 2004 | Plast Reconstr Surg2004，113，： | 1 |
| 8 | The identification of predictors of psychosis in a high risk group 显示文摘 | Phillips LJ Yung AR | 1999 | Schizophr Res1999，36，： | 1 |
| 9 | Identi cation of young people at risk of psychosis: validation of personal assessment and crisis evaluation clinic intake criteria显示文摘 | Phillips L J YungAR McGorry PD | 2000 | Aust New Zealand J Psychiatry2000，34，： | 1 |
| 10 | Medium term follow?up of a randomized controlled trial of interventions for young people at ultra high risk of psychosis显示文摘 | Phillips IJ McGorry PD Yuen HP | 2007 | Schizophr Res2007，96，13： | 1 |
| 11 | Randomizedcontrolled trial of interventions designed to reduce the riskof progression to first-episode psychosis in a clinicalsample with subthreshold symptoms 显示文摘 | Mcgorry PD Yung AR Phillips U | 2002 | Arch GenPsychiatry2002，59，10： | 1 |
| 12 | Technical Advances in Pediatric Laparoseopy Have Had a Beneficial Impact on SpIenectomy显示文摘 | Shaul DB Phillips JD | 2000 | J Pediatr Surg2000，35，： | 1 |
| 13 | Medium termfollow-up of a randomized controlled trial of interventionsfor young people at ultra high risk of psychosis 显示文摘 | Phillips U Mcgorfy PD Yuen HP | 2007 | Schizophr Res2007，96，13： | 1 |
| 14 | Identification of young people at risk of psychosis: validation of Personal Assessment and Crisis Evaluation Clinic intake criteria 显示文摘 | Yung AR McGorry PD | 2000 | Aust N Z J Psychiatry2000，，： | 1 |
| 15 | Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1 alpha显示文摘 | Phillips Pd Mestas J Gharaee-Kermani M | 2005 | J Biol Chem2005，280，22： | 1 |
| 16 | Randomizedcontrolled trial of interventions designed to reduce the riskof progression to first-episode psychosis in a clinicalsamplewith subthreshold symptoms 显示文摘 | McGorry PD Yung AR Phillips LJ | 2002 | Arch Gen Psychiatry2002，59，10： | 1 |
| 17 | Prediction of psychosis : A step towards indicated prevention of schizophrenia显示文摘 | Yung AR Phillips LJ McGorry PD | 1998 | Br J Psychiatry1998，172，33： | 1 |
| 18 | A review of psychosocial outcomes for patient s seeking cosmetic surgery 显示文摘 | Honigman PD Phillips KA Castle DJ | 2004 | Plast Reconstr Surg2004，113，： | 1 |
| 19 | Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms显示文摘 | McGorry PD Yung AR Phillips LJ | | 0，，： | 1 |
| 20 | Random ized controlled trial of interventions designed to reduce the risk of progression to first episode psychosis in a clinical sample with subthreshold symptoms显示文摘 | McGorry PD Yung AR Phillips LJ | 2002 | Arch Gen Psychiatry2002，59，： | 1 |
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