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1Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting.Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov 2014World Journal of Gastroenterology2014,20,45:9
2An in vivo comparison of the potential for extravertebral cement leak after vertebroplasty and kyphoplasty显示文摘Phillips FH Todd WF Lieberman I 2002Spine2002,27,19:1
3Resurreccion,Consumer- Based Optimization of a Third-Generation Product Made from Peanut and Rice Flour 显示文摘I D Choi R D Phillips A V A 2007Journal of Food Science2007,72,7:1
4An in vivo comparison of the potential for extravertebral cement leak after vertebroplasty and kyphoplasty 显示文摘Phillips PM Wetzel Todd F Lieberman I 2002Spine2002,27,19:1
5100 Gbit/s optical clock recovery using electrical phaselocked loop consisting of commercially available components 显示文摘I D Phillips A D Ellis 2000Electronics Letters2000,36,7:1
6CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy 显示文摘Phillips HA Favre I Kirkpatrick M 2001Am J Hum Genet2001,68,1:1
7The molecular hiology of the flavin-containing nlonooxygenases of man显示文摘Phillips I R Dolphin C T Clair P 1995Chem Biol Interact1995,96,1:1
8Big Pharma′s new model in orphan drugs and rare diseases显示文摘PHILLIPS M I 2013Expert Opinion on Orphan Drugs2013,1,1:1
9Influence of the attachment of acidophilic bacteria during the oxidation of mineral sulfides显示文摘 Phillips C V Blake Ⅱ R C 2000Minerals Engineering2000,13,4:1
10Hands as route of transmissions for Klebsiella species显示文摘 Phillips I 1977Br med J1977,2,:1
11Cellular Structure of Peanut-based Extruded Snack Products Using Scanning Electron Microscopy显示文摘I D Choi R D Phillips H S Jeong 2004Jonrnal of Texture Studies2004,35,:1
12The platelet membrane glycoprotein Ⅱb-Ⅲa complex显示文摘Phillips D R Charo I F Parise L V 1988Blood1988,714,:1
13Enteropathogenic and enterohaemorrhagic Escherichia coli:more subversive elements显示文摘Frankel G Phillips AD Rosenshine I 1998Mol Microbiol1998,30,:1
14Polyacrylamide+Al2 (SO4)3 and polyacrylamide +CaO remove coilform bacteria and nutrients from swine wasterwater显示文摘Entry J A Phillips I Stratton H 2003Environmental Pollution2003,121,:1
15Mangroves as filers of shrimp pond effluent:prelictions and biogeochemical research needs显示文摘Robertson A I Phillips M J 1995Hydrobiologia1995,295,:1
16Minireally invasive treatments of osteoporotic vertebral compression fractures:vertebroplasty and kyphoplasty显示文摘PHILLIPS F M PFEIFER B A LIEBERMAN I H 2003Instr Course Leet2003,52,3:1
17An in vivo comparison of the potential for extravertebral cement leak after vertebroplasty and kyphoplasty 显示文摘Phillips FM Todd Wetzel F Lieberman I 2002Spine ( Phila Pa 1976 )2002,27,19:1
18Enhancement of monocyte adhesion to endothelial cells by oxidatively modifide low density lipoprotein in mediated by activation of CD11b显示文摘WeberC Kajiyama S Phillips M I 1995Biolchem Biophys Res Comm1995,206,:1
19Modified natural-cycle in vitro fertilization should be considered as the first approach in young poor responders 显示文摘Kadoch I J Phillips S J Bissonnette F 2011Fertil Steri12011,96,5:1
20Conserva- tion of surfactant protein A: evidence for a single origin for vertebrate pulmonary surfactant显示文摘Sullivan L C Daniels C B Phillips I D 1998Mol Evol1998,46,2:1
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