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| 1 | Circular smooth muscle contributes to esophageal shortening during peristalsis显示文摘AIM:To study the angle between the circular smooth muscle(CSM) and longitudinal smooth muscle(LSM) fibers in the distal esophagus.METHODS:In order to identify possible mechanisms for greater shortening in the distal compared to proximal esophagus during peristalsis,the angles between the LSM and CSM layers were measured in 9 cadavers.The outer longitudinal layer of the muscularis propria was exposed after stripping the outer serosa.The inner circular layer of the muscularis propria was then revealed after dissection of the esophageal mucosa and the underlying muscularis mucosa.Photographs of each specimen were taken with half of the open esophagus folded back showing both the outer longitudinal and inner circular muscle layers.Angles were measured every one cm for 10 cm proximal to the squamocolumnar junction(SCJ) by two independent investigators.Two human esophagi were obtained from organ transplant donors and the angles between the circular and longitudinal smooth muscle layers were measured using micro-computed tomography(micro CT) and Image J software.RESULTS:All data are presented as mean ± SE.The CSM to LSM angle at the SCJ and 1 cm proximal to SCJ on the autopsy specimens was 69.3 ± 4.62 degrees vs 74.9 ± 3.09 degrees,P = 0.32.The CSM to LSM angle at SCJ were statistically significantly lower than at 2,3,4 and 5 cm proximal to the SCJ,69.3 ± 4.62 degrees vs 82.58 ± 1.34 degrees,84.04 ± 1.64 degrees,84.87 ± 1.04 degrees and 83.72 ± 1.42 degrees,P = 0.013,P = 0.008,P = 0.004,P = 0.009 respectively.The CSM to LSM angle at SCJ was also statistically significantly lower than the angles at 6,7 and 8 cm proximal to the SCJ,69.3 ± 4.62 degrees vs 80.18 ± 2.09 degrees,81.81 ± 1.75 degrees and 80.96 ± 2.04 degrees,P = 0.05,P = 0.02,P = 0.03 respectively.The CSM to LSM angle at 1 cm proximal to SCJ was statistically significantly lower than at 3,4 and 5 cm proximal to the SCJ,74.94 ± 3.09 degrees vs 84.04 ± 1.64 degrees,84.87 ± 1.04 degrees and 83.72 ± 1.42 degrees,P = 0.019,P = 0.008,P = 0.02 respectively.At 10 cm above SCJ the angle was 80.06 ± 2.13 degrees which is close to being perpendicular but less than 90 degrees.The CSM to LSM angles measured on virtual dissection of the esophagus and the stomach on micro CT at the SCJ and 1 cm proximal to the SCJ were 48.39 ± 0.72 degrees and 50.81 ± 1.59 degrees.Rather than the angle of the CSM and LSM being perpendicular in the esophagus we found an acute angulation between these two muscle groups throughout the lower 10 cm of the esophagus.CONCLUSION:The oblique angulation of the CSM may contribute to the significantly greater shortening of distal esophagus when compared to the mid and proximal esophagus during peristalsis. | Anil K Vegesna Keng-Yu Chuang Ramashesai Besetty Steven J Phillips Alan S Braverman Mary F Barbe Michael R Ruggieri Larry S Miller | 2012 | World Journal of Gastroenterology2012，18，32： | 7 |
| 2 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 3 | 含有菊粉但不含羽扇豆的饲粮有助预防实验诱导的猪痢疾显示文摘猪痢疾是一种传染性黏膜出血的腹泻疾病,由定植于肠道的猪痢疾短螺旋体引起,能够诱发盲肠和结肠发炎。据报道饲料中添加菊苣根和甜羽扇豆可预防猪痢疾。本试验旨在验证是菊苣根中的菊粉而不是羽扇豆中的半乳糖起到保护作用的假设。 | Hansen C F Phillips N D La T.(等) 闫轶洁(译) 无 | 2010 | 养猪2010，，6： | 2 |
| 4 | Cytokines in Mycoplasma pneumoniae infections显示文摘 | Jun Yang W.Craig Hooper Donald J Phillips Deborah F Talkington | 2003 | Cytokine and Growth Factor Reviews2003，，2： | 2 |
| 5 | Airbome laser hydrography in Australia 显示文摘 | PENNY M F ABBOT R H PHILLIPS D M | 1986 | App Opt1986，25，13： | 2 |
| 6 | Keratoconus in a patient with Alport syndrome: A case report显示文摘BACKGROUND Known ocular manifestations of Alport syndrome include features such as anterior lenticonus and fleck retinopathy. Reports of keratoconus in such patients are limited. We report tomographic findings consistent with keratoconus in a patient with Alport syndrome.CASE SUMMARY A 52-year-old female was referred to our ophthalmology clinic with decreased vision and increased tearing. She was diagnosed with stage Ⅲ Alport syndrome two years prior. Upon examination she was found to have average keratometries of 48D bilaterally with tomographic evidence of keratoconus.CONCLUSION Although a rare presentation, concurrent Alport syndrome and keratoconus should be considered when reviewing the ocular health of Alport syndrome patients and appropriate management steps should be taken upon the diagnosis. | Majid Moshirfar David F Skanchy Aaron T Gomez Yasmyne C Ronquillo Benjamin Buckner Phillip C Hoopes | 2019 | World Journal of Clinical Cases2019，7，19： | 2 |
| 7 | An in vivo comparison of the potential for extravertebral cement leak after vertebroplasty and kyphoplasty 显示文摘 | Phillips PM Wetzel Todd F Lieberman I | 2002 | Spine2002，27，19： | 1 |
| 8 | Rock excavation by disc cutter显示文摘 | ROXBOROUGH F F PHILLIPS H | 1975 | International Journal of Rock Mechanics and Mining Sciences1975，12，12： | 1 |
| 9 | Storage of light in atomic vapor显示文摘 | PHILLIPS D F FLEISCHHAUER A MAIR A ct al | 2001 | PHYS REV LETT2001，86，： | 1 |
| 10 | Differential utilization of summer rains by desert plants显示文摘 | Ehleringer J R Phillips S L Schuster S F | 1991 | Oecologia1991，88，： | 1 |
| 11 | Photophysics of 10-substi- tuted poly ( 2-(9-anthryl) ethyl methacrylates) 显示文摘 | Marye Anne Fox Phillip F Britt | 1990 | Macro- molecules1990，23，21： | 1 |
| 12 | Rock excavation by disccnt- ter显示文摘 | Roxborough F F Phillips H R | 1975 | International Journal of Rock Mechanics and Mining Sciences & Geomechanics Abstracts1975，12，12： | 1 |
| 13 | Storage of Light in Atomic Vapor显示文摘 | Phillips D F Fleischhauer A Mair A Walsworth R L Lukin M D | 2001 | Phys Rev Lett2001，86，78： | 1 |
| 14 | Minimally invasive treatments of osteoporotic vertebral compression fractures 显示文摘 | Phillips F M | 2013 | Spine2013，28，15： | 1 |
| 15 | A new continuum traffic model obtained from ki- netic theory显示文摘 | PHILLIPS W F | 1978 | IEEE Transactions on Automatic Control1978，23，： | 1 |
| 16 | The molecular structure of green fluorescent protein 显示文摘 | Yang F Moss L G Phillips G N Jr | 1996 | Nat Biotechnol1996，14，10： | 1 |
| 17 | The platelet membrane glycoprotein Ⅱb-Ⅲa complex显示文摘 | Phillips D R Charo I F Parise L V | 1988 | Blood1988，714，： | 1 |
| 18 | Parasite-specific IgM plays a significant role in the protective immune response to asexual erythrocytic stage Plasmodium chabaudi AS infection显示文摘 | Couper KN Phillips RS Brombacher F | 2005 | Parasite Immunol2005，27，5： | 1 |
| 19 | The structure of self-consciousness in children and young adolescents and relations to social anxiety显示文摘 | Charmaine K Higa Lisa K Phillips Bruce F Chorpita | 2008 | Journal of Psychopathology and Behavioral Assessment2008，30，4： | 1 |
| 20 | Manual on experimental stress analysis 显示文摘 | Doyle F James Phillips J | 1989 | Society for Experimental Mechanics1989，5，： | 1 |
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