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| 1 | Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis显示文摘AIM: To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis (B. lactis) in an adoptive transfer model of colitis. METHODS: Donor and recipient mice received either B. lactis or bacterial culture medium as control (deMan Rogosa Sharpe) in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice. RESULTS: All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis. CONCLUSION: Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis. | David Philippe Laurent Favre Francis Foata Oskar Adolfsson Genevieve Perruisseau-Carrier Karine Vidal Gloria Reuteler Johanna Dayer-Schneider Christoph Mueller Stéphanie Blum | 2011 | World Journal of Gastroenterology2011，17，4： | 12 |
| 2 | Anti-inflammatory effects of Lacto-Wolfberry in a mouse model of experimental colitis显示文摘AIM: To investigate the anti-inflammatory properties of Lacto-Wolfberry (LWB), bothin vitro and using a mouse model of experimental colitis. METHODS: The effects of LWB on lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) and interleukin (IL)-6 secretion were assessed in a murine macrophage cell line. in vitro assessment also included characterizing the effects of LWB on the activation of NF-E2 related 2 pathway and inhibition of tumor necrosis factor-α (TNF-α)-induced nuclear factor-κB (NFκB) activation, utilizing reporter cell lines. Following the in vitro assessment, the anti-inflammatory efficacy of an oral intervention with LWB was tested in vivo using a preclinical model of intestinal inflammation. Multiple outcomes including body weight, intestinal histology, colonic cytokine levels and anti-oxidative measures were investigated.RESULTS: LWB reduced the LPS-mediated inductionof ROS production [+LPS vs 1% LWB + LPS, 1590 ± 188.5 relative luminescence units (RLU) vs 389 ± 5.9 RLU, P < 0.001]. LWB was more effective than wolfberry alone in reducing LPS-induced IL-6 secretion in vitro (wolfberry vs 0.5% LWB, 15% ± 7.8% vs 64% ± 5%, P < 0.001). In addition, LWB increased reporter gene expression via the anti-oxidant response element activation (wolfberry vs LWB, 73% ± 6.9% vs 148% ± 28.3%, P < 0.001) and inhibited the TNF-α-induced activation of the NF-κB pathway (milk vs LWB, 10% ± 6.7% vs 35% ± 3.3%, P < 0.05). Furthermore, oral supplementation with LWB resulted in a reduction of macroscopic (-LWB vs +LWB, 5.39 ± 0.61 vs 3.66 ± 0.59, P = 0.0445) and histological scores (-LWB vs +LWB, 5.44 ± 0.32 vs 3.66 ± 0.59, P = 0.0087) in colitic mice. These effects were associated with a significant decrease in levels of inflammatory cytokines such as IL-1β (-LWB vs +LWB, 570 ± 245 μg/L vs 89 ± 38 μg/L, P = 0.0106), keratinocyte-derived chemokine/growth regulated protein-α (-LWB vs +LWB, 184 ± 49 μg/Lvs 75 ± 20 μg/L,P = 0.0244), IL-6 (-LWBvs +LWB, 318 ± 99 μg/L vs 117 ± 18 μg/L, P = 0.0315) and other pro-inflammatory proteins such as cyclooxygenase-2 (-LWB vs +LWB, 0.95 ± 0.12 AU vs 0.36 ± 0.11 AU, P = 0.0036) and phosphorylated signal transducer and activator of transcription-3 (-LWB vs +LWB, 0.51 ± 0.15 AU vs 0.1 ± 0.04 AU, P = 0.057). Moreover, antioxidant biomarkers, including expression of gene encoding for the glutathione peroxidase, in the colon and the plasma anti-oxidant capacity were significantly increased by supplementation with LWB (-LWB vs +LWB, 1.2 ± 0.21 mmol/L vs 2.1 ± 0.19 mmol/L, P = 0.0095).CONCLUSION: These results demonstrate the antiinflammatory properties of LWB and suggest that the underlying mechanism is at least in part due to NF-κB inhibition and improved anti-oxidative capacity. | David Philippe Viral Brahmbhatt Francis Foata Yen Saudan Patrick Serrant Stephanie Blum Jalil Benyacoub Karine Vidal | 2012 | World Journal of Gastroenterology2012，18，38： | 1 |
| 3 | Isotopic study of the Manaslu granite inferences on the age and source of Himalayan leucogranites 显示文摘 | Catherine Deniel Philippe Vidal Angel Fernandez | 1987 | Contributions to Mineralogy and Petrology1987，96，： | 1 |
| 4 | Isotopic study of the Manaslu granite inferences on the age and source of Himalayan leucogranites 显示文摘 | Catherine Deniel Philippe Vidal Angel Fernandez | 1987 | Contributions to Mineralogy and Petrology1987，96，： | 1 |
| 5 | Isotopic study of the Manaslu granite (Himalaya, Nepal): inferences on the age and source of Himalayan leucogranites显示文摘 | Catherine Deniel Philippe Vidal Angel Fernandez Patrick Fort Jean-Jacques Peucat | 1987 | Contributions to Mineralogy and Petrology1987，，1： | 1 |
| 6 | Identification and characterization of a second mouse Nramp gene显示文摘 | Samantha Gruenheid Mathieu Cellier Silvia Vidal Philippe Gros | 1995 | Genomics1995，，2： | 1 |
| 7 | User Context and Personalized Learning: a Federationof Contextualized Attention Metadata显示文摘 | Valentin Butoianu Philippe Vidal Katrien Verbert Erik Duval Julien Broisin | 2010 | Journal of Universal ComputerScience2010，16，16： | 1 |
| 8 | 2008我们的地球显示文摘2008年,这一刻,我们的地球怎样了?《明日风尚》在内地华文媒体之中,首先取得《法国世界外交论衡月刊》(Le Monde Diplomatique)特别授权,辑录了该国际性月刊今年推出的'世界地图集',以大量地图和图表,向华文读者展现我们地球的最新状况。地球明显盛载着战争、疾病、贫穷、疯狂和环境破坏。我们从'天视'的角度去俯瞰地球,不出我们所料,地球形势叫人不安。深海水产遭到可以装下整座巴黎铁塔的渔网的无情扫荡。森林采伐、疯狂贸易,进一步导致地球气温攀升。水源匮乏进入了五十年倒数的灾难阶段。紧接着令人忧心忡忡的基因改造生物技术,这年头,我们又迎来了'微不足道'同时危险莫测的'纳米科技'。文明国家可以联合起来做些什么吗?对不起,我们发现国际上普遍存在企业环保责任的'司法空白'。跨国企业一方面牟取暴利肆意破坏环境,一方面展开'伪绿色宣传',为企业形象'整容'。原来'国有国法,家有家规'之外,我们并没有一条'地球法'。'生物多样性'正呈现明显衰退,远古出现过五次大规模生物灭绝,现在我们是否已踏进第六波生物灭绝?下一页,你将从'地球人视角'看到宏观的世界。——编者—— | Josephine Shen A-Link Agnès Sinai Anne Rialhe Olivier Bailly Sabine RabOurdin Dominioue Vidal Donatien Garnier Alain Zecchini Marc Laimé Rémi Parmentier Michel Urvoy Dorothée Benoit-Browaeys Dominique Vidal Laurent Tubiana Nadège Figarol Thierry Salomono Philippe Bovet Claude Aubert | 2008 | 明日风尚2008，0，5： | 0 |
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