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| 1 | Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells显示文摘AIM:To investigate the effects of four probiotic bacteria and their combination on human mast cell gene expression using microarray analysis.METHODS:Human peripheral-blood-derived mast cells were stimulated with Lactobacillus rhamnosus (L.rhamnosus) GG (LGG),L.rhamnosus Lc705 (Lc705),Propionibacterium freudenreichii ssp.shermanii JS (PJS) and Bifidobacterium animalis ssp.lactis Bb12 (Bb12) and their combination for 3 or 24 h,and were subjected to global microarray analysis using an Affymetrix GeneChip Human Genome U133 Plus 2.0 Array.The gene expression differences between unstimulated and bacteria-stimulated samples were further analyzed with GOrilla Gene Enrichment Analysis and Visualization Tool and MeV Multiexperiment Viewer-tool.RESULTS:LGG and Lc705 were observed to suppress genes that encoded allergy-related high-affinity IgE receptor subunits α and γ (FCER1A and FCER1G,respectively) and histamine H4 receptor.LGG,Lc705 and the combination of four probiotics had the strongest effect on the expression of genes involved in mast cell immune system regulation,and on several genes that encoded proteins with a pro-inflammatory impact,such as interleukin (IL)-8 and tumour necrosis factor alpha.Also genes that encoded proteins with anti-inflammatory functions,such as IL-10,were upregulated.CONCLUSION:Certain probiotic bacteria might diminish mast cell allergy-related activation by downregulation of the expression of high-affinity IgE and histamine receptor genes,and by inducing a pro-inflammatory response. | Anna Oksaharju Matti Kankainen Riina A Kekkonen Ken A Lindstedtt Petri T Kovanen Riitta Korpela Minja Miettinen | 2011 | World Journal of Gastroenterology2011，17，6： | 3 |
| 2 | An experi- mental investigation of spur gear efficiency 显示文摘 | PETRY J T KAHRAMAN A ANDERSON N E | 2008 | Journal of Mechan- ical Design2008，130，06： | 1 |
| 3 | Information-Theoretic Measures of Uncertainty for Rough Relational Databases显示文摘 | Beaubouef T Petry F E Arora G | 1998 | Information Sciences1998，109，14： | 1 |
| 4 | Trophic cascades in a formerly cod-Dominated ecosystem 显示文摘 | Frank K T Petrie B Choi J S | 2005 | Science2005，308，10： | 1 |
| 5 | Recommen- dations on blood pressure measurement 显示文摘 | Petrie J C O'Brien E T Littler W A | 1986 | Br Med J (Clin Res Ed)1986，293，6547： | 1 |
| 6 | Information-theorefic measures of uncertainty for rough sets and rough relational database显示文摘 | Beaubouef T Petry F E Arora G | 1998 | Informafion Sciences1998，109，： | 1 |
| 7 | Review of stabilization of claysand expansive soils in pavements and lightly loadedstructures-history,practice and future显示文摘 | Petry T M Little D N | 2002 | Journal ofMaterials in Civil Engineering2002，，14： | 1 |
| 8 | A maximization technique occurring in the statistical analysis of proba bilistic functions pf Markov chains显示文摘 | Baum L E Petrie T Soules G | 1970 | Ann Math Statist1970，41，1： | 1 |
| 9 | Supporting the module sequencing decision in the ERP implementation process-an application of the ANP method显示文摘 | Petri H Hannu K Markku T | 2009 | Int J Production Economics2009，119，2： | 1 |
| 10 | Statistical inference for probabilistic functions of finite state markov chains 显示文摘 | Baum L E Petrie T | 1966 | The Annals ofMathematical Statistics1966，37，6： | 1 |
| 11 | The use of toxic equivalency factors in assessing occupational and environmental health risk associated with exposure to airborne mixtures of polycyclic aromatic hydrocarbons(PAHs)显示文摘 | Petry T Schmid P Schlatter C | 1996 | Chemosphere1996，32，4： | 1 |
| 12 | The use of toxic equivalency foctors in assessing occupational and environmental health risk associated with exposure to airborne mixtures of polycyclic aromatic hydrocarbons (PAHs)显示文摘 | PETRY T SCHMID P SCHLA3'TER C | 1996 | Chemosphere1996，32，： | 1 |
| 13 | Telomere-driven replicative senescence is a stress response显示文摘 | von Zglinicki T Petrie J Kirkwood T B | 2003 | Nat Biotechnol2003，21，3： | 1 |
| 14 | As, Cd, Hg and Pb in four edible shellfish species from breeding and harvesting areas along the eastern adriatic coast, croatia显示文摘 | Bogdanovi?T Ujevi?I Sedak M Liste? E ?imat V Petri?evic? S Poljak V | 2014 | Food Chemistry2014，146，3： | 1 |
| 15 | Role of the V-ATPase in regulation of the vacuolar fission-fusion equilibrium显示文摘 | Baars T L Petri S Peters C | 2007 | Mol Biol Cell2007，18，： | 1 |
| 16 | Sporadic cases of haemolytie uremic syndrome associated with faecal eytotoxin and cytotoxin-producing Escherichia coli in stools显示文摘 | Karmali M A Steele B T Petrie M | 1983 | Lancet1983，19，1： | 1 |
| 17 | A maximization technique occurring in the statistical analysis of probabilis- tic functions of Markov chains显示文摘 | Baum L E Petrie T Soules G | 1970 | Annals of Mathematical Statistics1970，41，1： | 1 |
| 18 | Distributed power generation and creating a 'virtual utility' to manage it显示文摘 | Jones T Petrie E | 2000 | tEBB Review2000，，3： | 1 |
| 19 | Immune response in progressive muhifocal |eukoencephalopathy: an overview 显示文摘 | Weber T Weber F Petry H | 2001 | J Neurovirot2001，7，4： | 1 |
| 20 | A maximization technique occurring in the statistical analysis of probabilistic functions of Markov Chains显示文摘 | Baum L E Petrie T P Soules G Weiss N | 1970 | Annals of Mathematical Statistics?1970，41，： | 1 |
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