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| 1 | Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats显示文摘瞄准:决定 melatonin 预告的处理的效果并且在 L 精氨酸(L-Arg ) 的严厉上处理以后在老鼠的导致的试验性的胰腺炎。方法:男 Wistar 老鼠(25 ) 被划分成五个组。那些在 1h 的间隔在组 A 收到了 3.2g/kg 体重 L-Arg i.p 的二注射。在组麻省,老鼠与 50 mg/kg 体重 melatonin i.p 被对待在 L-Arg 管理以前的 30 min。在组 AM,在 L-Arg 被给以后,老鼠收到了 melatonin 1h 的一样的剂量。在组 M, melatonin 的单次量是以前描述了被管理。在组 C,对照动物收到了生理盐水注射 i.p 所有老鼠被给在第二 L-Arg 注射以后的 24 h。结果:引起严重引起坏死胰腺炎的 L-Arg 管理在浆液淀粉酶水平,胰腺的重量 / 身体重量比率(pw/bw ) ,胰腺的 IL-6 内容和 myeloperoxidase 由重要举起证实了活动,相对控制值。浆液淀粉酶水平的举起显著地在与仅仅与 L-Arg 注射的老鼠相比给 melatonin 追随者 L-Arg 的老鼠被减少。胰腺的抗氧化剂酶(Cu/Zn-superoxide 歧化酶(Cu/Zn-SOD ) 和过氧化氢酶(猫)) 的活动显著地被增加在胰腺炎以后的 24 h 感应。显著地在 L-Arg 之前给的 Melatonin 在独自与 L-Arg 对待的老鼠相对那减少了胰腺的猫活动。在肝, L-Arg 显著地每氧化水平,和谷胱甘肽过氧化物酶和 Cu/Zn-SOD 活动增加了类脂化合物,而 Mn 草皮活动作为与控制老鼠相比被减少。Melatonin 预告的处理阻止了这些变化。结论:Melatonin 是能在尖锐胰腺炎期间抵抗一些 L-Arg-induced 变化的一种抗氧化剂,并且可能因此在有尖锐引起坏死胰腺炎的病人的支持的治疗有用。 | Annamaria Szabolcs Russel J Reiter Tamas Letoha Peter Hegyi Gabor Papai Ilona Varga Katalin Jarmay Jozsef Kaszaki Reka Sari Zoltan Rakonczay Jr Janos Lonovics Tamas Takacs | 2006 | World Journal of Gastroenterology2006，12，2： | 13 |
| 2 | Twelve weeks of dance exergaming in overweight and obese adolescent girls:Transfer effects on physical activity,screen time,and self-efficacy显示文摘Background: Given the low levels of physical activity(PA) among adolescent girls in the US, there is a need to identify tools to motivate increased PA. Although there is limited evidence that adolescents transfer PA from one context to another, exergames(i.e., video games that require gross motor activity) may act as a gateway to promote overall PA outside game play. The purpose of this study was to examine potential transfer effects(i.e., influences on external behaviors and psychological constructs) of a 12-week exergaming intervention on adolescent girls' PA, screen time,and self-efficacy toward PA, as well as the intrinsic motivation of exergaming.Methods: Participants were 37 girls aged 14–18 years(65% African American, 35% white) who were overweight or obese(body mass index ≥ 85 th percentile) and were recruited from the community via school, physicians, news media, and social media websites. Adolescents were randomly assigned to a 12-week group exergaming intervention(thirty-six 60 min sessions of group-based dance exergaming in a research laboratory using Kinect for Xbox360(Microsoft Corporation, Redmond, WA, USA)) or to a no-treatment control group. Outcome variables included objectively measured PA(total) and self-reported leisure-time PA(discretionary time only) 1 week before vs. 1 week after the intervention; selected type and intensity of PA when placed in a gym setting for 30 min('cardio free choice'); screen time; self-efficacy toward PA; and intrinsic motivation toward exergaming.Results: Attendance at the exergaming sessions was high(80%). Compared with the control group, the intervention group self-reported an increase in PA(p = 0.035) and fewer hours watching television or videos(p = 0.01) after the intervention, but there were no significant differences in sedentary, light, moderate, or vigorous PA measured by accelerometry. The intervention group significantly improved self-efficacy toward PA(p = 0.028). The intervention group highly rated intrinsic motivation toward exergaming.Conclusion: Exergaming for 12 weeks was associated with positive impacts on adolescent girls' self-reported PA, television viewing, self-efficacy,and intrinsic motivation. Future research is warranted to leverage exergames as an enjoyable, motivating, and effective PA tool. | Amanda E.Staiano Robbie A.Beyl Daniel S.Hsia Peter T.Katzmarzyk Robert L.Newton Jr | 2017 | Journal of Sport and Health Science2017，6，1： | 9 |
| 3 | 动脉瘤性蛛网膜下腔出血患者的重症监护处理:神经危重症监护学会多学科共识会议的推荐意见显示文摘蛛网膜下腔出血(subarachnoidhemorrhage,SAH)是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏,使得治疗方法各异,可供选择的指导意见不多。现有的指南主要强调危险因素、预防、自然史以及再出血的预防,很少涉及SAH患者的重症监护问题。美国神经危重症监护学会组织了一次国际性多学科共识会议来探讨SAH的重症监护处理。根据发表的文章和研究领域,此次会议召集了来自欧洲和北美地区的神经重症监护科、神经外科、神经内科、介入神经放射科和神经麻醉科方面的专家。根据临床经验和制定实践指南方面的经验,选择4名经验丰富的神经重症监护专家组成评判委员会。应用推荐分级的评估、制定与评价(GradesofRecommendationsAssessment,DevelopmentandEvaluation,GRADE)系统进行文献回顾,结合参会者的经验、评判委员会的审评以及文献讨论产生推荐意见。应用GRADE系统制定推荐意见,其制定原则不仅强调研究资料的质量,而且还重视利弊权衡与实践转化。对SAH患者日常处理过程中面临的所有问题均提供指导和推荐意见,即使缺乏高质量的证据。 | Michael N. Diringer Thomas P. Bleck J. Claude Hemphill David Menon Lori Shutter Paul Vespa Nicolas Bruder E. Sander Connolly Jr Giuseppe Citerio Daryl Gress Daniel Hanggi Brian L. Hoh Giuseppe Lanzino Peter Le Roux Alejandro Rabinstein, Erich Schmut zhard Nino Stocchetti Jose I. Suarez Miriam Tresgiari Ming-Yuan Tseng Mervyn D. I. Vergouwen Stefan Wolf Gregory Zip fel 田飞(译) 宿 英英(译) | 2013 | 国际脑血管病杂志2013，21，5： | 5 |
| 4 | Inflammation-related gene expression profiles of salivary extracellular vesicles in patients with head trauma显示文摘At present,there is no reliable biomarker for the diagnosis of traumatic brain injury(TBI).Studies have shown that extracellular vesicles released by damaged cells into biological fluids can be used as potential biomarkers for diagnosis of TBI and evaluation of TBI severity.We hypothesize that the genetic profile of salivary extracellular vesicles in patients with head trauma differs from that in uninjured subjects.Findings from this hypothesis would help investigate the severity of TBI.This study included 19 subjects,consisting of seven healthy controls who denied history of head trauma,six patients diagnosed with concussion injury from an outpatient concussion clinic,and six patients with TBI who received treatment in the emergency department within 24 hours after injury.Real-time PCR analysis of salivary extracellular vesicles in participants was performed using TaqMan Human Inflammation array.Gene expression analysis revealed nine upregulated genes in emergency department patients(LOX5,ANXA3,CASP1,IL2RG,ITGAM,ITGB2,LTA4H,MAPK14,and TNFRSF1A)and 13 upregulated genes in concussion clinic patients compared with healthy participants(ADRB1,ADRB2,BDKRB1,HRH1,HRH2,LTB4R2,LTB4R,PTAFR,CYSLTR1,CES1,KLK1,MC2R,and PTGER3).Each patient group had a unique profile.Comparison between groups showed that 15 inflammation-related genes had significant expression change.Our results indicate that inflammation biomarkers can be used for diagnosis of TBI and evaluation of disease severity.This study was approved by the Institutional Review Board on December 18,2015(approval No.0078-12)and on June 9,2016(approval No.4093-16). | Yan Cheng Mandy Pereira Neha P.Raukar John L.Reagan Mathew Quesenberry Laura Goldberg Theodor Borgovan W Curt LaFrance Jr Mark Dooner Maria Deregibus Giovanni Camussi Bharat Ramratnam Peter Quesenberry | 2020 | Neural Regeneration Research2020，15，4： | 2 |
| 5 | Treatment trends of muscle invasive bladder cancer: Evidence from the Surveillance, Epidemiology, and End Results database, 1988 to 2013显示文摘Objective:Guidelines for muscle-invasive bladder cancer(MIBC)recommend that patients receive neoadjuvant chemotherapy with radical cystectomy as treatment over radical cystectomy alone.Though trends and practice patterns of MIBC have been defined using the National Cancer Database,data using the Surveillance,Epidemiology,and End Results(SEER)program have been poorly described.Methods:Using the SEER database,we collected data of MIBC according to the American Joint Commission on Cancer.We considered differences in patient demographics and tumor charac-teristics based on three treatment groups:chemotherapy(both adjuvant and neoadjuvant)with radical cystectomy,radical cystectomy,and chemoradiotherapy.Multinomial logistic regression was performed to compare likelihood ratios.Temporal trends were included for each treatment group.Kaplan-Meier curves were performed to compare cause-specific sur-vival.A Cox proportional-hazards model was utilized to describe predictors of survival.Results:Of 16728 patients,10468 patients received radical cystectomy alone,3236 received chemotherapy with radical cystectomy,and 3024 received chemoradiotherapy.Patients who received chemoradiotherapy over radical cystectomy were older and more likely to be African American;stage III patients tended to be divorced.Patients who received chemotherapy with radical cystectomy tended to be males;stage II patients were less likely to be Asian than Caucasian.Stage III patients were less likely to receive chemoradiotherapy as a treatment op-tion than stage II.Chemotherapy with radical cystectomy and chemoradiotherapy are both un-derutilized treatment options,though increasingly utilized.Kaplan-Meier survival curves showed significant differences between stage II and III tumors at each interval.A Cox proportional-hazards model showed differences in gender,tumor stage,treatment modality,age,andmarital status.Conclusion:Radical cystectomy alone is still the most commonly used treatment for muscle-invasive bladder cancer based on temporal trends.Significant disparities exist in those who receive radical cystectomy over chemoradiotherapy for treatment. | Victor Chalfant Michael L.Blute Jr Peter Silberstein | 2023 | Asian Journal of Urology2023，10，1： | 2 |
| 6 | Treatment of ac-quired esotropia:for augmented surgery显示文摘 | Greenwald MJ Eagle JR Peters C | | 0，，： | 1 |
| 7 | Survival as a function of HbA1cin people with type 2 diabetes:a retrospective cohort study显示文摘 | Currie CJ Peters JR Tynan A | 2010 | Lancet2010，375，9713： | 1 |
| 8 | Survival as a function of HbA ( 1 e) in people with type 2 diabetes: a retrospective cohort study显示文摘 | Currie CJ Peters JR Tynan A | 2010 | Lancet2010，375，9713： | 1 |
| 9 | The capsaicinoid:their Separation,synthesis and mutagenicith显示文摘 | Peter MG Donald LN Pam JR 1988 | 1988 | J Org Chem1988，53，5： | 1 |
| 10 | Identification of Treponema pallidum in amniotic fluid and fetal blood from pregnancies by congenital syphilis 显示文摘 | Wendel GD Jr Sanehez PJ Peters MT | 1991 | Obstet Gynecol1991，78，52： | 1 |
| 11 | Research Design Effects on the Reliability of Rating Scales : A Meta - analysis 显示文摘 | Churchill Jr G A J P Peter | 1984 | Journal of Marketing Research1984，21，： | 1 |
| 12 | Paul alivisatos semiconductor nanocrystals as fluorescent biological labels显示文摘 | Marcel Bruchez Jr Mario M Peter G Shimon W | 1998 | Science1998，281，： | 1 |
| 13 | Reevaluating the way we classify the diabetic foot: restructuring the diabetic foot risk classification system of the International Working Group on the Diabetic Foot显示文摘 | Lavery LA Peters EJ Williams JR | 2008 | Diabetes Care2008，31，1： | 1 |
| 14 | Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer pain 显示文摘 | Peters CM Ghilardi JR Keyser CP | 2005 | Exp Neurnl2005，193，1： | 1 |
| 15 | Making alliances work - Guidelines for success 显示文摘 | Pekar Peter Jr Robert Allio | 1994 | Long Range Planning1994，，4： | 1 |
| 16 | Neovascularization in atherectomy specimens from patients with unstable angina: implications for pathogenesis of unstable angina 显示文摘 | Tenaglia AN Peters KG Sketch MH Jr | 1998 | Am Heart J1998，135，1： | 1 |
| 17 | Patterns of in and out-patient activity for diabetes: a district survey 显示文摘 | Currie C J Williams R Peters JR | 1996 | Diabetic Med1996，，13： | 1 |
| 18 | Gemcitaline-cisplatin: a schedule finding study显示文摘 | Kroep JR Peters GJ van Moofsel CJ | 1999 | Ann Oncol1999，10，12： | 1 |
| 19 | Protection of the oral mucosa by salivary histatin-5 against Candida albicans in an ex vivo murine model of oral infection显示文摘 | Peters B M Zhu J Fidel P L Jr | 2010 | FEMS Yeast Res2010，10，59： | 1 |
| 20 | Anti-inflammatory effects of a triterpenoid isolated from Wilbrandia ebracteata Cogn 显示文摘 | SIQUEIRA J M JR PETERS R R GAZOLA A C | 2007 | Life Sci2007，80，： | 1 |
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