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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 上颌窦癌的术后放疗显示文摘副鼻窦癌在美国很少见,年发病率约为1/100000。由于发病隐匿,在诊断时往往已到中晚期。而副鼻窦又邻近重要器官,如眼眶、颅底、脑,彻底的肿瘤切除较为困难,满意的放疗设计也受到限制。所以,中晚期副鼻窦癌的治疗十分棘手。本文是回顾性分析,着重研究上颌窦癌的术后放疗。 | 蒋国樑 Ang KK Peters JL wendt CD Oswald MJ Ceopfer TH | 1991 | 中华放射肿瘤学杂志1991，0，3： | 5 |
| 3 | Fondaparinux cumpared to enoxaparin in patients with acute coronary syndromes without STsegment elevation: outcomes and treatment effect across different levels of risk显示文摘 | Joyner CD Peters RJ Afzal R | 2009 | Am Heart J2009，157，3： | 1 |
| 4 | PACS infrastructure supporting e-learning显示文摘 | Peter Mildenberger Kerstin Brtiggemann Freya RCisner et cd | 2011 | European Journal of Radiol- ogy2011，78，： | 1 |
| 5 | Acute profound thrombocytopenia secondary to local abciximab infusion显示文摘 | Peters MN Press CD Moscona JC | 2012 | Proc(Bayl Univ Med Cent)2012，25，4： | 1 |
| 6 | AlphaLISA versus ELISA- based detection of interleukin 18 in healthy subjects and patients with end-stage renal disease显示文摘 | Peters CD Jespersen B Norregaard R | 2012 | Scand J Clin Lab Invest2012，72，8： | 1 |
| 7 | Renal and cardio vascular effects of irbesartan in dialysis patients: a randomized controlled trial protocol (SAFIR study)显示文摘 | Peters CD Kjaergaard KD Jespersen B | 2013 | Dan Med J2013，60，4： | 1 |
| 8 | Functional significance of Tie2 signaling in the adult vasculature显示文摘 | Peters KG Kontos CD Lin PC | | 0，，： | 1 |
| 9 | Chorea subsequent :to acute rheumatic fever in a 9-year-old girl 显示文摘 | ISeheurer CD Peters AC van Furth AM | 1998 | Ned Tijdsehr Geneesk1998，142，51： | 1 |
| 10 | Fondaparinux compared toenoxaparin in patients with acute coronary syndromes without ST-segraent elevation : outcomes and treatment effect across differentlevels of risk 显示文摘 | Joyner CD Peters RJ Afzal R | 2009 | Am Heart J2009，157，3： | 1 |
| 11 | Functional significance of Tie2 signaling in the adult vasculature 显示文摘 | Peters KG Kontos CD Lin PC | 2004 | Recent Prog Horm Res2004，59，1： | 1 |
| 12 | Primary radiotherapy in the treatment of stageⅠandⅡoral tongue cancers:Importance of the proportion of therapy delivered with interstitial therapy显示文摘 | Wendt CD Peters LJ Delclos L | | 0，，： | 1 |
| 13 | The transcription factors hypoxia-inducible factor lalpha and Ets-1 colocalize in the hypoxic synovium of inflamed joints in adjuvant-induced arthritis 显示文摘 | Peters CL Morris C J Mapp PI et cd | 2004 | Arthritis Rheum2004，50，1： | 1 |
| 14 | Functional significance of Tie2 signaling in the adult vasculature显示文摘 | Peters KG Kontos CD Lin PC | | 0，，： | 1 |
| 15 | Primary radiotherapy in the treatment of stage Ⅰ and Ⅱ oral tongue cancers:Importance of the proportion of therapy delivered with interstitial therapy显示文摘 | Peters LJ Delclos L | 1990 | Int J Radat Oncol Biol Phys1990，，18： | 1 |
| 16 | Use of high content analy- sis in toxicologic clinical pathology for identification and monitoring of translational safety biomarkers 显示文摘 | Peter O Margarida CD | 2009 | Drug Discovery2009，，1： | 1 |
| 17 | Functional significance of Tie2 signaling in the adult vasculature显示文摘 | Peters KG Kontos CD Lin PC | 2004 | Recent Prog Horm Res2004，59，： | 1 |
| 18 | Proteome analysis of the rat cornea during angiogcnesis 显示文摘 | Thompson LJ Wang F Proia AD Peters KG Jarrold B Greis KD et cd | 2003 | Proteomics2003，3，11： | 1 |
| 19 | Lower prenatal vitamin D status and postpartum depressive symptomatology inAfrican American women:Preliminary evidence for moder-ation by inflammatorycytokines 显示文摘 | Accortt EE Schetter CD Peters RM | 2015 | Arch Womens Ment Health2015，10，15： | 1 |
| 20 | Role of infection in Guillain-Barresyndrome:Laboratory confirmation of herpesviruses in 41 cases显示文摘 | Peter CD Stuart DC | 2004 | Annanls of Neurology2004，，： | 1 |
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