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| 1 | Transcriptome profile of human neuroblastoma cells in the hypomagnetic field显示文摘Research has shown that the hypomagnetic field(HMF)can affect embryo development,cell proliferation,learning and memory,and in vitro tubulin assembly.In the present study,we aimed to elucidate the molecular mechanism by which the HMF exerts its effect,by comparing the transcriptome profiles of human neuroblastoma cells exposed to either the HMF or the geomagnetic field.A total of 2464 differentially expressed genes(DEGs)were identified,216 of which were up-regulated and2248 of which were down-regulated after exposure to the HMF.These DEGs were found to be significantly clustered into several key processes,namely macromolecule localization,protein transport,RNA processing,and brain function.Seventeen DEGs were verified by real-time quantitative PCR,and the expression levels of nine of these DEGs were measured every 6 h.Most notably,MAPK1 and CRY2,showed significant up-and down-regulation,respectively,during the first 6 h of HMF exposure,which suggests involvement of the MAPK pathway and cryptochrome in the early bio-HMF response.Our results provide insights into the molecular mechanisms underlying the observed biological effects of the HMF. | MO WeiChuan LIU Ying BARTLETT Perry F HE RongQiao | 2014 | Science China(Life Sciences)2014，57，4： | 8 |
| 2 | Elimination of the geomagnetic field stimulates the proliferation of mouse neural progenitor and stem cells显示文摘生活有机体在整个他们的 lifespan 暴露于地磁气的领域(GMF ) 。GMF 的消除,导致一块 hypogeomagnetic 地(HMF ) ,在动物导致中央神经系统机能障碍和反常开发。然而,位于这些效果下面的细胞的机制到目前为止没被识别。这里,我们显示出那暴露到 HMF (< 200 nT ) ,由防护房间的一个磁场生产了,从 C57BL/6 老鼠支持神经祖先 / 茎房间(NPCs/NSCs ) 的增长。后面的七天的 HMF 暴露,主要 neurospheres (NS ) 在尺寸是显著地更大的,并且两次,更多的 NPCs/NSCs 从新生的 NS 被收获,什么时候与 GMF 控制相比。因为暴露 HMF 的 NS 为 NSC 标记(Nestin 和 Sox2 ) 是积极的, NS 的自强能力和 multipotency 被维持,并且能区分进神经原和 astrocyte/glial 房间并且连续地是 passaged。另外,暴露于 HMF 一个月的成年老鼠被观察在 subventricular 地区有很多 proliferative 房间。这些调查结果显示连续 HMF 暴露增加 NPCs/NSCs 的增长,在 vitro 并且在 vivo。扰乱 HMF 的 NPCs/NSCs 生产可能影响大脑开发和功能,它为阐明提供新奇线索 bio-HMF 反应的细胞的机制。 | Jing-Peng Fu Wei-Chuan Mo Ying Liu Perry F. Bartlett Rong-Qiao He | 2016 | Protein & Cell2016，7，9： | 4 |
| 3 | Urethral injuries in female subjects following pelvic fractures显示文摘 | Perry MO Husmann DA | 1992 | J Urol1992，147，： | 1 |
| 4 | Low monocyte HLA-DR expression helpful to predict outcome in severe sepsis显示文摘 | Perry SE Mo stafa SM Wenstone R | 2003 | Intensive Care Med2003，29，： | 1 |
| 5 | Major renal lacerations with a devitalized fragment following blunt abdominal trauma:a comparison between nonoperative (expectant) versus surgical management显示文摘 | Husmann DA Giling PJ Perry MO | 1993 | J Urol1993，150，230： | 1 |
| 6 | Incomplete recovery of muscle cell function following partial but not complete ischemia显示文摘 | Perry MO Hariri RJ | 1985 | Circ Shock1985，17，： | 1 |
| 7 | Urethral injuries in female subjects following pelvic fractures显示文摘 | Perry MO Husmann DA | 1992 | J Urol1992，147，： | 1 |
| 8 | Urethral injuries in female subjects following pelvic fractures显示文摘 | Perry MO Husmann DA | 1992 | J Urol1992，147，： | 1 |
| 9 | Incomplete recovery of muscle cell function following partial but not complete ischemia显示文摘 | Robets JP Perry MO Hariri RJ | 1985 | Circ Shock1985，17，： | 1 |
| 10 | Abdominal aortic aneurysm surgery: the basic evaluation of cardiac risk显示文摘 | Perry MO Calcagno D | 1998 | Ann Surg1998，208，7： | 1 |
| 11 | Urethral injuries in female subjects following pelvic fractures 显示文摘 | Perry MO Husmann DA | 1992 | J Urol1992，147，1： | 1 |
| 12 | Incomplete recovery of muscle cell function following partial but not complete ischemia显示文摘 | Roberts JP Perry MO Hariri RJ | 1985 | Circ Shock1985，17，： | 1 |
| 13 | Urethral injuries in female subjects followingpelvic fractures显示文摘 | Perry MO Husmann DA | 1992 | JUrol1992，147，： | 1 |
| 14 | Major renal lacerations with a devitalized fragment following blunt abdominal tranma: a comparison between nonoperative (expectant) versus surgical management显示文摘 | Husmann DA Gilling PJ Perry MO | 1993 | J Urol1993，150，： | 1 |
| 15 | Urethral injuries in the female following pelvic fractures显示文摘 | Perry MO Husmann DA | 1992 | J Urol1992，147，1： | 1 |
| 16 | Qualitative studies on the patient's experience of weaning from mechanical ventilation显示文摘 | Meade MO Perry AG | 2001 | Chest2001，120，6： | 1 |
| 17 | Urethral injuries in femals subjects following pelvic fractures显示文摘 | Perry MO Husmann DA | 1992 | J Urol1992，147，： | 1 |
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