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| 1 | Urine-derived stem/progenitor cells:A focus on their characterization and potential显示文摘Cell therapy,i.e.,the use of cells to repair an affected tissue or organ,is at the forefront of regenerative and personalized medicine.Among the multiple cell types that have been used for this purpose[including adult stem cells such as mesenchymal stem cells or pluripotent stem cells],urine-derived stem cells(USCs)have aroused interest in the past years.USCs display classical features of mesenchymal stem cells such as differentiation capacity and immunomodulation.Importantly,they have the main advantage of being isolable from one sample of voided urine with a cheap and unpainful procedure,which is broadly applicable,whereas most adult stem cell types require invasive procedure.Moreover,USCs can be differentiated into renal cell types.This is of high interest for renal cell therapy-based regenerative approaches.This review will firstly describe the isolation and characterization of USCs.We will specifically present USC phenotype,which is not an object of consensus in the literature,as well as detail their differentiation capacity.In the second part of this review,we will present and discuss the main applications of USCs.These include use as a substrate to generate human induced pluripotent stem cells,but we will deeply focus on the use of USCs for cell therapy approaches with a detailed analysis depending on the targeted organ or system.Importantly,we will also focus on the applications that rely on the use of USC-derived products such as microvesicles including exosomes,which is a strategy being increasingly employed.In the last section,we will discuss the remaining barriers and challenges in the field of USC-based regenerative medicine. | Perrine Burdeyron Sébastien Giraud Thierry Hauet Clara Steichen | 2020 | World Journal of Stem Cells2020，12，10： | 6 |
| 2 | The increase of childhood chronic conditions in the united states显示文摘 | Perrin J M Bloom S R Gortmaker SL | 2007 | JA- MA2007，297，24： | 4 |
| 3 | 查看详情显示文摘 | Chauveau S Perrin M Y Riviere P Soufiani A | | 0，，： | 1 |
| 4 | Local delivery of ni- modipine by prolonged release micropartieles feasi- bility,effectiveness and dosefinding in experimental subarachnoidhemorrhage 显示文摘 | H nggi D Perrin J Eicker S | 2012 | PLoS One2012，7，42： | 1 |
| 5 | DSM-III-R anxiety disorders in children:Sociodemographic and clinical characteristics显示文摘 | Last CG Perrin S Hersen M | 1992 | J Am Acad Child Adolesc Psychiatry1992，31，： | 1 |
| 6 | Actigraphic assessment of the circadian rest-activity rhythm in elderly patients hospitalized in an acute care unit显示文摘 | Vinzio S Ruellan A Perrin AE | 2003 | Psychiatry Clin Neurosci2003，57，： | 1 |
| 7 | Successful management of heparin-induced thrombocytopenia using argatroban in a very old woman: a case report显示文摘 | Putot A Perrin S Sordet-Guepet H | 2013 | Case Rep Med2013，2013，58： | 1 |
| 8 | Mature dendritic cell generation promoted by lysophosphatidylcholine显示文摘 | Perrin Cocon L Agaugue S | 2002 | J Immunol2002，169，4： | 1 |
| 9 | Optimizing Great Tits Clutch Size in a Fluctuating Environment显示文摘 | BOYCE M S PERRINS C M | 1987 | Ecology(S 0012-9658)1987，68，： | 1 |
| 10 | Erythroid K-ruppel-like factor(EKLF)is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivatives显示文摘 | PERRINE S P MANKIDY R BOOSALIS M S | 2009 | Eur J Haematol2009，82，6： | 1 |
| 11 | Calpain-mediated proteolysis of talin regulates adhesion dynamics 显示文摘 | Franco S J Rodgers M A Perrin B J | 2004 | Nat Cell Biol2004，6，10： | 1 |
| 12 | Travel and the spread of HIV-1 genetic variants 显示文摘 | Perrin L Kaiser L Yerly S | 2003 | Lancet Infect Dis2003，3，1： | 1 |
| 13 | Analysis of cytokine mRNA and DNA:Detection and quantitation by competitive polymerase chain reaction显示文摘 | Gilliland G Perrin S Blanchard K | 1990 | Proc Natl Acad Sci USA1990，87，7： | 1 |
| 14 | A new setup for very small angle correlation measurements显示文摘 | MERCHEZ F KOX S PERRIN C | 1989 | Nucl Instrum Methods A1989，275，： | 1 |
| 15 | The HITRAN 2008 molecular spectroscopic database 显示文摘 | Rothman L S Gordon I E Barbe A ChrisBenner D Bernath P F Birk M Boudon V Brown L R Campargue A Champi-on J P Chance K Coudert L H Dana V Devi V M Fally S Flaud J M Gamache R R Goldman A Jacquemart D Klein er I Lacome N Lafferty W J Mandin J Y Massie S T Mikhailenko S N Miller C E Moazzen A N Naumenko 0 VNikitin A V Orphal J Perevalov V I Perrin A Predoi C A Rinsland C P Rotger M ime kovd M Smith M A H Sung K Tashkun S A Tennyson J Toth R A Vandaele A C Vander A J | 2009 | Journal of Quantitative Spectroscopy Radiative Transfer2009，110，： | 1 |
| 16 | A case-control study of seated immobility at work as a risk factor for venous thromboembolism显示文摘 | West J Perrin K Aldington S | 2008 | J R Soc Med2008，101，5： | 1 |
| 17 | Use of PCR-targeted Mutagenesis to disrupt production of fusaricidin-type antifun-gal antibiotics in Paenibacillus polymyxa显示文摘 | Jingru L Perrin K B Saleh S | 2007 | Applied and En-vironmental Microbiology2007，，： | 1 |
| 18 | Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies显示文摘 | Stoger E Vaquero C Tortes E Sack M Nicholson L Drossard J Williams S Keen D Perrin Y Christou P and Fischer R | 2000 | Plant Molecular Biology2000，42，： | 1 |
| 19 | A case-control study of seated immobility at work as a risk factor for venous thromboembolism显示文摘 | West J Perrin K Aldington S | 2008 | J R Soc Med2008，101，： | 1 |
| 20 | The Twist gene, isolation of a Drosoph-ila zygotic gene necessary for the establishment of dorsoventral pattern 显示文摘 | Thisse B Messal M Perrin S | 1987 | Nucleic Acids Res1987，15，： | 1 |
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