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| 1 | Ischemia/reperfusion injury and cardioprotective mechanisms:Role of mitochondria and reactive oxygen species显示文摘Reperfusion therapy must be applied as soon as possible to attenuate the ischemic insult of acute myocardial infarction(AMI).However reperfusion is responsible for additional myocardial damage,which likely involves opening of the mitochondrial permeability transition pore(mPTP).In reperfusion injury,mitochondrial damage is a determining factor in causing loss of cardiomyocyte function and viability.Major mechanisms of mitochondrial dysfunction include the long lasting opening of mPTPs and the oxidative stress resulting from formation of reactive oxygen species(ROS).Several signaling cardioprotective pathways are activated by stimuli such as preconditioning and postconditioning,obtained with brief intermittent ischemia or with pharmacological agents.These pathways converge on a common target,the mitochondria,to preserve their function after ischemia/reperfusion.The present review discusses the role of mitochondria in cardioprotection,especially the involvement of adenosine triphosphate-dependent potassium channels,ROS signaling,and the mPTP.Ischemic postconditioning has emerged as a new way to target the mitochondria,and to drastically reduce lethal reperfusion injury.Several clinical studies using ischemic postconditioning during angioplasty now support its protective effects,and an interesting alternative is pharmacological postconditioning.In fact ischemic postconditioning and the mPTP desensitizer,cyclosporine A,have been shown to induce comparable protection in AMI patients. | Maria-Giulia Perrelli Pasquale Pagliaro Claudia Penna | 2011 | World Journal of Cardiology2011，3，6： | 64 |
| 2 | Microvascular dysfunction induced by reperfusion injure and protective effect of ischemia preconditioning 显示文摘 | Juan C Cutrin Maria-giulia Perrelli Barbara Cavalieri | 2002 | Free Radical Biology & Medicine2002，，9： | 1 |
| 3 | Post-ischemic early acidosis in cardiac postconditioning modifies the activity of antioxidant enzymes,reduces nitration,and favors protein S-nitrosylation显示文摘 | Penna C Perrelli MG Tullio F | | 0，，： | 1 |
| 4 | Postconditioning induces an anti-apoptotic effect and preserves mitochondrial integrity in isolated rat hearts显示文摘 | Penna C Perrelli MG Raimondo S | 2009 | Biochim Biophys Acta2009，1787，7： | 1 |
| 5 | 'Mitochondrial pathways, permeability transition pore, and redox signaling in cardioprotec- tion: therapeutic implications显示文摘 | Penna C Perrelli MG Pagliaro P | 2013 | Antioxid Redox Signal2013，18，5： | 1 |
| 6 | Xanthine oxidase-indnced oxidative stress causes activation of NF-kappaB and inflammation in the liver of type I diabetic rats 显示文摘 | ROMAGNOLI M GOMEZ-CABRERA M C PERRELLI M G | 2010 | Free Radic Biol Med2010，49，2： | 1 |
| 7 | Microvascular dysfunction induced by reperfusion injury and protective effect of ischemic pre- conditioning显示文摘 | Cutrn JC Perrelli MG Cavalieri B | 2002 | Free Radic Biol Med2002，33，9： | 1 |
| 8 | Microvascular dysfunction induced by reperfusion injury and protective effect of ischemic preconditioning显示文摘 | Perrelli MG Cavalieri B | 2002 | Free Radical Biology & Medicine2002，33，9： | 1 |
| 9 | Mitochondrial pathways,permeability transition pore,and redox signaling in cardioprotection:therapeutic implications显示文摘 | Penna C Perrelli MG Pagliaro P | 2013 | Antioxid Redox Signal2013，18，5： | 1 |
| 10 | Microvascula r dysfunetion induced by reperfusion injury and protective effect of ischemic preconditioning显示文摘 | Cutrn JC Perrelli MG Cavalieri B el al | 2007 | Free Radical Biology & Medicine2007，33，9： | 1 |
| 11 | Microvascular dysfunction induced by reperfusion injury and protective effect of ischemic preconditioning 显示文摘 | Cutrn JC Perrelli MG Cavalieri B | 2002 | Free Radical Biology & Medicine2002，33，9： | 1 |
| 12 | Diagnostic accu racy of criteria for urinary tract infection in a cohort of nursing home residents显示文摘 | J uthani-Mehta M Tinetti M Perrelli E | 2007 | J Am Geriatric Soc2007，55，7： | 1 |
| 13 | Microvascular dysfunction induced by reperfusion injury and protective effect of ischemic preconditioning 显示文摘 | Cutrn JC Perrelli MG Cavalieri B | 2002 | Free Radic Bio Med2002，33，9： | 1 |
| 14 | Diagnostic accuracy of criteria for urinary tract infection in a cohort of nursing home residents显示文摘 | Juthani-Mehta M Tinetti M Perrelli E | 2007 | J Am Geriatr Soc2007，55，7： | 1 |
| 15 | Predictors of Pregnancy Outcome in Antiphospholipid Syndrome: A Review显示文摘 | Sara Carolis Angela Botta Stefania Santucci Serafina Garofalo Carmelinda Martino Alessandra Perrelli Silvia Salvi Sergio Ferrazzani Leonardo Caforio Giovanni Scambia | 2010 | Clinical Reviews in Allergy & Immunology2010，，2： | 1 |
| 16 | Enhanced growth of colorectal aberrant crypt loci in fasted/refed rats involves changes in TGF/31 and p21CIP expressions显示文摘 | Caderni G Perrelli MG Cecchini F | 2002 | Carcinogenesis2002，23，： | 1 |
| 17 | Catestatin reduces myocardial ischaemia/reperfusion injury: involvement of PI3K/Akt, PKCs, mitochon- drial KATP channels and ROS signalling显示文摘 | PERRELLI M G TULLIO F ANGOTTI C | 2013 | Pflugers Arch2013，465，： | 1 |
| 18 | Postconditioning with glucagon like peptide-2 reduces ischemia/reperfusion injury in isolated rat hearts:role of survival kinases and mitochondrial KATP channels显示文摘 | Penna C Pasqua T Perrelli MG | | 0，，04： | 1 |
| 19 | Catestatin reduces myocardial ischaemia/reperfiasion injury: involvement of PI3K/Akt, PKCs, mitochondrial K ATP channels and ROS signalling显示文摘 | Maria-Giulia Perrelli Francesca Tullio Carmelina Angotti | 2013 | Pfl ti gets Archiv-European Journal of Physiology2013，25，7： | 1 |
| 20 | Politics, the WTO and trade disputes: Evidence from US case显示文摘 | Earl L Grinols Roberto Perrelli | 2000 | Pacific Economics Review2000，7，2： | 1 |
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