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| 1 | Compound screening platform using human induced pluripotent stem cells to identify small molecules that promote chondrogenesis显示文摘Articular cartilage,which is mainly composed of collagen Ⅱ,enables smooth skeletal movement.Degeneration of collagen Ⅱ can be caused by various events,such as injury,but degeneration especially increases over the course of normal aging.Unfortunately,the body does not fully repair itself from this type of degeneration,resulting in impaired movement.Microfracture,an articular cartilage repair surgical technique,has been commonly used in the clinic to induce the repair of tissue at damage sites.Mesenchymal stem cells(MSC)have also been used as cell therapy to repair degenerated cartilage.However,the therapeutic outcomes of all these techniques vary in different patients depending on their age,health,lesion size and the extent of damage to the cartilage.The repairing tissues either form fibrocartilage or go into a hypertrophic stage,both of which do not reproduce the equivalent functionality of endogenous hyaline cartilage.One of the reasons for this is inefficient chondrogenesis by endogenous and exogenous MSC.Drugs that promote chondrogenesis could be used to induce self-repair of damaged cartilage as a non-invasive approach alone,or combined with other techniques to greatly assist the therapeutic outcomes.The recent development of human induced pluripotent stem cell(iPSCs),which are able to self-renew and differentiate into multiple cell types,provides a potentially valuable cell resource for drug screening in a“more relevant”cell type.Here we report a screening platform using human iPSCs in a multi-well plate format to identify compounds that could promote chondrogenesis. | Sheng-Lian Yang Erica Harnish Thomas Leeuw Uwe Dietz Erika Batchelder Paul SWright Jane Peppard Paul August Cecile Volle-Challier Francoise Bono Jean-Marc Herbert Juan Carlos Izpisua Belmonte | 2012 | Protein & Cell2012，3，12： | 3 |
| 2 | Customer Relationship Management (CRM) in financial services显示文摘 | Joe Peppard | 2000 | European Management Journal2000，，3： | 2 |
| 3 | Solid phase microextraction for flavour analysis显示文摘 | YANG Xiaogen PEPPARD T | 1994 | Agric Food Chem1994，42，： | 1 |
| 4 | Linezolid for the treatment of drug resistant infections 显示文摘 | Herrmann DJ Peppard WJ Ledeboer NA | 2008 | Expert Rev Antiinfect Ther2008，6，6： | 1 |
| 5 | Epidemiology of obstructive sleep apnea:a population health perspective显示文摘 | Young T Peppard PE Gottlieb DJ | 2002 | Am J Respir Crit Care Med2002，165，9： | 1 |
| 6 | Prospective study of the assocjation between sleep-disordered brething and hypertension显示文摘 | Peppard PE Young T Palta M | | 0，，： | 1 |
| 7 | Epidemiology of obstructive sleep apnea:a population health perspective显示文摘 | Young T Peppard PE Gottlieb DJ | 2002 | Am J Respir Crit Care Med2002，165，9： | 1 |
| 8 | Increased prevalence of sleep-disor- dered breathing in adults显示文摘 | Peppard PE Young T Barnet JH | 2013 | Am J Epidemio12013，177，： | 1 |
| 9 | Epidemiology of obstructive sleep apnea:s population health perspective显示文摘 | Young T Peppard PE Gottlieb DJ | 2002 | Am J Respir Crit Care Med2002，165，： | 1 |
| 10 | The extraction of selected M(Ⅲ) metals by dis 2-ethylhexyl phosphoric acid in n-heptane显示文摘 | Mason G W Metta D N Peppard D F | 1976 | J Inorg Nucl Chem1976，38，11： | 1 |
| 11 | Prospective study of the association between sleep disordered breathing and hypertension显示文摘 | Peppard PE Young T Palta M | 2000 | N Engl J Med2000，342，： | 1 |
| 12 | Epidemiology of obstructive sleep apnea:a population health perspective 显示文摘 | Young T Peppard P E Gottlieb D J | 2002 | Am J Respir Crit Care Med2002，165，9： | 1 |
| 13 | Population-based study of sleep-disordered breathing as a risk factor for hypertension显示文摘 | Young T Peppard P Palta M | | 0，，15： | 1 |
| 14 | A simple and rapid radioimmunoassay for human interleukin-6显示文摘 | Peppard J V Rediske J J Koehler J A et 8/ | 1992 | J Immu- nol Methods1992，148，12： | 1 |
| 15 | Dissocia-tion of obstructive sleep apnea from hypersom-nolence and obesity in patients with stroke显示文摘 | Arzt M Young T Peppard PE | 2010 | Stroke2010，41，3： | 1 |
| 16 | Linezolid for the treatment of drug-resistant infections显示文摘 | Herrmann D J Peppard W J Ledeboer NA eta/ | 2008 | Expert Rev Anti Infect Ther2008，6，6： | 1 |
| 17 | Prospective study of the association between sleep-disordered breathing and hypertension显示文摘 | Peppard PE Young T Palta M | 2000 | N Engl J Med2000，342，： | 1 |
| 18 | Prospective study of the association between sleep-disordered breathing and hypertension显示文摘 | Peppard P E Young T Palta M | 2000 | N Engl J Med2000，342，19： | 1 |
| 19 | Prospective study of the asso- ciation between sleep-disordered breathing and hyper- tension 显示文摘 | Peppard PE Young T | 2000 | N Engl J Med2000，342，8： | 1 |
| 20 | Association of alcohol consumption and sleep disordered breathing in men and women显示文摘 | Peppard PE Austin D Brown RL | 2007 | J Clin Sleep Med2007，3，3： | 1 |
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