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| 1 | Value of multi-disciplinary input into laparoscopic management of rectal cancer-An observational study显示文摘AIM To assess the impact of multi-disciplinary teams(MDTs)management in optimising the outcome for rectal cancers.METHODS We undertook a retrospective review of a prospectively maintained database of patients with rectal cancers(defined as tumours≤15 cm from anal verge)discussed at our MDT between Jan 2008 and Jan 2011.The data was validated against the national database to ensure completeness of dataset.The clinical course and follow-up data was validated using the institution’s electronic patient records.The data was analysed in terms of frequencies and percentages.Significance of any differences were analysed usingχ2 test.A Kaplan-Meier analysis was performed for overall survival and disease free survival.RESULTS Following appropriate staging,one hundred and thirtythree patients were suitable for potentially curative resections.Seventy two(54%)were upper rectal cancer(URC)-tumour was>6 cm from the anal verge and 61(46%)were lower rectal cancers(LRC)-lower extent of the tumour was palpable≤6 cm.Circumferential resection margin(CRM)appeared threatened on preoperative MRI in 19/61(31%)patients with LRC requiring neo-adjuvant therapy(NAT).Of the 133 resections,118(89%)were attempted laparoscopically(5%conversion rate).CRM was positive in 9(6.7%)patients;Median lymph node harvest was 12(2-37).Major complications occurred in 8(6%)patients.Median follow-up was 53 mo(0-82).The 90-d mortality was 2(1.5%).Over the followup period,disease related mortality was 11(8.2%)and overall mortality was 39(29.3%).Four(3%)patients had local recurrence and 22(16.5%)patients had distant metastases.CONCLUSION Management of rectal cancers can be optimized with multidisciplinary input to attain acceptable long-term oncological outcomes even when incorporating a laparoscopic approach to rectal cancer resection. | Pawan Kumar Dhruva Rao Sooriyaratchige Pradeep Manjula Peiris Seema Safia Arif Rhodri A Davies Ashraf Gergies Masoud Puthucode Narayanan Haray | 2017 | World Journal of Gastrointestinal Surgery2017，9，6： | 2 |
| 2 | Biopolymer production by a Klebsiella oxytoca isolate using whey as fermentation substrate显示文摘 | PEIRIS P S | 1997 | Biotechnology Letters1997，19，2： | 1 |
| 3 | Optimization of bioprocess conditions for exopolysaccharide production by Klebsiella oxytoca显示文摘 | DLAMINI A M BAVOR H J | 1998 | World Journal of Microbiology & Biotechnology1998，，14： | 1 |
| 4 | 2011, Novel reassortment of Eurasian avian-like and pandemic/2009 influenza viruses in swine: infectious potential for humans 显示文摘 | Zhu H Zhou B Fan X Lam T T Wang J Chen A Chen X Chen H Webster R G Webby R Peiris J S Smith D K Guan Y | 2011 | Journal of Virology2011，85，10： | 1 |
| 5 | Passive immunotherapy with dromedary immune serum in an experimental animal model for middle east respiratory syndrome coronavirus infection 显示文摘 | Zhao J Perera R A Kayali G Meyerholz D Perlman S Peiris M | 2015 | J Virol2015，89，11： | 1 |
| 6 | Coronavirus as a possible cause of severe acute respiratory syndrome 显示文摘 | Peiris J S M Lai A T Poon L L M | 2003 | Lancet2003，361，： | 1 |
| 7 | Exchange transfusions in the treatment of Russell's viper bite 显示文摘 | Peiris OA Wimalaratne KDP Nimalasuriya A | 1969 | Postgraduate Medical Journal1969，45，527： | 1 |
| 8 | Type 2 diabetes mellitus as risk factor for colorectal cancer显示文摘 | Gupta K Krishnaswamy G Karnad A Peiris AW | | 0，，03： | 1 |
| 9 | Secondary hyperparathyroidism:benign bystander or culpable contributor to adverse health outcomes?显示文摘 | Peiris A N Youssef D Grant W B | 2012 | South Med J2012，105，1： | 1 |
| 10 | Biopolymer production by a Klebsiella oxytoca isolate using whey as fermentation substrate 显示文摘 | Dlamini A M Peiris P S | 1997 | Biotechnology Letters1997，19，2： | 1 |
| 11 | Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic显示文摘 | Smith GJ Vijaykrishna D Bahl J Lycett SJ Worobey M Pybus OG Ma SK Cheung CL Raghwani J Bhatt S Peiris JS Guan Y Rambaut A | 2009 | Nature2009，459，7250： | 1 |
| 12 | Application of RBGR a simple way of screening of oxygen to lerance in probiotic bacteria 显示文摘 | Talwalkar A Kailasapathy K Peiris P | 2001 | Int J FoodMicrobiol2001，71，： | 1 |
| 13 | Role of total thyroidectomy in the treatment of thyroid diseases显示文摘 | Peiris A N Peiris P | | 0，，11： | 1 |
| 14 | The association of viral infection and chronic allograft nephropathy with graft dysfunction after renal transplantation显示文摘 | Tong CY Bakran A Peiris JS | 2002 | Transplantation2002，74，4： | 1 |
| 15 | Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR显示文摘 | Guan Y Peiris J S Lipatov A S | 2002 | Proc Natl Acad Sci U S A2002，99，13： | 1 |
| 16 | Secondary hyper-parathyroidism: benign bystander or culpable contributor to adverse health outcomes显示文摘 | Peiris A N Youssef D Grant W B | 2012 | South Med J2012，105，： | 1 |
| 17 | A novel luciferase immunosorbent assay performs better than a commercial enzyme-linked immunosorbent assay to detect MERS-CoV specific IgG in humans and animals显示文摘The Middle East respiratory syndrome(MERS)is a lethal zoonosis caused by MERS coronavirus(MERS-CoV)and poses a significant threat to public health worldwide.Therefore,a rapid,sensitive,and specific serologic test for detecting anti-MERS-CoV antibodies in both humans and animals is urgently needed for the successful management of this illness.Here,we evaluated various novel luciferase immunosorbent assays(LISA)based on nucleocapsid protein(NP)as well as fragments derived from spike protein(S)including subunit 1(S1),N terminal domain(NTD),receptorbinding domain(RBD)and subunit 2(S2)of S for the detection of MERS-CoV-specific IgG.Fusion proteins,including nanoluciferase(NLuc)and various fragments derived from the NP or S protein of MERS-CoV,were expressed in human embryonic kidney 293 T cells.LISAs that detected anti-MERS-CoV IgG were further developed using cell lysates expressing various fusion proteins.Panels of human or animal samples infected with MERS-CoV were used to analyze the sensitivity and specificity of various LISAs in reference to a MERS-CoV RT-PCR,commercial S1-based ELISA,and pseudovirus particle neutralization test(ppNT).Our results showed that the S1-,RBD-,and NP-LISAs were more sensitive than the NTD-and S2-LISAs for the detection of anti-MERS-CoV IgG.Furthermore,the S1-,RBD-,and NP-LISAs were more sensitive(by at least 16-fold)than the commercially available S1-ELISA.Moreover,the S1-,RBD-,and NPLISA specifically recognized anti-MERS-CoV IgG and did not cross-react with samples derived from other human CoV(OC43,229E,HKU1,NL63)-infected patients.More importantly,these LISAs proved their applicability and reliability for detecting anti-MERS-CoV IgG in samples from camels,monkeys,and mice,among which the RBD-LISA exhibited excellent performance.The results of this study suggest that the novel MERS-CoV RBD-and S1-LISAs are highly effective platforms for the rapid and sensitive detection of anti-MERS-CoV IgG in human and animal samples.These assays have the potential to be used as serologic tests for the management and control of MERS-CoV infection. | Wenling Wang Tianyu Wang Yao Deng Peihua Niu Ruhan A Jincun Zhao Malik Peiris Shixing Tang Wenjie Tan | 2019 | Biosafety and Health2019，1，3： | 1 |
| 18 | H5N1virus causes significant perturbations in host proteome very early in influenza virus-infected primary human monocytederived macrophages显示文摘 | Cheung C Y Chan E Y Krasnoselsky A Purdy D Navare A T Bryan J T Leung C K Hui K P Peiris J S Katze M G | 2012 | J Infect Dis2012，206，5： | 1 |
| 19 | Pneumonia research toreduce childhood mortality in the developing world显示文摘 | Scott JAG Brooks W A Peiris J S M | 2008 | The Journal ofClinical Investigation2008，118，4： | 1 |
| 20 | Body fat distrbution and free fatty acid metabolism 显示文摘 | Peiris A Kissebah AH | 1988 | Clin Res1988，36，： | 1 |
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