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| 1 | Immunobiology of hepatocarcinogenesis: Ways to go or almost there?显示文摘Hepatocellular carcinoma is on the rise and occurs in the setting of chronic liver disease and cirrhosis.Though treatment modalities are available,mortality from this cancer remains high.Medical therapy with the utilization of biologic compounds such as the Food and Drug Administration approved sorafenib might be the only option that can increase survival.Immunotherapy,with modern pharmacologic developments,is a new frontier in cancer therapy and therefore the immunobiology of hepatocarcinogenesis is under investigation.This review will discuss current concepts of immunobiology in hepatocarcinogenesis along with current treatment modalities employing immunotherapy.The tumor microenvironment along with a variety of immune cells coexists and interplays to lead to tumorigenesis.Tumor infiltrating lymphocytes including CD8+ T cells,CD4+ T cells along with regulatory T cells,tumor associated macrophages,tumor associated neutrophils,myeloid derived suppressor cells,and natural killer cells interact to actively provide anti-tumor or pro-tumor effects.Furthermore,oncogenic pathways such as Raf/mitogenactivated protein kinase/extracellular-signal-regulated kinase pathway,phosphatidyl-3-kinase/AKT/mammalian target or rapamycin,Wnt/β-catenin,nuclear factor-κB and signal transducers and activators of transcription 3 may lead to activation and proliferation of tumor cells and are also considered cornerstones in tumorigenesis.Immunotherapy directed at this complex milieu of cells has been showned to be successful in cancer treatment.The use of vaccines,adoptive cell therapy and immune checkpoint inhibitor modulation are current options for therapy.Further translational research will shed light to concepts such as anti-tumor immunity which can add another alternative in the therapeutic armamentarium. | Pavan Patel Steven E Schutzer Nikolaos Pyrsopoulos | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，3： | 3 |
| 2 | HSP27 is required for invasion and metastasis triggered by hepatocyte growth factor 显示文摘 | Pavan S Musiani D Torchiaro E etal | 2014 | IntJ Cancer2014，134，6： | 1 |
| 3 | 显示文摘 | Pavan F A Dias S L P Lima E C | 2008 | Dyes Pigments2008，76，： | 1 |
| 4 | Removal of methylene blue dye from aqueous solutions by adsorption using yellow passion fruit peel as adsorbent显示文摘 | Pavan E A Mazzocato A C Gushikem Y | 2008 | Bioresour Technol2008，99，： | 1 |
| 5 | Current Perspectives of therapeutic patient education in Italy显示文摘 | Marcolongo R Rossato E Pavan V | | 0，，： | 1 |
| 6 | Sorption of Anionic Surfactants on Layered Double Hydroxides 显示文摘 | Pavan P C Crepaldi E L Valim J B | 2000 | Journal of Colloid and Interface Science2000，229，2： | 1 |
| 7 | Genomic copy numberand expression variation within the C57BL/6J inbredmouse strain显示文摘 | Watkins Chow D E Pavan W J | 2008 | Genome Res2008，18，： | 1 |
| 8 | Comparative study of the coprecipitation methods for the preparation of layered double hydrox- ides显示文摘 | Crepaldi E L Pavan P C Valim | 2000 | Journal of the brazilian chemical society2000，11，1： | 1 |
| 9 | Graft-versus-host disease显示文摘 | James LM Ferrara John E Levine Pavan Reddy Ernst Holler | 2009 | The Lancet2009，，9674： | 1 |
| 10 | Chemical, Structural, and Thermal Properties of Zn( II )-Cr(III ) Layered Double Hydroxides Intercalated with Sulfated and Sulfonated Surfactants 显示文摘 | Crepaldi E L Pavan P C Tronto J | 2002 | J Colloid Interface Sci2002，248，42： | 1 |
| 11 | Monitoring propofol serum levels by rapid and sensitive reversed-phase high-performance liquid chromatography during prolonged sedation in ICU patients显示文摘 | PAVAN I BUGLIONE E MASSICCIO M | 1992 | J Chromatogr Sci1992，30，5： | 1 |
| 12 | A common image processing framework for 2D bareode reading显示文摘 | Ottaxiani E Pavan A Bottazi M | 1999 | IEE Conference on hnage Processing and its Applications1999，465，： | 1 |
| 13 | Experimental- numerical analysis of minipig's multi-rooted teeth 显示文摘 | Natali A N Camiel E L Pavan P G | 2007 | Journal of Biomechanies2007，40，8： | 1 |
| 14 | Sorption of anionic surfactants on layered double hydroxides显示文摘 | Pavan P C Crepaldi E L Valim J B | 2000 | Colloid Interface Sci2000，229，2： | 1 |
| 15 | Study of the mechanical behaviour of a macroscopic glass-polyester composite by ESPI method and numerical simulations 显示文摘 | Corigliano A Papa E Pavan A | 2004 | Compos Sci Technol2004，64，12： | 1 |
| 16 | Comparative Study of the Coprecipitation Methods for the Preparation of LayeredDouble Hydroxides显示文摘 | Crepaldi E L Pavan P C Valim J B | 2000 | J Braz Chem Soc2000，11，1： | 1 |
| 17 | Psychopathology and clinical features in an Italian sample of patients with myofascial and temporomandibular joint pain:preliminary data显示文摘 | Nifosì F Violato E Pavan C | 2007 | Int J Psychiatry Med2007，37，3： | 1 |
| 18 | Quantitative comparison of five current protocols in gait analysis显示文摘 | Ferrari A Benedetti MG Pavan E | | 0，，2： | 1 |
| 19 | Experimental - numeri-cal analysis of minipig 's multi - rooted teeth 显示文摘 | Natali AN Camiel EL Pavan PG e? al | 2007 | J Biomech2007，40，8： | 1 |
| 20 | Levofloxacin disposition over time in aqueous humor of patients undergoing cataract surgery 显示文摘 | Pea F Ferrari E Pavan F | 2005 | Antimicrob Agents Chemother2005，49，： | 1 |
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