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| 1 | Association of upper gastrointestinal symptoms with functional and clinical characteristics in the elderly显示文摘AIM:To evaluate the prevalence of upper gastrointestinal symptoms and their association with clinical and functional characteristics in elderly outpatients.METHODS:The study involved 3238 outpatients ≥ 60 years consecutively enrolled by 107 general practitioners.Information on social,behavioral and demographic characteristics,function in the activities of daily living (ADL),co-morbidities and drug use were collected by a structured interview.Upper gastrointestinal symptom data were collected by the 15-items upper gastro-intestinal symptom questionnaire for the elderly,a validated diagnostic tool which includes the following five symptom clusters:(1) abdominal pain syndrome;(2) reflux syndrome;(3) indigestion syndrome;(4) bleeding;and (5) non-specific symptoms.Presence and severity of gastrointestinal symptoms were analyzed through a logistic regression model.RESULTS:3100 subjects were included in the final analysis.The overall prevalence of upper gastrointestinal symptoms was 43.0%,i.e.cluster (1) 13.9%,(2) 21.9%,(3) 30.2%,(4) 1.2%,and (5) 4.5%.Upper gastrointestinal symptoms were more frequently reported by females (P < 0.0001),with high number of co-morbidities (P < 0.0001),who were taking higher number of drugs (P < 0.0001) and needed assistance in the ADL.Logistic regression analysis demonstrated that female sex (OR=1.39,95% CI:1.17-1.64),disability in the ADL (OR=1.47,95% CI:1.12-1.93),smoking habit (OR=1.29,95% CI:1.00-1.65),and body mass index (OR=1.06,95% CI:1.04-1.08),as well as the presence of upper (OR=3.01,95% CI:2.52-3.60) and lower gastroenterological diseases (OR=2.25,95%CI:1.70-2.97),psychiatric (OR=1.60,95% CI:1.28-2.01) and respiratory diseases (OR=1.25,95% CI:1.01-1.54) were significantly associated with the presence of upper gastrointestinal symptoms.CONCLUSION:Functional and clinical characteristics are associated with upper gastrointestinal symptoms.A multidimensional comprehensive evaluation may be useful when approaching upper gastrointestinal symptoms in older subjects. | Alberto Pilotto Stefania Maggi Marianna Noale Marilisa Franceschi Giancarlo Parisi Gaetano Crepaldi | 2011 | World Journal of Gastroenterology2011，17，25： | 3 |
| 2 | Nanocrystalline transition-metal oxide spheres with controlled multi-scale porosity 显示文摘 | Grosso D Soler Illia G J de A A Crepaldi E L | 2003 | Adv Funct Mater2003，13，1： | 1 |
| 3 | hpplication of body composition monitoring to peritoneal dialysis patients显示文摘 | Crepaldi C Soni S Chionh CY | 2009 | Contrib Nephrol2009，163，： | 1 |
| 4 | Assessing genetic diversity in Italia goat population using AFLP markers 显示文摘 | Ajmone-Marsan P Negrini R Crepaldi P | 2001 | Animal Genetics2001，32，： | 1 |
| 5 | Continuous subcutaneous glucose monitoring in diabetic patients显示文摘 | Maran A Crepaldi C Tiengo A | 2002 | Diabetes Care2002，25，2： | 1 |
| 6 | A novel G/C single-nucleotide polymorphism in the double 28-bp repeat thymidylate synthase allele 显示文摘 | GUSELLA M BOLZONELLA C CREPALDI G | 2006 | Pharmacogenomics J2006，6，6： | 1 |
| 7 | A novel G/C single-nucleotide polymorphism in the double 28-bp repeat thymidylate synthase allele显示文摘 | Gusella M Bolzonella C Crepaldi G | 2006 | Pharmacogenomics J2006，6，： | 1 |
| 8 | Altered dimerization of metabotropic glutamate receptor 3 in schizophrenia 显示文摘 | Corti C Crepaldi L Mion S | 2007 | Biol Psychiatry2007，62，7： | 1 |
| 9 | Sorption of Anionic Surfactants on Layered Double Hydroxides 显示文摘 | Pavan P C Crepaldi E L Valim J B | 2000 | Journal of Colloid and Interface Science2000，229，2： | 1 |
| 10 | Preliminary study on MC 1R polymorphism in some cattle breeds raised in Italy显示文摘 | Crepaldi P Marilli M Gorni C | 2010 | Italian Journal of Animal Science2010，，： | 1 |
| 11 | Comparative study of the coprecipitation methods for the preparation of layered double hydrox- ides显示文摘 | Crepaldi E L Pavan P C Valim | 2000 | Journal of the brazilian chemical society2000，11，1： | 1 |
| 12 | Prolactin induces maturation of glucose sensing mechanisms in cultured neonatal rat islets显示文摘 | Boschero AC Crepaldi SC Carneiro EM | 1993 | Endocrinology1993，133，2： | 1 |
| 13 | Stearoyl CoA desaturase (SCD) gene polymorphism in Italian cattle breeds 显示文摘 | MILANESI E NICOLOSO L CREPALDI P | 2008 | J Anita Breed Genet2008，125，1： | 1 |
| 14 | Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells 显示文摘 | Gautreau A Comoglio PM | 1997 | J Cell Biol1997，138，2： | 1 |
| 15 | Block copolymer-templated mesoporous oxides显示文摘 | Soler-Illia G J A A Crepaldi E L Grosso D | 2003 | Current Opinion in Colloid and Interface Science2003，8，1： | 1 |
| 16 | Chemical, Structural, and Thermal Properties of Zn( II )-Cr(III ) Layered Double Hydroxides Intercalated with Sulfated and Sulfonated Surfactants 显示文摘 | Crepaldi E L Pavan P C Tronto J | 2002 | J Colloid Interface Sci2002，248，42： | 1 |
| 17 | Resistance of hu- man erythrocyte membranes to Triton X-IO0 and CI2E8显示文摘 | Crepaldi Domingues C Ciana A Buttafava A | 2009 | J Membr Bio12009，227，1： | 1 |
| 18 | The receptor encoded by the human c-MET oncogene is expressed in hepatocytes,epithelial cells and solid tumors显示文摘 | Prat M Narsimhan RP Crepaldi T | 1991 | [Journal Article]International Journal of Cancer1991，49，3： | 1 |
| 19 | Ezrin is an ellector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells 显示文摘 | Crepaldi T Gautreau A Comoglio PM et ai | 1997 | J Cell Biol1997，138，2： | 1 |
| 20 | Bleeding, vertebral fractures and vascular calcifications in patients treated with warfarin : hope for lower risks with alternative therapies显示文摘 | Fusaro M Crepaldi G Maggi S | 2011 | Curt Vase Pharmacol2011，9，6： | 1 |
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