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| 1 | Zebrafish embryo toxicity of 15 chlorinated, brominated, and iodinated disinfection by-products显示文摘Disinfection to protect human health occurs at drinking water and wastewater facilities through application of non-selective oxidants including chlorine. Oxidants also transform organic material and form disinfection by-products(DBPs), many of which are halogenated and cyto-and genotoxic. Only a handful of assays have been used to compare DBP toxicity,and researchers are unsure which DBP(s) drive the increased cancer risk associated with drinking chlorinated water. The most extensive data set employs an in vitro model cell,Chinese hamster ovary cells. Traditionally, most DBP research focuses on the threat to human health, but the effects on aquatic species exposed to DBPs in wastewater effluents remain ill defined. We present the developmental toxicity for 15 DBPs and a chlorinated wastewater to a model aquatic vertebrate, zebrafish. Mono-halogenated DBPs followed the in vivo toxicity rank order: acetamides > acetic acids > acetonitriles ~ nitrosamines, which agrees well with previously published mammalian in vitro data. Di-and tri-halogenated acetonitriles were more toxic than their mono-halogenated analogues, and bromine-and iodine-substituted DBPs tended to be more toxic than chlorinated analogues. No zebrafish development effects were observed after exposure to undiluted or non-concentrated,chlorinated wastewater. We find zebrafish development to be a viable in vivo alternative or confirmatory assay to mammalian in vitro cell assays. | David Hanigan Lisa Truong Michael Simonich Robert Tanguay Paul Westerhoff | 2017 | Journal of Environmental Sciences2017，29，8： | 5 |
| 2 | The Nature of Systems Biology 显示文摘 | Bruggeman Frank J Hans V Westerhoff | 2006 | Trends in Microbiology2006，15，1： | 1 |
| 3 | Fate of endocrinedisruptor, pharmaceutical, and personal care product chemicals during simulated drinking water treatment processes 显示文摘 | Westerhoff P Yoon Y Snyder S | 2005 | Environ Sci Technol2005，39，： | 1 |
| 4 | Spectrofluorometric characterization of dissolved organic matter for indication of precursor organic materials and aromaticity显示文摘 | MCKNIGHT D M BOYER E W WESTERHOFF P K | 2001 | Limnology & Oceanography2001，46，1： | 1 |
| 5 | Dissolved organic nitrogen as a precursor for chloroform, dichloroaeetonitrile, N-nitrosodimethylamine, and trichloronitromethane 显示文摘 | Lee W Westerhoff P Croue J P | 2007 | Environ Sci Technol2007，41，15： | 1 |
| 6 | Fluorescence excitation-emission matrix regional integration to quantify spectra for dissolved organic matter 显示文摘 | CHEN Wen WESTERHOFF P JERRY A | 2003 | Environ Sci Technol2003，37，24： | 1 |
| 7 | Fluorescence excitation-emission matrix regional inteation to quantify spectra for dissolved organic matter 显示文摘 | CHEN W WESTERHOFF P LEENHEER J A | 2003 | Environmental Science & Technology2003，37，24： | 1 |
| 8 | Pharmaceuticals,personal care products,and endocrine disruptors in water:Implications for the water industry显示文摘 | Snyder S A Westerhoff P Yoon Y | 2003 | Environmental Engineering Science2003，20，5： | 1 |
| 9 | Impact of natural organic matter and divalent cations on the stability of aqueous nanoparticles显示文摘 | ZHANG Y CHEN Y S WESTERHOFF P | 2009 | Water Research2009，43，17： | 1 |
| 10 | Fluorescence excitation-emission matrix regional integration to quantify spectra for dissolved organic matter显示文摘 | Chen W Westerhoff P Leenheer JA | 2003 | Environmental Science & Technology2003，37，24： | 1 |
| 11 | Nanofiltra- tion and ultrafiltration of endocrine disrupting compounds, pharma- ceuticals and personal care products 显示文摘 | Yeomin Yoon Paul Westerhoff Shane A Snyder | 2006 | Joumal of Membrane Sci- ence2006，270，12： | 1 |
| 12 | Factors affecting formation of haloacetonitriles, haloketones, chloropicrin and cyanogen halides during chloramination显示文摘 | Yang Xin Shang Chii Westerhoff Paul | 2007 | Water Research2007，41，6： | 1 |
| 13 | Fate of endocrine-disruptor, pharmaceutical, and personal care product chemicals during simulated drinking water treatment processes 显示文摘 | Westerhoff P Yoon Y Snyder S | 2005 | Environmental Science and Technology2005，39，17： | 1 |
| 14 | Spectrofluorometric characterization of dissolved organic matter for indication of precursor organic material and aromaticity 显示文摘 | McKnight D M Boyer E W Westerhoff P K | 2001 | Limnology and Oceanography2001，46，1： | 1 |
| 15 | Nitrate removal in zero- valent iron packed columns显示文摘 | Westerhoff P James J | 2003 | Water Res2003，37，： | 1 |
| 16 | Dissolved organic nitrogen in drinking water supplies: a review 显示文摘 | Westerhoff P Mash H | 2002 | J Water Supply2002，51，8： | 1 |
| 17 | Dissolved organic nitrogen in drink- ing water supplies: a review 显示文摘 | Paul Westerhoff Heath Mash | 2002 | J Water SRT-Aqua2002，51，： | 1 |
| 18 | Capturing the lost phos- phorus 显示文摘 | Rittmann B E Mayer B Westerhoff P | 2011 | Chemosphere2011，84，6： | 1 |
| 19 | Fluorescence excitation-emission matrix regional integration to quantify spectra for dissolved organic matter显示文摘 | Chen W Westerhoff P Leenheer J A | 2003 | Environmental science & technology2003，37，24： | 1 |
| 20 | Spectrofluorometric characterization of dissolved organic matter for indication of precursor organic material and aromaticity 显示文摘 | McKnight D M Boyer E W Westerhoff P K | 2001 | Limnology and Oceanography2001，46，1： | 1 |
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