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| 1 | Single-atom heterogeneous catalysts based on distinct carbon nitride scaffolds显示文摘Carbon nitrides integrating macroheterocycles offer unique potential as hosts for stabilizing metal atoms due to their rich electronic structure. To date, only graphitic heptazine-based polymers have been studied.Here, we demonstrate that palladium atoms can be effectively isolated on other carbon nitride scaffolds including linear melem oligomers and poly(triazine/heptazine imides). Increased metal uptake was linked to the larger cavity size and the presence of chloride ions in the polyimide structures. Changing the host structure leads to significant variation in the average oxidation state of the metal, which can be tuned by exchange of the ionic species as evidenced by X-ray photoelectron spectroscopy and supported by density functional theory. Evaluation in the semi-hydrogenation of 2-methyl-3-butyn-2-ol reveals an inverse correlation between the activity and the degree of oxidation of palladium, with oligomers exhibiting the highest activity. These findings provide new mechanistic insights into the influence of the carbon nitride structure on metal stabilization. | Zupeng Chen Evgeniya Vorobyeva Sharon Mitchell Edvin Fako Núria López Sean M.Collins Rowan K.Leary Paul A.Midgley Roland Hauert Javier Pérez-Ramírez | 2018 | National Science Review2018，5，5： | 4 |
| 2 | Controlling the gelation temperature of biomimetic polyisocyanides显示文摘Thermosensitive polymers show an entropy-driven transition from a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conformation. The transition at the lower critical solution temperature(LCST) is often sharp, which allows for a wide range of smart material applications.At the LCST, oligo(ethylene glycol)-substituted polyisocyanides(PICs) form soft hydrogels, composed of polymer bundles similar to biological gels, such as actin, fibrin and intermediate filaments. Here, we show that the LCST of PICs strongly depends linearly on the length of the ethylene glycol(EG) tails; every EG group increases the LCSTand thus the gelation temperature by nearly 30 ℃. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 ℃ and 60 ℃and, consequently, tune the mechanical properties of the PIC gels. | Paul H.J. Kouwer Paula de Almeida Onno ven den Boomen Zaskia H. Eksteen-Akeroyd Roel Hammink Maarten Jaspers Stijn Kragt Mathijs F.J. Mabesoone RoelandJ.M. Nolte Alan E. Rowan Martin G.T.A. Rutten Vincent A.A. Le Sage Daniel C. Schoenmakers Chengfen Xing Jialiang xu | 2018 | Chinese Chemical Letters2018，29，2： | 2 |
| 3 | Strong optical nonlinearities of self-assembled polymorphic microstructures of phenylethynyl functionalized fluorenones显示文摘Highly efficient nonlinear optical(NLO) materials with well-defined architectures in the wavelength and subwavelength length scales are of particular importance for next generation of integrated photonic circuits. Fluorenone analogues have been demonstrated to be promising candidates as building blocks for assembly of organic NLO materials thanks to their synergistic supramolecular interactions and brilliant optical properties. Here we have studied the polymorphs of a phenylethynyl functionalized fluorenone derivative, and their controlled self-assembly for microstructures with different morphologies. These polymorphic microcrystals exhibit very distinctive NLO properties, highly related to their supramolecular and electronic structures. | Xinyue Li Sergey Semin Leandro A. Estrada Chunqing Yuan Yulong Duan Jonathan Cremers Paul Tinnemans Paul Kouwer Alan E. Rowan Theo Rasing Jialiang Xu | 2018 | Chinese Chemical Letters2018，29，2： | 2 |
| 4 | Psychosocial assessment and monitoring in the new era of non-interferon-alpha hepatitis C virus treatments显示文摘Chronic hepatitis C virus(HCV) is a global concern. With the 2014 Food and Drug Administration approvals of two direct-acting antiviral(DAA) regimens, ledipasvir/sofosbuvir regimen and the ombitasvir/paritaprevir/ritonavir and dasabuvir regimen, we may now be in the era of all-pill regimens for HCV. Until this development, interferon-alpha along with Ribavirin has remained part of the standard of care for HCV patients. That regimen necessitates psychosocial assessment of factors affecting treatment eligibility, including interferon-alpharelated depressive symptoms, confounding psychiatric conditions, and social aspects such as homelessness affecting treatment eligibility. These factors have delayed as much as 70% of otherwise eligible candidates from interferon-based treatment, and have required treating physicians to monitor psychiatric as well as medical side effects throughout treatment. Allpill DAA regimens with the efficaciousness that would preclude reliance upon interferon-alpha or ribavirin have been anticipated for years. Efficacy studies for these recently approved DAA regimens provide evidence to assess the degree that psychosocial assessment and monitoring will be required. With shorter treatment timelines, greatly reduced side effect profiles, and easier regimens, psychosocial contraindications are greatly reduced. However, current or recent psychiatric comorbidity, and drug-drug interactions with psychiatric drugs, will require some level of clinical attention. Evidence from these efficacy studies tentatively demonstrate that the era of needing significant psychosocial assessment and monitoring may be at an end, as long as a manageable handful of clinical issues are managed. | Paul J Rowan Nizar Bhulani | 2015 | World Journal of Hepatology2015，7，19： | 1 |
| 5 | Psychosocial Factors Are the Most Common Contraindications for Antiviral Therapy at Initial Evaluation in Veterans With Chronic Hepatitis C显示文摘 | Paul J Rowan Shahriar Tabasi Mariam Abdul-latif Mark E Kunik Hashem B El-Serag | 2004 | Journal of Clinical Gastroenterology2004，，6： | 1 |
| 6 | Does prophylactic antidepressant treatment boost interferon-alpha treatment completion in HCV?显示文摘Depression is often a side effect of interferon-alpha treatment for hepatitis C, and is recognized as a cause for treatment discontinuation. When detected, antidepressant treatment begins promptly. In contrast to this rescue approach, prophylactic antidepressant treatment has been considered as a superior approach. While studies indicate that depression is lower with prophylaxis, no study has prospectively evaluated the degree that treatment completion might be boosted by the prophylactic strategy. A structured literature search was conducted to discover all trials of antidepressant prophylaxis for patients undergoing antiviral treatment for chronic hepatitis C. Selection criteria included: antidepressant prophylaxis study; report of depression treatment outcome; report of numbers discontinuing and reason for discontinuation(including any of the following: discontinuation data for medical side effects(i.e., thrombocytopenia); discontinuation due to lack of antiviral response; discontinuation due to lack of antidepressant effect; discontinuation due to antidepressant side effects; discontinuation due to patient preference; discontinuation due to loss to follow-up; or unspecified discontinuation). Across the studies, total enrollees were determined for the prophylaxis arms and the rescue arms, and then, again across studies,those discontinuing for reasons other than lack of antiviral response or medical side effect were summed for each of these two arms. Twelve studies were discovered. One was a retrospective chart review, one was an uncontrolled trial, and ten were controlled trials. Discontinuation of antiviral therapy was not less common in the prophylaxis arms: of the 396 patients treated by the prophylaxis strategy, 47(11.9%) discontinued; of the 380 patients in the rescue strategy, 45(11.8%) discontinued. While the prophylaxis strategy seems to manage depression symptoms, it does not seem to boost treatment completion. Rescue was a very successful strategy when indicated. While antidepressant prophylaxis has benefit in antiviral treatment, it should not generally be valued for boosting the likelihood of treatment completion. | Paul J Rowan | 2013 | World Journal of Virology2013，2，4： | 1 |
| 7 | The effect of allochthonous salt on the petroleum systems of northern Green Canyon and Ewing Bank (offshore Louisiana),northern Gulf of Mexico显示文摘 | Barry C McBride Paul Weimer Mark G Rowan | 1998 | AAPG Bulletin1998，82，5： | 1 |
| 8 | The effect of allochthonous salt on the petroleum systems of northern Green Canyon and Ewing Bank (offShore Louisiana), northern Gulf of Mexico显示文摘 | Barry C McBride Paul Weimer Mark G Rowan | 1998 | AAPG Bulletin1998，82，5： | 1 |
| 9 | Depressive Symptoms Have an Independent, Gradient Risk for Coronary Heart Disease Incidence in a Random, Population-based Sample显示文摘 | Paul J. Rowan Donald Haas John A. Campbell David R. Maclean Karina W. Davidson | 2004 | Annals of Epidemiology2004，，4： | 1 |
| 10 | Nanoscale electron tomography and atomic scale high-resolution electron microscopy of nanoparticles and nanoclusters:A short survey显示文摘The outstanding merits of scanning transmission electron tomography as a technique for the investigation of the internal structure and morphology of nanoparticle and nanocluster materials are summarized with the aid of numerous typical illustrations.Reference is made also to the significant advances that have arisen in probing ultrastructural characteristics of nanoscale solids using aberrationcorrected(AC) electron microscopy(EM).Information of a unique kind may be retrieved by combining the imaging and analytical power of ACEM. | John Meurig Thomas Paul A.Midgley Caterina Ducati Rowan K.Leary | 2013 | Progress in Natural Science:Materials International2013，23，3： | 1 |
| 11 | “纳”样的生活显示文摘日常生活中,家居收纳是不得不面临的一大难题,要想做到好的收纳,同时还能起到装饰美化居室的效果还真得花点心思。“断含离”是由日本杂物管理咨询师山下英子提出的生活理念,所谓“断舍离”就是断绝不需要的东西,舍弃多余的废物,脱离对物品的执着,透过整理物品了解自己,整理心中的混沌,让人生轻松而愉快。 | Andrea Rekalidis Alan Wisniewski Anthony Keeler ferm LIVING Flamant j-me Jan Hoekstra Jordan Murphy Michael Bang Maria Berntsen Mika Tolvanen Paul Rowan Sarah Bttger StokkeAustad Sung Wook ParkUmbra Theresa Arns 伏平 范嘉苑 | 2015 | 现代装饰(家居)2015，0，9： | 0 |
| 12 | 双星报喜显示文摘Twingo卷土重来,可喜可贺。为此TG走了一趟法属里维耶拉,跟基本型TWingo招摇过市后,再与比较贴合TG口味的涡轮增压版玩两手。 | DAN READ PAUL HORRELL ROWAN HoRNCASTLE LEE BRIMBLE TONY | 2014 | 汽车测试报告2014，0，11： | 0 |
| 13 | 感人肺腑显示文摘几个月前,Rowan Horncastle和我在欧洲四处兜风,飞快越过意大利之际触及了一个非常简单扼要的问题:是什么造就汽车的乐趣?我俩开始就着这个问题各抒己见:转向感有其趣, | RORY REID OLLIE MARRIAGE OLLIE KEW PAUL HORRELL ROWAN HORNCASTLE TOM FORD JACK RIX TONY | 2016 | 汽车测试报告2016，0，11： | 0 |
| 14 | 箭在弦上,不得不发显示文摘聊汽车而不知双离台为何物,那种格格不入的程度如同谈足球而不知何谓四三三,不过情况现已有所不同。与I-PACE共度的这两天,我遇上的每一个人(真的是每一个人)都提出了一至五个头头是道的问题,就充电基建设施提出了好些尖锐意见。 | JACK RIX OLLIE MARPIAOE OLLIE KEW PAUL HORRELL ROWAN HORNCASTLE(图) TONY(译) | 2018 | 汽车测试报告2018，0，10： | 0 |
| 15 | What psychiatric screening and monitoring might be needed with the new generation of hepatitis C treatments?显示文摘Psychiatric difficulties, including depression and alcohol use disorders, pose a challenge to treatment decisionmaking for chronic hepatitis C. This is especially made worse because interferon-alpha, as part of the standard of care, may exacerbate depressive symptoms and cause suicidal symptoms to appear. This requires a treatment setting that has the capacity to carry out psychiatric assessment and monitoring, and the capability to deliver patient education regarding these aspects of care. Psychiatric comorbidities create a challenging decisionmaking situation, especially since success rates for the most common hepatitis C genotype, genotype 1, hover around 40%. In recent years, new treatmentshave emerged. These significantly boost the likelihood of sustained viral response, including for genotype 1, and do not seem to have the side effects of interferonalpha or ribavirin. Relevant data are reviewed to assess the degree that these new treatments might reduce the portion not eligible for treatment due to psychiatric comorbidities, and might reduce the emergence of psychiatric symptoms during treatment. Several organizations have recently released evidence-based treatment recommendation guidelines. It is apparent that interferon-alpha continues to be a standard of care, with the new drugs added to this recognized regimen in order to shorten treatment and to boost efficacy. Clinical settings must continue to assess appropriateness for treatment, including current or recent psychiatric comorbidities, and must continue to closely monitor patients for the emergence of psychiatric side effects. The newly developed hepatitis C treatments may affect the metabolism of several categories of psychiatric drugs, and so drug-drug interactions must also be considered and monitored. With many promising drugs under development, an all-pill regimen, with no interferon-alpha and no ribavirin, may emerge in the near future. This will greatly change the challenge of treatment decision-making, and should expand the portion of patients able to successfully complete a treatment regimen. | Paul J Rowan | 2015 | World Journal of Virology2015，4，1： | 0 |
| 16 | 面包车一族的大跃进显示文摘福特全顺默默从事“迎送”生涯的日子实在太久,干得实在太出色,致使大家毫不在意它的存在,平常得好像每天呼吸的空气,每天饮用的清水,性质俨如普通名词,彷佛所有人已惯于把东西塞进它的行李舱,就像用吸尘机清理地毡,或者把家中4×4唤作吉普一样理所当然(尽管此举令路虎好不甘心)。这种超乎常理的实用性能,使得全顺莫名帅酷。所以TG很高兴今天有幸请出这位只问耕耘的英雄,向它深深一鞠躬。 | Paul Horrell Rowan Horncastle Tony | 2016 | 汽车测试报告2016，0，1： | 0 |
| 17 | 午夜狂奔显示文摘警卫把CaymanGT4车钥匙交到我手中时,保时捷位于斯图加特的灰色厂房已被残阳染成一片桃红,我的十二小时任务也宣告正式开始。夜游神将会看着我们取道高速公路、僻静乡径、丛林山野和开阔平原奔往英伦。等到第二天早上,TG校场便会打开大闸,届时这辆跑车就可以彻底发扬保时捷Motorsport精神。 | PAUL HDRRELL ROWAN HORNCASTLE TONY | 2015 | 汽车测试报告2015，0，7： | 0 |
| 18 | 天地本来 万籁俱寂,直到……显示文摘登机之前,世上首屈一指的地图店Stanfords给我泼了头冷水。冰岛地图和旅游指南居然放在欧洲分类的同一层,我最初还以为异国情调会比较浓,最少也应该涉及另一片大陆嘛。然而经过一整天马不停蹄的实地勘察,我可以告诉大家冰岛岂止是另一个世界,简直跟欧洲相隔几个世界之遥。 | PAUL HORRELL ROWAN HORNCASTLE TONY | 2016 | 汽车测试报告2016，0，12： | 0 |
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