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| 1 | Defining the nature of human pluripotent stem cell progeny显示文摘当人的 pluripotent 干细胞(hPSCs ) 能区分产生各种各样的房间类型的一件礼服,是清楚的时,在 vitro,开发怎么仔细反射那,是未知的哪个发生在 vivo。决定人的胚胎的干细胞(hESCs ) 和导致人的 pluripotent 干细胞(hiPSCs ) 是否做相等的子孙,并且是否也使房间成为那类似于导出织物的房间,我们执行了净化的 PSC 衍生物和他们的导出织物的对应物介绍的全面 transcriptome。表示介绍证明 hESCs 和 hiPSCs 在 hiPSC 子孙用外长的 reprogramming 因素为重新表示的神经、肝、间充质的系,和缺席做将近相同的子孙。不管多么与一个导出织物的对应物相比, hESCs 和 hiPSCs 的子孙维持了通常与早哺乳动物的开发联系的基因的一个子集的表示,不管产生的房间的类型。当 pluripotent 基因(OCT4, SOX2, REX1,和 NANOG ) 看起来在从 hPSCs 的区别之上立即是 silenced 时,对早胚胎(LIN28A, LIN28B, DPPA4,和其它) 通常独特的基因不是充分在 hPSC 衍生物的 silenced。从在早人的胎儿的织物(开发的 3-16 星期) 的表达式模式的这些数据和证据建议 hPSCs 的区分的子孙很早人的开发是反射的(< 6 个星期) 。这些调查结果为 hPSCs 能在早人的开发的 vitro 模型作为有用服务的想法提供支持,而且为疾病建模和 hPSC 衍生物的临床的申请提出重要问题。 | Michaela Patterson David N Chan IrisHa Dana Case Yongyan Cui Ben Van Hande Hanna KA Mikkola William E Lowry | 2012 | Cell Research2012，22，1： | 2 |
| 2 | Methods for high-density admixture mapping of disease genes 显示文摘 | PATTERSON N HATrANGADI N LANE B | 2004 | Am J of Hum Genet2004，74，： | 1 |
| 3 | Patterns of known and novel small RNAs in human cervical cancer 显示文摘 | Lui WO Pourmand N Patterson BK | 2007 | Cancer Res2007，67，13： | 1 |
| 4 | The Impact of Communication Effectiveness and Service Quality On Relationship Commitment in Con-sumer,Professional Services显示文摘 | Sharma N Patterson P.G | | 0，，02： | 1 |
| 5 | 查看详情显示文摘 | Haynam C A Wegner P J Auerbach J M Bowers M W Dixit S N Erbert G V Heestand G M Henesian M A Hermann M R Jancaitis K S Manes K R Marshall C D Mehta N C Menapace J Moses E Murray J R Nostrand M C Orth C D Patterson R SacksR A Shaw M J Spaeth M Sutton S B W | | 0，，： | 1 |
| 6 | Human peripheral blood contains two distinct lineages of dendritic cells显示文摘 | Robinson SP Patterson S English N | 1999 | Eur J Immunol1999，29，27： | 1 |
| 7 | The effect of proximity between Pt and BaO on uptake, release, and reduction of NOx on storage catalysts显示文摘 | CANT N W LIU I O Y PATTERSON M J | 2006 | J Catal2006，243，2： | 1 |
| 8 | Neuropeptide secretion in exercise显示文摘 | Onuoha G N Nicholls D P Patterson A | 1998 | Neuropeptides1998，32，： | 1 |
| 9 | The effect of carbon monoxide on the oxidation of four C6 to C8 hydrocarbons over platinum, palladium and rhodium 显示文摘 | Patterson M J Angove D E Cant N W | 2000 | Applied Catalysis B: Environmental2000，26，： | 1 |
| 10 | Potential neurotoxicity of ketamine in the developing rat brain显示文摘 | Zou X Patterson TA Sadovova N | 2009 | Toxicol Sci2009，108，1： | 1 |
| 11 | Advances in fluorescent protein technology显示文摘 | Shaner N C Patterson G H Davidson M W | 2007 | J Cell Sci2007，120，24： | 1 |
| 12 | Principal components analysis corrects for stratification in genome-wide association studies 显示文摘 | Price A L Patterson N J Plenge R M Weinblatt M E Sbadick N A Reich D | 2006 | Nature Genetics2006，38，8： | 1 |
| 13 | Effects of structure on pyrolysis gases from amino acids 显示文摘 | Haidar N F Patterson J M Moors M | 1981 | Journal of Agricultural and Food Chemistry1981，29，1： | 1 |
| 14 | Patterns of known and novel small RNAs in human cervical cancer显示文摘 | Lui WO Pourmand N Patterson BK | 2007 | Cancer Res2007，67，： | 1 |
| 15 | Down' s syndrome 显示文摘 | Roizen N J Patterson D | 2003 | Lancet2003，361，9365： | 1 |
| 16 | New tricks for old dogs: nonthrombotic effects of thrombin in vessel wall biology 显示文摘 | Patterson C Stouffer GA Madamanchi N | 2001 | Circ Res2001，88，10： | 1 |
| 17 | Pyrolysis of phenylalanine, 3,6-dibenzyl-2,5-piperazinedione, and phenethylamine 显示文摘 | Patterson J M Haidar N F Papadopoulos E P | 1973 | The Journal of Organic Chemistry1973，38，4： | 1 |
| 18 | Potential neurotoxicity of ketamine in the developing rat brain显示文摘 | ZOU X PATTERSON TA SADOVOVA N | 2009 | Toxicol Sci2009，08，1： | 1 |
| 19 | Swallowing Performance in Patients with Head and Neck Cancer:A Simple Clinical Test显示文摘 | Patterson J M McColl E Carding P N | 2009 | Oral Oncol2009，45，10： | 1 |
| 20 | Comprehensive method of analyzing the results of photoastigmatic refractive keratectomy for the treatment of post-cataract myopic anisometropia显示文摘 | PATTERSON A KAYE S B O'DONNELL N P | 2000 | J Cataract Refract Surg2000，26，2： | 1 |
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