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| 1 | Evaluation of the safety and effectiveness of direct oral anticoagulants and low molecular weight heparin in gastrointestinal cancer-associated venous thromboembolism显示文摘BACKGROUND Gastrointestinal cancer(GICA)is associated with a higher incidence of venous thromboembolism(VTE)compared to other solid tumors,moreover,recurrent VTE and major bleeding(MB)complications during anticoagulation treatment have an associated increase rate.GICA-VTE remains a challenging clinical scenario with MB concerns for utilization of direct oral anticoagulants(DOAC),especially with active cancer therapies.AIM To evaluate patient risk factors,effectiveness(VTE)and safety(MB)of DOACs and low molecular weight heparin(LMWH)in patients with active GICA-VTE.METHODS A retrospective chart review of patients receiving DOACs and LMWH with GICA and symptomatic or incidental VTE treated at comprehensive cancer center from November 2013 to February 2017 was performed.Inclusion criteria included active GI cancer diagnosed at any stage or treatment+/-6 mo of VTE diagnosis,whom were prescribed 6 mo or more of DOACs or LMWH.The Chi-squared test was used for overall and the Fisher exact test for pairwise comparisons of the proportions of patients experiencing recurrent VTE and MB events.Odds ratios were used to compare the relative odds of the occurrence of the outcome given exposure to the risk factor.RESULTS A total of 144 patients were prescribed anticoagulation,in which 106 fulfilled inclusion criteria apixaban(27.3%),rivaroxaban(34.9%)and enoxaparin(37.7%),and 38 were excluded.Patients median age was 66.5 years at GICA diagnosis and 67 years at CAVTE event,with 62%males,80%Caucasian,70%stage IV,pancreatic cancer(40.5%),30%Khorana Score(≥3 points),and 43.5%on active chemotherapy.Sixty-four percent of patients completed anticoagulation therapy(range 1 to 43 mo).Recurrent VTE at 6 mo was noted in 7.5%(n=3),6.8%(n=2)and 2.7%(n=1)of patients on enoxaparin,apixaban and rivaroxaban,respectively(all P=NS).MB at 6 mo were 5%(n=2)for enoxaparin,6.8%(n=2)for apixaban and 21.6%(n=8)for rivaroxaban(overall P=0.048;vs LMWH P=0.0423;all other P=NS).Significant predictors of a primary or secondary outcome for all anticoagulation therapies included:Active systemic treatment(OR=5.1,95%CI:1.3-19.3),high Khorana Score[≥3 points](OR=5.5,95%CI:1.7-17.1),active smoker(OR=6.7,95%CI:2.1-21.0),pancreatic cancer(OR=6.8,95%CI:1.9-23.2),and stage IV disease(OR=9.9,95%CI:1.2-79.1).CONCLUSION Rivaroxaban compared to apixaban and enoxaparin had a significantly higher risk of MB on GICA-VTE patients with equivocal efficacy. | Alejandro Recio-Boiles Sumana Veeravelli Jessica Vondrak Hani M Babiker Aaron J Scott Rachna T Shroff Hitendra Patel Emad Elquza Ali McBride | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 3 |
| 2 | The “Colonial Wig” pancreaticojejunostomy:zero leaks with a novel technique for reconstruction after pancreaticoduodenectomy显示文摘BACKGROUND: Postoperative pancreatic fistula(POPF) remains common and morbid after pancreaticoduodenectomy(PD). A major advance in the study of POPF is the fistula risk score(FRS).METHODS: We analyzed 48 consecutive patients undergoing PD. The 'Colonial Wig' pancreaticojejunostomy(CWPJ) technique was used in the last 22 PDs, we compared 22 CWPJ to 26 conventional PDs. RESULTS: Postoperative morbidity was 49%(27% Clavien grade >2). The median length of hospital stay was 11 days. In the first 26 PDs, the PJ was performed according to standard techniques and the clinically relevant POPF(CR-POPF) rate was 15%, similar to the FRS-predicted rate(14%). In the next 22 PJs, the CWPJ was employed. Although the FRS-predicted rates were similar in these two groups(14% vs 13%), the CRPOPF rate in the CWPJ group was 0(P=0.052).CONCLUSION: Early experience with the CWPJ is encouraging, and this anastomosis may be a safe and effective way to lower POPF rates. | Xihua Yang Pouya Aghajafari Naeem Goussous Shirali T Patel Steven C Cunningham | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，5： | 2 |
| 3 | Prevalence of advanced liver fibrosis and steatosis in type-2 diabetics with normal transaminases:A prospective cohort study显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)and type-2 diabetes mellitus(T2DM)have an intricate bidirectional relationship.Individuals with T2DM,not only have a higher prevalence of non-alcoholic steatosis,but also carry a higher risk of progression to nonalcoholic steatohepatitis.Experts still differ in their recommendations of screening for NAFLD among patients with T2DM.AIM To study the prevalence of NAFLD and advanced fibrosis among our patient population with T2DM.METHODS During the study period(November 2018 to January 2020),59 adult patients with T2DM and 26 non-diabetic control group individuals were recruited prospectively.Patients with known significant liver disease and alcohol use were excluded.Demographic data and lab parameters were recorded.Liver elastography was performed in all patients.RESULTS In the study group comprised of patients with T2DM and normal alanine aminotransferase levels(mean 17.8±7 U/L),81%had hepatic steatosis as diagnosed by elastography.Advanced hepatic fibrosis(stage F3 or F4)was present in 12%of patients with T2DM as compared to none in the control group.Patients with T2DM also had higher number of individuals with grade 3 steatosis[45.8%vs 11.5%,(P<0.00001)and metabolic syndrome(84.7%vs 11.5%,P<0.00001)].CONCLUSION A significant number of patients with T2DM,despite having normal transaminase levels,have NAFLD,grade 3 steatosis and advanced hepatic fibrosis as measured by liver elastography. | Jasbir Makker Hassan Tariq Kishore Kumar Madhavi Ravi Danial Haris Shaikh Vivien Leung Umar Hayat Muhammad T Hassan Harish Patel Suresh Nayudu Sridhar Chilimuri | 2021 | World Journal of Gastroenterology2021，27，6： | 2 |
| 4 | Artificial intelligence applications in inflammatory bowel disease:Emerging technologies and future directions显示文摘Inflammatory bowel disease(IBD)is a complex and multifaceted disorder of the gastrointestinal tract that is increasing in incidence worldwide and associated with significant morbidity.The rapid accumulation of large datasets from electronic health records,high-definition multi-omics(including genomics,proteomics,transcriptomics,and metagenomics),and imaging modalities(endoscopy and endomicroscopy)have provided powerful tools to unravel novel mechanistic insights and help address unmet clinical needs in IBD.Although the application of artificial intelligence(AI)methods has facilitated the analysis,integration,and interpretation of large datasets in IBD,significant heterogeneity in AI methods,datasets,and clinical outcomes and the need for unbiased prospective validations studies are current barriers to incorporation of AI into clinical practice.The purpose of this review is to summarize the most recent advances in the application of AI and machine learning technologies in the diagnosis and risk prediction,assessment of disease severity,and prediction of clinical outcomes in patients with IBD. | John Gubatan Steven Levitte Akshar Patel Tatiana Balabanis Mike T Wei Sidhartha R Sinha | 2021 | World Journal of Gastroenterology2021，27，17： | 2 |
| 5 | 肥胖Zucker大鼠肾脏血管紧张素Ⅱ2型受体及Mas受体共定位,且功能相互依赖显示文摘血管紧张素Ⅱ2型受体(angiotensinⅡtype 2receptor,AT_2R)与Mas受体(the receptor Mas,MasR)作用复杂,但均具有相似的前利钠作用,尤其是在肥胖/糖尿病大鼠肾脏中AT_2R表达及利钠作用增强。根据一些报道提示的这些受体之间的潜在正相互作用,研究者在肥胖大鼠中验证肾脏AT_2R及MasR生理上相互作用、相互依赖地刺激细胞信号转导及促进利钠作用的假设。 | Patel SN Ali Q Samuel P Steckelings UM Hussain T 赵狄 练桂丽 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 6 | Fusion neutron and ion emission from deuterium and deuterated methane cluster plasmas显示文摘 | K W Madison P K Patel D Price A Edens, M Allen, T E Cowan, J Zweiback, T Ditmire | | 0，，： | 2 |
| 7 | A Novel Approach To Investigate the Uptake and Internalization of Escherichia coli O157:H7 in Spinach Cultivated in Soil and Hydroponic Medium 显示文摘 | Sharma M Ingram D T Patel J R | 2009 | J Food Protection2009，72，7： | 1 |
| 8 | Midterm experience with the endovascular treatment of isolated iliac aneurysms显示文摘 | Sanchez LA Patel AV Ohki T | 1999 | J Vasc Surg1999，30，5： | 1 |
| 9 | Efficacy and safety of ten day moxifloxacin 400mg once daily in the treatment of patients with community-acquired pneumonia显示文摘 | Patel T Pearl J Williams J | 2000 | Respir Med2000，94，2： | 1 |
| 10 | Impaired repair activity of a truncated DNA polymerase beta protein显示文摘 | Bhattacharyya N Banerjee T Patel U | 2001 | Life Sci2001，69，3： | 1 |
| 11 | An intrusiondetection and prevention system in cloud computing:Asystematic review显示文摘 | Patel A Mona T Bakhtiyari K | 2013 | Journal of Network and ComputerApplications2013，36，1： | 1 |
| 12 | Multivariate EMD andfull spectrum based condition monitoring for rotatingmachinery显示文摘 | ZHAO X M Patel T H ZUO M J | 2012 | Mechanical Systems and Signal Processing2012，27，2： | 1 |
| 13 | Outcomes with delayed dorsal vein complex ligation during robotic assisted laparoscopic prostatectomy 显示文摘 | Woldu SL Patel T Shapiro EY | 2013 | Can J Urol2013，20，： | 1 |
| 14 | MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes显示文摘 | Braconi C Huang N Patel T | 2010 | Hepatology2010，51，3： | 1 |
| 15 | Onset of hydrodynamic mix in high-velocity* highly compressed inertial confinement fusion implosions显示文摘 | Ma T Patel P K Izumi N | 2013 | Phys Rev Lett2013，111，08： | 1 |
| 16 | Hypocholesterolemic and antiaggregatory properties of 2-hydroxytetronic acid redox analogs and their relationship to clofibric acid显示文摘 | Witiak D T Kokrady S S Patel S T | 1982 | J Med Chem1982，25，1： | 1 |
| 17 | Van- comycin-resistant Staphylococcus aureus in the United States, 2002-2006 显示文摘 | SIEVERT D M RUDRIK J T PATEL J B | 2008 | Clin Infect Dis2008，，5： | 1 |
| 18 | Adsorption of crystal violet dye onto Tamarind Seed Powder显示文摘 | Patel H Vashi R T | 2010 | E-Journal of Chemistry2010，7，3： | 1 |
| 19 | Axillary lymph node metastasis from an occult beast cancer显示文摘 | Patel I Nemoto T Rosner D | 1981 | Cancer1981，47，12： | 1 |
| 20 | Soluble monomeric P - selectin containing only the lectin and epidermal growth factor domains binds to P - selectin glycoprotein ligand - 1 on leukocytes 显示文摘 | MEHTA P PATEL K D LAUE T M | 1997 | Blood1997，90，6： | 1 |
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