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| 1 | Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD)is a condition in which excess fat accumulates in the liver of a patient with no history of alcohol abuse or other causes for secondary hepatic steatosis.The pathogenesis of NAFLD and nonalcoholic steatohepatitis(NASH)has not been fully elucidated.The'two-hit'hypothesis is probably a too simplified model to elaborate complex pathogenetic events occurring in patients with NASH.It should be better regarded as a multiple step process,with accumulation of liver fat being the first step,followed by the development of necroinflammation and fibrosis.Adipose tissue,which has emerged as anendocrine organ with a key role in energy homeostasis,is responsive to both central and peripheral metabolic signals and is itself capable of secreting a number of proteins.These adipocyte-specific or enriched proteins,termed adipokines,have been shown to have a variety of local,peripheral,and central effects.In the current review,we explore the role of adipocytokines and proinflammatory cytokines in the pathogenesis of NAFLD.We particularly focus on adiponectin,leptin and ghrelin,with a brief mention of resistin,visfatin and retinol-binding protein 4 among adipokines,and tumor necrosis factor-α,interleukin(IL)-6,IL-1,and briefly IL-18 among proinflammatory cytokines.We update their role in NAFLD,as elucidated in experimental models and clinical practice. | Sanja Stojsavljevi? Marija Gomer?i? Pal?i? Lucija Virovi? Juki? Lea Smir?i? Duvnjak Marko Duvnjak | 2014 | World Journal of Gastroenterology2014，20，48： | 42 |
| 2 | Mini-loop ligation of a bleeding duodenal Dieulafoy's lesion显示文摘Two percent of gastrointestinal hemorrhages are caused by Dieulafoy's lesions, which are located in duodenum in only 15% of cases. There are no recommendations regarding the prime endoscopic treatment technique for this condition. A 61-year-old woman presented with melena without signs of hemodynamic instability. During an urgent upper endoscopy, blood oozing from the normal mucosa of the duodenum was seen and this was classified as a Dieulafoy's lesion. A mini-loop was opened at the rim of a transparent ligation chamber, at the end of the endoscope, and after aspiration of the lesion, closed and detached. Complete hemostasis was achieved without early or postponed complications. In every day clinical practice, mini-loop ligation is rarely used because of possible complications, such as site ulceration, organ perforation, re-bleeding and possible inexperience of the operator. To the best of our knowledge this is the first case of successful treatment of bleeding duodenal Dieulafoy's lesion by mini-loop ligation. | Marija Gomeri Pali Neven Ljubii | 2013 | World Journal of Gastroenterology2013，19，22： | 3 |
| 3 | High-pressure synthesis and characterization of diamond from a sulfur–carbon system显示文摘 | Yu Pal’yanov Yu Borzdov I Kupriyanov V Gusev A Khokhryakov A Sokol | 2001 | Diamond & Related Materials2001，，： | 2 |
| 4 | Activation of caspases and poly(ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cells by Inula racemosa显示文摘 | Pal H C Sehar I Bhushan S | 2010 | Toxicol In Vitro2010，24，6： | 1 |
| 5 | Amperometric biosensors for detection of the prostate cancer marker (PSA)显示文摘 | Sarkar P Pal P S Ghosh D Setford S J Tothill I E | 2002 | Int J Pharm2002，238，12： | 1 |
| 6 | Polyethylene glycolgraft-ed polyethylenimine used to enhance adenovirus gene de-livery 显示文摘 | Singarapu K Pal I Ramsey JD | 2013 | J Biomed Mater Res A2013，101，： | 1 |
| 7 | Phloroglucinol compounds of natural origin 显示文摘 | Pal Singh I Bharate SB | 2006 | Nat Prod Rep2006，23，： | 1 |
| 8 | Monoclonal immunoglobulin a antibody to the major outer membrane protein of the chlamydia trachomatis mouse pneumonitis biovar protects mice against a chlamydial genital challenge显示文摘 | Pal S Theodor I Peterson EM | 2004 | Vaccine2004，15，5： | 1 |
| 9 | Alkanes from plants of the genus Achillea 显示文摘 | Pal R Eglinton T I Benitez-nelson B C | 1999 | Journal of the Serbian Chemical Society1999，64，78： | 1 |
| 10 | Germline truncatingmutations in bothMSH2 and BRCA2 in a single kindred显示文摘 | Thiffault I Hamel N Pal T | 2004 | Br J Cancer2004，90，2： | 1 |
| 11 | Parenteral nutrition-associat- ed cholestasis in premature babies:risk factors and predictors 显示文摘 | Hsieh M H Pal W Tseng H I | 2009 | Pediatr Neonatol2009，50，5： | 1 |
| 12 | The MRC dyspnoea scale by telephone interview to monitor health status in elderly COPD patients显示文摘 | Pal adini L Hodder R Cecchini I | 2010 | Respir Med2010，104，7： | 1 |
| 13 | Effects of N-doping on the microstructure,mechanical and tribological behavior of Cr-DLC films显示文摘 | Pal S K Jiang J C Meletis E I | 2007 | Surf Coat Technol2007，201，： | 1 |
| 14 | The role d the lymphatic systen in vaccine treking and immune response 显示文摘 | Pal I JD | 2011 | Adv Drug Deliv Rev2011，63，1011： | 1 |
| 15 | Rhabdomyosarcoma of nose, nasopharynx and paranasal sinuses 显示文摘 | Mondal PK Pal I Misra S | 2009 | Indian J Otolaryngol Head Neck Surg2009，61，4： | 1 |
| 16 | Impaired electrical signaling disrupts gamma frequency oscillations in connexin 36-deficient mice显示文摘 | Hormuzdi SG Pals I LeBeau FEN | | 0，，03： | 1 |
| 17 | Non-linear differential polynomials sharing 1-points 显示文摘 | Lahiri I Pal R | 2006 | Bull Korean Math2006，43，： | 1 |
| 18 | Clustering of image data using K- means and fuzzy K-Means 显示文摘 | Rahmani M K I Pal N Arora K | 2014 | International Journal of Advanced Computer Science and Applications ( IJACSA )2014，5，7： | 1 |
| 19 | Trends in seasonal precipitation extremes-An indicator of climate change’in Kerala,India显示文摘 | Pal I Al-Tabbaa A | 2009 | Journal of Hydrology2009，，367： | 1 |
| 20 | Reduced graphene oxide/copper phthalocyanine composite and its optoelectrical properties显示文摘 | Chunder A Pal T Khondaker S I | 2010 | The Journal of Physical Chemistry C2010，114，15： | 1 |
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