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| 1 | 用熔解曲线法分析插入/缺失多态性和Y染色体SNPs多态性显示文摘随着单核苷酸多态性SNPs (SingleNucleotidePolymorphisms)及插入 /缺失多态性Indels (Insertion/Dele tion)的分型技术研究的深入 ,SNPs和Indels在法医学上的应用将受到深刻的影响。本文研究和探讨Indels的分型方法 ,通过测定扩增DNA片段在溶液中的溶解曲线图确定每个样品的基因型 ,称为溶解曲线Indels基因分型方法(McI/D)。溶解曲线图由被测样品DNA片段的特殊溶解温度组成 ,扩增结果直接由仪器分析不需要繁杂的PCR后期操作。 | 叶健 郑秀芬 季安全 Esteban J Parra Donna M Sosnoski Mark D Shriver | 2001 | 中国法医学杂志2001，16，4： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Solar space heating and cooling for Spanish housing: potential energy savings and emissions reduction 显示文摘 | Marcos J D Izquierdo M Parra D | 2011 | Solar Energy2011，85，11： | 1 |
| 4 | Exposure to Volatile Organic Compounds(VOC) in Public Buses of Pamplona,Northern Span显示文摘 | Parra M A Elustondo D Bermejo R | 2008 | Science of The TotalEnvironment2008，，404： | 1 |
| 5 | An experimental study on pitch compensation in pedestrian-protection systems for collision avoidance and mitigation 显示文摘 | Llorca D R Sotelo M A Parra I | 2009 | IEEE Transactions on Intelligent Transportation Systems2009，10，3： | 1 |
| 6 | Comparison of doxorubicin-eluting bead transarterial chemoembolization (DEB-TACE) with conventional transarterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma显示文摘 | Ferrer Puchol M D la Parra C Esteban E | 2011 | Radiologia2011，53，3： | 1 |
| 7 | Heavy metal distribution in dust from elementary schools in Hermosillo, Sonora, Mexico 显示文摘 | Meza-Figueroa D De la O-Villanueva M De la Parra M L | 2007 | ATMOSPHERIC ENVIRONMENT2007，14，2： | 1 |
| 8 | Recovery of iron from copper flash smelting slags 显示文摘 | BUSOLIC D PARADA F PARRA R SANCHEZ M PALACIOS J HINO M | 2011 | Trans Inst Min Metall C2011，120，： | 1 |
| 9 | Porcine Acute Phase Protein Concentrations in Different Diseases in Field Conditions显示文摘 | M D Parra P Fuentes F Tecles | 2006 | Journal of Veterinary Medicine2006，53，10： | 1 |
| 10 | Mechanical and microstructural investigation of friction spot welded AA6181-T4 aluminum alloy显示文摘 | ROSENDO T PARRA B TIER M A D | | 0，，： | 1 |
| 11 | Mechanical and micro- structual investigation of friction spot welded AA6181-T4 alumin- ium alloy显示文摘 | Rosenda T Parra B Tier M A D | 2011 | Materials & Dsign2011，32，3： | 1 |
| 12 | Autonomous pedestrian collision avoidance using a fuzzy steering controller 显示文摘 | FERNANDEZ L D MILANES V PARRA A I GAVILAN M GARCIA D I PEREZ J SOTELO M A | 2011 | IEEE Transactions on Intelligent Transportation Systems2011，12，： | 1 |
| 13 | Robust visual odometry for vehicle localization in urban environments显示文摘 | Parra I Sotelo M A Llorca D F | 2010 | Robotica2010，28，3： | 1 |
| 14 | Destratification by mechanical mixers: Mixing efficiency and flow scaling显示文摘 | Hill D F Vergara A M Parra E J | 2008 | Journal of Hydraulic Engineering2008，134，12： | 1 |
| 15 | Heavy metal distribution in dust from elementary schools in Hermosillo, Sonora,Mexico 显示文摘 | Meza-Figueroa D De la O-Villanueva M De la Parra M L | 2007 | Atmospheric Environment2007，41，2： | 1 |
| 16 | Heat Transfer in Pressurized Wlater Reactor Components Most Ofter Subject to Thermal Shock显示文摘 | Parras E Bosser M Milan D | 1980 | Nuclear Technology1980，47，12： | 1 |
| 17 | Quantification of indoor and outdoor volatile organic compounds (VOCs) in pubs and caf6's in Pamplona, Spain 显示文摘 | PARRA M A ELUSTONDO D BERMEJO R | 2008 | Atmospheric Environment2008，42，27： | 1 |
| 18 | Allelopathic potential of Poqueria trinervia(Aomposite) and piquerola A and B显示文摘 | GONZALEZ D E PARRA M ANAYA A L | 1981 | Chem Ecol1981，，7： | 1 |
| 19 | Heavy metal distribution in dust from elementary schools in Hermosillo, Sonora, Mexico显示文摘 | Meza - Figueroa D De LA O - Villanueva M De LA PARRA M L | 2007 | Atmospheric Environment2007，41，2： | 1 |
| 20 | Large-scale SNP a- nalysis reveals clustered and continuous patterns of human genetic variation 显示文摘 | SHRIVER M D MEI R PARRA E J | 2005 | Hum Genomics2005，2，2： | 1 |
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