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| 1 | Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer显示文摘AIM:To develop a panel of blood-based diagnostic biomarkers consisting of circulating microRNAs for the detection of pancreatic cancer at an early stage.METHODS:Blood-based circulating microRNAs were profiled by high throughput screening using microarray analysis,comparing differential expression between early stage pancreatic cancer patients(n = 8) and healthy controls(n = 11).A panel of candidate microRNAs was generated based on the microarray signature profiling,including unsupervised clustering and statistical analysis of differential expression levels,and findings from the published literature.The selected candidate microRNAs were then confirmed using TaqMan real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR) to further narrow down to a three-microRNA diagnostic panel.The three-microRNA diagnostic panel was validated with independent experimental proce-dures and instrumentation of RT-qPCR at an independent venue with a new cohort of cancer patients(n = 11),healthy controls(n = 11),and a group of high risk controls(n = 11).Receiver operating characteristic curve analysis was performed to assess the diagnostic capability of the three-microRNA panel.RESULTS:In the initial high throughput screening,1220 known human microRNAs were screened for differential expression in pancreatic cancer patients versus controls.A subset of 42 microRNAs was then generated based on this data analysis and current published literature.Eight microRNAs were selected from the list of 42 targets for confirmation study,and three-microRNAs,miR-642b,miR-885-5p,and miR-22,were confirmed to show consistent expression between microarray and RT-qPCR.These three microRNAs were then validated and evaluated as a diagnostic panel with a new cohort of patients and controls and found to yield high sensitivity(91%) and specificity(91%) with an area under the curve of 0.97(P < 0.001).Compared to the CA19-9 marker at 73%,the three-microRNA panel has higher sensitivity although CA19-9 has higher specificity of 100%.CONCLUSION:The identified panel of three microRNA biomarkers can potentially be used as a diagnostic tool for early stage pancreatic cancer. | Ganepola AP Ganepola John R Rutledge Paritosh Suman Anusak Yiengpruksawan David H Chang | 2014 | World Journal of Gastrointestinal Oncology2014，6，1： | 9 |
| 2 | Electrical properties of bulk and nano Li_(2)TiO_(3) ceramics:A comparative study显示文摘Nanocrystalline and bulk Li_(2)TiO_(3) having monoclinic structure were prepared by mechanical alloying as well as conventional ceramic route.Complex impedance analysis in the frequency range of 100 Hz-1 MHz over a wide range of temperature(50-500℃)indicates the presence of grain boundary effect along with the bulk contribution.The frequency-dependent conductivity plots exhibit power law dependence,suggesting three types of conduction in the material:low-frequency(100 Hz-1 kHz)conductivity showing long-range translational motion of electrons(frequency independent),mid-frequency(1-10 kHz)conductivity showing short-range hopping of charge carriers and high-frequency(10 kHz-1 MHz)conductivity showing conduction due to localized orientation of hopping mechanism.The electrical conductivity measurement of nanocrystalline and bulk Li_(2)TiO_(3) with temperature shows the negative temperature coefficient of resistance(NTCR)behavior.The activation energy(0.77 eV for nano sample and 0.88 eV for bulk sample)study shows the conduction mechanism in both samples.The low activation energies of the samples suggest the presence of singly ionized oxygen vacancies in the conduction process. | Umasankar DASH Subhanarayan SAHOO Paritosh CHAUDHURI S.K.S.PARASHAR Kajal PARASHAR | 2014 | Journal of Advanced Ceramics2014，3，2： | 2 |
| 3 | Effect of Li^(+)ion mobility on the grain boundary conductivity of Li_(2)TiO_(3) nanoceramics显示文摘Lithium titanate(Li_(2)TiO_(3))is one of the most promising candidates among the tritium breeding materials because of its good tritium release capacity.Li concentration has much significance on the diffusivity of tritium in the material.The nanocrystalline single-phase Li_(2)TiO_(3) with monoclinic structure has been prepared by high energy ball milling followed by calcination at 700℃for 2 h.The field emission scanning electron microscopy(FESEM)studies confirmed uniform distribution of nanocrystalline phase with particle size below 100 nm.The study of the Li^(+)ion diffusion on the sintered sample was investigated by means of electrical conductivity measurements.Electrical properties of the samples were studied in wide temperature(50-500℃)and frequency(100 Hz-1 MHz)ranges.The complex impedance spectroscopy(CIS)studies showed the presence of both bulk and grain boundary effects in nanocrystalline Li_(2)TiO_(3).The bulk resistance of the samples has been observed to decrease with rise in temperature showing a typical negative temperature coefficient of resistance(NTCR)behavior.The low activation energies of the samples suggested the presence of singly ionized oxygen vacancies in the conduction process.The hopping frequency shifted toward higher frequency with increase in temperature.Activation energy of 0.86 eV was calculated from AC conductivity. | Umasankar DASH Subhanarayan SAHOO S.K.S.PARASHAR Paritosh CHAUDHURI | 2014 | Journal of Advanced Ceramics2014，3，2： | 2 |
| 4 | Theory of Market Timing and Asymmetric Information: Empirical Evidence with Dynamic Views 显示文摘 | Sinha Paritosh Chandra Ghosh Santanu Kumar | 2009 | IUP Journal of Ap- plied Finance2009，15，4： | 1 |
| 5 | Optimization of an azo dye batch adsorption parameters using Box-Behnken design显示文摘 | Paritosh T Srivastava V.C Kumar A | | 0，，03： | 1 |
| 6 | Synthesis of N-amino and N-nitramino-nitroimidazoles显示文摘 | Raja D Paritosh R D Reddy D | 2010 | Terahedron letters2010，51，： | 1 |
| 7 | The synthesis and complete' H and 13 C NMR spec-tral assignment of 2,2,4,4,6, 6-hexanitroadamantane and itsprecursor nitroketones by 2D NMR spectroscopy 显示文摘 | Paritosh R D | 1992 | Tetrahed-ron1992，48，： | 1 |
| 8 | Modifying the microstructure and morphology of film surface layers by manipulating chemical vapor deposition reactor conditions显示文摘 | PARITOSH F SROLOVITZ D J | 2001 | Journal of Applied Physics2001，89，9： | 1 |
| 9 | M Variables and Firms' Adjustment - speed in Capital Stmc- ture Choice: Indian Evidence显示文摘 | Paritosh Chandra Sinha Santanu Kumar Ghosh | 2010 | The IUP Journal of Applied Finance2010，16，4： | 1 |
| 10 | Molecular regula- tion of cytokine gene expression: interferon-gamma as a model system显示文摘 | Howard A Young Paritosh Ghosh | 1997 | Prog Nucleic Acid Res Mol Biol1997，56，： | 1 |
| 11 | Shadowing effects on the microstructure of obliquely deposited films显示文摘 | Paritosh Srolovitz D J | 2002 | J Appl Phys2002，91，： | 1 |
| 12 | Optimization of an azo dye batch adsorption parameters using Box-Behnkendesign 显示文摘 | Paritosh T ~imal C S Arvind K | 2009 | Desalination2009，249，3： | 1 |
| 13 | Combined radial and median nerve injury in diaphysea fracture of humerus: a case report显示文摘 | Rajesh Rohilla Rohit Singla Narender Kumar Magu Roop Singh Ashish Devgun Reetadyuti Mukhopadhyay Paritosh Gogna | 2013 | Chinese Journal of Traumatology2013，16，6： | 1 |
| 14 | 显示文摘 | Paritosh F Srolovitz D J | 2001 | Journal of Applied Physics2001，，89： | 1 |
| 15 | , An improved oxidation of alkyl halides to aldehydes显示文摘 | Paritosh Dave Hoe - Sup Byun Robert Engel | 1986 | Synthetic Commun1986，16，11： | 1 |
| 16 | Optimization of an AZO dye batch adsorption parameters using Box-Behnken design 显示文摘 | Paritosh T Vimal C S Arvind K | 2009 | Desalination2009，219，3： | 1 |
| 17 | Design and thermal-hydraulic analysis of PFC baking for SST-1 Tokamak 显示文摘 | Paritosh Chaudhuri Chenna Reddy D Khirwadkar S | 2001 | Fusion Engineering and Design2001，55，： | 1 |
| 18 | The synthesis and complete H and 13C NMR spectral assignment of 2,2,4,4,6,6-hexanitroadamantane and its precursor nitroketones by 2D NMR spectroscopy显示文摘 | Paritosh R D | 1992 | Tetrahed- ton1992，48，： | 1 |
| 19 | Study of radiation heat wansfer between PFC and vacuum vessel during SST-1 baking显示文摘 | PARITOSH C CHENNA-REDDY D SANTRA P | 2003 | Fusion Engineering and Design2003，65，1： | 1 |
| 20 | Permeability transition pore-mediated mitochondrial superoxide flashes mediate an early inhibitory effect of amyloid beta1?42 on neural progenitor cell proliferation显示文摘 | Yan Hou Paritosh Ghosh Ruiqian Wan Xin Ouyang Heping Cheng Mark P. Mattson Aiwu Cheng | 2013 | Neurobiology of Aging2013，，： | 1 |
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