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| 1 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 2 | New totally intracorporeal reconstructive approach after robotic total gastrectomy: Technical details and short-term outcomes显示文摘AIM To show outcomes of our series of patients that underwent a total gastrectomy with a robotic approach and highlight the technical details of a proposed solution for the reconstruction phase.METHODS Data of gastrectomies performed from May 2014 to October 2016, were extracted and analyzed. Basic characteristics of patients, surgical and clinical outcomes were reported. The technique for reconstruction(Parisi Technique) consists on a loop of bowel shifted up antecolic to directly perform the esophago-enteric anastomosis followed by a second loop, measured up to 40 cm starting from the esojejunostomy, fixed to the biliary limb to create an enteroenteric anastomosis. The continuity between the two anastomoses is interrupted just firing a linear stapler, so obtaining the Roux-en-Y by avoiding to interrupt the mesentery.RESULTS Fifty-five patients were considered in the present analysis. Estimated blood loss was 126.55 ± 73 m L, no conversions to open surgery occurred, R0 resections were obtained in all cases. Hospital stay was 5(3-17) d, no anastomotic leakage occurred. Overall, a fast functional recovery was shown with a median of 3(3-6) d in starting a solid diet.CONCLUSION Robotic surgery and the adoption of a tailored reconstruction technique have increased the feasibility and safety of a minimally invasive approach for total gastrectomy. The present series of patients shows its implementation in a western center with satisfying short-term outcomes. | Amilcare Parisi Francesco Ricci Alessandro Gemini Stefano Trastulli Roberto Cirocchi Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，23： | 4 |
| 3 | Fluorescence image-guided lymphadenectomy using indocyanine green and near infrared technology in robotic gastrectomy显示文摘In recent years, some researchers have tried to find a way to improve the surgical identification of the lymphatic drainage routes and lymph node stations during radical gastrectomy, thus starting a new research frontier in this field called 'navigation surgery'. Among the different reported solutions, the introduction of the indocyanine green(ICG) has drawn attention for its characteristics, a fluorescence dye that can be detected in the near infrared spectral band(NIR). A fluorescence imaging technology has been integrated in the latest version of the Da Vinci robotic system and surgeons have extensively reported their experiences in colorectal and hepato-biliary surgery for tumors, vascular and lymphatic structures visualization. However, up to date, the combined use of fluorescence imaging and robotic technology has not been adequately investigated during lymphadenectomy in gastric cancer. | Jacopo Desiderio Stefano Trastulli AlessANDro Gemini Domenico Di Nardo Giorgio Palazzini Amilcare Parisi Vito D'ANDrea | 2018 | Chinese Journal of Cancer Research2018，30，5： | 3 |
| 4 | Long-term survival of patients with stage Ⅱ and Ⅲgastric cancer who underwent gastrectomy with inadequate nodal assessment显示文摘BACKGROUND Gastric cancer is an aggressive disease with frequent lymph node(LN)involvement.The NCCN recommends a D2 lymphadenectomy and the harvesting of at least 16 LNs.This threshold has been the subject of great debate,not only for the extent of surgery but also for more appropriate staging.The reclassification of stage IIB through IIIC based on N3b nodal staging in the eighth edition of the American Joint Committee on Cancer(AJCC)staging system highlights the efforts to more accurately discriminate survival expectancy based on nodal number.Furthermore,studies have suggested that pathologic assessment of 30 or more LNs improve prognostic accuracy and is required for proper staging of gastriccancer.AIM To evaluate the long-term survival of advanced gastric cancer patients who deviated from expected survival curves because of inadequate nodal evaluation.METHODS Eligible patients were identified from the Surveillance,Epidemiology,and End Results database.Those with stage II-III gastric cancer were considered for inclusion.Three groups were compared based on the number of analyzed LNs.They were inadequate LN assessment(ILA,<16 LNs),adequate LN assessment(ALA,16-29 LNs),and optimal LN assessment(OLA,≥30 LNs).The main outcomes were overall survival(OS)and cancer-specific survival.Data were analyzed by the Kaplan-Meier product-limit method,log-rank test,hazard risk,and Cox proportional univariate and multivariate models.Propensity score matching(PSM)was used to compare the ALA and OLA groups.RESULTS The analysis included 11607 patients.Most had advanced T stages(T3=48%;T4=42%).The pathological AJCC stage distribution was IIA=22%,IIB=18%,IIIA=26%,IIIB=22%,and IIIC=12%.The overall sample divided by the study objective included ILA(50%),ALA(35%),and OLA(15%).Median OS was 24 mo for the ILA group,29 mo for the ALA group,and 34 mo for the OLA group(P<0.001).Univariate analysis showed that the ALA and OLA groups had better OS than the ILA group[ALA hazard ratio(HR)=0.84,95%confidence interval(CI):0.79-0.88,P<0.001 and OLA HR=0.73,95%CI:0.68-0.79,P<0.001].The OS outcome was confirmed by multivariate analysis(ALA HR=0.68,95%CI:0.64-0.71,P<0.001 and OLA:HR=0.48,95%CI:0.44-0.52,P<0.001).A 1:1 PSM analysis in 3428 patients found that the OLA group had better survival than the ALA group(OS:OLA median=34 mo vs ALA median=26 mo,P<0.001,which was confirmed by univariate analysis(HR=0.81,95%CI:0.75-0.89,P<0.001)and multivariate analysis:(HR=0.71,95%CI:0.65-0.78,P<0.001).CONCLUSION Proper nodal staging is a critical issue in gastric cancer.Assessment of an inadequate number of LNs places patients at high risk of adverse long-term survival outcomes. | Jacopo Desiderio Andrea Sagnotta Irene Terrenato Eleonora Garofoli Claudia Mosillo Stefano Trastulli Federica Arteritano Federico Tozzi Vito D'Andrea Yuman Fong Yanghee Woo Sergio Bracarda Amilcare Parisi | 2021 | World Journal of Gastrointestinal Surgery2021，13，11： | 2 |
| 5 | Differentiated pediatric thyroid cancer : corre- lates with adult disease, controversies in treatment显示文摘 | Parisi MT Mankoff D | 2007 | Semin Nucl Med2007，37，： | 1 |
| 6 | Modeling of Counter Current Mov- ing Bed Gas-Solid Reactor Used in Direct Reduction of Iron Ore显示文摘 | Parisi D R Laborde M A | 2004 | Chemical Engineering Journal2004，104，1： | 1 |
| 7 | Vascular dementia in a population-based autopsy study显示文摘 | KNOPMAN D S PARISI J E BOEVE B F | 2003 | Arch Neurol2003，60，4： | 1 |
| 8 | Assessment of left ventricular ejection fraction and volumes by real-time, 2 dimensional echocardiography: comparison of cineangiographic and radionuclide techniques显示文摘 | FOLLAND E D PARISI A F MOYNIHAN P F | 1979 | Circulation1979，60，： | 1 |
| 9 | Influence of nanomorphology on the photovoltaic action of polymerfullerene composites 显示文摘 | Chirvase D Parisi J Hummelen J C | 2004 | Nanotechnology2004，15，9： | 1 |
| 10 | Forecasting Gold Price Changes:Rolling and Recursive Neural Network Models显示文摘 | PARISI A PARISI F DIAZ D | 2007 | Journal of Multinational Financial Management2007，18，47： | 1 |
| 11 | Differentiated pediatric thyroid cancer: correlates with adult disease,controversies in treatment显示文摘 | Parisi MT Mankoff D | 2008 | Semin Nucl Med2008，37，5： | 1 |
| 12 | Efficient, diode-pumped Tm^3+:BaY2F8 vibronic laser 显示文摘 | CORNACCHIA F PARISI D BERNARDINI C | 2004 | Opt Express2004，12，9： | 1 |
| 13 | Influence of process variables on the modelling and design of a rotating biological surface显示文摘 | Borghi M D Palazzi E Parisi F | 1985 | Water Research?1985，19，5： | 1 |
| 14 | Global epidemiology of psoriasis:a systematic review of incidence and prevalence显示文摘 | Parisi R Symmons D Griffiths C | 2013 | J Invest Dermatol2013，133，2： | 1 |
| 15 | Microscopic dynamics of pedestrian evacuation 显示文摘 | D R Parisi C O Dorso | 2005 | Physica A (S0031-8914)2005，3，： | 1 |
| 16 | A comparison of polyglycolic acid versus type 1 collagen bioabsorbable nerve conduits in a rat model:an alternative to autografting显示文摘 | Waitayawinyu T Parisi D M Miller B | 2007 | J Hand Surg Am2007，32，10： | 1 |
| 17 | Levetiracetam in childhood epilepsy 显示文摘 | Verrotti A D Adamo E Parisi P | 2010 | Paediatr Drugs2010，12，3： | 1 |
| 18 | Differentiated pediatric thyroid cancer:cor-relates with adult disease,controversies in treatment显示文摘 | Parisi MT Mankoff D | | 0，，： | 1 |
| 19 | Simple and rapid tec- hnique for monitoring the quality of meningococcal polysac- charides by high performance size-exclusion chromatography 显示文摘 | von Hunolstein C Parisi L Bottaro D | 2003 | J Biochem Biophys Methods2003，56，13： | 1 |
| 20 | Differentiated pediatric thyroid canc- er: correlates with adult disease, controversies in treatment 显示文摘 | Parisi MT Mankoff D | 2007 | Semin Nucl Med2007，37，5： | 1 |
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