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| 1 | Moving forward in the treatment of cholangiocarcinoma显示文摘Despite being the second most frequent primary liver tumor in humans,early diagnosis and treatment of cholangiocarcinoma(CCA)are still unsatisfactory.In fact,survival after 5 years is expected in less than one fourth of patients diagnosed with this disease.Rare incidence,late appearance of symptoms and heterogeneous biology are all factors contributing to our limited knowledge of this cancer and determining its poor prognosis in the clinical setting.Several efforts have been made in the last decades in order to achieve an improved classification/understanding with regard to the diverse CCA forms.Location within the biliary tree has helped to distinguish between intrahepatic,perihilar and distal CCA types.Sequence analysis contributed to identifying several characteristic genetic aberrations in CCA that may also serve as possible targets for therapy.Novel findings are expected to significantly improve the management of this malignancy in the near future.In this changing scenario our review focuses on the current and future strategies for CCA treatment.Both systemic and surgical treatments are discussed in detail.The results of the main studies in this field are reported,together with the ongoing trials.The current findings suggest that an integrated multidisciplinary approach to this malignancy would be helpful to improve its outcome. | Tommaso M Manzia Alessandro Parente Ilaria Lenci Bruno Sensi Martina Milana Carlo Gazia Alessandro Signorello Roberta Angelico Giuseppe Grassi Giuseppe Tisone Leonardo Baiocchi | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 6 |
| 2 | Numericaland experimental investigation of a mild combustion burner 显示文摘 | Galletti Chiara Parente Alessandro Tognotti Leonardo | 2007 | Combustion and Flame2007，151，4： | 1 |
| 3 | Assessment of advanced age candidates for liver transplantation warrants more caution显示文摘For patients with fulminant liver failure and end-stage liver disease,liver transplantation remains the only effective treatment.Over the years,as a result of the ageing population,the average age of liver transplant donors and recipients has increased and currently about one quarter of patients receiving transplantation in the United States are above the age of 65.Recently,a study reported that patients aged 65 years or older had lower one-year survival compared to a younger cohort.Herein,we express our opinion about this interesting publication. | Alessandro Parente Vincenzo Ronca | 2022 | World Journal of Transplantation2022，12，2： | 0 |
| 4 | Prophylactic drains in totally laparoscopic distal gastrectomy:are they always necessary?显示文摘Prophylactic drains have always been a useful tool to detect early complications and prevent postoperative fluid collections,particularly in gastrointestinal surgery.Recently,the utilization of such drains has been debated,due to mounting evidence that they could be harmful rather than beneficial.Based on recent published articles,Liu et al reported that the routine use of prophylactic drains in total laparoscopic distal gastrectomy might not be necessary for all patients.Herein,we express our opinion regarding this interesting publication. | Tommaso Maria Manzia Alessandro Parente Roberta Angelico | 2022 | World Journal of Gastroenterology2022，28，3： | 0 |
| 5 | Routine utilization of machine perfusion in liver transplantation:Ready for prime time?显示文摘The last decade has been notable for increasing high-quality research and dramatic improvement in outcomes with dynamic liver preservation.Robust evidence from numerous randomized controlled trials has been pooled by meta-analyses,providing the highest available evidence on the protective effect of machine perfusion(MP)over static cold storage in liver transplantation(LT).Based on a protective effect with less complications and improved graft survival,the field has seen a paradigm shift in organ preservation.This editorial focuses on the role of MP in LT and how it could become the new“gold standard”.Strong collaborative efforts are needed to explore its effects on long-term outcomes. | Alessandro Parente Keyue Sun Philipp Dutkowski AM James Shapiro Andrea Schlegel | 2024 | World Journal of Gastroenterology2024，30，11： | 0 |
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