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| 1 | 甲状腺影像报告和数据系统在超声检查甲状腺结节中的应用显示文摘目的探讨甲状腺影像报告和数据系统(thyroid imaging reporting and data system,TI-RADS)在超声检查甲状腺结节中的诊断价值。方法收集292例(423个)甲状腺结节患者的超声资料,以组织病理学结果为参照标准,采用TI-RADS分级诊断标准进行回顾性评价。结果 423个甲状腺结节中,TI-RADS分级为1-5级者其恶性结节所占百分率分别为0(0/129)、6.3%(11/176)、33.3%(10/30)、86.8%(46/53)和100%(35/35)。对甲状腺良性结节超声检查TI-RADS分级的灵敏度、特异度、正确率、阳性预测值和阴性预测值分别为96.3%(309/321)、83.3%(85/102)、93.1%(394/423)、94.8%(309/326)和87.6%(85/97),阳性似然比、阴性似然比及Youden指数分别为5.77、0.04和79.6%。TI-RADS分级的良、恶性结节在形态、边界、内部回声、回声质地、内部构成和钙化灶方面所占比例的差异均有统计学意义(P〈0.001)。结论在甲状腺结节的超声检查中,应用TI-RADS分级诊断标准对临床诊断和治疗具有重要的指导价值。 | 马步云 Parajuly Shyam Sundar 彭玉兰 时莹瑜 | 2011 | 中国普外基础与临床杂志2011，18，8： | 50 |
| 2 | 甲状腺乳头状癌的超声造影表现及其病理基础显示文摘目的探讨甲状腺乳头状癌的超声造影表现及其病理基础。方法对72例甲状腺结节患者进行常规超声和彩色多普勒超声检查,将TI-RADS≥3级的86个结节进行超声造影(CEUS)检查,经过手术和病理证实均为甲状腺乳头状癌;分析结节及甲状腺的CEUS表现,术后结节及甲状腺的病理进行CD34免疫组织化学染色。结果 86个结节的Adler血流分级分别为:0级26个,Ⅰ级34个,Ⅱ级23个,Ⅲ级3个。CEUS增强强度为低增强71个,等增强12个,高增强3个。结节与周围组织的平均强度、峰值强度、曲线下面积和CD34计数的差异有统计学意义(P<0.001),均明显低于周围组织。结论甲状腺乳头状癌的CEUS增强强度以低增强为主,其病理基础是与周围组织的微血管密度差异。 | 马步云 金亚 Parajuly Shyam Sundar 赵海娜 姜勇 周洁宏 | 2014 | 四川大学学报(医学版)2014，45，6： | 27 |
| 3 | 结节性筋膜炎的组织病理学分型及其超声表现显示文摘目的分析结节性筋膜炎的组织病理学分型及其相应二维及彩色多普勒超声声像图特征,探讨超声诊断结节性筋膜炎的价值。方法分析27例经手术病理证实的结节性筋膜炎患者的二维和彩色多普勒超声声像图特征及与其组织病理学分型的相关性。结果结节性筋膜炎超声声像图表现多样,共有特征为皮下或肌层内弱回声团块,病变多数小于3 cm。不同组织病理学分型的超声表现具有一定特征。按照病变部位可分为皮下型、筋膜型及肌内型,其中皮下型多与深筋膜关系密切;筋膜型具有特征性的沿浅筋膜和皮下脂肪小叶的纤维间隔伸展,呈'星状'突起的超声表现。根据病变结构不同可分为黏液型、细胞型和纤维型,黏液型团块内部可有小片状无回声区,边缘有血流;细胞型团块内部及边缘有血流,且边缘血流明显,而纤维型无明显血流。结论不同分型结节性筋膜炎具有一定特征;二维及彩色多普勒超声可作为结节性筋膜炎诊断的重要辅助检查。 | 张静漪 邱逦 Shyam Sundar Parajuly | 2011 | 中国医学影像技术2011，27，4： | 15 |
| 4 | 男性乳腺发育症的超声表现和诊断评估显示文摘目的了解男性乳腺发育症的年龄特征和超声图像表现。方法回顾性分析我院近10年经病理证实和临床随访诊断的1618男性乳腺发育症患者的临床、超声和病理资料。结果 1618例患者年龄呈双峰分布,发病高峰为16~20岁,其次为36~40岁。其声像图表现可分为结节型(41.9%)、树根型(11.6%)和类女性乳腺型(46.5%);手术组83例腺体层厚度(12.2±4.3)mm,与非手术组1535例腺体层厚度(8.3±4.8)mm比较差异有统计学意义(P<0.05),超声诊断男性乳腺发育症的敏感性为92.0%,特异性为94.7%,准确性为93.3%。结论超声测量男性乳腺腺体厚度是临床治疗的客观依据,超声检查可作为首选。 | 赵海娜 彭玉兰 Parajuly SS 骆洪浩 马步云 | 2012 | 临床超声医学杂志2012，14，6： | 14 |
| 5 | 多中心研究:弹性应变率比值对弹性评分法评估乳腺病灶良恶性的辅助价值探讨显示文摘目的探讨弹性成像应变率比值对改良弹性评分法评估乳腺良恶性病灶的辅助价值。方法通过对多中心收集的已行常规超声检查和弹性成像检查的846例患者(1071个病灶)超声影像资料进行回顾性分析,结合病理结果,评价应变率比值法对改良弹性评分法对乳腺良恶性病灶评估的辅助价值。结果512例恶性病灶的应变率比值为8.1±5.9,559例良性病灶的应变率比值为2.7±1.4,其差异有统计学意义(P〈0.001)。当应变率比值法诊断界点为3.03时,敏感性为81.6%,特异性为89.7%,准确性为81.7%,阳性预测值为80.2%,阴性预测值为84.2%。弹性评分法与应变率比值法ROC曲线下的面积(AUC)分别为0.862、0.865(P=0.622)。对于3~4分病灶弹性评分法与应变率比值法的AUC分别为0.629、0.711(P=0.020)。结论本研究中,改良弹性评分法与应变率比值法总体上具有相同的诊断表现,但对于3~4分的病灶,应变率比值法具有更高的诊断效能,对于弹性评分法正确诊断乳腺病灶具有一定的辅助价值。 | 欧冰 吴嘉仪 周薪传 姚继祎 梁铭 罗葆明 智慧 彭玉兰 Shyam Sunder Parajuly 王怡 许萍 柳莉莎 郝翼 肖莹 刘守军 李靖 吴长君 姜玉新 | 2017 | 中华超声影像学杂志2017，26，10： | 12 |
| 6 | 滑膜肉瘤的二维及彩色多普勒超声特征显示文摘目的探讨滑膜肉瘤的二维及彩色多普勒声像图特征。方法回顾性分析26例经手术病理证实的滑膜肉瘤患者的超声声像图特征。结果 26例滑膜肉瘤中,17例发生于中青年,二维超声显示均未累及关节腔,表现为弱回声团块,其中20例内部回声不均匀,19例伴液化,7例伴钙化;血流分级:0级5例,Ⅰ级1例,Ⅱ级7例,Ⅲ级13例。15例位于关节旁,与11例非关节旁病灶在深度、最大径、边界、形态、血流信号等方面的差异均无统计学意义(P均>0.05)。20例病变体积较大,与6例体积较小者在病变位置、形态、内部回声及血流信号方面的差异均有统计学意义(P均<0.05)。结论滑膜肉瘤的超声表现具有一定特征性,有助于提高诊断准确率。 | 唐远姣 冷钱英 Parajuly Shyam Sundar 邱逦 | 2014 | 中国医学影像技术2014，30，2： | 10 |
| 7 | 超声引导下乳腺肿瘤穿刺活检术的护理配合流程显示文摘近年来,乳腺疾病的发病率呈上升趋势,乳腺癌的高发病率及年轻化,严重威胁女性的身体和心理健康。由于乳腺肿瘤病理性质的判定,对选择不同的治疗方案和外科术式具有重要的临床意义比。目前,对乳腺肿瘤多采用高频超声引导下粗针穿刺活检术(ultrasound—guidedpuncturebiopsy,UPB), | 梁丽 彭玉兰 Parajuly Shyam Sundar 李伟 | 2013 | 护士进修杂志2013，28，5： | 9 |
| 8 | Antioxidant activity and phenol and flavonoid contents of eight medicinal plants from Western Nepal显示文摘OBJECTIVE: The purpose of this study was to evaluate the antioxidant activity, phenolic and flavonoids contents of selected medicinal plants form the Western region of Nepal.METHODS: The antioxidant activity of selected medicinal plants were determined by using 2, 2-diphenyl-1-picrylhydrazyl radical scavenging activity; total ferric ion reducing ability through spectroscopic analysis. The content of total phenols was determined using Folin-Ciocalteu reagent, whereas Aluminum chloride colorimetric method was used for flavonoid determination.RESULTS: Extracts of Syzygium Operculatus(87%),Astilbe Rivularis(83%) and Mallotus Philippnensis(88%) showed significant free radical scavenging activity with effective concentration(EC50) close to that of ascorbic acid. Syzygium Operculatus(96%),Astilbe Rivularis(97%) and Mallotus Philippnensis(97%) had potent reducing power in concentration dependent fashion. Those plant extract with higher free radical scavenging and ferric reducing effect also showed the greater content of both phenols and flavonoids, suggesting the correlation between polyphenolic content and antioxidant activity. Those plant extracts which showed better antioxidant activity assays, also demonstrated higher total phenol and flavonoid contents. These three plants showed the presence of higher amount of phenols and flavonoids.CONCLUSION: This study may provide the scientific basis for the traditional use of those plants and may provide valuable idea for further research. | Lalita Subedi Sunita Timalsena Pabitra Duwadi Ritu Thapa Anita Paudel Kalpana Parajuli | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 8 |
| 9 | Diagnostic value of contrast enhanced ultrasound for splenic artery complications following acute pancreatitis显示文摘AIM:To assess the value of contrast-enhanced ultrasound(CEUS)in diagnosing splenic artery complications(SACs)after acute pancreatitis(AP).METHODS:One hundred and eighteen patients with AP were enrolled in the study.All patients were examined by CEUS and contrast-enhanced computed tomography(CECT).CECT was accepted as a gold standard for the diagnosis of SACs in AP.The diagnostic accuracy of splenic CEUS and pancreatic CEUS was compared with that of CECT.Splenic infarction was the diagnostic criterion for splenic artery embolism and local dysperfusion of the splenic parenchyma was the diagnostic criterion for splenic arterial stenosis.The incidence of splenic sub-capsular hemorrhage,splenic artery aneurysms,and splenic rupture was all lower than that of SACs.RESULTS:Nine patients were diagnosed as having SACs after AP by CECT among the 118 patients.The patients with SACs were diagnosed with severe acute pancreatitis(SAP).Among them,6 lesions were diagnosed as splenic artery embolism,5 as splenic artery aneurysms,and 1 as splenic arterial stenosis.No lesion was diagnosed by pancreatic CEUS and 5 lesions were diagnosed by splenic CEUS.By splenic CEUS,4 cases were diagnosed as splenic artery embolism and 1 as splenic arterial stenosis.The accuracy of splenic CEUS in diagnosis of SACs in SAP was 41.7%(5/12),which was higher than that of pancreatic CEUS(0%).CONCLUSION:Splenic CEUS is a supplementary method for pancreatic CEUS in AP patients,which can decrease missed diagnosis of SACs. | Di-Ming Cai Shyam Sundar Parajuly Wen-Wu Ling Yong-Zhong Li Yan Luo | 2014 | World Journal of Gastroenterology2014，20，4： | 8 |
| 10 | 乳腺脓肿行超声引导抽脓灌洗术的围手术期护理显示文摘乳腺脓肿是乳腺外科常见疾病,病人多是产后哺乳的妇女,以初产妇更为多见,常由于急性乳腺炎处理不当或不及时所致[1]。乳腺脓肿一经确诊,必须采取手术引流。传统的外科切开引流创伤大,换药时疼痛剧烈,治疗时间长,愈合后瘢痕明显,严重者可导致乳房变形,故难以被患者接受[2]。近年来,随着高频超声设备的不断发展,超声引导穿刺抽脓灌洗术因其经济、微创、有效率高及术后几乎无疤痕、美观性高等优点,逐渐在临床上得到广泛应用[3]。2009年1月~2013年1月,我院应用该技术治疗乳腺脓肿30例,效果满意。现将围手术期护理报告如下。 | 梁丽 马步云 Parajuly Shyam Sundar 陈启锐 于波洋 | 2014 | 护士进修杂志2014，29，5： | 6 |
| 11 | Utilising digital health to improve medication-related quality of care for hypertensive patients:An integrative literature review显示文摘BACKGROUND Hypertension or high blood pressure is considered as a significant contributor and risk factor to many serious conditions,approximately 1.13 billion people have hypertension globally.However,the integrated technologies can upscale health provisions and improve the effectiveness of the healthcare system.WHO has recommended that the digital health interventions(DHIs)and the Health System Challenges should be used in tandem in addressing health.AIM To summarise the outcomes from a range of research which investigated the use of DHI to improve the medication-related quality of care(MRQOC)for hypertensive patients.METHODS An integrative literature review was undertaken in October 2019 using the Medline,Cumulative Index of Nursing and Allied Health Literature,and Scopus databases for publications in English with no date limit.RESULTS In total,18433 participants were included in this review from 28 studies meeting the eligibility criteria.There were 19 DHI identified within eight countries:Australia,Canada,India,South Korea,Lebanon,Pakistan,the United Kingdom,and the United States of America.The DHI were provided as community-based,clinical-based and home-based program through mobile phone,mobile health system,short message service,and telehealth,digital medicine,and online healthcare(web-based).The mean age of participants was 59 ranging from 42 to 81 years with an average mean systolic blood pressure of 143.3 mmHg at baseline,ranging from 129.0 mmHg to 159.0 mmHg.The proportion of male participants ranged from 13.9%to 92.0%.Eighteen interventions showed evidence of reduction in blood pressure and improvement of self-management in relation to medication adherence and blood pressure control.The reduction of systolic blood pressure ranged between 1.9 mmHg and 26.0 mmHg,with a mean of 10.8 mmHg.The digital health was found positively associated with the MRQOC for hypertensive patients such as improvement in medication adherence and medication management;better blood pressure control;maintaining followups appointment and self-management;increasing access to healthcare particularly among patients living in rural area;and reducing adverse events.However,some interventions found no significant effect on hypertensive care.The follow up duration varied between 2 mo and 18 mo with an average attrition rate of 10.1%,ranging from 0.0%to 17.4%.CONCLUSION Utilising digital health innovation for hypertensive care in different settings with tailored interventions positively impacted on MRQOC leading to an improvement of patient outcomes and their quality of life.Nevertheless,inconclusive findings were found in some interventions,and inconsistent outcomes between DHI were noted.A future research and evidence-based DHI for hypertension or chronic diseases should be developed through the evidenceto-decision framework and guidelines. | Kannikar Wechkunanukul Daya Ram Parajuli Mohammad Hamiduzzaman | 2020 | World Journal of Clinical Cases2020，8，11： | 3 |
| 12 | Liver Transplantation in the Management of Hepatic Epithelioid Hemangioendothelioma: A Single-Center Experience and Review of the Literature显示文摘 | N. Agrawal S. Parajuli P. Zhao R. Satoskar J. Laurin N. Azumi C. Matsumoto K. Shetty | 2011 | Transplantation Proceedings2011，，7： | 2 |
| 13 | Histopathological characteristics and causes of kidney graft failure in the current era of immunosuppression显示文摘BACKGROUND The histopathological findings on the failing kidney allograft in the modern era is not well studied. In this study, we present our experience working with kidney transplant recipients with graft failure within one year of the biopsy.AIM To report the histopathological characteristics of failed kidney allografts in the current era of immunosuppression based on the time after transplant, cause of the end-stage renal disease and induction immunosuppressive medications.METHODS In a single-center observational study, we characterized the histopathological findings of allograft biopsies in kidney transplant recipients with graft failure within one year after the biopsy.RESULTS We identified 329 patients with graft failure that met the selection criteria between January 1, 2006 and December 31, 2016. The three most common biopsy findings were interstitial fibrosis and tubular atrophy(IFTA, 53%), acute rejection (AR, 43%) and transplant glomerulopathy(TG, 33%). Similarly, the three most common causes of graft failure based on the primary diagnosis were AR(40%),TG(17%), and IFTA(13%). Most grafts failed within two years of post-transplant(36%). Subsequently, approximately 10%-15% of grafts failed every two years: >2-4 years(16%), > 4-6 years(13%), > 6-8 years(11%), > 8-10 years(9%) and > 10 years(16%). AR was the most common cause of graft failure in the first six years(48%), whereas TG was the most prevalent cause of graft failure after 6 years(32%) of transplant.CONCLUSION In the current era of immunosuppression, AR is still the most common cause of early graft failure, while TG is the most prevalent cause of late graft failure. | Sandesh Parajuli Fahad Aziz Neetika Garg Sarah E Panzer Emily Joachim Brenda Muth Maha Mohamed Justin Blazel Weixiong Zhong Brad C Astor Didier A Mandelbrot Arjang Djamali | 2019 | World Journal of Transplantation2019，9，6： | 2 |
| 14 | Flt3 ligand enhances the immunogenicity of a gag-based HIV-1 vaccine 显示文摘 | Pisarev VM Parajuli P Mosley RL | 2000 | Int J Immunopharmacol2000，22，11： | 2 |
| 15 | Impacts and challenges of United States medical students during the COVID-19 pandemic显示文摘The delivery of medical student education has changed rapidly during the coronavirus disease 2019(COVID-19)pandemic.Students in their pre-clinical years have transitioned to online courses and examinations.Students in their clinical years are not permitted on clinical rotations,and face uncertainties in career exploration and the residency application process.Medical students in all stages of training are volunteering and helping their communities.The future presence of COVID-19 throughout the United States is unknown,and medical students are eager to return to their training.This paper outlines current challenges in medical student education and the various responses that have been adopted.We also discuss possible future directions for students through involvement in telemedicine,outpatient clinic visits,and non-respiratory inpatient care tasks as adequate personal protective equipment,COVID-19 testing,and resources become more widely available. | Stacey Rolak Alexis M Keefe Emily L Davidson Prabesh Aryal Sandesh Parajuli | 2020 | World Journal of Clinical Cases2020，8，15： | 2 |
| 16 | Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury显示文摘 | Patil NK Parajuli N MacMillan-Crow LA | 2014 | AmJ Physiol Renal Physiol2014，306，7： | 1 |
| 17 | Phosphatase PTEN is critically involved in post-myocardial infarction remodeling through the Akt/interleukin-10 signaling pathway显示文摘 | Parajuli N Yuan Y Zheng X | 2012 | Basic Res Cardiol2012，107，2： | 1 |
| 18 | Reduction and accumulation of Au(Ⅲ) by grape waste:A kinetic approach显示文摘 | Parajuli D Adhikari C R Kawakita H | 2008 | Reactive & Functional Polymers2008，68，11： | 1 |
| 19 | Production and functions of IL-33 in the central nervous system显示文摘 | Yasuoka S Kawanokuchi J Parajuli B | 2011 | Brain Res2011，1385，： | 1 |
| 20 | Chestnut pellicle for the recovery of gold显示文摘 | Parajuli D Adhikari C R Kawakita H | 2009 | Bioresource Technology2009，100，2： | 1 |
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