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| 1 | Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: Phenotype-genotype correlations显示文摘AIM: To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with CD.METHODS: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included. DNA was screened for possible NOD2/CARD15 mutations by denaturing highperformance liquid chromatography (confirmed by direct sequencing). TLR4 D299G was tested by PCR-RFLP.RESULTS: NOD2/CARD15 mutations were found in 185patients (35.1%) and in 33 controls (16.5%, P<0.0001).SNP8/R702W (10.8% vs 6%, P = 0.02), SNP13/3020insC (19.4% vs 5%, P<0.0001) and exon4 R703C (2.1% vs 0%, P = 0.02) mutations were more frequent in CD, while the frequency of SNP12/G908R was not increased. The frequency of TLR4 D299G was not different (CD: 9.9% vscontrols: 12.0%). Variant NOD2/CARD15 allele was associated with an increased risk for CD (ORhet = 1.71,95%CI = 1.12-2.6, P= 0.0001, ORtwo-riskalleles = 25.2,95%CI = 4.37- , P<0.0001), early disease onset (carrier:26.4 years vs non-carrier: 29.8 years, P = 0.0006), ileal disease (81.9% vs 69.5%, OR = 1.99, 95%CI = 1.29-3.08,P = 0.02, presence of NOD2/CARD15 and TLR4: 86.7% vs64.8%), stricturing behavior (OR = 1.69, 95%CI = 1.13-2.55,P = 0.026) and increased need for resection (OR=1.71,95%CI: 1.13-2.62, P= 0.01), but not with duration, extraintestinal manifestations, familial disease or smoking. TLR4exhibited a modifier effect: age of onset in wt/TLR4 D299G carriers: 27.4 years vs NOD2mut/TLR D299G: 23 years (P= 0.06), in NOD2mut/wt: 26.7 years.CONCLUSION: These results confirm that variant NOD2/CARD15 (R702W, R703C and 3020insC) alleles are associated with earlier disease onset, ileal disease,stricturing disease behavior in Hungarian CD patients. In contrast, although the frequency of TLR4 D299G polymorphism was not different from controls, NOD2/TLR4mutation carriers tended to present at earlier age. | Peter Laszlo Lakatos Laszlo Lakatos Ferenc Szalay Claudia Willheim-Polli Christoph (O|¨)sterreicher Zsolt Tulassay Tamas Molnar Walter Reinisch Janos Papp Gyula Mozsik Hungarian IBD Study Group Peter Ferenci | 2005 | World Journal of Gastroenterology2005，11，10： | 14 |
| 2 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 3 | mieroRNA modulation of circadian-clock period and entrainment显示文摘 | Cheng H Y Papp J W Varlamova O Dziema H Russell B Cur- fman J P | 2007 | Neuron2007，54，： | 1 |
| 4 | Distinct isoforms of the cofactor BAG-1 differentially affect Hsc70 chaperone function 显示文摘 | Liiders J Demand J Papp O | 2000 | J Biol Chem2000，275，14： | 1 |
| 5 | Distinct isoforms of the cofactor BAG-1 differentially affect Hsc70 chapomne function显示文摘 | Luders J Demand J Papp O | 2000 | J Biol Chem2000，275，14： | 1 |
| 6 | MicroRNA modulation of circadian clock period and entrainment显示文摘 | Cheng HY Papp JW Varlamova O | 2007 | Neuron2007，54，： | 1 |
| 7 | microRNA modulation of circadian-clock period and entrainment显示文摘 | PAPP J W VARLAMOVA O | 2007 | Neuron2007，54，： | 1 |
| 8 | microRNA modulation of circadian-clock period and entrainment 显示文摘 | Cheng HY Papp JW Varlamova O | 2007 | Neuron2007，54，5： | 1 |
| 9 | Comparative inves- tigation of behavioral, neurotoxicological, and immuno- toxicological indices in detection of subacute com- bined exposure with methyl parathion and propomar in rats 显示文摘 | Institoris L Papp A Siroki O | 2004 | Ecotoxicology and Environmental Safety2004，57，3： | 1 |
| 10 | Correlation between structure and gas chromatographic behaviour of nitrogen-containing heterocyclic compounds显示文摘 | Papp O Szasz G Orfi L | 1991 | J Chromatogr1991，537，： | 1 |
| 11 | A new β-glucosidase gene from the zygomycete fungus Rhizomucor miehei显示文摘 | Takó M Tóth A Nagy L G Krisch J Vágv(o)lgyi C Papp T | | 0，，01： | 1 |
| 12 | microRNA modulation of circadian-clock period and entrainment显示文摘 | CHENG H Y PAPP J W VARLAMOVA O | 2007 | Neu- ron2007，54，5： | 1 |
| 13 | MicroRNA modulation of circadian-clock period and entrainment显示文摘 | Cheng HYM Papp JW Varlamova O | 2007 | Neuron2007，54，5： | 1 |
| 14 | Phylogeny and character evolution of the coprinoid mushroom genus Parasola as inferred from ISU and ITS data显示文摘 | Nagy L Kocsubé S Papp T Vágv(o)lgyi Cs | | 0，，22： | 1 |
| 15 | mieroRNA modulation of circadian-clock period and entrainment 显示文摘 | Cheng HY Papp JW Varlamova O | 2007 | Neuron2007，54，5： | 1 |
| 16 | MicroRNA modulation of circadian-clock period and entrainment显示文摘 | CHENG H Y PAPP J W VARLAMOVA O | 2007 | Neuron2007，54，5： | 1 |
| 17 | microRNA modulation of circadian-clock period and entrainment显示文摘 | Cheng HY Papp JW Varlamova O | 2007 | Neuron2007，54，5： | 1 |
| 18 | microRNA modulation of circadian-clock period and entrainment 显示文摘 | Cheng HY Papp JW Varlamova O | 2007 | Neuron2007，54，5： | 1 |
| 19 | SO2 adsorption and thermal evolution on clean and oxygen precovered Pt 显示文摘 | STREBER R PAPP C LORENZ M P A HOFERT O DARLATT E BAYER A DENECKE R STEINROCK H P | 2010 | Chemical Physics Letters2010，494，456： | 1 |
| 20 | Comparative investigation of behavioral, neurotoxicological, and immunotoxicological indices in detection of subacute combined exposure with methyl parathion and propoxur in rats显示文摘 | Institoris L Papp A Siroki O | 2004 | Ecotoxicol Environ Saf2004，57，： | 1 |
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