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| 1 | LINX^(■) reflux management system to bridge the “treatment gap” in gastroesophageal reflux disease: A systematic review of 35 studies显示文摘BACKGROUND Gastroesophageal reflux disease(GERD) occurs when the reflux of stomach contents causes troublesome symptoms and/or complications. When medical therapy is insufficient, surgical therapy is indicated and, until now, Laparoscopic fundoplication(LF) constitutes the gold-standard method. However, magnetic sphincter augmentation(MSA) using the LINX^® Reflux Management System has recently emerged and disputes the standard therapeutic approach.AIM To investigate the device’s safety and efficacy in resolving GERD symptoms.METHODS This is a systematic review conducted in accordance to the PRISMA guidelines.We searched MEDLINE, Clinicaltrials.gov, EMBASE, Cochrane Central Register of Controlled Trials CENTRAL databases from inception until September 2019.RESULTS Overall, 35 studies with a total number of 2511 MSA patients were included and analyzed. Post-operative proton-pump inhibitor(PPI) cessation rates reached 100%, with less bloating symptoms and a better ability to belch or vomit in comparison to LF. Special patient groups(e.g., bariatric or large hiatal-hernias)had promising results too. The most common postoperative complication was dysphagia ranging between 6% and 83%. Dilation due to dysphagia occurred in 8% of patients with typical inclusion criteria. Esophageal erosion may occur in up to 0.03% of patients. Furthermore, a recent trial indicated MSA as an efficient alternative to double-dose PPIs in moderate-to-severe GERD.CONCLUSION The findings of our review suggest that MSA has the potential to bridge the treatment gap between maxed-out medical treatment and LF. However, further studies with longer follow-up are needed for a better elucidation of these results. | Dimitrios Schizas Aikaterini Mastoraki Eleni Papoutsi Vassilis G Giannakoulis Prodromos Kanavidis Diamantis Tsilimigras Dimitrios Ntourakis Orestis Lyros Theodore Liakakos Dimitrios Moris | 2020 | World Journal of Clinical Cases2020，8，2： | 3 |
| 2 | Associations between serum relaxin 2, aneurysm formation/size and severity of atherosclerosis: a preliminary prospective analysis显示文摘(RL2 ) 浆液松弛激素 2 是对各种各样的机关和系统起作用的多种的荷尔蒙,特别地心血管的系统。尽管 RL2 似乎是氮的一氧化物的合成到 upregulate (没有) 并且它在动脉粥样硬化和动脉瘤形成的角色上的矩阵 metalloproteinase (MMP )-2 和 -9, 水流文学是少见的。这研究的目的是与一个动脉的动脉瘤以及在动脉粥样硬化患者病人在病人调查浆液 RL2 的层次,并且相关他们与他们的相关脉管的疾病的严厉。53 个题目的一个总数在这研究被注册:37 个病人被安排经历外科:为动脉粥样硬化患者疾病(ATH ) 的不同形式的 21 个病人,为一个动脉的动脉瘤(AA ) 的 16 个病人,为经历时间的动脉活体检视(标签) 的 6 个病人,和 10 个健康献血者(HBD ) 担任了控制组。RL2 用 enzymelinked immunosorbent 试金被测量。RL2 在与 ATH 相比的 AA 病人是显著地更高的(P < 0.01 ) ,标签(P < 0.001 ) 并且 HBD (P < 0.01 ) 。没有重要差别在 ATH 和标签组之间被发现(P > 0.05 ) 。另外, ATH 和 AA 病人进一步基于他们的疾病的严厉被细分。浆液 RL2 日益增多地与动脉的动脉瘤在病人被增加,显示出与 aneurysmatic 膨胀的尺寸的一种积极关系。由对比, RL2 水平是相反地与动脉粥样硬化患者疾病的严厉有关。有合并一张一致学习人口的一个更大的队的研究被保证验证我们的结果并且使这些过程的机械学的背景清楚些。 | Konstantinos PAPOUTSIS Alkistis KAPELOUZOU Diamantis I TSILIMIGRAS Nikolaos PATELIS Georgios KOUVELOS Dimitrios SCHIZAS Ioannis KARAVOKYROS Sotirios GEORGOPOULOS | 2018 | Acta Pharmacologica Sinica2018，39，7： | 2 |
| 3 | The transcription factor Proxl is a marker for lymphatic endothelial cells in normal and diseased human tissues显示文摘 | Wilting J Papoutsi M Christ B | 2002 | FASEB J2002，16，10： | 1 |
| 4 | Interaction of rat tumor cells with blood vessels and lymphatics of the avian chorioallantoic membrane显示文摘 | Papoutsi M Sleeman JP Wilting J | 2001 | Microsc Res Tech2001，55，2： | 1 |
| 5 | Micellezation of Two Triquar Ternary Ammonium Surfactants in Aqueous Solution显示文摘 | Zana R Levy H Papoutsi D | 1995 | Langmuir1995，11，10： | 1 |
| 6 | BRCA-1 promoter hypermethylation and silencing induced by the aromatic hydrocarbon receptor-ligand TCDD are prevented by resveratrol in MCF-7 cells显示文摘 | Papoutsis AJ Borg JL Selmin OI | | 0，，10： | 1 |
| 7 | Effect of ellagic acid on the expression of human telomerase reverse transcriptase(h TERT)α+β+transcript in estrogen receptor-positive MCF-7 breast cancer cells显示文摘 | Strati A Papoutsi Z Lianidou E | 2009 | Clin Biochem2009，42，13： | 1 |
| 8 | Induction of the blood-brain barrier marker neurothelin/HT7 in endothelial cells by a variety of tumors in chick embryos显示文摘 | Papoutsi M Kurz H Schachtele C | 2000 | Histochem Cell Biol2000，113，2： | 1 |
| 9 | User selection and resource allocation algorithm with fairness in MISO-OFDMA显示文摘 | Papoutsis V D Fraimis I G Kotsopoulos S A | 2010 | IEEE Communications Letters2010，14，5： | 1 |
| 10 | Endogenous origin of the lymphatics in the avian chorioallantoic membrane显示文摘 | Papoutsi M Tomarev SI Eichmann A | 2001 | Dev Dyn2001，222，2： | 1 |
| 11 | Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) α+β+transcript in estrogen receptor-positive MCF-7 breast cancer cells显示文摘 | Strati A Papoutsi Z Lianidou E | | 0，，13： | 1 |
| 12 | Fairnessaware user selection and resource allocation in MISOOFDMA显示文摘 | Papoutsis V D Fraimis I G Kotsopoulos S A | 2010 | European Transactions on Telecommunications2010，21，6： | 1 |
| 13 | Micellezation of two triquaternary ammonium surfactants in aqueous solution显示文摘 | Zana R Levy H Papoutsi D | 1995 | Langmuir1995，11，10： | 1 |
| 14 | The transcription factor Proxl is a marker for lymphatic endothelial cells in normal and diseased human tissues显示文摘 | Witting J Papoutsi M Christ B | 2002 | FASEB J2002，16，10： | 1 |
| 15 | Development and validation of a gas chromatography mass spectrometric method for the determination of sildenafil and desmethyI-sildenafil in whole blood 显示文摘 | Papoutsis I Nikolaou P Athanaselis S | 2011 | J Sep Sei2011，34，21： | 1 |
| 16 | Mucocele of the vermiform appendix misdiagnosed as an adnexal mass on transvaginal sonography显示文摘 | Papoutsis D Protopappas A Belitsos P | | 0，，： | 1 |
| 17 | Induction of the blood-brain barrier marker neurothelin/ HT7 in endothelial cells by a variety of tumors in chick embryos显示文摘 | Papoutsi M Kurz H Schachtelec C | 2000 | Histochem Cell Biol2000，113，2： | 1 |
| 18 | Micellization of two triquaternary ammonium surfactants in aqueous solution 显示文摘 | Zara R Levy H Papoutsi D | 1995 | Langmuir1995，11，： | 1 |
| 19 | An audit of using the H Pipelle for endometrial sampling at outpa- tient hysteroscopy and literature review comparison with the Pipelle de Cornier显示文摘 | Daceop MD Moustafa M Papoutsis D | 2012 | Eur J Obstet Gyneeol Reprod Biol2012，165，2： | 1 |
| 20 | An audit of using the H Pipelle for endometrial sampling at outpatient hysteroscopy and literature review comparison with the Pipelle de Cornier显示文摘 | Dacco' MD Moustafa M Papoutsis D | 2012 | Eur J Obstet Gynecol Reprod Biol2012，165，2： | 1 |
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