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| 1 | Fertility preservation in female cancer patients:a single center experience显示文摘Advances in cancer treatment allow women to be cured and live longer. However, the necessary chemotherapy and radiotherapy regimens have a negative impact on future fertility. Oncofertility has emerged as a new interdisciplinary field to address the issue of gonadotoxicity associated with cancer treatment and to facilitate fertility preservation, including oocyte and ovarian tissue cryopreservation. These fertility issues are often inadequately addressed, and referral rates to oncofertility centers are low. The aim of this study was to report the 3-year experience of the San Raffaele Oncofertility Unit. A total of 96 patients were referred to the Oncofertility Unit for evaluation after the diagnosis of cancer and before gonadotoxic treatment between April 2011 and June 2014. Of the 96 patients, 30(31.2%) were affected by breast cancers, 20(20.8%) by sarcomas, 28(29.2%) by hematologic malignancies, 13(13.5%) by central nervous system cancers, 3(3.1%) by bowel tumors, 1(1.0%) by Wilms' tumor, and 1(1.0%) by a thyroid tumor; 47(49.0%) were referred for oocyte cryopreservation before starting chemotherapy, 20(20.8%) were referred for ovarian tissue cryopreservation, and 29(30.2%) were not recruited. The mean time between the patients' counseling and oocyte retrieval was 15 days(range, 2–37 days). The mean time between the laparoscopic surgery and the beginning of treatment was 4 days(range, 2–10 days). The number of patients who were referred increased over time, whereas the rate of patients who were not recruited decreased, showing an improvement in referrals to the Oncofertility Unit and in the patients' counseling and understanding. Our results indicate that an effective multidisciplinary oncofertility team is necessary for prompt referrals and treatment. | Cristina Sigismondi Enrico Papaleo Paola Viganò Simona Vailati Massimo Candiani Jessica Ottolina Valentina E. Di Mattei Giorgia Mangili | 2015 | Chinese Journal of Cancer2015，34，1： | 7 |
| 2 | Cabergoline influences ovarian stimulation in hyperprolactinaemib patients with polyeystic ovary syndrome显示文摘 | PapaleoE Doldi N De Santis L | 2001 | Hum Reprod2001，16，11： | 1 |
| 3 | Genetic dissection of the role of catechol-O-methyltransferasc in cognition and stress reactivity in mice显示文摘 | Papaleo F Crawley JN Song J | 2008 | Neuroscience2008，28，： | 1 |
| 4 | Proinflammatory genetic profiles in subjects with history of ischemic stroke显示文摘 | Flex A Gaetani E Papaleo P | 2004 | Stroke2004，35，： | 1 |
| 5 | Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways显示文摘 | Papaleo F Yang F Garcia S | 2012 | Mol Psychiatry2012，17，1： | 1 |
| 6 | Mouse models of genetic effects on cognition : relevance to schizophrenia 显示文摘 | Papaleo F Lipska BK Weinberger DR | 2012 | Neuropharma- cology2012，62，3： | 1 |
| 7 | Neurotoxic Effects of Aluminium Among Foundry Workers and Alzheimer’s Disease显示文摘 | Salvatore Polizzi Enrico Pira Mauro Ferrara Massimiliano Bugiani Andrea Papaleo Roberto Albera Silvana Palmi | 2002 | Neurotoxicology2002，，6： | 1 |
| 8 | Flexibility of cold- and heat-adapted subtilisin-like serine proteinases evaluated with fluorescence quenching and molecular dynamics 显示文摘 | Sigtryggsd6ttir R A Papaleo E Sigd6ur H | 2014 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics2014，1844，4： | 1 |
| 9 | Identification of species of the Burkholderia eepacia complex by sequence analysis of the hisA gene显示文摘 | Papaleo MC Perrin E Maida I | 2010 | J Med Microbiol2010，59，10： | 1 |
| 10 | The combination of genetic vari- ants of the FSHB and FSHR genes affects serum FSH in women of re- productive age 显示文摘 | La Marca A Papaleo E Alviggi C | 2013 | Human reproduction (Oxford England)2013，28，5： | 1 |
| 11 | Fresh blastocyst transfer as a clinical approach to overcome the detrimental effect of progesterone elevation at hCG triggering:a strategy in the context o{ the Italian law 显示文摘 | Corti L Papaleo E Pagliardini L | 2013 | Eur J Obstet Gynecol Reprod Biol2013，171，： | 1 |
| 12 | Identification of species of the Burkhalderia cepacia complex by sequence analysis of the hisA gene显示文摘 | Papaleo MC Perrin E Maida I | 2010 | J Ned Microbial2010，59，10： | 1 |
| 13 | Basal progesterone level as the main determinant of progesterone elevation on the day of hCG triggering in controlled ovarian stimulation cycles显示文摘 | Papaleo E Corti L Vanni VS | 2014 | Arch Gynecol Obstet2014，290，： | 1 |
| 14 | Dynamics fingerprint and inherent asymmetric flexibility of a cold-adapted homodimeric enzyme, a case study of the vibrio alkaline phosphatase 显示文摘 | Papaleo E Renzetti G Invernizzi G | 2013 | Biochimica et Biophysica Acta (BBA) - General Subjects2013，1830，4： | 1 |
| 15 | Randomized,double blind placebo-controlled trial:effects of myo-inositol on ovarian function and metabolic factors in women with PCOS显示文摘 | Gerli S Papaleo E Ferrari A | 2007 | Eur Rev Med Pharmacol Sci2007，11，5： | 1 |
| 16 | Chronic exposure and the cardiovascular system in aircraft pilotes显示文摘 | Tomei F Papaleo B Baccolo TP | 1996 | Med Lay1996，87，5： | 1 |
| 17 | Identification of species of the Burkholderia cepacia complex by sequence analysis of the hi- sA gene 显示文摘 | Papaleo MC Perrin E Maida I | 2010 | J Med Microbio12010，59，10： | 1 |
| 18 | Myo-inositol in patients with polycystic ovary syndrome:a novel method for ovulation induction显示文摘 | Papaleo E Unfer V Baillargeon JP | 2007 | Gynecol Endocrinol2007，23，12： | 1 |
| 19 | DVB-S2 LDPC Decoding Using Robust Check Node Update Approxima- tions 显示文摘 | PAPAHARALABOS S PAPALEO M TAKIS P | 2008 | IEEE Transactions On Broadcasting2008，54，1： | 1 |
| 20 | Chronic exposure and the cardiovas- cular system in aricaft Pilotes显示文摘 | Tomei F Papaleo B Baccolo TP | 1996 | Med Lay1996，87，： | 1 |
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