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| 1 | Reduction of Oxidative Stress and Inflammation by Blunting Daily Acute Glucose Fluctuations in Patients With Type 2 Diabetes显示文摘 | Maria Rosaria Rizzo Michelangela Barbieri Raffaele Marfella Giuseppe Paolisso | 2012 | Diabetes Care2012，，10： | 3 |
| 2 | Successful multidisciplinary clinical approach and molecular characterization by whole transcriptome sequencing of a cardiac myxofibrosarcoma: A case report显示文摘BACKGROUND Cardiac tumors are rare and complex entities.Surgery represents the cornerstone of therapy,while the role of adjuvant treatment remains unclear and,in case of relapse or metastatic disease,the prognosis is very poor.Lack of prospective,randomized clinical trials hinders the generation of high level evidence for the optimal diagnostic workup and multimodal treatment of cardiac sarcomas.Herein,we describe the multidisciplinary clinical management and molecular characterization of a rare case of cardiac myxofibrosarcoma in an elderly woman.CASE SUMMARY A 73-year-old woman presented signs and symptoms of acute left-sided heart failure.Imaging examination revealed a large,left atrial mass.With suspicion of a myxoma,she underwent surgery,and symptoms were promptly relieved.Histology showed a cardiac myxofibrosarcoma,a rare histotype of cardiac sarcoma.Eight months later,disease unfortunately relapsed,and after a multidisciplinary discussion,a chemotherapy with doxorubicin and then gemcitabine was started,achieving partial radiologic and complete metabolic response,which was maintained up to 2 years and is still present.This report is focused on the entire clinical path of our patient from diagnosis to follow-up,through surgery and strategies adopted at relapse.Moreover,due to their rarity,very little is known about the molecular landscape of myxofibrosarcomas.Thus,we also performed and described preliminary genome analysis of the tumor tissue to get further insight on mechanisms involved in tumor growth,and to possibly unveil new clinically actionable targets.CONCLUSION We report a case of cardiac myxofibrosarcoma that achieved a very good prognosis due to an integrated surgical,cardiac and oncologic treatment strategy. | Maristella Saponara Valentina Indio Carmine Pizzi Elena-Daniela Serban Milena Urbini Annalisa Astolfi Pasquale Paolisso Sofia Martin Suarez Margherita Nannini Davide Pacini Valentina Agostini Ornella Leone Valentina Ambrosini Giuseppe Tarantino Stefano Fanti Fabio Niro Francesco Buia Domenico Attinà Maria Abbondanza Pantaleo | 2019 | World Journal of Clinical Cases2019，7，19： | 2 |
| 3 | A high concentration of fasting plasma non -esterified fatty acids is a risk factor for the development of NIDDM 显示文摘 | Paolisso G Tataranni PA Foley JE | 1995 | Diabetologia1995，38，： | 1 |
| 4 | Primary and secondary prevention of atherosclerosis:is there a role for antiox-idants显示文摘 | Paolisso G Esposito R D′Alessio MA Barbieri M | | 0，，04： | 1 |
| 5 | Relevance of Plasma Obestatin and Early Arteriosclerosis in Patients with Type 2 Diabetes Mellitus显示文摘 | Peng-ying Gu Dong-mei Kang Wei-dong Wang Yan Chen Zhi-hong Zhao Hui Zheng Shan-dong Ye Giuseppe Paolisso | 2013 | Journal of Diabetes Research2013，，： | 1 |
| 6 | Insulin resistance in cognitive impairment:the InCHIANTI study显示文摘 | Geroldi C Frisoni GB Paolisso G | 2005 | Arch Neurol2005，62，7： | 1 |
| 7 | ACE gene polymorphism and insulin action in older subjects and healthy centenarians显示文摘 | Paolisso G Tagliamonte MR De Lucia D | 2001 | J Am Geriatr Soc2001，49，： | 1 |
| 8 | Changes in glucose turnover pa- rameters and improvement of glucose oxidation after 4 week magne- sium administration in eldly non-insulin-dependent(type 2) diabetic pa- tients 显示文摘 | Paolisso G Scheen A Cozzolino D | 1994 | Journal of Clinical Endocrinology and Metabolism1994，，78： | 1 |
| 9 | Cardiovascular risk in type 2 diabeties and pharmacological regulation of mealtime glucose excursions显示文摘 | Paolisso G Rizzo MR Barbieri M | 2003 | Diabetes Metab2003，29，： | 1 |
| 10 | Oxidative stress and diabetic vascular complications显示文摘 | Giugliano D Paolisso G Ceriello A | 1996 | Diabetes Care1996，19，： | 1 |
| 11 | Chronic Vitamin E Administration Improves Brachial Reactivity and Increases Intracellular Magnesium Concentration in Type II Diabetic Patients 显示文摘 | G Paolisso MR Tagliamonte M Barbieri | 2000 | J Clin Endocrinol Metabol2000，85，1： | 1 |
| 12 | Oxidative stress and diabetic vascular complications显示文摘 | GIUGLIANO D CERIELLO A PAOLISSO G | 1996 | Diabetes Care1996，19，： | 1 |
| 13 | The BBparaoxonase genotype is associated with impaired brachial reactivity after acute hypertriglyceridemia in healthy subjects显示文摘 | Paolisso G Manzella D Tagliamonte MR | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 14 | Cardiac autonomic activity and Type Ⅱ diabetes mellitus显示文摘 | Manzella D Paolisso G | 2005 | lin Sci(Lond)2005，108，2： | 1 |
| 15 | A multicen- tre, randomized study of telmisartan versus carvedilol for prevention of atrial fibrillation recurrence in hypertensive patients显示文摘 | Galzerano D Di Michele S Paolisso G | 2012 | J Renin Angiotensin Aldosterone Syst2012，13，4： | 1 |
| 16 | Pulsatile insulin de-livery has greater metabolic effects than continuous hormone adm in istration in man:importance of pulse frequency显示文摘 | PAOLISSO G SCHEEN AJ GIUGLIANOD | 1991 | J Clin Endocrinol Metab1991，72，3： | 1 |
| 17 | Pharmacologic doses of vitamin E improve insulin action in healthy subjects and noninsulin-dependent diabetic patients显示文摘 | Paolisso G D' Amore A Giugliano D | 1993 | Am J Clin Nutr1993，57，： | 1 |
| 18 | Effects of simvastatin and atorvastatin adminstration on insulin resistance and respiratory patient in aged dyslipidemic non-insulin dependent diabetic patients显示文摘 | PAOLISSO G BARBAGALLO M PETRELLA G | 2000 | Atherosclerosis2000，150，2： | 1 |
| 19 | Effect of metformin on food intake in obese subjects显示文摘 | Paolisso G Amato L Eccellente R | 1998 | Eur J Clin Invest1998，28，6： | 1 |
| 20 | Pulsatile in sulin delivery has greatmetabolic effects than con tinulus homon e adm in istration in man importance of pulse frequency 显示文摘 | Paolisso G Scheen A J Gingliano D | 1991 | J Clin Endocrinol Metab1991，72，3： | 1 |
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