|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Anti-angiogenesis and anti-inflammatory effects of Moringa oleifera leaf extract in the early stages of streptozotocin-induced diabetic nephropathy in rats显示文摘Objective:To investigate the effect of Moringa oleifera leaf extract on angiogenesis and inflammatory process in a rat model of streptozotocin-induced diabetic nephropathy.Methods:Four weeks after a single injection of 50 mg/kg streptozotocin,rats were treated with 100 or 200 mg/kg/day Moringa oleifera leaf extract,1 mg/kg/day dapagliflozin,or a combination of Moringa oleifera leaf extract and dapagliflozin for further eight weeks.Renal function,kidney histology,and gene expression were evaluated at the end of the experiment.Results:Renal function of diabetic rats was significantly impaired as evidenced by increased blood urea nitrogen,albuminuria,24-h proteinuria,and high creatinine clearance which indicated glomerular hyperfiltration.In addition,diabetic rats showed an increase in gene expressions of vascular endothelial growth factor-A(VEGF-A),angiopoietin-2(Ang2),the Ang2/Ang1 ratio,tumor necrosis factor-α,interleukin-1βand monocyte chemoattractant protein-1.Immunohistochemical staining demonstrated a significant increase in the density of glycoprotein CD34.Moringa oleifera leaf extract markedly improved all renal dysfunction markers and modulated the upregulated expression of angiogenic factors and inflammatory genes.Conclusions:Moringa oleifera leaf extract could suppress abnormal angiogenesis and inflammatory processes possibly by downregulating gene expression of angiogenesis factors and proinflammatory cytokines. | Ruttiya Thongrung Laddawan Senggunprai Wiphawi Hipkaeo Panot Tangsucharit Patchareewan Pannangpetch | 2022 | Asian Pacific Journal of Tropical Biomedicine2022，12，7： | 2 |
| 2 | Single dose dexamethasone prophylaxis of postembolisation syndrome after chemoembolisation in hepatocellular carcinoma patient:A randomised,double-blind,placebo-controlled study显示文摘BACKGROUND Even in the immuno-oncology era,transcatheter arterial chemoembolisation(TACE)is the most effective way to treat intermediate stage hepatocellular carcinoma(HCC).Postembolisation syndrome(PES)is the most common side effect from TACE and there is still no standard prevention guideline.AIM To evaluate the efficacy of single dose intravenous dexamethasone regimen to prevent PES after TACE among patients with HCC.METHODS This study enrolled patients with HCC who had eligible indication for TACE without macrovascular invasion/extrahepatic metastasis.Patients were randomly assigned to either an intravenous single dose of dexamethasone 8 mg or placebo one hour before TACE.The primary outcome was a negative result of PES at 48 h after TACE,which was defined as score<2 of Southwest Oncology Group toxicity coding criteria using fever,nausea,vomiting and pain to calculated.And the secondary end point was duration of admission between two groups.RESULTS One hundred patients were randomly assigned 1:1.Under intention-to-treat analysis,49 patients were randomly assigned to the dexamethasone and 51 to the placebo groups.Both groups were similar for baseline characteristics.The negative PES rate was significantly higher in the dexamethasone group than in the placebo group(63.3%vs 29.4%;P=0.005).Mean Southwest Oncology Group toxicity coding PES was 2.14(95%CI:1.41-2.8)vs 3.71(95%CI:2.97-4.45)between the dexamethasone and placebo groups,respectively.Cumulative incidence of fever was significantly lower in dexamethasone group with P<0.001,pain,nausea and vomiting were also lower in the dexamethasone group compared with the placebo group(P=0.16,P=0.11,and P=0.49).The dexamethasone regimen was generally well tolerated by patients with HCC patients including those with hepatitis B virus infection and well-controlled diabetes mellitus.CONCLUSION Single dose dexamethasone was effective at preventing PES among patients with HCC treated with TACE.The study showed no adverse events of special interest related to dexamethasone. | Panot Sainamthip Chutcharn Kongphanich Naiyarat Prasongsook Sakkarin Chirapongsathorn | 2021 | World Journal of Clinical Cases2021，9，30： | 2 |
| 3 | Inactivation of the RNase activity of glycoprotein E^rns of classical swine fever virus results in a cytopat hogenic virus 显示文摘 | Hulst M M Panote F E Hoekman A | 1998 | Journal of Virology1998，72，： | 1 |
| 4 | Microtrap modulated flame ionization detector for on-line monitoring of methane显示文摘 | Chongdee Thammakhet Panote Thavarungkul Roman Brukh Somenath Mitra Proespichaya Kanatharana | 2005 | Journal of Chromatography A2005，，： | 1 |
| 5 | Semi disposable reactor biosensors for detecting carbamate pesticides in water显示文摘 | Siriwan Suwansa - ard Proespichaya Kanatharana Panote Thavarungkul | 2005 | Bisensors and Bioelectronics2005，21，： | 1 |
| 6 | Inactivation of the RNase activity of glycoprotein Erns of classical swine fever virus results in a cytopathogenic virus显示文摘 | Hulst M M Panote F E Hoekman A | 1998 | J Virol1998，72，： | 1 |
| 7 | Inactivation of the RNase activity of glycoprotein Erns of classical swine fever virus results in a cytopathogenic virus 显示文摘 | Hulst M M Panote F E Hoekman A | 1998 | Journal of Virology1998，72，： | 1 |
| 8 | Inactivation of the RNase activity of glycoprotein Erns ol classical swine fever virus results in a cytopathogenic virus 显示文摘 | Hulst M M Panote F E Hoekman A | 1998 | J Virol1998，72，： | 1 |
| 9 | Fabrication of Nanoporous Copper Film for Electrochemical DetectionofGlucose 显示文摘 | Sirilak S Panote T Chongdee T | 2009 | Electroanalysis2009，21，21： | 1 |
| 10 | Cost effective passive sampling device for volatile organic compounds monitoring显示文摘 | Vilailuk M Panote T | 2006 | Atmospheric Environment2006，40，： | 1 |
| 11 | Comparative study of controlled pore glass,silica gel and Poraver(R) for the immobilization of urease to determine urea in a flow injection conductimetric biosensor system显示文摘 | Warakom L Panote T Proespichaya K | 2004 | Biosensors and Bioelectronics2004，，19： | 1 |
| 12 | Detecting penicillin G in milk with impedimetric label-free immunosensor显示文摘 | Panote Thavarungkul Supaporn Dawan Proespichaya Kanatharana Punnee Asawatreratanakul | 2007 | Biosensors and Bioelectronics2007，，5： | 1 |
| 13 | Inactivation of the Rnase activity of glycoprotein E rns of classical swine fever virus results in a cytopathogenic virus显示文摘 | Hulst M M Panote F E Hoekman A | 1998 | J Virol1998，72，： | 1 |
| 14 | Inactivation of the RNase activity of glycoprotein E^rns of classical swine fever virus results in a cytopathogenic virus显示文摘 | Hulst M M Panote F E Hoekman A ct al | 1998 | J Virol1998，72，： | 1 |
| 15 | Production of a polyclonal antibody to the VP26 nucleocapsid protein of white spot syndrome virus (wssv) and its use as a biosensor显示文摘白点症候群病毒(WSSV ) 是在在整个世界的有教养的虾的高死亡的一个主要原因。VP26 是被假定在认出它的宿主帮助并且帮助病毒的 nucleocapsid 向宿主细胞的原子核移动的 WSSV 的结构的蛋白质之一。这个工作的目的是对 VP26 生产 polyclonal 抗体并且把它用作一个生物传感器。recombinant VP26 蛋白质(rVP26 ) 在 E 被生产。coli (BL21 ) ,净化并且使用了使兔子免疫获得 polyclonal 抗体。西方的污点分析证实抗血清有特定的 immunoreactivity 到 WSSV 的 VP26。这 VP26 抗血清用作察觉到的表面被使不能调动到一个金电极上在一个流动注射系统下面检测 WSSV。阻抗变化在实时面对 VP26 被监视。生物传感器的敏感在 WSSV 的 160160000 个拷贝的线性范围,显示它对 WSSV 的分析好、敏感。生物传感器的特性被没有阻抗变化甚至在高集中被检测是否使用黄头病毒(YHV ) 的观察支持。这个生物传感器可以被使用在虾耕作期间在水里监视 WSSV 的数量。 | Suchera LOYPRASERT-THANANIMIT Akrapon SALEEDANG Proespichaya KANATHARANA Panote THAVARUNGKUL Wilaiwan CHOTIGEAT | 2012 | Frontiers of Chemical Science and Engineering2012，6，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员