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| 1 | Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle显示文摘Whether glucose is predomi nantly metabolized via oxidative phosphorylati on or glycolysis differs between quiesce nt versus proliferating cells,iincluding tumor cells.However,how glucose metabolism is coordinated with cell cycle in mammalian cells remains elusive.Here,we report that mammalian cells predominantly utilize the tricarboxylic acid(TCA)cycle in G1 phase,but prefer glycolysis in S phase.Mechanistically,coupling cell cycle with metabolism is largely achieved by timely destruction of IDH1/2,key TCA cycle enzymes,in a Skp2-dependent manner.As such,depleting SKP2 abolishes cell cycle-dependent fluctuation of IDH1 protein abundance,leading to reduced glycolysis in S phase.Furthermore,elevated Skp2 abundance in prostate cancer cells destabilizes IDH1 to favor glycolysis and subsequent tumorigenesis.Therefore,our study reveals a mechanistic link between two cancer hallmarks,aberrant cell cycle and addiction to glycolysis,and provides the underlying mechanism for the coupling of metabolic fluctuation with periodic cell cycle in mammalian cells. | Jing Liu Yunhua Peng Le Shi Lixin Wan Hiroyuki Inuzuka Jiangang Long Jianping Guo Jinfang Zhang Min Yuan Shuangxi Zhang Xun Wang Jing Gao Xiangpeng Dai Shozo Furumoto Lijun Jia Pier Paolo Pandolfic John M.Asara William G.Kaelin Jr. Jjankang Liu Wenyi Wei | 2021 | Cell Research2021，31，1： | 2 |
| 2 | A physiological strain index to evaluate heat stress显示文摘 | Moran D S Shitzer A Pandolf K B | 1998 | Am J Physiol1998，275，44： | 1 |
| 3 | An environment stress index (ESI) as a substitute for the wet bulb globe temperature (WBGT)显示文摘 | MORAN D S PANDOLF K B SHAPIRO Y | 2001 | Journal of Thermal Biology2001，，26： | 1 |
| 4 | Dietary fibre binding of bile acid through mineral supplementation显示文摘 | Pandolf J Clydesdale F M | 1992 | J Food Sci1992，57，5： | 1 |
| 5 | Mechanisms of thermal acclimation to exercise and heat显示文摘 | E R Nadel K B Pandolf M F Roberts | | 0，，04： | 1 |
| 6 | Hypohydration and heat acclimation: Plasma renin and aldosterone during exercise显示文摘 | Francesconi R P Sawka M N Pandolf K B | 1983 | J Appl Physiol1983，55，6： | 1 |
| 7 | Auxiliary cooling: Comparison of air - cooled vs water - cooled vests in hot - dry and hot -wet environments显示文摘 | Shapiro Y Pandolf K B Sawka M N | 1982 | Aviat Space Environ Med1982，53，8： | 1 |
| 8 | Heat acclimation and decline in sweating during humidity transients 显示文摘 | Gonzalez R R Pandolf K B Gagge A P | 1974 | J Appl Physiol1974，36，： | 1 |
| 9 | Physiological responses of men and women to humid and dry heat 显示文摘 | Shapiro Y Pandolf K B Avellini B A | 1980 | Journal of Applied Physiology: Respiratory Envi- ronmental and Exercise Physiology1980，49，1： | 1 |
| 10 | Evaluation of the environmental stress index for physiological variables 显示文摘 | Moran DS Pandolf KB Shapiro Y | 2003 | J ThermalBid2003，28，： | 1 |
| 11 | Physiological responses of men and women to humid and dry heat显示文摘 | Shapiro Y Pandolf K B Avellini B A Pimental N A Goldman R F | 1980 | J Appl Physiol1980，49，： | 1 |
| 12 | Advances in the study and application of perceived exertion 显示文摘 | PANDOLF K B | 1983 | Exercise and sports science reviews1983，，11： | 1 |
| 13 | United States Army Research Institute of Environmental Medicine: War:fighter research focusing on the past 25 years 显示文摘 | Pandolf KB Francesconi R Sawka MN | 2011 | Adv Physiol Edue2011，35，4： | 1 |
| 14 | An environmental stress index(ESI) as a substitute for the wet bulb globe temperature (WBGT)显示文摘 | Moran D S Pandolf K B Shapiro Y | 2001 | Journal of Thermal Biology2001，26，： | 1 |
| 15 | Wet bulb globe temperature (WBGT) : To what extent is GT essential 显示文摘 | Moran D S Pandolf K B | 1999 | Aviation Space and Environmental Medicine1999，70，5： | 1 |
| 16 | Evaluation of the environmental stress index for physiological variables显示文摘 | Moran D S Pandolf K B Shapiro Y | 2003 | Journal of Thermal Biology2003，28，： | 1 |
| 17 | Heat acclimation and decline in sweating during humidity transients 显示文摘 | Gonzalez R R Pandolf K B Gagge A P | 1974 | Journal of Applied Physiology1974，36，4： | 1 |
| 18 | Perceived exertion associated with breathing hyperoxic mixtures during submaximal work 显示文摘 | ALLEN P D PANDOLF K B | 1977 | Medicine and science in sports1977，，9： | 1 |
| 19 | The tran- scription factor Pokemon:A new key player in cancer pathogenesis显示文摘 | MAEDA T HOBBS R M PANDOLF P P | 2005 | Cancer Research2005，65，19： | 1 |
| 20 | Differentiated Ratings of Perceived Exer- tion during Physical Exercise 显示文摘 | Pandolf KB | 1982 | Medicine and Sci- ence in Sports and Exercise1982，14，5： | 1 |
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