3篇
您的检索式：作者名="Pandi Peng"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration显示文摘The circadian clock participates in maintaining homeostasis in peripheral tissues,including intervertebral discs(IVDs).Abnormal mechanical loading is a known risk factor for intervertebral disc degeneration(IDD).Based on the rhythmic daily loading pattern of rest and activity,we hypothesized that abnormal mechanical loading could dampen the IVD clock,contributing to IDD.Here,we investigated the effects of abnormal loading on the IVD clock and aimed to inhibit compression-induced IDD by targeting the core clock molecule brain and muscle Arnt-like protein-1(BMAL1).In this study,we showed that BMAL1 KO mice exhibit radiographic features similar to those of human IDD and that BMAL1 expression was negatively correlated with IDD severity by systematic analysis based on 149 human IVD samples.The intrinsic circadian clock in the IVD was dampened by excessive loading,and BMAL1 overexpression by lentivirus attenuated compression-induced IDD.Inhibition of the RhoA/ROCK pathway by Y-27632 or melatonin attenuated the compression-induced decrease in BMAL1 expression.Finally,the two drugs partially restored BMAL1 expression and alleviated IDD in a diurnal compression model.Our results first show that excessive loading dampens the circadian clock of nucleus pulposus tissues via the RhoA/ROCK pathway,the inhibition of which potentially protects against compression-induced IDD by preserving BMAL1 expression.These findings underline the importance of the circadian clock for IVD homeostasis and provide a potentially effective therapeutic strategy for IDD. | Dong Wang Pandi Peng Michal Dudek Xueyu Hu Xiaolong Xu Qiliang Shang Di Wang Haoruo Jia Han Wang Bo Gao Chao Zheng Jianxin Mao Chu Gao Xin He Pengzhen Cheng Huanbo Wang Jianmin Zheng Judith A.Hoyland Qing-Jun Meng Zhuojing Luo Liu Yang | 2022 | Bone Research2022，10，2： | 2 |
| 2 | Decoding the annulus fibrosus cell atlas by scRNA-seq to develop an inducible composite hydrogel:A novel strategy for disc reconstruction显示文摘Low back pain is one of the most serious public health problems worldwide and the major clinical manifestation of intervertebral disc degeneration(IVDD).The key pathological change during IVDD is dysfunction of the annulus fibrosus(AF).However,due to the lack of an in-depth understanding of AF biology,the methods to reconstruct the AF are very limited.In this study,the mice AF cell atlas were decoded by single-cell RNA sequencing to provide a guide for AF reconstruction.The results first identify a new population of AF cells,fibrochondrocyte-like AF cells,which synthesize both collagen Ⅰ and collagen Ⅱ and are potential functional cells for AF reconstruction.According to the dual features of the AF extracellular matrix,a composite hydrogel based on the acylation of methacrylated silk fibroin with methacrylated hyaluronic acid was produced.To obtain the ability to stimulate differentiation,the composite hydrogels were combined with a fibrochondrocyte-inducing supplement.Finally,reconstruction of the AF defects,by the novel AF stem cell-loaded composite hydrogel,could be observed,its amount of chondroid matrices recovered to 31.7% of AF aera which is significantly higher than that in other control groups.In summary,this study decodes the AF cell atlas,based on which a novel strategy for AF reconstruction is proposed. | Han Wang Di Wang Beier Luo Dong Wang Haoruo Jia Pandi Peng Qiliang Shang Jianxin Mao Chu Gao Ye Peng Lu Gan Junjie Du Zhuojing Luo Liu Yang | 2022 | Bioactive Materials2022，7，8： | 1 |
| 3 | Nanoagent-based theranostic strategies against human coronaviruses显示文摘The emergence of human coronaviruses(HCoVs),especially the current pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),engender severe threats to public health globally.Despite the outstanding breakthrough of new vaccines and therapeutic medicines in the past years,HCoVs still undergo unpredictable mutations,thus demanding more effective diagnostic and therapeutic strategies.Benefitting from the unique physicochemical properties and multiple nano-bio interactions,nanomaterials hold promising potential to fight against various HCoVs,either by providing sensitive and economic nanosensors for rapid viral detection,or by developing translatable nanovaccines and broad-spectrum nanomedicines for HCoV treatment.Herein,we systemically summarized the recent applications of nanoagents in diagnostics and therapeutics for HCoV-induced diseases,as well as their limitations and perspectives against HCoV variants.We believe this review will promote the design of innovative theranostic nanoagents for the current and future HCoV-caused pandemics. | Tao Feng Chaofan Nie Pandi Peng Hui Lu Tengjiao Wang Peng Li Wei Huang | 2022 | Nano Research2022，15，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员