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| 1 | Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes显示文摘Macro and microvascular disease are the main cause of morbi-mortality in type 1 diabetes(T1DM).Although there is a clear association between endothelial dysfunction and atherosclerosis in type 2 diabetes,a cause-effect relationship is less clear in T1 DM.Although endothelial dysfunction(ED) precedes atherosclerosis,it is not clear weather,in recent onset T1 DM,it may progress to clinical macrovascular disease.Moreover,endothelial dysfunction may either be reversed spontaneously or in response to intensive glycemic control,long-term exercise training and use of statins.Acute,long-term and post-prandial hyperglycemia as well as duration of diabetes and microalbuminuria are all conditions associated with ED in T1 DM.The pathogenesis of endothelial dysfunction is closely related to oxidative-stress.NAD(P)H oxidase over activity induces excessive superoxide production inside the mitochondrial oxidative chain of endothelial cells,thus reducing nitric oxide bioavailability and resulting in peroxynitrite formation,a potent oxidant agent.Moreover,oxidative stress also uncouples endothelial nitric oxide synthase,which becomes dysfunctional,inducing formation of superoxide.Other important mechanisms are the activation of both the polyol and protein kinase C pathways as well as the presence of advanced glycation end-products.Future studies are needed to evaluate the potential clinical applicability of endothelial dysfunction as a marker for early vascular complications in T1 DM. | Marcello C Bertoluci Gislaine V Cé Antonio MV da Silva Marco V Wainstein Winston Boff Marcia Punales | 2015 | World Journal of Diabetes2015，6，5： | 5 |
| 2 | Clinical effectivenes- sand quality life conventional haemodialysis verus short daily haemo- dialysis: A systematic review 显示文摘 | Punal J Lema LV Sanhez-Guisande D | 2008 | Nephrol Dial Transplant2008，23，8： | 1 |
| 3 | An expert system for monitoring and diagnosis of anaerobic wastewater treatment plants显示文摘 | Punal A Rocca E | 2002 | Water Research2002，，16： | 1 |
| 4 | Three I patients with congenital unilateral faeialy due to CAw - 22q11 deletion 显示文摘 | Punal JE Siebert MF Angueira FB | 2001 | J Child Neurol2001，16，6： | 1 |
| 5 | Adcanced monitoring and control of anaerobic wastewater treatment plants: diagnosis and supervision by a fuzzybased expert system 显示文摘 | Punal A | 2001 | Water Science and Technology2001，43，7： | 1 |
| 6 | Appendiceal mucocele misdiagnosed with infected urachal cyst:a differential diagnosis to keep in mind显示文摘 | Pérez Fentes DA Cortegoso González M Punal Pereira A | 2009 | Actas Urológicas Espa?olas2009，，02： | 1 |
| 7 | Adcanced monitoring and control of anaerobic wastewater treatment plants: Diagnosis and supervision by a fuzzy based expert system 显示文摘 | Punal A | 2001 | Water Sic & Tech2001，43，7： | 1 |
| 8 | RET codon 634 mutations in multiple endocrine neoplasia type 2 :variable clinical features and clinical outcome 显示文摘 | Punales MK | 2003 | J Clin Endocrinol Metab2003，88，： | 1 |
| 9 | Clinical effectiveness and quality of life of conventional haemodialysis versus short daily haemodialysis: A systematic review 显示文摘 | Punal J Lema LV Sanhez-Guisande D | 2008 | Nephrol Dial Transplant2008，23，： | 1 |
| 10 | An Expert System for Monitoring and Diagnosis of Anaerobic Wastewater Treatment Plants显示文摘 | PUNAL A ROCCA E | | 0，，02： | 1 |
| 11 | An Expert System for Monitoring and Diagnosis of Anaerobic Wastewater Treatment Plants 显示文摘 | PUNAL A ROCCA E | 2002 | Water Research2002，，16： | 1 |
| 12 | An expert system for monitoring and diagnosis of anaerobic wastewater treatment plants 显示文摘 | PUNAL A ROCA E LEMA J M | 2002 | Water Research2002，36，10： | 1 |
| 13 | Clinical effective- ness and quality of life of conventional hemodialysis versus short daily hemodialysis:a systematic review显示文摘 | Punal J Lema LV Sanhez - Guisande D | 2008 | Nephrol Dial Trans- plant2008，23，8： | 1 |
| 14 | Influence of C: N ratio on the start-up of up-flow anaerobic filter reactors 显示文摘 | Punal A Trevisan M Rozzi A | 2000 | Wat Res2000，34，9： | 1 |
| 15 | Modular expert system for the diagnosis of operating conditions of industrial anaerobic digestion plants 显示文摘 | Lardon L Punal A Martinez J A | 2005 | Water Science and Technology2005，52，12： | 1 |
| 16 | Multi-fed upflow anaerobic filter development and features显示文摘 | PUNAL A MENDEZ R LEMA J M | 1998 | J Environ Eng1998，124，12： | 1 |
| 17 | Influence of C∶N Ratio on the start-Up of Up-Flow Anaerobic Filter Reactors显示文摘 | A Punal M Trrevisan etc | 2000 | Wat Res2000，34，9： | 1 |
| 18 | Characterization and comparison of biomass from single-and multi-fed upflow anaerobic filters显示文摘 | PUNAL A MENDEZ R LEMA J M | 1999 | Bioresource Technology1999，68，2： | 1 |
| 19 | Influence of C : N ratio on the start-up of up-flow anaerobic filter reactors 显示文摘 | Punal A Trevisan M Rozzi A | 2000 | Water Res2000，34，9： | 1 |
| 20 | An Expert System for Monitoring and Diagnosis of Anaerobic Wastewater Treatment Plants 显示文摘 | PUNAL A ROCCA E | 2002 | Water Research2002，，16： | 1 |
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