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| 1 | 急性心肌梗塞尿激酶临床应用研究(1138例)显示文摘为探讨急性心肌梗塞(AMI)静脉法应用国产尿激酶(UK)不同剂量的疗效和副作用,以及延迟用药的疗效。(1)对1023例发病6小时以内的AMI患者随机分为:低剂量组[1.7万U(2.2万IU)/kg]539例和高剂量组[2.3万U(3.0万IU)/kg]484例。两组血管再通率分别为67.3%和67.8%,4周病死率分别为9.5%和8.7%,各种严重并发症差异均无显著性,说明两组疗效相似,出血并发症在高剂量组略高于低剂量组,但差异无显著性。值得指出的是,在高剂量组有2例发生了致命性脑出血。认为1.7万U(2.2万IU)/kg是安全有效的剂量。(2)延迟治疗的效果,发病后6~12小时AMI患者115例[应用UK2.0万U(2.6万IU)/kg]与发病6小时内用药组相比:血管再通率低(40.0%对67.5%,P<0.001),4周病死率较高(13.9%对9.1%,但P>0.05);重度心力衰竭发生率也较高(13.0%对6.6%,P<0.02)。说明延迟治疗组疗效明显低于发病6小时内治疗者。 | ResearchGroupofNationalProject85-915-02-01(Correspondence:FuWaiHospi-tal,CAMS&PUMC,Beijing100037) | 1996 | 中华心血管病杂志1996，24，3： | 156 |
| 2 | 急性心肌梗死尿激酶溶栓治疗开始时间对疗效的影响显示文摘目的:为探讨治疗在急性心肌梗死(AMI)发病后各不同时间开始用尿激酶(静脉法)对疗效的影响。方法:37所协作医院收治的AMI患者1138例按统一的治疗方案应用尿激酶,血管再通采用统一的临床间接指标标准判定。比较发病后不同时间开始用药患者的血管再通率和4周病死率。结果:发病后2小时内、2~4小时内、4~6小时内和6~12小时开始用尿激酶的患者分别为128例、461例、434例和115例。其血管再通率分别为71.9%、70.1%、63.6%和40.0%;4周病死率分别为7.0%、6.5%、12.2%和13.9%。发病后2小时内和2~4小时内组血管再通率与4周病死率均无统计学差异,故合并为4小时内组,与4~6小时内组和6~12小时组比较,血管再通率(70.5%)都显著高于后两组,P均<0.001;4周病死率(6.6%)都明显低于后两组,P均<0.01。4~6小时内组与6~12小时组比较:血管再通率前者显著高于后者,P<0.001;4周病死率无显著性差异。 | Collaborative Research Group of National“Eighth Five year”Project(85 915 02 01) (Fu Wai Hospital,CAMS and PUMC,Beijing 100037) | 1996 | 中国循环杂志1996，11，7： | 47 |
| 3 | 全国第二次冠心病介入性治疗病例注册登记资料分析显示文摘目的 分析 1997年和 1998年我国冠心病介入性治疗发展趋势。方法 采用填写统一发放的表格的方法 ,收集 1997、1998两年各医院冠心病介入性治疗病例资料 ,进行回顾性分析。结果共注册经皮冠状动脉腔内成形术 (PTCA)病例总数 872 5例 ,来自全国范围内 75所医院 ,总成功数 83 69例 (95 9% )。其中 1997年 3 74 0例 ,成功 3 5 5 3例 (95 0 % ) ;1998年 4 985例 ,成功 4 816例 (96 6% )。共扩张病变 10 2 18处 ,成功 965 0处 ,病变成功率为 94 4 %。急性心肌梗死 (AMI)急诊PTCA 10 4 5例 ,成功10 0 1例 (95 8% )。全组患者发生重要并发症 95 9例 (11 0 % ) ,包括死亡 3 2例 (0 3 7% )。冠状动脉支架置入术 63 2 9例 ,共置入支架 774 8只 ,其中左冠状动脉主干置入支架 86只 (占 1 1% )。置入成功7677只 (99 1% )。发生重要并发症 5 10例 (8 1% ) ,包括死亡 2 5例 (0 4 0 % )。全部患者服用噻氯匹啶 ,其中 13 8例 (1 8% )发生粒细胞减少症。另外 ,注册登记冠状动脉斑块旋磨术 93例 (94支血管 ) ,成功率为 93 6%。结论 1997年和 1998年我国冠心病介入治疗例数有大幅度增长 ,两年内完成病例数远远超过过去 12年积累病例总数 ,成功率较过去有增加趋势 ,但地区间及医院间发展仍很不平衡。 | Section of Interventional Cardiology, Chinese Society of Cardiology, Chinese Medical Association, et al. (Correspondent: GAO Runlin. Fu Wai Hospital, PUMC & CAMS, Beijing 100037, China) | 2000 | 中华心血管病杂志2000，28，1： | 50 |
| 4 | Study on expresion of adherent proteins related to regulation of hematopoiesis in long-term cultured human bone marrow stromal cells显示文摘Studyonexpresionofadherentproteinsrelatedtoregulationofhematopoiesisinlongtermculturedhumanbonemarrowstromalcels.LiuJiewen,... | Liu Jiewen, Qi Shuling, E de Wynter, et al. Institute of Hematology, CAMS and PUMC, Tianjin 300020, China. | 1998 | Chinese Medical Journal1998，，2： | 8 |
| 5 | Activity of boanmycin against colorectal cancer显示文摘INTRODUCTIONBoanmycin (Bleomycin A6, BAM ), a newantitumor antibiotic, was isolated from manycomponents of bleomycin (BLM) produced bystreptomyces pingyangensis which were obtainedfrom a soil sample collected in Pingyang County,Zhejiang Province, China. Boanmycin has a similarchemical structure to that of BLM, but the terminalamine moiety is different[ 1]. | Yong Chuan Deng1 Yong Su Zhen2 Shu Zheng1 Yu Chuan Xue2 1Cancer Institute, Medical School, Zhejiang University, Hangzhou 310009, Zhejiang Province, China2Institute of Medicinal Biotechnology, CAMS & PUMC, Beijing 100050, China | 2001 | World Journal of Gastroenterology2001，7，1： | 5 |
| 6 | An Epidemiological Study of Knee Osteoarthritis.显示文摘2,063 adults people of a Beijing suburban village were surveyed for osteoarthritis of the knees. Questionnaire was completed in all. 799 (38.7% responded to have knee joint pain. 311 with knee joint pain and 212 without knee | Zhang Naizheng et al. PUMC Hospital. Beijing 100730 | 1995 | Chinese Medical Journal1995，，7： | 4 |
| 7 | INHIBITION OF FARNESYL PROTEIN TRANSFERASE AND P21^(RAS) MEMEBRANE ASSOCIATION BY D-LIMONENE IN HUMAN PANCREAS TUMOR CELLS IN VITRO显示文摘INTRODUCTIONOncogenicRasproteinsarecausalyimplicatedincertainhumanmalignancies.About50%ofhumancoloncarcinomasand90%ofpancre... | Chen Xiaoguang 1 (陈晓光),Yoshihisa Yano 2, Tadayoshi Hasuma 2, Toshiko Yoshimata 2, Wang Yinna 2 and Shuzo Otani 2 1Department of Pharmacology, Institute of Materia Medica, CAMS & PUMC, Beijing 100050 2Department of Biochemistry | 1999 | Chinese Medical Sciences Journal1999，14，3： | 3 |
| 8 | Immediate-early gene product ICP22 inhibits the trans-transcription activating function of P53-mdm-2显示文摘As a product of HSVI immediate-early gene, ICP22 is capable of interacting with various cellular tran-scriptive and regulatory molecules during viral infection so as to impact the normal cellular molecular mechanism. ICP22 expressed in transfected cells can push the cells’ entering into S phase with binding to mdm-1 promoter region and impact its trans-transcription activating effect by P53. Consequently, the MDM-2 binds to P53, and the degradation effects by the ubiquitous pathway are decreased, improving indirectly the P53 levels in cells and making the cells progress into the S phase. | GUO HongXiong, CUN Wei, LIU LongDing, WANG LiChun, ZHAO HongLing, DONG ChengHong & LI QiHan Department of Viral Immunology, Institute of Medical Biology, CAMS and PUMC, Kunming 650118, China These authors contributed equally to this work | 2007 | Science China(Life Sciences)2007，50，4： | 2 |
| 9 | 急性心肌梗塞溶栓治疗梗塞相关冠状动脉再通对长期预后的影响(1267例长期随诊)显示文摘 | ColaborativeResearchGroupofNationalProject85-915-02-01(Correspon-dence:FuWaiHospital CAMS&PUMC Beijing100037) | 1996 | 中华心血管病杂志1996，，03： | 1 |
| 10 | 中国心脏研究:卡托普利对急性心肌梗塞患者早期病死率和并发症影响的多中心临床试验——全国大规模随机双盲安慰剂对照临床试验14962例资料总结显示文摘 | Chinese Cardiac Study 1 (CCS 1) Collaborative Group (correspondence: Liu Lisheng Wang Wen Tao Shouqi. Fu Wai Hospital CAMS and PUMC Beijing 100037) | 1997 | 中华心血管病杂志1997，，04： | 1 |
| 11 | Screening and genetic analysis of fragile X syndrome in Tongling Anhui province of China显示文摘Objective: To investigate the prevalence of fragile X syndrome in the Chinese. Methods: Fragile X syndrome was screened from 172,600 people living in Tongling city, Anhui province. Suspected | SHEN Yan, et al. Basic Med Sci Instit, CAMS & PUMC, Beijing, 100005. | 1997 | China Medical Abstracts(Internal Medicine)1997，14，2： | 1 |
| 12 | 急性心肌梗塞溶栓治疗梗塞相关冠状动脉再通对长期预后的影响(1267例长期随诊)显示文摘 | ColaborativeResearchGroupofNationalProject85-915-02-01(Correspon-dence:FuWaiHospital CAMS&PUMC Beijing100037) | 1996 | 中华心血管病杂志1996，，03： | 1 |
| 13 | 急性心肌梗塞溶栓治疗梗塞相关冠状动脉再通对长期预后的影响(1267例长期随诊)显示文摘 | ColaborativeResearchGroupofNationalProject85-915-02-01(Correspon-dence:FuWaiHospital CAMS&PUMC Beijing100037) | 1996 | 中华心血管病杂志1996，，03： | 1 |
| 14 | 急性心肌梗塞溶栓治疗梗塞相关冠状动脉再通对急性期预后的影响(1138例观察分析)显示文摘 | ColaborativeResearchGroupofNationalProject85-915-02-01(Corespondance:FuWaiHospital CAMS&PUMC Beijing100037) | 1996 | 中华心血管病杂志1996，，03： | 1 |
| 15 | THE ROLE OF INTRONIC HSE IN THE HEAT SHOCK INDUCED EXPRESSION OF HUMAN hsp 90β GENE | Wang Xiaozhe, Wang Yanlin, Liu Juhong , Wu Ninghua and Shen Yufei (沈) National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005 | 1998 | Chinese Medical Sciences Journal1998，13，4： | 1 |
| 16 | Measurement of Cardiac Reserve in Rat by Impedance Cardiography显示文摘 | Zhu Longkun Qi Baoshen Deng Xikian(Institue of Basic Medical Sciences,PUMC & CAMC,Beijing 100005,China)(Department of Phyiology Fuian Medical College,FuZhou 350004,China) | 1999 | Chinese Journal of Biomedical Engineering(English Edition)1999，8，3： | 1 |
| 17 | 中国心脏研究:卡托普利对急性心肌梗塞患者早期病死率和并发症影响的多中心临床试验——全国大规模随机双盲安慰剂对照临床试验14962例资料总结显示文摘 | Chinese Cardiac Study 1 (CCS 1) Collaborative Group (correspondence: Liu Lisheng Wang Wen Tao Shouqi. Fu Wai Hospital CAMS and PUMC Beijing 100037) | 1997 | 中华心血管病杂志1997，，04： | 1 |
| 18 | An Improved Multi-functional Electrolytic Treatment Unit and Its Clinical Application显示文摘This paper will introduce the system constructions and new features of animproved potable multi-functional electrolytic treatment unit and its preliminaryapplications in the dermatology and ophthalmology. | Wang Jianming Wang Baoming Peng Yi Lin Jinsen(Institute of Basic Medical Sciences, CAMS, PUMC, Beijing 100005)(Division of Dermatology, Peking Union Hospital, CAMS, PUMC, Beijing 100005) | 1999 | Chinese Journal of Biomedical Engineering(English Edition)1999，8，4： | 0 |
| 19 | THE HEMODYNAMIC EFFECTS OF THE DOUBLE CHAMBER INTRA-AORTIC BALLOON PUMPING显示文摘Our experimental results showed that the effect of the double chamber intra-aortic balloon pumping was better than that of single chamber intraaortic balloon pumping. It significantly improved the hemodynamic parameters andimproved the efficiency of the counterpulsation. The result is consistent with the design of the computer simulation. | Songfang Lu Yi Peng Yusheng Bao Chunren Wang Xiaojun Yu Hua Kong Zibin Yang(Institute of Basic Medical Sciences,CAMS and PUMC,Beijing 100005,China) | 1998 | Chinese Journal of Biomedical Engineering(English Edition)1998，7，2： | 0 |
| 20 | Effects on the renal artery blood flow during the intra-aortic balloonpumping was used显示文摘The effects of intra-aortic balloon pumping(IABP) on hemodynamic parameters inthe kidney were studied. The pulse produced by pumping activated the renal nervoussystem and reduced the renal vascular resistance. Therefore, the reduction of the renalvascular resistance is an important reason for the increase the renal blood flow duringintra-aortic balloon pumping. | Songfang Lu Yusheng Bao Yi Peng Chunren Wang Zibin Yang(Institute of Basic Medical Sciences, PUMC & CAMS, Beijing 100005, China) | 1998 | Chinese Journal of Biomedical Engineering(English Edition)1998，7，3： | 0 |
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