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| 1 | Over expression of resistin in adipose tissue of the obese induces insulin resistance显示文摘AIM: To compare resistin mRNA expression in subcutaneous adipose tissue (SAT) and its correlation with insulin resistance (IR) in postmenopausal obese women. METHODS: A total of 68 postmenopausal women (non obese = 34 and obese = 34) were enrolled for the study. The women of the two groups were age matched (49-70 years). Fasting blood samples were collected at admission and abdominal SAT was obtained during surgery for gall bladder stones or hysterectomy. Physical parameters [age, height, weight, body mass index (BMI)] were measured. Biochemical (plasma insulin and plasma glucose) parameters were estimated by enzymatic methods. RNA was isolated by the Trizol method.SAT resistin mRNA expression was done by real time- reverse transcription polymerase chain reaction (RT-PCR) by using Quanti Tect SYBR Green RT-PCR master mix. Data was analyzed using independent Student's t test, correlation and simple linear regression analysis. RESULTS: The mean weight (52.81 ± 8.04 kg vs 79.56 ± 9.91 kg; P < 0.001), BMI (20.23 ± 3.05 kg/m 2 vs 32.19 ± 4.86 kg/m 2 ; P < 0.001), insulin (8.47 ± 3.24 U/mL vs 14.67 ± 2.18 U/mL; P < 0.001), glucose (97.44 ± 11.31 mg/dL vs 109.67 ± 8.02 mg/dL; P < 0.001) and homeostasis model assessment index (2.01 ± 0.73 vs 3.96 ± 0.61; P < 0.001) were significantly higher in postmenopausal obese women compared to postmenopausal non obese women. The mean serum resistin level was also significantly higher in postmeno-pausal obese women compared to postmenopausal non obese women (9.05 ± 5.15 vs 13.92 ± 6.32, P < 0.001). Furthermore, the mean SAT resistin mRNA expression was also significantly (0.023 ± 0.008 vs 0.036 ± 0.009; P < 0.001) higher and over expressed 1.62 fold (upregulated) in postmenopausal obese women compared to postmenopausal non obese women. In postmeno-pausal obese women, the relative SAT resistin mRNA expression showed positive (direct) and significant correlation with BMI (r = 0.78, P < 0.001) and serum resistin (r = 0.76, P < 0.001). Furthermore, the SAT resistin mRNA expression in postmenopausal obese women also showed significant and direct association (r = 0.45, P < 0.01) with IR, while in postmenopausal non obese women it did not show any association (r = -0.04, P > 0.05). CONCLUSION: Increased SAT resistin mRNA expres-sion probably leads to inducing insulin resistance and thus may be associated with obesity-related disorders in postmenopausal obese women. | Sadashiv Sunita Tiwari S Dhananjai Bhola N Paul Sandeep Kumar Abhijit Chandra Mahendra PS Negi | 2012 | World Journal of Diabetes2012，3，7： | 10 |
| 2 | Antioxidant, an-timutagenic and antibacterial activities of curcumin-p-diglucoside显示文摘 | Parvathy KS Negi PS Srinivas P | 2009 | Food Chem2009，115，1： | 1 |
| 3 | Cordyceps sinensis promotes exercise endurance capacity of rats by activating skeletal muscle metabolic regulators显示文摘 | Kumar R Negi PS Singh B | 2011 | Juurnal of Ethnopharmacology2011，136，： | 1 |
| 4 | Antioxidant, antimutagenic and antibacterial activities of curcumin - - diglucoside 显示文摘 | Parvathy KS Negi PS Srinivas P | 2009 | Food Chemistry2009，115，： | 1 |
| 5 | Antioxidant, antimuta genic and antibacterial activities of curcumin-- diglucoside 显示文摘 | Parvathy K S Negi PS Srinivas P | 2009 | Food Chemistry2009，115，： | 1 |
| 6 | Synthesis of quinoline derivatives of tetrahydrocurcumin and zingerone and evaluation of their antioxidant and anti bacterial attributes显示文摘 | Manjunatha JR Bettadaiah BK Negi PS | 2013 | Food Chem2013，136，2： | 1 |
| 7 | Plant extracts for the control of bacterial growth: Effi- cacy, stability and safety issues for food application显示文摘 | Negi PS | 2012 | Int J Food Microbiol2012，156，1： | 1 |
| 8 | Antioxidant and antibacterial activities of various seabuckthorn (Hippophaerhamnoides L) seed extracts显示文摘 | PS Negi AS Chauhan GA Sadia | 2005 | Food Chemistry2005，92，： | 1 |
| 9 | Antioxidant and antimutagenic activities of pomegranate peel extracts显示文摘 | Negi PS Jayaprakasha GK Jena BS | 2003 | Food Chemistry2003，80，3： | 1 |
| 10 | Evaluation of antioxidant activities and antimutagenicity of turmeric oil:a byproduct from curcumin production显示文摘 | Jayaprakasha GK Jena BS Negi PS etal | 2002 | Z Naturforsch2002，57，910： | 1 |
| 11 | Synthesis of quino- line derivatives of tetrahydrocurcumin and zingerone and evaluation of their antioxidant and antibacterial attributes 显示文摘 | Manjunatha JR Bettadaiah BK Negi PS | 2013 | Food Chemis- try2013，136，2： | 1 |
| 12 | Antioxidant and antimutagenic activities of pomegranate peel extracts 显示文摘 | Negi PS Jayaprakasha GK Jena BS | 2003 | Food C hem2003，80，： | 1 |
| 13 | Antioxidant and antibacterial ac tivities of puniea granatum peel extracts显示文摘 | Negi PS Jayaprakasha GK | 2003 | J Food Sci2003，68，4： | 1 |
| 14 | Cordyceps sinensis promotes exercise endurance capacity of rats by activating skeletal muscle metabolic regulators显示文摘 | Kumar R Negi PS Singh B Ilavazhagan G Bhargava K Sethy NK | 2011 | J Ethnopharmacol2011，136，1： | 1 |
| 15 | Antioxidant and anti- mutagenic activities of pomegranate peel extracts显示文摘 | Negi PS Jayaprakasha GK Jena BS | 2003 | Food Chem2003，80，： | 1 |
| 16 | Cordyceps sinensis promotes exercise endurance capacity of rats by activating skeletal muscle metabolic regulators 显示文摘 | Kumar R Negi PS Singh B | 2011 | J Ethnopharmacol2011，136，1： | 1 |
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