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您的检索式：作者名="PROBODH GHOSH"
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| 1 | In Vivo and in Vitro Acetylcholinesterase Inhibition by Metacid-50 and Carbaryl in Channa punctatus under Natural Field Condition显示文摘Channa punctatus(Bloch),cultiveated under paddy-cum-fish culture programs,was exposed to non-lethal levels of 0.239 ppb of Metacid-50 and 3.73 ppm of Carbary for 7 days in the field.These insecticides effected significant inhibition of brain acetylcholinesterase(AChE) activity accompaniced by a concurrent increase in acetylcholine(ACh),In vitro inhibition of brain acetylcholinesterase was also compared between unexposed and pesticide exposed fish.Data revealed that the time taken for 50% inhibition(t0.5)of the enzyme was less in the pesticide exposed fish as compared to that of the unexposed fish.This indicates a preformed effect of the test pesticides on fish brain AChE during the in vivo exposure while the in vitro effect is an addivive inhibition of the enzyme caused by the cirulating inhibitors reducing the t0.5.Acetylcholinesterase inhibition may thus be utilized to monitor pesticide pollution in agricultural fields. | PROBODH GHOSH SHELLEY BHATTACHARYA | 1992 | Biomedical and Environmental Sciences1992，5，1： | 1 |
| 2 | Acetylcholinesterase Characteristics of Termite Queen Exposed to Anticholinesterase Compounds显示文摘A regional profile of AChE activity was noted in the Indian termite queen Odontotermes redemanni with the head recording the higher and body the lower range o activity.The enzyme characteristics suh as substrate and temperature optima were more or less similar while pH requirement for optimum AChE activity varied from 7.0 to 7.6In vitro inhibition of head and body AChE was studied using pure and commercial anticholinesterase compounds.Interestingly,the commercial formulations like Metacid-50 and Carbaryl are potent enough at 1×10^-8M to produce 50% in vitro inhibition of AChE of head and body regions within 15 min of preincubation.A 20 min or preincubation(t0.5)was necessary to record 50% in vitro inhibition of AChE with known and pure anticholinesterase compounds such as DFP(3.5×10^-10M) and physostigmine(3.6×10^-10M).It is surmised that (a)the response of the head and body AChE tp the commercial formulations of the insecticides may be used as a reliable and sensitive biolindicator of pesticidal contamination of the terrestrial environment and (b)termite control may be successfully done with the application of organophosphate or carbamate compounds. | SHELLEY BHATTACHARYA PROBODH GHOSH SHAMPA GHOSH NINA GHOSH B.BHATTACHARYA P.HALDER | 1992 | Biomedical and Environmental Sciences1992，5，2： | 0 |
| 3 | Time Dependent Tissue Distribution of ^(203)Hg in the White Rat and Anabas testudineus, a Freshwater Teleost显示文摘The distribution of mercury,an environmentally important toxicant,has been evaluated in a time dependent manner i different tissues of white rat and a freshwater teleost.Anabas testudineus.Sampling was performed at 15min,2,6and 48h post injection(im)of ^203Hg mercuric nitrate.Radioactivity of the 5% tissue homogenate,serum and bile was measured in a Gamma Counter.The rate of ^203Hg accumulation is higher in fish immediately after administration which,however,is more or less of equal rate in the later period of observation in both the experimental animals.Partitioning of ^203Hg occurs in a species specific manner with higher levels recorded in the brain and gonad or white rat.Spleen,liver and kidney,however,are the major tissues to accumulate mercury in both the species.The present study highlights that kidney is the target site of mercury retention with a higher kidney/liver ration of mercury. | SHAMBHUNATH BOSE PROBODH GHOSH SHAMPA GHOSH SHIBANI CHAUDHURY SHELLEY BHATTACHARYA | 1992 | Biomedical and Environmental Sciences1992，5，4： | 0 |
| 4 | Impairment of the Regulation of Gonadal Function in Channa punctatus by Metacid-50 and Carbaryl under Laboratory and Field Conditions显示文摘Regulation of gonadal function by gonadotropic hormone (GtH) and gonadotropin-releasing hormone (GnRH) in Channa punctatus was significantly affected by nonlethal levels of Metacid-50 and Carbaryl. Under laboratory conditions, the time-dependent decrease in serum GtH level was higher in Carbaryl-treated fish than in Metacid-50-treated fish. The situation was reversed in the field, with a higher inhibitory effect of Metacid-50 being recorded. On the other hand, pituitary GtH content and GnRH activity were inhibited to a greater extent by Metacid-50 than by Carbaryl under both field and laboratory conditions. The present findings highlight that even low doses of Metacid-50 and Carbaryl are effective enough to cause reproductive damage, as evidenced by homeostatic unbalance of the reproductive regulatory system. 1990 Academic Press. Inc. | PROBODH GHOSH SAMIR BHATTACHARYA SHELLEY BHATTACHARYA | 1990 | Biomedical and Environmental Sciences1990，3，1： | 0 |
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